P066: Lower serum concentration of sulfated bile acids is associated with Primary Sclerosing Cholangitis Inflammatory Bowel Disease comorbidity and advanced liver fibrosisECCO'22Year: 2022
Authors: Leibovitzh, H.(1);Nayeri, S.(2);Borowski, K.(2);Hernandez-Rocha, C.(1);Lee, S.H.(1);Turpin, W.(1);Stempak, J.(2);Sandhu, I.(2);Milgrom, R.(2);Smith, M.I.(2);Croitoru, K.(1);Hirschfield, G.M.(3);Gulamhusein, A.(3);Silverberg, M.S.(1);
(1)Zane Cohen Centre for Digestive Diseases- Mount Sinai Hospital, Division of Gastroenterology & Hepatology- Temerty Faculty of Medicine- University of Toronto, Toronto, Canada;(2)Zane Cohen Centre for Digestive Diseases- Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute- Sinai Health System, Toronto, Canada;(3)University of Toronto, Toronto Centre for Liver Disease- Division of Gastroenterology and Hepatology, Toronto, Canada;
P067: Human intestinal CD103+SIRPα+ conventional dendritic cells from patients with Crohn´s disease prime IL-17+ T-cells.ECCO'22Year: 2022
Authors: Bernardo, D.(1,2);Arribas-Rodriguez, E.(1);De Castro, C.G.(1);Fiz-Lopez, A.(1);De Prado, A.(1,3);Fernandez-Salazar, L.(4);Barrio, J.(3);Izquierdo, S.(4);Garcia-Alonso, J.(3);De Andres, B.(5);Garcia-Abril, J.M.(6);Romero, A.(5);Sanchez-Gonzalez, J.(6);Garrote, J.A.(1);Arranz, E.(1);
(1)Universidad de Valladolid, Instituto de Biomedicina y Genética Molecular, Valladolid, Spain;(2)Centro de Investigaciones Biomédicas en Red, Enfermedades Hepáticas y Digestivas CIBERehd, Madrid, Spain;(3)Hospital Universitario Río Hortega. Valladolid, Servicio de Gastroenterología, Valladolid, Spain;(4)Hospital Clínico Universitario. Valladolid. Spain, Servicio de Gastroenterología, Valladolid, Spain;(5)Hospital Clinico Universitario. Valladolid, Servicio de Cirugía General y del Aparato Digestivo, Vallasolid, Spain;(6)Hospital Universitario Río Hortega. Valladolid, Servicio de Cirugía, Valladolid, Spain;
P068: Discovery of IBD3540: A Novel Gut-Restricted Glutamate Carboxypeptidase II Inhibitor with Preclinical Anti-Colitis ActivityECCO'22Year: 2022
Authors: Peters, D.(1);Norris, L.(2);Tenora, L.(3);Snajdr, I.(3);Zhu, X.(4);Sakamoto, S.(4);Veeravalli, V.(2);Thomas, A.(2);Majer, P.(3);Rais, R.(2);Slusher, B.(2);
(1)Johns Hopkins University School of Medicine, Pharmacology and Molecular Sciences, Baltimore, United States;(2)Johns Hopkins University School of Medicine, Johns Hopkins Drug Discovery, Baltimore, United States;(3)Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic;(4)Johns Hopkins University School of Medicine, Psychiatry, Baltimore, United States;
P069: Design and delivery of anti-oxidant inorganic complexes mimicking the superoxide dismutase for inflammatory bowel diseases treatment.ECCO'22Year: 2022
Authors: Schanne, G.(1);Zoumpoulaki, M.(2);Demignot, S.(3);Delsuc, N.(2);Policar, C.(2);Seksik, P.(3);
(1)Sorbonne University, Saint Antoine Research Center, Paris, France;(2)Ecole Normale Supérieure, Department of chemistry, Paris, France;(3)INSERM, Saint Antoine Research Center, Paris, France;
P070: Novel long-acting lipidated interleukin-22 normalises colonic inflammation in an acute DSS colitis modelECCO'22Year: 2022
Authors: Van De Bunt, M.(1);Norrild, J.C.(2);Sass-Ørum, K.(3);Kjølbye, A.L.(1);Jorgensen, R.(1);
(1)Cytoki Pharma, Research & Development, Copenhagen, Denmark;(2)Cytoki Pharma, CMC and Quality, Copenhagen, Denmark;(3)Novo Nordisk A/S, Global Research Technologies, Copenhagen, Denmark;
P071: Intestinal CD8+ T cell exhaustion is linked to disease activity in ulcerative colitisECCO'22Year: 2022
Authors: Grigorian, M.(1);Salié, H.(1);Mayer, L.S.(1);Globig, A.M.(1);Hockenjos, B.(1);Krimmel, L.(1);Thimme, R.(1);Bengsch, B.(1);Hasselblatt, P.(1);
(1)Freiburg University Hospital, Department of Medicine II, Freiburg, Germany;
P072: Melanocortin MC3 and MC5 receptors expression is different according to colonic disease activity in Crohn’s Disease and Ulcerative Colitis biopsies: results from an immunohistochemical observational study.ECCO'22Year: 2022
Authors: GravinaMD, A.G.(1);Panarese, I.(2);Trotta, M.C.(3);D'Amico, M.(3);Pellegrino, R.(1);Ferraraccio, F.(2);Galdiero, M.(3);Alfano, R.(4);Loguercio, C.(1);Romano, M.(1);Grieco, P.(5);Federico, A.(1);
(1)University of Campania @Luigi Vanvitelli@, Precision Medicine, Naples, Italy;(2)University of Campania @Luigi Vanvitelli@, Mental and Physical Health and Preventive Medicine, Naples, Italy;(3)University of Campania @Luigi Vanvitelli@, Experimental Medicine- Division of Pharmacology, Naples, Italy;(4)University of Campania @Luigi Vanvitelli@, Advanced Medical and Surgical Sciences DAMSS, Naples, Italy;(5)University of Naples @Federico II@, Pharmacy Department, Naples, Italy;
P073: Eosinophil depletion partially protects from colonic inflammation, but increases colonic collagen deposition in a DSS colitis modelECCO'22Year: 2022
Authors: Jacobs, I.(1);Deleu, S.(2);Cremer, J.(1,2);Guedelha Sabino, J.(2,3);Ferrante, M.(2,3);Vermeire, S.(2,3);Breynaert, C.(1,4);Verstockt, B.(2,3);Vanuytsel, T.(2,3);
(1)KU Leuven, Microbiology- Immunology and transplantation, Leuven, Belgium;(2)KU Leuven, Chronic diseases and metabolism, Leuven, Belgium;(3)University Hostpitals Leuven, Gastroenterology and Hepatology, Leuven, Belgium;(4)University Hostpitals Leuven, General Internal Medicine, Leuven, Belgium;
P074: SZN-1326 promotes colonic mucosal healing in an acute injury model of IBD by first accelerating epithelial regeneration and secondarily reducing inflammationECCO'22Year: 2022
Authors: Fletcher, R.(1);Xie, L.(2);Phipps, J.(1);Sanman, L.(1);Deshmukh, S.(1);Shah, D.(1);Hill, N.(1);Liu, A.(2);Gupta, S.(3);Sura, A.(3);Chen, H.(3);Ye, J.(3);Yeh, W.C.(2);Li, Y.(1);Lu, C.(1);
(1)Surrozen- Inc., Discovery Biology, South San Francisco, United States;(2)Surrozen- Inc., In Vivo Pharmacology, South San Francisco, United States;(3)Surrozen- Inc., Protein Sciences, South San Francisco, United States;
P075: Neutrophils prevent rectal bleeding in Ulcerative Colitis by peptidyl-arginine deiminase-4-dependent immunothrombosisECCO'22Year: 2022
Authors: Leppkes, M.(1);Lindemann, A.(1);Gößwein, S.(1);Paulus, S.(1);Roth, D.(1);Hartung, A.(1);Liebing, E.(1);Zundler, S.(1);Acera, M.G.(1);Patankar, J.V.(1);Mascia, F.(1);Scheibe, K.(1);Hoffmann, M.(2);Uderhardt, S.(2);Schauer, C.(2);Foersch, S.(3);Neufert, C.(1);Vieth, M.(4);Schett, G.(2);Atreya, R.(1);Kühl, A.A.(5);Bleich, A.(6);Becker, C.(1);Herrmann, M.(2);Neurath, M.F.(1);
(1)Universitätskliniken Erlangen, Medizin 1, Erlangen, Germany;(2)Universitätskliniken Erlangen, Medizin 3, Erlangen, Germany;(3)Universitätsmedizin Mainz, Institut für Pathologie, Mainz, Germany;(4)Friedrich-Alexander University of Erlangen-Nürnberg, Institute of Pathology- Klinikum Bayreuth, Erlangen, Germany;(5)Charité, Universitätsmedizin Berlin, Berlin, Germany;(6)Medizinische Hochschule Hannover, Institut für Versuchstierkunde, Hannover, Germany;
P076: Patients with Inflammatory Bowel Disease show IgG immune responses towards disease-associated small intestinal bacteriaECCO'22Year: 2022
Authors: Bourgonje, A.R.(1);Roo-Brand, G.(2);Lisotto, P.(2);Sadaghian Sadabad, M.(2);Reitsema, R.D.(3);de Goffau, M.C.(4);Faber, K.N.(1);Dijkstra, G.(1);Harmsen, H.J.M.(2);
(1)University of Groningen- University Medical Center Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(2)University of Groningen- University Medical Center Groningen, Medical Microbiology, Groningen, The Netherlands;(3)University of Groningen- University Medical Center Groningen, Rheumatology and Clinical Immunology, Groningen, The Netherlands;(4)Amsterdam University Medical Center- University of Amsterdam, Vascular Medicine, Amsterdam, The Netherlands;
P077: Different granulocyte subsets are involved in the pathogenesis in Crohn’s disease fistulaECCO'22Year: 2022
Authors: Beckerdrs., M.(1);Koelink, P.(1);de Krijger, M.(1);Bemelman, W.(2);de Jonge, W.(1);Buskens, C.(2);Wildenberg, M.(1);
(1)Tytgat Institute for Liver and Intestinal Research, Gastroenterology, Amsterdam, The Netherlands;(2)Amsterdam UMC, Surgery, Amsterdam, The Netherlands;DigeST
P078: Vedolizumab Treatment of ex-vivo Human Ulcerative Colitis (UC) Explants Results in Altered Inflammatory Protein Secretion ProfilesECCO'22Year: 2022
Authors: Corcoran, R.(1);O'Connell, F.(2);O'Sullivan, J.(2);Kevans, D.(1);
(1)St James’s Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity Translational Medicine Institute- Trinity College Dublin, Department of Surgery- Trinity College Dublin- St James’s Hospital- Dublin 8- Ireland, Dublin, Ireland;
P081: Therapeutic Drug Monitoring of infliximab in Crohn’s Disease: Cut-off points during maintenance therapy.ECCO'22Year: 2022
Authors: Valdes, T.(1);Vilches Arenas, A.(2);Maldonado Perez, B.(1);Castro Laria, L.(1);Merino Bohorquez, V.(3);Argüelles Arias, F.(1);
(1)University Hospital Virgen Macarena, Gastroenterology Department, Sevilla, Spain;(2)University Hospital Virgen Macarena, Preventive Medicine, Sevilla, Spain;(3)University Hospital Virgen Macarena, Pharmacy Department, Sevilla, Spain;
P082: The profibrogenic role of neutrophil extracellular traps in stenotic Crohn's disease: a new antifibrotic target?ECCO'22Year: 2022
Authors: Dragoni, G.(1,2);Ke, B.J.(3);Verstockt, B.(3,4);Abdurahiman, S.(3);Innocenti, T.(1,2);Giudici, F.(5);De Hertogh, G.(6);Milla, M.(1);Bagnoli, S.(1);Picariello, L.(2);Galli, A.(1,2);Matteoli, G.(3);Vermeire, S.(3,4);
(1)Careggi University Hospital, Department of Gastroenterology, Firenze, Italy;(2)University of Florence, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, Firenze, Italy;(3)KU Leuven, Department of Chronic Diseases- Metabolism and Ageing CHROMETA, Leuven, Belgium;(4)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(5)University of Florence, Department of Clinical and Experimental Medicine- Surgical Unit, Firenze, Italy;(6)KU Leuven, Department of Imaging and Pathology- Translational Cell & Tissue Research, Leuven, Belgium;
P083: An integrative analysis of DNA methylation and RNA-Seq data in human adipose-stem cells of Crohn’s Disease patients with different clinical activityECCO'22Year: 2022
Authors: Serena, C.(1);Montfort-Ferré, D.(1);Caro, A.(2);Menacho, M.(3);Espina, B.(2);Boronat-Toscano, A.(1);Martí, M.(4);Espín, E.(4);Millán, M.(5);Vendrell, J.(1);Fernández-Veledo, S.(1);
(1)Health Institute Pere Virgili IISPV, Hospital Joan XXIII of Tarragona, Tarragona, Spain;(2)Hospital Universitari Joan XXIII of Tarragona, Surgery Service, Tarragona, Spain;(3)Hospital Universitari Joan XXIII of Tarragona, Gastroenterology Service, Tarragona, Spain;(4)Hospital Univeristari Vall Hebrón, Surgery Service, Barcelona, Spain;(5)Hospital La Fe, Surgery Service, Valencia, Spain;
P084: Secreted inflammatory protein profiles following treatment of ex-vivo human Ulcerative Colitis and Crohn’s Disease explants with licenced biologic therapiesECCO'22Year: 2022
Authors: Corcoran, R.(1);O'Connell, F.(2);O'Sullivan, J.(2);Kevans, D.(1);
(1)St James’s Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity Translational Medicine Institute- Trinity College Dublin- Ireland, Department of Surgery, Dublin, Ireland;
P085: Paneth cells translate dietary lipid exposure into gut inflammationECCO'22Year: 2022
Authors: Grabherr, F.(1);Meyer, M.(1);Schmitz, J.J.(1);Schwärzler, J.(1);Mayr, L.(1);Philipp, M.(1);Jukic, A.(1);Grander, C.(1);Tilg, H.(1);Adolph, T.E.(1);
(1)Medizinische Universität Innsbruck, Innere Medizin 1 - Gastroenterologie- Hepatologie und Endokrinologie, Innsbruck, Austria;
