P046: Effects of CB2 and TRPV1 stimulation on osteoclast overactivity induced by iron in pediatric inflammatory bowel diseaseECCO'22Year: 2022
Authors: Strisciuglio, C.(1);Tortora, C.(1);Di Paola, A.(2);Creoli, M.(2);Cenni, S.(3);Argenziano, M.(1);Martinelli, M.(3);Miele, E.(3);Rossi, F.(1);
(1)Department of pediatrics- University of Campania @Vanvitelli@, Department of Woman- Child and General and Specialist Surgery, Naples, Italy;(2)University of Campania “Luigi Vanvitelli”, Department of Experimental Medicine, Naples, Italy;(3)University of Naples @Federico II@, Department of Translational Medical Science- Section of Pediatrics, Naples, Italy;
P047: Effect of infliximab and vedolizumab on M1 and M2 macrophages derived from THP-1 cells.ECCO'22Year: 2022
Authors: Notararigo, S.(1);Viñuela-Roldán, J.(1);Zurita-Gonzalez, M.J.(1);Dominguez Medina, E.(2);Dominguez-Munos, J.E.(1);Barreiro-de Acosta, M.(1);
(1)Fundacion IDIS, Digestive, Santiago de Compostela, Spain;(2)Fundacion IDIS, BioPharma, Santiago de Compostela, Spain;Fundación IDIS Complejo Hospitalario Santiago de Compostela A Coruña 15706 Spain
P048: Bridging the Gap Between Body and Soul: A Pilot Study Examining Inflammation and Depression / Anxiety in Inflammatory Bowel Disease PatientsECCO'22Year: 2022
Authors: Mekori - Domachevsky, E..(1);Avinir, A.(2);Dar, S.(3);Haj, O.(1);Ben - Horin, S.(1);Gothelf, D.(4);Kopylov, U.(1);Taler, M.(3);
(1)Sheba Medical Center, Gastroenterology Department, Ramat Gan, Israel;(2)Sheba Medical Center, Child and Adolescent Psychiatry Clinic, Ramat Gan, Israel;(3)Sheba Medical Center, Laboratory of Pediatric Molecular Psychiatry, Ramat Gan, Israel;(4)Sheba Medical Center, Child and Adolescent Psychiatry Division, Ramat Gan, Israel;
P049: The treatment effect of tonsil-derived mesenchymal stem cells (T-MSCs) via regulating programmed death-1/programmed death ligand-1 (PD-1/PD-L1) in ulcerative colitisECCO'22Year: 2022
Authors: Song, E.M.(1);Joo, Y.H.(1);Park, Y.(1);Choe, A.R.(1);Tae, C.H.(1);Moon, C.M.(1);Kim, S.E.(1);Jung, H.K.(1);Shim, K.N.(1);Jung, S.A.(1);
(1)EWHA Womans University- School of Medicine, Department of Internal Medicine- Department of Gastroenterology, Seoul, Korea- Republic Of;
P050: A comparison of the Gut Microbiota in Pregnant Women with and without Inflammatory Bowel Disease and Their Offspring in Hong Kong and United StatesECCO'22Year: 2022
Authors: Hu, J.(1);Agrawal, M.(2);Tarassishin, L.(1);Rendon, A.(1);Picker, M.(1);Kalash, O.(1);Eisele, C.(1);Ching, J.Y.(3);Wong, A.(3);Zhan, H.(3);Ng, S.C.(3);Colombel, J.F.(2);Peter, I.(1);
(1)Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York City, United States;(2)Icahn School of Medicine at Mount Sinai, The Henry D. Janowitz Division of Gastroenterology- Department of Medicine, New York City, United States;(3)The Chinese University of Hong Kong, Department of Medicine and Therapeutics- Microbiota I-Center MagIC, Hong Kong, China;
P051: IFNγ-macrophages could mediate EMT in Crohn’s disease through the WNT pathwayECCO'22Year: 2022
Authors: Edo, M.M.(1);Macias-Ceja, D.C.(2);Bauset, C.(2);Lis-Lopez, L.(2);Coll, S.(2);Seco-Cervera, M.(3);Cosin-Roger, J.(3);Calatayud, S.(2);Barrachina, M.D.(2);Ortiz-Masiá, D.(1);
(1)Universitat de Valencia, Medicine, Valencia, Spain;(2)Universitat de Valencia, Pharmacology, Valencia, Spain;(3)FISABIO, Pharmacology, Valencia, Spain;
P052: Comparing T cell responses to food antigens in Inflammatory Bowel Disease patients and healthy donorsECCO'22Year: 2022
Authors: Schiffer, A.(1);Tran, F.(4);Sievers, L.K.(2);Kümpers, J.(2);Hinrichsen, H.(3);Seegers, B.(3);Bergfeld, A.(2);Lessing, M.(2);Schreiber, S.(4);Bacher, P.(4);
(1)Christian-Albrechts-University, Institute of Immunology, Kiel, Germany;(2)UKSH Schleswig-Holstein, Department of Internal Medicine I, Kiel, Germany;(3)Gastroenterologisch-Hepatologisches Zentrum, Gastroenterology and Hepatology, Kiel, Germany;(4)Christian-Albrechts-University, Institute of Clinical Molecular Biology, Kiel, Germany;
P053: The intestinal complement system and its role in dysregulation of the intestinal B-cell compartment in Crohn’s Disease patientsECCO'22Year: 2022
Authors: Raschdorf, A.(1);Preisker, S.(1);Brethack, A.K.(1);Bokemeyer, A.(2);Bettenworth, D.(2,3);Sina, C.(1,4);Derer, S.(1);
(1)Institute of Nutritional Medicine-UKSH Lübeck, Molecular Gastroenterology, Lübeck, Germany;(2)Department of Medicine B-University Hospital Münster, Gastroenterology and Hepatology, Münster, Germany;(3)Practice of Internal Medicine Münster, IBD focus, Münster, Germany;(4)1st Department of Medicine-UKSH Lübeck, Section of Nutritional Medicine, Lübeck, Germany;
P054: LHFPL3-AS2 long non-coding (lncRNA) is reduced in mucosal biopsies of Crohn Disease, and its reduction in tissue culture disrupts epithelial polarityECCO'22Year: 2022
Authors: Sosnovski, K.(1);BenShoShan , M.(2);Braun , T.(3);Barshack , I.(4);Denson , L.(5);Haberman , Y.(6);
(1)Tel-Aviv University, Sackler, Tel-Aviv, Israel;(2)Tel-Aviv, Sackler, Tel-Aviv, Israel;(3)Sheba Medical Centre, Gastroenterology, Ramat-Gan, Israel;(4)Sheba Medical Center, Pathology, Ramat-Gan, Israel;(5)Cincinnati Children’s Hospital, Gastroenterology, Cincinnati, United States;(6)Sheba Medical Center, Gastroenterology, Ramat-Gan, Israel;
P056: Local nanocarrier delivery of JAK1 siRNA for IBD treatment: an in vivo mouse modelECCO'22Year: 2022
Authors: Garrido Trigo, A.(1);Veny, M.(1);Dotti, I.(1);Esteller, M.(1);Sulpice, E.(2);Jary, D.(3);Clément, F.(4);Gidrol, X.(2);Navarro, F.(3);Salas, A.(1);
(1)IDIBAPS, Inflammatory bowel disease group, Barcelona, Spain;(2)University of Grenoble Alpes- CEA- INSERM- IRIG-BGE, UGA/Biomics, Grenoble, France;(3)University of Grenoble Alpes- CEA- LETI, Microfluidic Systems and Bioengineering, Grenoble, France;(4)Institute for Advanced Biosciences, Inserm, La Tronche, France;
P057: Mucosal microbiota adapts to ATF6-induced alterations in host lipid metabolism with prognostic value in colorectal cancerECCO'22Year: 2022
Authors: Bierwirth, S.(1);Sorbie, A.(1);Coleman, O.(1);Reuß , E.(1);Weber, P.(2);Köhler, N.(3);Kacprowski, T.(3);Dunkel, A.(4);Pauling, J.(3);Ecker, J.(5);Baumbach, J.(3);Rosenstiel, P.(6);Steiger, K.(7);Wirbel, J.(8);Zeller, G.(8);Janssen, K.P.(9);Haller, D.(1,10);
(1)Technical University of Munich, Chair of Nutrition and Immunology, Freising-Weihenstephan, Germany;(2)University of Southern Denmark, Department of Mathematics and Computer Science IMADA, Odense, Denmark;(3)Technical University of Munich, Chair of Experimental Bioinformatics, Freising-Weihenstephan, Germany;(4)Technical University of Munich, Chair of Food Chemistry and Molecular Sensory Science, Freising-Weihenstephan, Germany;(5)Technical University of Munich, Research Group Lipid Metabolism ZIEL, Freising-Weihenstephan, Germany;(6)University Hospital Schleswig-Holstein and Kiel University, Institute of Clinical Molecular Biology, Kiel, Germany;(7)Technical University of Munich, Institute of Pathology, Munich, Germany;(8)European Molecular Biology Laboratory, Structural and Computational Biology, Heidelberg, Germany;(9)Technical University of Munich, Department of Surgery Klinikum rechts der Isar, Munich, Germany;(10)Technical University of Munich, ZIEL Institute for Food and Health, Freising-Weihenstephan, Germany;
P058: IL-36 signaling in Crohn’s disease – characterization of a patient with an IL36RA mutationECCO'22Year: 2022
Authors: Hecker, J.(1);Letizia, M.(1);Loescher, B.S.(2);Franke, A.(2);Weidinger, C.(1);Siegmund, B.(1);
(1)Charité- Universitätsmedizin Berlin, Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany;
P059: Diet controls segmented filamentous bacteria in driving Crohn’s disease-like inflammation in TNFdeltaARE miceECCO'22Year: 2022
Authors: Metwaly, A.(1);Calasan, J.(1);Waldschmitt, N.(1);Khaloian, S.(1);Häcker, D.(1);Ahmed, M.(1);F. Butto, L.(1); Hammoudi, N.(2); Le Bourhis, L.(2);Mayorgas, A.(3);Siebert, K.(4);Basic, M.(5);Zeissig, S.(6);Schwerd, T.(4);Allez, M.(2);Panes, J.(3);Salas, A.(3); Bleich, A.(5);Cominelli, F.(7);Haller, D.(1);
(1)Technical University Munich, Chair of Nutrition and Immunology, Freising, Germany;(2)APHP- Hôpital Saint Louis-INSERM UMRS 1160- Sorbonne Paris-Cité University, Department of Gastroenterology, Paris, France;(3)Instituto de Investigaciones Biomédicas de Barcelona CSIC- IDIBAPS- CIBERehd, Department of Experimental Pathology, Barcelona, Spain;(4)Dr. von Hauner Children's Hospital- University Hospital- LMU Munich, Department of Pediatrics, Munich, Germany;(5)Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany;(6)University Hospital Dresden- Technische Universität TU Dresden, Department of Medicine, Dresden, Germany;(7)Case Western Reserve University School of Medicine, Digestive Health Research Institute, Clevelad, United States;
P061: Circulating inflammatory protein and cellular profiles at time of diagnosis classify inflammatory bowel disease patients according to their underlying immune response and clinical disease courseECCO'22Year: 2022
Authors: Heredia, M.(1);Charrout, M.(2);Klomberg, R.C.W.(3);Aardoom, M.A.(3);Jongsma, M.M.E.(3);Kemos, P.(4);van Haaften, D.H.(1);Tuk, B.(1);van Berkel, L.A.(1);Bley Folly, B.(1);Mahfouz, A.(2,5);Reinders, M.J.T.(2);Ruemmele, F.(6);Croft, N.(4);Escher, J.C.(3);de Ridder, L.(3);Samsom, J.N.(1);
(1)Erasmus University Medical Center-Sophia Children’s Hospital, Laboratory of Pediatric Gastroenterology, Rotterdam, The Netherlands;(2)Delft University of Technology, Delft Bioinformatics Lab, Delft, The Netherlands;(3)Erasmus University Medical Center-Sophia Children’s Hospital, Pediatric Gastroenterology, Rotterdam, The Netherlands;(4)Blizard Institute- Queen Mary University of London, Centre for Immunobiology, London, United Kingdom;(5)Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands;(6)Hôpital Necker-Enfants Malades- Institut Imagine- AP-HP- Université de Paris, Pediatric Gastroenterology, Paris, France;
P062: 31P MRS and MRI phenotyping of muscle metabolic quality in IBD fatigueECCO'22Year: 2022
Authors: Mcging, J.(1,2);Nicholas, R.(2);Serres, S.(3);Greenhaff, P.(3,4,5);Francis, S.(2);Moran, G.W.(1,5);
(1)University of Nottingham, School of Medicine, Nottingham, United Kingdom;(2)University of Nottingham, Sir Peter Mansfield Imaging Centre, Nottingham, United Kingdom;(3)University of Nottingham, School of Life Sciences, Nottingham, United Kingdom;(4)University of Nottingham, MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Nottingham, United Kingdom;(5)National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, United Kingdom;
P065: Determination of the cytokine pattern of human colon organoids derived from Inflammatory Bowel Disease patientsECCO'22Year: 2022
Authors: Molnár, T.(1,2);Jójárt, B.(1,2,3);Resál , T.(1);Szántó, K.(1);Kata, D.(4);Földesi, I.(4);Molnár, T.(1);Maléth, J.(1,2,3,5);Farkas, K.(1);
(1)University of Szeged, First Department of Medicine, Szeged, Hungary;(2)Hungarian Academy of Science, University of Szeged Momentum Epithelial Cell Signaling and Secretion Research Group, Szeged, Hungary;(3)Hungarian Centre of Excellence of Molecular Medicine, University of Szeged Molecular Gastroenterology Research Group, Szeged, Hungary;(4)University of Szeged, Institute of Laboratory Medicine, Szeged, Hungary;(5)University of Szeged, Department of Public Health, Szeged, Hungary;
