OP26: Efficacy and safety of mirikizumab as induction therapy in patients with moderately to severely active Ulcerative Colitis: Results from the Phase 3 LUCENT-1 studyECCO'22Year: 2022
Authors: D'Haens, G.(1);Kobayashi, T.(2);Morris, N.(3);Lissoos, T.(3);Hoover, A.(3);Li, X.(3);Arora, V.(3);Milch, C.(3);Sandborn, W.J.(4);Sands, B.E.(5);
(1)Amsterdam University Medical Centers, Gastroenterology, Amsterdam, The Netherlands;(2)Kitasato University Kitasato Institute Hospital, Center for Advanced IBD Research and Treatment, Tokyo, Japan;(3)Eli Lilly and Company, Biomedicines, Indianapolis, United States;(4)University of California San Diego, Gastroenterology, San Diego, United States;(5)Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, United States;
OP27: A Phase 1 Study Evaluating the Bioequivalence of the Proposed Commercial and Clinical Formulations of Etrasimod 2mg, and the Effect of Food on the Pharmacokinetics of the Proposed Commercial Formulation in Healthy VolunteersECCO'22Year: 2022
Authors: Lee, C.(1);Ramaiya, A.(1);Tang , Y.(1);Sapone, A.(2);Shan , K.(3);Randle, A.(4);Grundy, J.(1);
(1)Arena Pharmaceuticals- Inc., Nonclinical Dev & Clinical Pharmacology, San Diego, United States;(2)Arena Pharmaceuticals- Inc., Clinical Development, San Diego, United States;(3)Arena Pharmaceuticals- Inc., Biostatistics & Data Mgmt, San Diego, United States;(4)Arena Pharmaceuticals- Inc., Clinical Operations, San Diego, United States;
OP28: A randomized placebo controlled clinical trial with 5-hydroxytryptophan in patients with quiescent Inflammatory Bowel Disease and fatigue (Trp-IBD)ECCO'22Year: 2022
Authors: Truyens, M.(1,2,3);Lobaton, T.(1,3);Peeters, A.(1);Ferrante, M.(4,5);Vermeire, S.(4,5);Bossuyt, P.(6);Pouillon, L.(6);Dewint, P.(7,8);Cremer, A.(9);Peeters, H.(10);Lambrecht, G.(11);Louis, E.(12);Rahier, J.F.(13);Dewit, O.(14);Muls, V.(15);Holvoet, T.(1,16);Vandermeulen, L.(17);Gonzales, G.B.(2,3,18);Laukens, D.(2,3);De Vos, M.(3);
(1)University Hospital Ghent, Department of Gastroenterology, Ghent, Belgium;(2)Ghent University, VIB center for Inflammation Research IRC, Ghent, Belgium;(3)Ghent University, Department of Internal Medicine and Pediatrics, Ghent, Belgium;(4)KU Leuven, Department of Chronic Diseases- Metabolism and Ageing CHROMETA- Translational Research Center for Gastrointestinal Disorders TARGID, Leuven, Belgium;(5)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(6)Imelda General Hospital, Imelda GI Clinical Research Center, Bonheiden, Belgium;(7)AZ Maria Middelares, Department of Gastroenterology, Ghent, Belgium;(8)UZ Antwerp, Department of Gastroenterology, Antwerp, Belgium;(9)Erasme Hospital, Department of Gastroenterology, Brussels, Belgium;(10)AZ Sint-Lucas, St-Lucas IBD Clinic, Ghent, Belgium;(11)AZ Damiaan, Department of Gastroenterology, Oostende, Belgium;(12)CHU Liège University Hospital, Department of Gastroenterology, Liège, Belgium;(13)CHU UCL Namur, Department of Gastroenterology, Yvoir, Belgium;(14)UCL Saint Luc, Service d’Hépato-Gastroentérologie, Brussels, Belgium;(15)Saint-Pierre University Hospital Center - Université Libre de Bruxelles ULB, Department of Gastroenterology and Endoscopy, Brussels, Belgium;(16)AZ Nikolaas General Hospital, Department of Gastroenterology, Sint-Niklaas, Belgium;(17)Universitair Ziekenhuis Brussel UZ Brussel - Vrije Universiteit Brussel VUB, Department of Gastroenterology-Hepatology, Brussels, Belgium;(18)Wageningen University and Research, Nutrition- Metabolism and Genomics Group - Division of Human Nutrition and Health, Wageningen, Belgium;
OP29: Peripheral blood DNA methylation biomarkers accurately predict clinical- and endoscopic response to vedolizumab in a real-life cohort of Crohn’s Disease patientsECCO'22Year: 2022
Authors: Joustra, V.(1);Hageman, I.(1,2);Li Yim, A.(2,3);Levin, E.(4,5);Satsangi, J.(6);Adams, A.(6);De Jonge, W.(2);Henneman, P.(3);D'Haens, G.(1); on behalf of the EPIC consortium
(1)Amsterdam UMC- University of Amsterdam, Department of Gastroenterology & Hepatology, Amsterdam, The Netherlands;(2)Amsterdam UMC- University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(3)Amsterdam UMC- University of Amsterdam, Genome Diagnostics Laboratory- Department of Clinical Genetics, Amsterdam, The Netherlands;(4)Horaizon, Bv, Delft, The Netherlands;(5)Amsterdam UMC- University of Amsterdam, Department of Vascular Medicine, Amsterdam, The Netherlands;(6)Oxford University- Hospitals NHS Foundation Trust- John Radcliffe Hospital, Translational Gastroenterology Unit- NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom;
OP30: Upadacitinib modulates inflammatory pathways in gut tissue in patients with Ulcerative Colitis: Transcriptomic profiling from the Phase 2b study, U-ACHIEVEECCO'22Year: 2022
Authors: Verstockt, B.(1);Blink Polakow, S.(2);Mahi, N.(2);Lee, J.(2);Wang, J.(3);Guay, H.(4);Salas, A.(5);Panés, J.(5);Ungaro, R.C.(6);Vermeire, S.(1);
(1)University Hospitals Leuven & KU Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(2)AbbVie Inc, Immunology, North Chicago, United States;(3)AbbVie Inc, Genomic Research Center, Cambridge, United States;(4)AbbVie Inc, Bioresearch Center, Worcester, United States;(5)Hospital Clinic de Barcelona, IDIBAPS CIBERehd, Barcelona, Spain;(6)The Mount Sinai Hospital, Icahn School of Medicine, New York, United States;
OP31: Dietary and Multi-Omic characterization of new onset treatment naive Crohn Disease identifies factors that may contribute to disease pathogenesisECCO'22Year: 2022
Authors: Haberman Ziv, Y.(1);Braun, T.(1);Amir, A.(1);Levhar , N.(1);Malik, A.(1);Neuman, S.(1);Picard, O.(1);Yavzuri, M.(1);Efroni, G.(1);Hadar, R.(1);Ben-Horin, S.(1);
(1)Tel-HaShomer Sheba Medical Center, Department of Pediatric Gastroenterology, Ramat Gan, Israel;for the Helmsley Charitable Trust SOURCE consortium investigators
OP33: Effect of upadacitinib (UPA) treatment on extraintestinal manifestations (EIMs) in patients with moderate-to-severe Ulcerative Colitis (UC): Results from the UPA Phase 3 programmeECCO'22Year: 2022
Authors: Colombel, J.F.(1);Cao, Q.(2);Ghosh, S.(3);Reinisch, W.(4);Zhou, W.(5);Ilo, D.(5);Shu, L.(5);Yao, X.(6);Rubin, D.T.(7);
(1)Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, United States;(2)Sir Run Run Shaw Hospital- College of Medicine- Zhejiang University, Department of Gastroenterology, Hangzhou- Zhejiang, China;(3)University College Cork, College of Medicine and Health, Cork, Ireland;(4)Medical University of Vienna, Department of Gastroenterology and Hepatology, Vienna, Austria;(5)AbbVie Inc, Research and Development, North Chicago- Illinois, United States;(6)AbbVie Inc, Data & Statistical Sciences, North Chicago- Illinois, United States;(7)University of Chicago Medicine, Inflammatory Bowel Disease Center, Chicago- Illinois, United States;
OP34: Efficacy and safety of advanced induction and maintenance therapies in patients with moderately to severely active Ulcerative Colitis: An indirect treatment comparison using Bayesian network meta-analysisECCO'22Year: 2022
Authors: Panaccione, R.(1);Collins, E.B.(2);Melmed, G.Y.(3);Vermeire, S.(4);Danese, S.(5);Higgins, P.D.R.(6);Zhou, W.(7);Ilo, D.(7);Sharma, D.(7);Sanchez Gonzalez, Y.(7);Wang, S.T.(2);
(1)University of Calgary, Inflammatory Bowel Disease Unit- Division of Gastroenterology and Hepatology, Calgary, Canada;(2)Medicus Economics LLC, n/a, Milton, United States;(3)Cedars-Sinai Medical Center, n/a, Los Angeles, United States;(4)University Hospital Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(5)Gastroenterology and Endoscopy IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele, n/a, Milan, Italy;(6)University of Michigan, Department of Medicine- Division of Gastroenterology, Ann Arbor, United States;(7)AbbVie Inc., n/a, North Chicago, United States;
OP35: Natural history of anal ulcerations in pediatric-onset Crohn's Disease: A population-based studyECCO'22Year: 2022
Authors: Mortreux, P.(1);Leroyer, A.(2);Dupont, C.(3);Ley, D.(4);Bertrand, V.(5);Spyckerelle, C.(6);Guillon, N.(2);Desreumaux, P.(1);Gower-Rousseau, C.(2);Savoye, G.(7);Fumery, M.(8);Turck, D.(4);Siproudhis, L.(9);Sarter, H.(2);
(1)CHU Lille, Gastro-enterology, Lille, France;(2)Lille 2 University- CHU Lille- EPIMAD Registry, Epidemiology Unit, Lille, France;(3)CHU Caen, Pediatric unit, Caen, France;(4)CHU Lille, Pediatric unit, Lille, France;(5)CH Le Havre, Pediatric unit, Le Havre, France;(6)GHICL, Pediatric unit, Lille, France;(7)CHU Rouen, Gastro-enterology, Rouen, France;(8)CHU Amiens, Gastro-enterology, Amiens, France;(9)CHU Rennes, Gastro-enterology, Rennes, France;EPIMAD
OP36: Efficacy and safety of combination induction therapy with guselkumab and golimumab in participants with moderately-to-severely active Ulcerative Colitis: Results through week 12 of a phase 2a randomized, double-blind, active-controlled, parallel-group, multicenter, proof-of-concept studyECCO'22Year: 2022
Authors: Sands, B.E.(1);Feagan, B.G.(2);Sandborn, W.J.(3);Shipitofsky, N.(4);Marko, M.(4);Sheng, S.(4);Johanns, J.(4);Germinaro, M.(4);Vetter, M.(4);Panés, J.(5);
(1)Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States;(2)Robarts Research Institute, Western University, London, Canada;(3)University of California San Diego, Division of Gastroenterology, La Jolla, United States;(4)Janssen Research & Development- LLC, Immunology, Spring House, United States;(5)Hospital Clínic de Barcelona, Gastroenterology, Barcelona, Spain;VEGA
OP37: Bacterial suppression of intestinal fungi via activation of human gut Vδ2+ T-cellsECCO'22Year: 2022
Authors: Mathew, L.(1);Savage, M.(1);Pardieu, C.(1);O'Brien, M.(1);Sze, S.K.(2);Eberl, M.(3);Stagg, A.(1);Gasparetto, M.(4);Kok, K.(4);Lindsay, J.(4);McCarthy, N.(1);
(1)Barts and The London- Queen Mary's School of Medicine and Dentistry, The Blizard Institute- Centre for Immunobiology, London, United Kingdom;(2)Brock University, Department of Health Sciences, St. Catharines, Canada;(3)Cardiff University, Division of Infection and Immunity, Cardiff, United Kingdom;(4)Bart's Health NHS Trust, Department of Gastroenterology, London, United Kingdom;
OP38: Tofacitinib for the treatment of Ulcerative Colitis: An integrated summary of safety data from the global OCTAVE and RIVETING clinical trialsECCO'22Year: 2022
Authors: Sandborn, W.J.(1);D'Haens, G.R.(2);Sands, B.E.(3);Panaccione, R.(4);Ng, S.C.(5);Lawendy, N.(6);Kulisek, N.(6);Guo, X.(6);Mundayat, R.(7);Su, C.(7);Panés, J.(8);
(1)University of California San Diego, Division of Gastroenterology, La Jolla- CA, United States;(2)Amsterdam University Medical Centres, Department of Gastroenterology, Amsterdam, The Netherlands;(3)Icahn School of Medicine at Mount Sinai, Dr. Henry D. Janowitz Division of Gastroenterology, New York- NY, United States;(4)University of Calgary, Division of Gastroenterology and Hepatology- Department of Medicine, Calgary- AB, Canada;(5)LKS Institute of Health Science- Chinese University of Hong Kong, Institute of Digestive Disease- Department of Medicine and Therapeutics, Hong Kong, China;(6)-, Pfizer Inc, Collegeville- PA, United States;(7)-, Pfizer Inc, New York- NY, United States;(8)Hospital Clínic de Barcelona- IDIBAPS- CIBERehd, Department of Gastroenterology, Barcelona, Spain;
OP39: Shorter disease duration is associated with better outcomes in patients with moderately to severely active Crohn’s Disease treated with risankizumab: Results from the phase 3 ADVANCE, MOTIVATE, and FORTIFY studiesECCO'22Year: 2022
Authors: Peyrin-Biroulet, L.(1);Colombel, J.F.(2);Louis, E.(3);Ferrante, M.(4);Motoya, S.(5);Panaccione, R.(6);Torres, J.(7);Ungaro, R.C.(2);Kligys, K.(8);Kalabic, J.(9);Zambrano, J.(8);Zhang, Y.(8);D’Haens, G.R.(10);
(1)University Hospital of Nancy- Lorraine University, Gastroenterology, Vandoeuvre, France;(2)Icahn School of Medicine at Mt Sinai, Gastroenterology, New York, United States;(3)University Hospital CHU of Liège, Gastroenterology, Liège, Belgium;(4)University Hospitals Leuven, Gastroenterology, Leuven, Belgium;(5)IBD Center- Sapporo Kosei General Hospital, Gastroenterology, Sapporo, Japan;(6)University of Calgary, Gastroenterology, Calgary, Canada;(7)Hospital Beatriz Ângelo, Gastroenterology, Loures, Portugal;(8)AbbVie Inc., Gastroenterology, North Chicago, United States;(9)9AbbVie Deutschland GmbH & Co. KG, Gastroenterology, Ludwigshafen, Germany;(10)Amsterdam University Medical Centers, Gastroenterology, Amsterdam, The Netherlands;
OP40: Efficacy of risankizumab induction and maintenance therapy by baseline Crohn’s Disease location: Post hoc analysis of the phase 3 ADVANCE, MOTIVATE, and FORTIFY studiesECCO'22Year: 2022
Authors: Bossuyt, P.(1);Bresso, F.(2);Dubinsky, M.(3);Ha, C.(4);Siegel, C.(5);Zambrano, J.(6);Kligys, K.(6);Kalabic, J.(6);Zhang, Y.(6);Panaccione, R.(7);
(1)Imelda General Hospital, Gastroenterology, Bonheiden, Belgium;(2)Karolinska University Hospital, Gastroenterology- Dermatology- and Rheumatology, Stockholm, Sweden;(3)Icahn School of Medicine at Mount Sinai, Pediatrics, New York, United States;(4)Cedars-Sinai Medical Center, Gastroenterology, Los Angeles, United States;(5)Dartmouth-Hitchcock Medical Center, Gastroenterology and Hepatology, Lebanon, United States;(6)AbbVie Inc., Gastroenterology, North Chicago, United States;(7)Cumming School of Medicine- University of Calgary, Gastroenterology and Hepatology, Calgary, Canada;
P001: Immune checkpoint inhibitor-induced colitis is mediated by polyfunctional lymphocytes and is dependent on the IL23/IFNg axisECCO'22Year: 2022
Authors: Lo, J.(1);Cozzetto, D.(1);Madgwick, M.(2,3);Sieh, J.Y.X.S.(4);Olbei, M.(2,3);Alexander, J.L.(1);Miguens Blanco, J.(1);Kudo, H.(1);Ibraheim, H.(1);Liu, Z.(1);Castro Seoane, R.(1);Goldin, R.(1);Marchesi, J.(1);Korcsmaros, T.(1,2,3);Lord, G.(5);Powell, N.(1);
(1)Imperial College London, Department of Metabolism- Digestion and Reproduction, London, United Kingdom;(2)Earlham Institute, Organisms and Ecosystems, Norwich, United Kingdom;(3)Quadram Institute Bioscience, Gut Microbes and Health Programme, Norwich, United Kingdom;(4)School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom;(5)University of Manchester, Faculty of Biology, Manchester, United Kingdom;
P004: Microbiota, not host origin drives ex vivo epithelial response in ulcerative colitis patients and non-IBD controls.ECCO'22Year: 2022
Authors: Arnauts, K.(1);Sudhakar, P.(1);Verstockt, S.(1);Lapierre, C.(1);Potche, S.(1);Caenepeel, C.(1);Verstockt, B.(1,2);Raes, J.(3);Vermeire, S.(1,2);Sabino, J.(1,2);Verfaillie, C.(4);Ferrante, M.(1,2);
(1)KU Leuven, TARGID- Department of Chronic Diseases- Metabolism & Ageing, Leuven, Belgium;(2)UZ Leuven, Department of Gastroenterology and Hepatology- University Hospitals Leuven, Leuven, Belgium;(3)KU Leuven, Department of Microbiology and Immunology- Rega Institute, Leuven, Belgium;(4)KU Leuven, Stem Cell Institute Leuven- Department of Development and Regeneration- Leuven- Belgium., Leuven, Belgium;
P005: The solute carrier LC22A4/Organic Cation Transporter (OCTN)-1 as a novel Inflammatory Bowel Disease determinant at the microbe-host interface.ECCO'22Year: 2022
Authors: Masi, L.(1);Petito, V.(1);Fidaleo, M.(2);Palucci, I.(3);Del Chierico, F.(4);Ivagnes, V.(3);Mercuri, A.(5);Graziani, C.(1);Lopetuso, L.R.(1);Armuzzi, A.(1);Gasbarrini, A.(1);Pani, G.(5);Scaldaferri, F.(1);
(1)Fondazione Policlinico Universitario A. Gemelli IRCCS, Department of Gastroenterology and Internal Medicine, Rome, Italy;(2)Università La Sapienza, Department of Biology and Biotechnologies Charles Darwin, Rome, Italy;(3)Fondazione Policlinico Universitario A. Gemelli IRCCS, Department of Microbiology, Rome, Italy;(4)Children Hospital Bambino Gesù IRCCS, Unit of Human Microbiome, Rome, Italy;(5)Catholic University of the Sacred Heart, Department of Translational Medicine, Rome, Italy;
