P0071: Host fecal proteolytic activity is increased following antibiotic treatment in healthy individuals, but not patients with pouchitisECCO'25Year: 2025
Authors: Werner, L.(1,2)*;Nissenbaum, T.(3);Izhar, R.(1);Hirsch, A.(1);Fibelman, M.(1);Leibovitzh, H.(1);Cohen, N.(1);Lobel, L.(3);Maharshak, N.(1);
(1)Tel Aviv Medical Center, Gastro, Tel Aviv, Israel;(2)Tel Aviv University, Faculty of Medical and Health Sciences, Tel Aviv, Israel;(3)Bar-Ilan University, The Goodman Faculty of Life Sciences, Ramat Gan, Israel;
P0072: Unveiling mesenteric and intestinal changes in Crohn’s disease: insights into fibrosis from surgical specimensECCO'25Year: 2025
Authors: Joo, Y.H.(1)*;Park, Y.(1);Song, E.M.(1);Choe , A.R.(1);Byeon, J.R.(1);Noh, G.T.(2);Kim, H.S.(2);Choi , E.(3);Byun , J.(4);Park , J.(5);Ahn, Y.H.(5);Jung , S.A.(1);
(1)Ewha Womans University College of Medicine, Department of Internal Medicine, Seoul, Korea- Republic Of;(2)Ewha Womans University College of Medicine, Department of Surgery, Seoul, Korea- Republic Of;(3)Ewha Womans University College of Medicine, Department of Pathology, Seoul, Korea- Republic Of;(4)Ewha Womans University College of Medicine, Department of Radiology, Seoul, Korea- Republic Of;(5)Ewha Womans University College of Medicine, Department of Molecular Medicine, Seoul, Korea- Republic Of;
P0073: Evaluation of PYGL as a Biomarker and Therapeutic Target in Ulcerative ColitisECCO'25Year: 2025
Authors: KangMD.- PhD., S.B.(1)*;Yang, C.H.(2);
(1)St. Mary's Hospital- The Catholic University of Korea, Division of Gastroenterology- Department of Internal Medicine, Daejeon, Korea- Republic Of;(2)Daegu catholic university chilgok catholic hospital, Division of Gastroenterology- Department of Internal Medicine, Daegu, Korea- Republic Of;
Ji Q, Li H, Cai Z, Yuan X et al. Share PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer. Int J Biol Sci. 2023 Mar 21;19(6):1894-1909.
Ma J, Wei K, Liu J et al. Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Nat Commun. 2020 Apr 14;11(1):1769.
Roach PJ, Depaoli-Roach AA, Hurley TD, Tagliabracci VS. Glycogen and its metabolism: some new developments and old themes. Biochem J. 2012 Feb 1;441(3):763-87.
Thwe PM, Pelgrom LR, Cooper R et al. Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses. Cell Metab. 2019 Jul 2;30(1):225.
P0074: Colonic goblet cell dysfunction and gastric intestinal metaplasia in patients with anterior gradient 2 defects and infantile Inflammatory bowel diseaseECCO'25Year: 2025
Authors: Azabdaftari, A.(1)*;Al-Shaibi, A.(1);Thomas, T.(2);Jainarayanan, A.(2);Capitani, M.(1);Verleur, N.(1);Agarwal, D.(2);Dooley, K.(1);Rich-Griffin, C.(2);Provine, N.(1);Klenerman, P.(1);Elawad, M.(3);Travis, S.(2);Buckley, C.(2);Dendrou, C.(2);Lo, B.(4);Uhlig, H.(1);
(1)University of Oxford, Translational Gastroenterology and Liver Unit- Nuffield Department of Medicine, Oxford, United Kingdom;(2)University of Oxford, Kennedy Institute of Rheumatology- Nuffield Department of Orthopaedics- Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom;(3)Sidra Medicine, Department of Gastroenterology, Doha, Qatar;(4)Sidra Medicine, Research Branch, Doha, Qatar;
P0075: Evaluation of the modulatory potential of polyphenolic compounds on intestinal inflammation at the transcriptomic levelECCO'25Year: 2025
Authors: Inčiūraitė, R.(1)*;Kūlokienė, U.(1);Tilindė, D.(1);Kiudelis, V.(2);Jonaitis, L.V.(2);Kiudelis, G.(2);Kupčinskas, J.(2);Skiecevičienė, J.(1);
(1)Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania;(2)Lithuanian University of Health Sciences, Institute for Digestive Research and Department of Gastroenterology, Kaunas, Lithuania;
1 Jostins, L., et al. (2012). Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature, 491(7422), 119-124. https://doi.org/10.1038/nature11582
2 Cleynen, I., et al. (2016). Inherited determinants of Crohn’s disease and ulcerative colitis phenotypes: a genetic association study. The Lancet, 387(10014), 156-167. https://doi.org/10.1016/S0140-6736(15)00465-1
P0077: Identification of symbiote candidates for pouchitis in patients with ulcerative colitis.ECCO'25Year: 2025
Authors: Uchino, M.(1)*;Son, A.(2);Kato, T.(3);Nakanishi, Y.(3);Hanawa, S.(4);Matsuo, Y.(5);Ogura, H.(2);Ohno, H.(3);Ishido, S.(2);Nomura, K.(1);Tomoo, Y.(1);Kusunoki, K.(1);Horio, Y.(1);Kuwahara, R.(1);Ikeuchi, H.(1);
(1)Hyogo Medical University, Department of Gastroenterological Surgery- Division of Inflammatory Bowel Disease, Nishinomiya, Japan;(2)Hyogo Medical University, Department of Microbiology, Nishinomiya, Japan;(3)RIKEN Center for Integrative Medical Sciences, Laboratory for Intestinal Ecosystem, Yokohama, Japan;(4)Hyogo Medical University, Department of Oral and Maxillofacial Surgery, Nishinomiya, Japan;(5)Institute of Biomedical Science- Kansai Medical University, Department of Human Stress Response Science, Hirakata, Japan;
P0078: The role of epithelial STING in a genetic IBD Model of autophagy deficiency and its interplay with the Integrated stress responseECCO'25Year: 2025
Authors: Springer, E.(1)*;Bornhäuser, J.(1);Bakr, M.(1);Van den Bossche, S.(1);Kakavand, N.(1);Yang, G.(1);Xiang, H.(1);Wu, Q.(1);Schreiber, S.(2);Welz, L.(1);Rosenstiel, P.(1);Aden, K.(2);
(1)Kiel University, Institute of Clinical Molecular Biology, Kiel, Germany;(2)University Hospital Schleswig-Holstein Campus Kiel, Department of Internal Medicine I, Kiel, Germany;
1. Wottawa F, Bordoni D, Baran N, Rosenstiel P, Aden K. The role of cGAS/STING in intestinal immunity. Eur J Immunol. 2021;51(4):785-797. doi:10.1002/eji.202048777
2. Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, et al. ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING. J Exp Medicine. 2018;215(11):2868-2886. doi:10.1084/jem.20171029
3. Martin GR, Blomquist CM, Henare KL, Jirik FR. Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice. Sci Rep. 2019;9(1):14281. doi:10.1038/s41598-019-50656-5
4. Pakos-Zebrucka K, Koryga I, Mnich K, Ljujic M, Samali A, Gorman AM. The integrated stress response. Embo Rep. 2016;17(10):1374-1395. doi:10.15252/embr.201642195 4
P0079: SERUM CALPROTECTIN [CPa9-HNE], A BIOMARKER OF NEUTROPHIL ACTIVITY, IS ASSOCIATED WITH HISTOLOGICAL INFLAMMATION AND FIBROSIS BURDENECCO'25Year: 2025
Authors: Sorokina Alexdóttir, M.(1)*;Poulsen, A.(2);Tsapanou Katranara, T.(1,3);Buhl Riis, L.(4);Pehrsson, M.(1);Rasmussen, J.(5);Gögeneur, I.(6);Burisch, J.(7);A. Karsdal, M.(1);Bay-Jensen, A.C.(1);Seidelin, J.B.(2);Mortensen, J.H.(1);
(1)Nordic Bioscience, Biomarkers and Research, Herlev, Denmark;(2)University Hospital of Copenhagen- Rigshospitalet, Department of Digestive Diseases- Transplantation and General Surgery- Section for IBD, Copenhagen, Denmark;(3)University of Southern Denmark, Faculty of Health Sciences, Odense, Denmark;(4)Copenhagen University Hospital- Herlev and Gentofte, Department of Pathology, Herlev, Denmark;(5)Zealand University Hospital, Department of Medical Gastroenterology, Køge, Denmark;(6)Zealand University Hospital, Center for Surgical Science, Køge, Denmark;(7)Copenhagen University Hospital - Amager and Hvidovre, Gastrounit Medical Section - Copenhagen Center for Inflammatory Bowel Disease in Children- Adolescents and Adults, Hvidovre, Denmark;
P0080: Thalidomide-Carbomer Gel for Rectal Administration Alleviates DSS-Induced Colitis and fibrosis in Mouse by Targeting S1pr5 and Il1f9（Il36γ）ECCO'25Year: 2025
Authors: He, X.(1)*;Jiang, L.(2);Hu, J.(3);Yang, H.(1);
(1)Peking Union Medical College Hospital- Chinese Academy of Medical Sciences & Peking Union Medical College, Gastroenterology, Beijing, China;(2)Peking Union Medical College Hospital- Chinese Academy of Medical Sciences & Peking Union Medical College, Biomarker Discovery and Validation Facility- Institute of Clinical Medicine, Beijing, China;(3)Peking Union Medical College Hospital- Chinese Academy of Medical Sciences & Peking Union Medical College, Research Office, Beijing, China;
P0081: Novel in vitro protocol to isolate and expand murine polyclonal Treg cells for efficacy testing in murine models of IBDECCO'25Year: 2025
Authors: Bretin, A.(1)*;González-King Garibotti, H.(1);Benonisson, H.(1);Preti, M.(1);Peris, E.(1);Burgueno, J.(1);Vaithilingam, V.(2);Häll, M.(2);Brännud, I.(2);Kurhe, Y.(2);Aldridge, J.(2);Jennbacken, K.(2);Nilsson, G.(2);Piras, A.(1);Dazzi, F.(3);Kozlowska, A.(1);Borde, A.(1);Birrell, M.(4);Preite, S.(1);
(1)AstraZeneca, Bioscience In Vivo- Early R&I- BioPharma R&D, Mölndal, Sweden;(2)Astrazeneca, Cell Therapy- Early CVRM- BioPharma R&D, Mölndal, Sweden;(3)Astrazeneca, Cell Therapy- Early CVRM- BioPharma R&D, Cambridge, United Kingdom;(4)Astrazeneca, Bioscience In Vivo- Early R&I- BioPharma R&D, Cambridge, United Kingdom;
P0082: Proteomic profiling of colonic mucosa in patients with ulcerative colitis: detection of molecular patterns of inflammation.ECCO'25Year: 2025
Authors: Iakovlev, A.A.(1)*;Nukhova, S.(2);Tarasova, G.(2);Volkov, A.(2);Zubova, A.(2);Bashtovaya, O.(2);Piskovets, V.(2);
(1)Rostov State Medical University, Department of Gastroenterology, Rostov-on-Don, Russian Federation;(2)Federal State Budgetary Educational Institution of Higher Education- Rostov State Medical University of the Ministry of Health of Russia, Gastroenterology, Rostov-on-Don, Russian Federation;
P0083: Decisional needs among patients and physicians in Crohn's disease: A qualitative analysisECCO'25Year: 2025
Authors: Cloots, M.(1,2)*;Hendrix, E.M.B.(1,2);Okegunna, Y.(3,4);Mingels, S.M.B.(3,4);van de Koppel, I.(1,2);Mujagic, Z.(1,2);Jeuring, S.(2);Dijkstra, G.(5);Duijvestein, M.(6);Römkens, T.E.H.(7);Dekker, A.L.A.J.(3,4);Pierik, M.J.(1,2);Fijten, R.R.R.(3,4);
(1)Maastricht University, Institute for Nutrition and Translational Research in Metabolism NUTRIM, Maastricht, The Netherlands;(2)Maastricht University Medical Center+, Department of Gastroenterology and Hepatology, Maastricht, The Netherlands;(3)Maastricht University, Research Institute for Oncology and Reproduction GROW, Maastricht, The Netherlands;(4)Maastricht University Medical Center+, Department of Radiation Oncology MAASTRO, Maastricht, The Netherlands;(5)University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands;(6)Radboud University Medical Center, Department of Gastroenterology and Hepatology, Nijmegen, The Netherlands;(7)Jeroen Bosch Hospital, Department of Gastroenterology and Hepatology, 's-Hertogenbosch, The Netherlands;
P0084: Secreted inflammatory protein profiles of human inflammatory bowel disease explants following treatment ex-vivo with licenced biologic therapies and patients’ in-vivo responseECCO'25Year: 2025
Authors: Corcoran, R.(1,2)*;O'Connell, F.(2);Schellenberg, N.(2);O'Sullivan, J.(2);Kevans, D.(2,3);
(1)St James’s Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity College Dublin, Trinity Translational Medicine Institute, Dublin, Ireland;(3)St James's Hospital, Department of Gastroenterology, Dublin, Ireland;
P0085: Faecalibacterium prausnitzii induces an anti-inflammatory response and a metabolic reprogramming in human monocytesECCO'25Year: 2025
Authors: Rolhion, N.(1)*;Danne, C.(2);Creusot, L.(2);Formiga, R.(2);Marquet, F.(2);Sedda, D.(3);Hua, L.(3);Ruffié, P.(3);Pham, H.P.(4);Alonso Salgueiro, I.(2);Brot, L.(2);Michel, M.L.(5);Lefevre, J.(6);Sokol, H.(2);
(1)Sorbonne Université- INSERM- Centre de Recherche Saint Antoine, Equipe microbiote- Intestin et Inflammation, Paris, France;(2)Sorbonne Université- INSERM- Centre de Recherche Saint-Antoine, Equipe Microbiote- Intestin et Inflammation, Paris, France;(3)Exeliom Biosciences, R and D, Dijon, France;(4)Parean Biotechnologies, Data sciences, Saint-Malo, France;(5)Université Paris-Saclay- INRAE- AgroParisTech, Micalis Institute, Jouy-en-Josas, France;(6)Sorbonne Université- AP-HP- Hôpital Saint Antoine, Department of Digestive Surgery, Paris, France;
P0086: The role of enteric glial cells in patients with ulcerative colitis.ECCO'25Year: 2025
Authors: Miyazaki, H.(1)*;Ogino, T.(1);Sekido, Y.(1);Takeda, M.(1);Hata, T.(1);Miyoshi, N.(1);Uemura, M.(1);Mizushima, T.(2);Doki, Y.(1);Eguchi, H.(1);
(1)Osaka University, Department of Gastroenterological Surgery- Graduate School of Medicine, Suita city, Japan;(2)Dokkyo medical University, Department of Colorectal Surgery, Shimotsuga gun, Japan;
P0087: Calprotectin contributes to refractory Crohn’s disease fistula through dysregulation of epithelial wound healing responsesECCO'25Year: 2025
Authors: Becker, M.(1);Koelink, P.(1);Ouahoud, S.(1);Meisner, S.(1);Muncan, V.(2);Frei, A.(3);Nabozny, G.(4);li, F.(5);Saris, J.(6);Bemelman, W.(7);D'Haens, G.(8);Buskens, C.(7);WildenbergPhD, M.(6)*;
(1)Amsterdam UMC, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(2)Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(3)F. Hoffmann-La Roche Ltd, Roche Pharma Research & Early Development pRED, Basel, Switzerland;(4)Boehringer Ingelheim Pharmaceuticals- Inc, Department of Immunology and Respiratory Diseases Research, Ridgefield CT, United States;(5)Boehringer Ingelheim Pharmaceuticals- Inc, Department of Global Computational Biology and Data Sciences, Ridgefield CT, United States;(6)Amsterdam UMC, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands;(7)Amsterdam UMC, Dept of Surgery, Amsterdam, The Netherlands;(8)Amsterdam UMC, Dept of Gastroenterology and Hepatology, Amsterdam, The Netherlands;
P0088: 3D tissue-level analysis of intestinal T cell dynamics reveals dual effects of etrasimod on recruitment and tissue exit in experimental colitisECCO'25Year: 2025
Authors: Fontes, V.(1);Müller, T.(2);Derdau, J.(2);Schett, G.(1);Neurath, M.F.(2);Zundler, S.(2)*;Uderhardt, S.(1);
(1)University Hospital Erlangen, Department of Medicine 3, Erlangen, Germany;(2)University Hospital Erlangen, Department of Medicine 1, Erlangen, Germany;
P0089: Infra-red microspectroscopy provides quantitative assessment of fibro-inflammation in Crohn’s disease strictures and predicts post-operative recurrenceECCO'25Year: 2025
Authors: Keung, C.(1,2,3)*;Pawlowski, R.(4);Ryan, A.(5);Kwan, E.(4);Longano, A.(3,5,6);Lim, R.(2);Sievert, W.(1,3);Moore, G.T.(1,3);Wood, B.(7);
(1)Monash Health, Gastroenterology, Melbourne, Australia;(2)Hudson Institute of Medical Research, The Ritchie Centre, Melbourne, Australia;(3)Monash University, Medicine, Melbourne, Australia;(4)Monash Health, Pathology, Melbourne, Australia;(5)TissuPath Specialist Pathology Services, Pathology, Melbourne, Australia;(6)Eastern Health, Pathology, Melbourne, Australia;(7)Monash University, Chemistry, Melbourne, Australia;
1. Keung C, Heraud P, Kuk N, Lim R, Sievert W, Moore G, et al. Fourier-Transform Infra-Red Microspectroscopy Can Accurately Diagnose Colitis and Assess Severity of Inflammation. Int J Mol Sci. 2022;23(5).
2. Rutgeerts P, Geboes K, Vantrappen G, Beyls J, Kerremans R, Hiele M. Predictability of the postoperative course of Crohn's disease. Gastroenterology. 1990;99(4):956-63.
P0090: Synergistic reduction of inflammatory cytokines with obefazimod and etrasimod in combination treatment vs. either monotherapy in a mouse model of inflammatory bowel diseaseECCO'25Year: 2025
Authors: Garcel, A.(1);Cataldi, F.(2);Scherrer, D.(1)*;
(1)Abivax, Research and Development, Montpellier, France;(2)Abivax, Medical Affairs, Paris, France;
1. Vermeire S, et al. J Crohns Colitis 2023
2. Vermeire S, et al. The Lancet Gastroenterol & Hepatol 2022
3. Solitano V, et al. Gastroenterol & Hepatol 2023.
