P026: Inflammatory bowel disease does not preclude the presence of environmental enteropathy in Zambian adultsECCO'22Year: 2022
Authors: Hodges, P.(1);Mulenga, C.(2);Banda, R.(2);Kelly, P.(1);
(1)Queen Mary University of London, Blizard Institute- Barts and the London School of Medicine and Dentistry, London, United Kingdom;(2)University of Zambia School of Medicine, Tropical Gastroenterology and Nutrition Group, Lusaka, Zambia;
P027: Effects of anti-TNF and anti-α4β7 drugs on circulating monocytes migratory capacity in inflammatory bowel diseaseECCO'22Year: 2022
Authors: Soleto, I.(1);Fernández-Tomé, S.(2);Mora-Gutiérrez, I.(3);Baldan-Martin, M.(1);Ramirez, C.(1);Santander, C.(1);Moreno-Monteagudo, J.A.(1);Casanova, M.J.(1);Casals, F.(1);Casabona, S.(1);Becerro, I.(1);Chaparro, M.(1);Bernardo, D.(4);Gisbert, J.P.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria IIS-IP and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Unidad de Enfermedad Inflamatoria Intestinal, Madrid, Spain;(2)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria IIS-IP and Departamento de Nutrición y Ciencia de los Alimentos- Facultad de Farmacia- Universidad Complutense de Madrid, Unidad de Enfermedad Inflamatoria Intestinal, Madrid, Spain;(3)Biobanco del sistema de salud de Aragón, Biobanco, Zaragoza, Spain;(4)Mucosal Immunology Lab- Instituto de Biología y Genética Molecular IBGM- Universidad de Valladolid-CISC, Mucosal Immunology, Valladolid, Spain;
P028: Inhibition of stromal glycolysis by targeting PFKFB3 decreases experimental colitisECCO'22Year: 2022
Authors: Zhou, Z.(1);Plug, L.G.(1);de Jonge-Muller, E.S.M.(1);Abou Elmagd , A.(1);van der Meulen-de Jong, A.E.(1);Barnhoorn , M.C.(1);Hawinkels, L.J.A.C.(1);
(1)Leiden University Medical Center, Department of Gastroenterology and Hepatology, Leiden, The Netherlands;
P029: Expression of miR-21 in mucosal biopsies give clues to anti-TNF treatment non-response in IBD children and adultsECCO'22Year: 2022
Authors: Pallikkunnath James, J.(1);Schnack Nielsen, B.(2);Langholz, E.(3,4);Mikkel , M.(5,6,7);Estrid , H.(1);Buhl Riis, L.(8);
(1)Herlev University Hospital, Department of Pathology, 2730- Herlev, Denmark;(2)Bioneer A/S, Molecular histology and detection, 2970 Hørsholm, Denmark;(3)Herlev University Hospital, Gastroenheden D, 2730 Herlev, Denmark;(4)University of Copenhagen, Institute for Clinical Medicine, 2200 Copenhagen, Denmark;(5)Hvidovre Hospital- Universty of Copenhagen, The Pediatric Department, 2650 Hvidovre, Denmark;(6)Hvidovre Hospital- University of Copenhagen, Copenhagen Center for Inflammatory Bowel Disease in Children- Adolescents and Adults, 2650 Hvidovre, Denmark;(7)Holbæk Sygehus, The Pediatric Department, 4300 Holbæk, Denmark;(8)Herlev University Hospital, Department of Pathology-, 2730- Herlev, Denmark;
P030: Distinct molecular profiles between idiopathic cryptoglandular and Crohn-related perianal fistulasECCO'22Year: 2022
Authors: Verstockt., B.(1,2);Verstockt, S.(2);Bislenghi, G.(3);Sabino, J.(1,2);Ferrante, M.(1,2);D'Hoore, A.(3);Vermeire, S.(1,2);
(1)University Hospitals Leuven, Dpt. Gastroenterology and Hepatology, Leuven, Belgium;(2)KU Leuven, Dpt. Chronic Diseases and Metabolism, Leuven, Belgium;(3)University Hospitals Leuven, Dpt. Abdominal Surgery, Leuven, Belgium;
P031: Intestinal lymphoepithelial interactions in Crohn's disease: modeling alphaE-beta7 and NKG2D blockadeECCO'22Year: 2022
Authors: Hammoudi, N.(1);Hamoudi, S.(2);Bonnereau, J.(2);Bottois, H.(2);Perez, K.(2);Bezault, M.(2);Hassid, D.(1);Chardiny, V.(2);Celine, G.(2);Gergaud, B.(2);Bonnet, J.(1);Chedouba, L.(1);Tran Minh, M.L.(1);Gornet, J.M.(1);Baudry, C.(1);Corte, H.(3);Maggiori, L.(3);Toubert, A.(2);McBride, J.(4);Brochier, C.(5);Neighbors, M.(4);Le Bourhis, L.(2);Allez, M.(1);
(1)APHP Saint Louis, Gastroenterology, Paris, France;(2)Inserm, Unit 1160, Paris, France;(3)APHP Saint Louis, Digestive Surgery, Paris, France;(4)Genentech, OMNI Biomarker Development, San Francisco, United States;(5)Roche, Roche, Boulogne-Billancourt, France;
P032: Host transcriptome signatures in human fecal-washes predict histological remission in IBD patientsECCO'22Year: 2022
Authors: Ungar, B.(1);Yavzori, M.(1);Fudim, E.(1);Picard, O.(1);Kopylov, U.(1);Eliakim, R.(1);Shouval, D.(2);Levin, Y.(3);Savidor, A.(3);Ben-Moshe, S.(4);Manco, R.(4);Dan, S.(4);Egozi, A.(4);Bahar Halpern, K.(4);Mayer, C.(5);Barshak, I.(5);Ben-Horin, S.(1);Itzkovitz, S.(4);
(1)Tel-HaShomer Sheba Medical Center, Department of Gastroenterology, Ramat Gan, Israel;(2)Schneider Children’s Medical Center, Gastroentreology- Nutrition and Liver Diseases, Petah Tikva, Israel;(3)The Nancy and Stephen Grand Israel National Center for Personalized Medicine, The De Botton Institute for Protein Profiling, Rehovot, Israel;(4)Weizmann Institute of Science- Rehovot- Israel, Molecular Cell Biology, Rehovot, Israel;(5)Sheba Medical Center Tel Hashomer, Pathology Institute, Ramat Gan, Israel;
P033: Single-cell analysis of gut mucosal- and peripheral blood cells in ulcerative colitis patients undergoing vedolizumab treatmentECCO'22Year: 2022
Authors: Karmi, N.(1);Sun, S.(1);de Jong, S.(1);Bangma, A.(1);Teunis, J.(2);Paraskevopoulou, M.(3);Juarez, J.(3);Bleck, B.(3);Farahmand, S.(3);Weersma, R.(1);Bigaeva, E.(1);Festen, E.(1);
(1)University Medical Center Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(2)University Medical Center Groningen, Flow Cytometry Unit, Groningen, The Netherlands;(3)Takeda Pharmaceuticals, GI Drug Discovery Unit, Cambridge MA, United States;
P034: DISRUPTive liquid biopsies in Inflammatory Bowel Disease (DISRUPT-IBD): Release of exosomal and molecular tissue signals by transabdominal ultrasound?ECCO'22Year: 2022
Authors: Tran, F.(1,2);Scharmacher, A.(1);Mishra, N.(1);Barann, N.(1);Sievers, L.K.(1,2);Juzenas, S.(1);Bernardes, J.P.(1);Lessing, M.(2);Lassen, A.(2);Rosenstiel, P.(1);Schreiber, S.(1,2);
(1)University Medical Center- Schleswig-Holstein- Kiel Campus, Institute of Clinical Molecular Biology, Kiel, Germany;(2)University Medical Center- Schleswig-Holstein- Kiel Campus, Department of Internal Medicine I, Kiel, Germany;
P035: An examination of resting state functional connectivity in patients with active Crohn’s diseaseECCO'22Year: 2022
Authors: Thapaliya, G.(1);Eldeghaidy, S.(2);Radford, S.(3);Francis, S.(2);Moran, G.(3);
(1)Johns Hopkins- School of Medicine, Department of Psychiatry, Baltimore, United States;(2)University of Nottingham, Sir Peter Mansfield Imaging Centre- School of Physics and Astronomy, Nottingham, United Kingdom;(3)University of Nottingham, NIHR Nottingham Biomedical Research Centre- Nottingham University Hospitals NHS Trust and School of Medicine, Nottingham, United Kingdom;
P036: Identification and functional analysis of stromal subsets in experimental IBD mouse modelsECCO'22Year: 2022
Authors: Zhou, Z.(1);Plug, L.G.(1);de Jonge-Muller, E.S.M.(1);van de Beek, L.M.(1);Brands, L.(1);van der Meulen-de Jong, A.E.(1);Hawinkels, L.J.A.C.(1);Barnhoorn, M.C.(1);
(1)Leiden University Medical Center, Department of Gastroenterology and Hepatology, Leiden, The Netherlands;
P037: MicroRNA-31 and microRNA-200 family reflect disease activity in Crohn’s disease: results from the BIOMIR studyECCO'22Year: 2022
Authors: Cristina, T.(1);Mateescu, B.(2);Mitroi, A.(3);Cozaru, G.(3);Brinzan, C.(3);State, M.(2);Dumitru, A.(1);Rafti, R.(1);Dina, E.(1);Alexandrescu, L.(1);Dumitru, E.(1);
(1)County Clinical Emergency Hospital of Constanta, Gastroenterology, Constanta, Romania;(2)Colentina Hospital Bucharest, Gastroenterology, Bucharest, Romania;(3)County Clinical Emergency Hospital of Constanta, Genetics, Constanta, Romania;
P038: Targeting the hepcidin-ferroportin axis with Nrf2 agonists to treat iron deficiency anaemia in Inflammatory Bowel DiseaseECCO'22Year: 2022
Authors: Martin, J.(1,2);Aksan, A.(1,2,3);Steinhilber, D.(2);Ulrich-Rückert, S.(1,2);Stein, J.M.(1,2,4);
(1)Interdisciplinary Crohn-Colitis Centre Rhein-Main, Clinical Research, Frankfurt am Main, Germany;(2)Goethe University Frankfurt, Institute of Pharmaceutical Chemistry, Frankfurt am Main, Germany;(3)Justus-Liebig University Giessen, Institute of Nutritional Science, Giessen, Germany;(4)DGD Clinics Sachsenhausen, Department of Gastroenterology and Clinical Nutrition, Frankfurt am Main, Germany;
P039: The role of α4β7+CLA+ ‘dual tropic’ T cells in inflammatory bowel diseaseECCO'22Year: 2022
Authors: Gordon, H.(1);Rodger, B.(2);Hornsby, E.(2);McGuire, J.(1);Kok, K.B.(1);Lindsay, J.O.(1);Stagg, A.J.(2);
(1)Royal London Hospital, Department of Gastroenterology- Barts Health NHS Trust, London, United Kingdom;(2)The Blizard Institute, Department of Immunobiology, London, United Kingdom;
P040: Reduced serological response to COVID-19 vaccines in patients with IBD is further diminished by TNF inhibitor therapy; Early results of the VARIATION study (VAriability in Response in IBD Against SARS-COV-2 ImmunisatiON)ECCO'22Year: 2022
Authors: Doherty, J.(1);Stack, R.(1);O' Morain, N.(1);Girod, P.(1);Tosetto, M.(1);Inzitari, R.(2);Sheridan, J.(1);Cullen, G.(1);Buckley, M.(3);Mulcahy, H.(1);Ryan, E.J.(4);Daghfal, D.(5);Doran, P.(2);O Morain, C.(6);Doherty, G.(1);
(1)Centre for Colorectal Disease- St Vincent's University Hospital, Gastroenterology, Dublin, Ireland;(2)School of Medicine- University College Dublin, School of Medicine- University College Dublin, Dublin, Ireland;(3)St Michaels Hospital- Dun Laoighre, Gastroenterology, Dublin, Ireland;(4)University of Limerick, Department of Biological Sciences- Health Research Institute, Limerick, Ireland;(5)Abbot Diagnostics, Lake Forest, Illinois, United States;(6)Beacon Hospital, Gastroenterology, Dublin, Ireland;INITIative IBD research network (www.initiativeibd.ie)
P041: Characterization of cytokine and drug concentrations in serum, mucosa and faeces during induction treatment of moderate-to-severe ulcerative colitis with anti-TNF monoclonal antibodiesECCO'22Year: 2022
Authors: Van Oostrom, J.(1);Hanzel, J.(1,2);Verstockt, B.(3,4);Singh, S.(5);Smith, J.(5);Stylli, J.(5);Vermeire, S.(3);D'Haens, G.(1);
(1)Amsterdam UMC- Meibergdreef 9- 1105 AZ Amsterdam- The Netherlands, Gastroenterology, Amsterdam, The Netherlands;(2)UMC Ljubljana- Japljeva ul. 2- 1000 Ljubljana- Slovenia, Gastroenterology, Lubljana, Slovenia;(3)University Hospitals Leuven- KU Leuven- Leuven- Belgium, Department of Gastroenterology and Hepatology, Leuven, Belgium;(4)KU Leuven- Leuven- Belgium, Department of Chronic Diseases and Metabolism-, Leuven, Belgium;(5)Progenity Inc, Progenity laboratories, San Diego, United States;
P042: Succinate promotes the conversion from white to beige adipose tissue in Crohn’s DiseaseECCO'22Year: 2022
Authors: Montfort-Ferré, D.(1);Menacho, M.(2);Caro, A.(3);Espina, B.(3);Boronat-Toscano, A.(1);Nuñez-Roa, C.(1);Martí, M.(4);Espin, E.(4);Vendrell, J.(1);Fernández-Veledo, S.(1);Serena, C.(1);
(1)Health Institute Pere Virgili IISPV, Hospital Joan XXIII of Tarragona, Tarragona, Spain;(2)Hospital Joan XXIII of tarragona, Gastroenterology Service, Tarragona, Spain;(3)Hospital Joan XXIII of Tarragona, Surgery Service, Tarragona, Spain;(4)Hospital Universitari Vall Hebron, Surgery Service, Barcelona, Spain;
P043: 3-oxo-C12:2, a Quorum Sensing molecule from the gut, exerts anti-inflammatory effects through a bitter taste receptorECCO'22Year: 2022
Authors: Coquant, G.(1);Aguanno, D.(2);Brot, L.(1);Belloir, C.(3);Briand, L.(3);Grill, J.P.(1);De Sordi, L.(1);Thenet, S.(4);Seksik, P.(1);
(1)Sorbonne Université, Medecine Faculty, Paris, France;(2)Technische Universität München, Lehrstuhl für Ernährung und Immunologie, Freising, Germany;(3)INRAE, Centre des Sciences du Goût et de l'Alimentation, Dijon, France;(4)PSL university, Ecole Pratique des Hautes Etudes, Paris, France;
P044: Enteric dopaminergic pathways in mouse and human intestinal inflammationECCO'22Year: 2022
Authors: Cerantola, S.(1);Faggin, S.(1);Caputi, V.(2);Cortese, V.(1);Bosi, A.(3);Banfi, D.(3);Rambaldo, A.(4);Porzionato, A.(4);Giaroni, C.(3);Savarino, E.V.(5);Giron, M.C.(1);
(1)University of Padova, Department of Pharmaceutical and Pharmacological Sciences, Padova, Italy;(2)University of Arkansas, Department of Poultry Science, Fayetteville, United States;(3)University of Insubria, Department of Clinical and Experimental Medicine, Varese, Italy;(4)University of Padova, Department of Neuroscience, Padova, Italy;(5)University of Padova, Department of Surgery- Oncology and Gastroenterology, Padova, Italy;
P045: TIGIT expression differentiates regulatory from inflammatory Th1* gut-homing effector CD4+ T cells in inflammatory bowel disease patientsECCO'22Year: 2022
Authors: Heredia, M.(1);Costes, L.M.M.(1);Tindemans, I.(1);Aardoom, M.A.(2);Klomberg, R.C.W.(2);Kemos, P.(3);Joosse, M.E.(1);van Haaften, D.H.(1);Tuk, B.(1);Ruemmele, F.(4);Croft, N.M.(3);Escher, J.C.(2);de Ridder, L.(2);Samsom, J.N.(1);
(1)Erasmus University Medical Center-Sophia Children’s Hospital, Laboratory of Pediatric Gastroenterology, Rotterdam, The Netherlands;(2)Erasmus University Medical Center-Sophia Children’s Hospital, Pediatric Gastroenterology, Rotterdam, The Netherlands;(3)Blizard Institute- Queen Mary University of London, Centre for Immunobiology, London, United Kingdom;(4)Hôpital Necker-Enfants Malades- Institut Imagine- AP-HP- Université de Paris, Pediatric Gastroenterology, Paris, France;
