P0031: The role of LAT1 in colitis and colitis-associated tumourigenesisECCO'25Year: 2025
Authors: Sui, Y.(1)*;Okamoto, N.(2);Hoshi*, N.(2);Inoue, Y.(2);Funatsu, T.(3);Ku, Y.(2);Ooi, M.(2);Watanabe, D.(2);Miyazaki, H.(2);Agawa, M.(2);Nakamura, H.(2);Yang, H.(1);Kodama , Y.(2);
(1)The Second Affiliated Hospital of Guangzhou Medical University, Department of Gastroenterology, guangzhou, China;(2)Kobe University Graduate School of Medicine, Division of Gastroenterology, kobe, Japan;(3)Kobe University Graduate School of Medicine, Division of Integrated Analyses of Bioresource and Health Care, kobe, Japan; IBD group
[1] Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114):2769-2778.
[2] Shah SC, Itzkowitz SH. Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management. Gastroenterology. 2022;162(3):715-730.e713.
[3] Sakata T, Hana K, Mikami T, et al. Positive correlation of expression of L-type amino-acid transporter 1 with colorectal tumor progression and prognosis: Higher expression in sporadic colorectal tumors compared with ulcerative colitis-associated neoplasia. Pathol Res Pract. 2020;216(6):152972.
[4] Najumudeen AK, Ceteci F, Fey SK, et al. The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nat Genet. 2021;53(1):16-26.
P0032: Human Extrachromosomal Circular DNA (EccDNA) is a Novel Biomarker in Inflammatory Bowel DiseaseECCO'25Year: 2025
Authors: Di Vincenzo, F.(1)*;Petito, V.(2);Gerovska, D.(3);Piazzesi, A.(4);Russo, A.(5);Turchini, L.(6);Masi, L.(2);Lopetuso, L.R.(6);Regenberg, B.(7);Gasbarrini, A.(8);Putignani, L.(5);Aruzo-Bravo, M.J.(9);Scaldaferri, F.(10);
(1)Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy;(2)Fondazione Policlinico Universitario "A. Gemelli" IRCCS- Università Cattolica del Sacro Cuore, CeMAD Translational Research Laboratories- Digestive Disease center CeMAD- Department of Medical and Surgical Sciences, Roma, Italy;(3)Biogipuzkoa Health Research Institute, Computational Biology and Systems Biomedicine, San Sebastian, Spain;(4)Bambino Gesù Children’s Hospital- IRCCS, Multimodal Laboratory Medicine Research Area- Unit of Human Microbiome, Roma, Italy;(5)Bambino Gesù Children’s Hospital- IRCCS, Department of Diagnostic and Laboratory Medicine- Unit of Microbiology and Diagnostic Immunlogy- Unit of Microbiomics, Roma, Italy;(6)Fondazione Policlinico Universitario "A. Gemelli" IRCCS- Università Cattolica del Sacro Cuore, IBD Unit- Digestive Disease center CeMAD- Department of Medical and Surgical Sciences, Roma, Italy;(7)University of Copenhagen, Department of Biology- SECTION FOR ECOLOGY AND EVOLUTION, Copenhagen, Italy;(8)Fondazione Policlinico Universitario "A. Gemelli" IRCCS- Università Cattolica del Sacro Cuore, UOC Medicina Interna e Gastroenterologia- Centro Malattie Digestive CeMAD- Dipartimento di Scienze Mediche e Chirurgiche- Dipartimento di Medicina e Chirurgia Traslazionale, Roma, Italy;(9)University of Basque Country UPV/EHU- Biogipuzkoa Health Research Institute, Department of Cell Biology and Histology- Faculty of Medicine and Nursing- Computational Biology and Systems Biomedicine, Roma, Italy;(10)Fondazione Policlinico Universitario "A. Gemelli" IRCCS- Università Cattolica del Sacro Cuore, IBD Unit- CeMAD Translational Research Laboratories- Digestive Disease Center CeMAD- Dipartimento di Scienze Mediche e Chirurgiche- Dipartimento di Medicina e Chirurgia Traslazionale- Università Cattolica del Sacro Cuore, Rome, Italy;
P0033: GPR84, which is increased in Ulcerative Colitis patients, regulates the cytokine secretion of macrophagesECCO'25Year: 2025
Authors: Cejudo-Garcés, A.(1)*;Patel, J.(1);Jarén, A.(1);Macias-Ceja, D.(1);Navarro-Vicente, F.(2);Calatayud, S.(1,3);Barrachina, M.D.(1,3);Ortiz-Masiá, D.(3,4,5);Cosín-Roger, J.(1,3);
(1)Universitat de València, Pharmacology department, Valencia, Spain;(2)Hospital de Manises, Surgery and Coloproctology department, Valencia, Spain;(3)Centro de investigaciones en red CIBER, Enfermedades Hepáticas y DIgestivas, Valencia, Spain;(4)Universitat de València, Medicine department, Valencia, Spain;(5)Grupo español de trabajo en enfermedad de Crohn y Colitis GETECCU, Grupo de investigación básica y translacional, Madrid, Spain;
P0034: Glycosylation as new molecular mechanism underlying Pediatric Inflammatory Bowel DiseaseECCO'25Year: 2025
Authors: Amorim, R.(1,2,3)*;Santos-Pereira, B.(2,3);M. Dias, A.(2);Sousa Pinto, B.(3,4,5);J. Lefeber, D.(6,7);Espinheira, C.(1,8);Trindade, E.(1,8);Carneiro, F.(3,9,10);Gaifem, J.(2);Pinho, S.(2,3,11);
(1)Unidade Local de Saúde São João, Pediatrics, Porto, Portugal;(2)Institute for Research and Innovation in Health i3S, Immunology- Cancer and Glycomedicine group, Porto, Portugal;(3)University of Porto, Faculty of Medicine, Porto, Portugal;(4)Centre for Health Technologies and Services Research, Centre for Health Technologies and Services Research, Porto, Portugal;(5)Information and Health Decision Sciences MEDCIDS, Department of Community Medicine, Porto, Portugal;(6)Radboud Institute for Molecular Life Sciences- Radboud University Medical Center, Translational Metabolic Laboratory- Laboratory Medicine, Nijmegen, The Netherlands;(7)Donders Institute for Brain- Cognition- and Behavior- Radboud University Medical Center, Neurology, Nijmegen, The Netherlands;(8)Unidade Local de Saúde São João, Pediatric Gastroenterology Unit, Porto, Portugal;(9)University of Porto, Institute of Molecular Pathology and Immunology, Porto, Portugal;(10)Unidade Local de Saúde São João, Anatomic Pathology, Porto, Portugal;(11)School of Medicine and Biomedical Sciences, School of Medicine and Biomedical Sciences, Porto, Portugal;
P0035: Food compounds associated with disease activity in Inflammatory Bowel Disease: a novel approachECCO'25Year: 2025
Authors: Meima, M.(1,2)*;Westerhout, J.(1);Meijerink, M.(1);Bijlsma, S.(1);van Schaik, F.(2);Oldenburg, B.(2);Houben , G.(1,3);
(1)The Netherlands Organization for Applied Scientific Research TNO, Risk Analysis for Prevention- Innovation and Development, Utrecht, The Netherlands;(2)University Medical Center Utrecht, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands;(3)University Medical Center Utrecht, Center for Translational Immunology, Utrecht, The Netherlands;
Meima, M. Y., Westerhout, J., Bijlsma, S., Meijerink, M., & Houben, G. F. (2023). Coupling food compounds data from FooDB and Phenol‐Explorer to the Dutch food coding system NEVO: towards a novel approach to studying the role of food in health and disease. Journal of Food Composition and Analysis, 123, 105550.
Meima, M. Y., Westerhout, J., Bijlsma, S., van Schaik, F. D. M., Oldenburg, B., Campmans-Kuijpers, M.J.E., Dijkstra G., Meijerink, M., Houben, G.F. (2024, submitted). Calculation of Compound Intake Levels using Integrated Food Compound Databases and Food Intake Data. Journal of Food Composition and Analysis.
P0036: NRG1, a gene significantly detected from intestinal mucosa eccDNA, may predict therapeutic response in Inflammatory Bowel DiseaseECCO'25Year: 2025
Authors: Emoli, V.(1);Foscarini, E.(1)*;Di Vincenzo, F.(2,3);Masi, L.(1);Troisi, S.(1,4);Pane, C.(1,4);Migliore, G.(1);Piazzesi, A.(5);Turchini, L.(3);Pugliese, D.(3);Laterza, L.(3);Lopetuso, L.R.(2,4,6);Papa, A.(2,3);Cammarota, G.(2,7);Putignani, L.(5);Gasbarrini, A.(1,2,3);Scaldaferri, F.(1,2,3);Petito, V.(1);
(1)Fondazione Policlinico Universitario “A. Gemelli”- IRCCS, CeMAD Translational Research Laboratories- Digestive Disease center CeMAD- Department of Medical and Surgical Sciences, Rome, Italy;(2)Catholic University of the Sacred Heart, Department of Translational Medicine and Surgery, Rome, Italy;(3)Fondazione Policlinico Universitario “A. Gemelli” IRCCS, IBD unit- Digestive Disease center CeMAD- Department of Medical and Surgical Sciences, Rome, Italy;(4)University of Chieti-Pescara, Center for Advanced Studies and Technology CAST- ‘G. D’Annunzio’, Chieti, Italy;(5)Bambino Gesù Children's Hospital- IRCCS, Unit of Microbiology and Diagnostic Immunology- Unit of Microbiomics and Immunology- Rheumatology and Infectious Diseases Research Area- Unit of Human Microbiome, Rome, Italy;(6)University of Chieti-Pescara, Department of Medicine and Ageing Sciences- ‘G. D’Annunzio’, Chieti, Italy;(7)Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Department of Medical and Surgical Sciences- Gastroenterology Unit, Rome, Italy;
- Di Vincenzo F, Yadid Y, Petito V. et al. Circular and Circulating DNA in Inflammatory Bowel Disease: From Pathogenesis to Potential Molecular Therapies. Cells. 2023 Jul 27;12(15):1953.
2. Møller H.D., Bojsen RK., Tachibana C. et al. Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells. J Vis Exp. 2016 Apr 4;(110):e54239
3. Møller H.D., Mohiyuddin M., Prada-Luengo I. et al. Circular DNA elements of chromosomal origin are common in healthy human somatic tissue. Nat Commun 9, 1069 (2018).
P0038: Perianal Fistula Closure after Heterologous Mesenchymal Stem Cell Injections is Associated with Protein Levels indicating Lower Tissue Immune Infiltrate, Specific Proteins Involved in the Control of Apoptosis, and Probable Higher Tissues Remodeling and Proteasome ActivityECCO'25Year: 2025
Authors: Meuwis, M.A.(1,2)*;Baiwir, D.(3);Fleron, M.(4);Mazzucchelli, G.(4,5);Boutaffala, L.(6);Reenaers, C.(6);Van Kemseke, C.(6);Vieujean, S.(6,7,8);Bettonville, V.(9);Briquet, A.(10);Lechanteur, C.(11);Coimbra Marques, C.(12);Louis, E.(6,13);
(1)University hospital CHU- Liège, Department Hepato-Gastroenterology And Digestive Oncology, Liege, Belgium;(2)University of Liège- GIGA institute, and laboratory of translational gastroenterology, Liège, Belgium;(3)University of Liege, GIGA Proteomics facility, Liege, Belgium;(4)University of Liège, GIGA Proteomics facility, Liège, Belgium;(5)University of Liège, Laboratory of mass spectrometry MSLab, Liège, Belgium;(6)University hospital of Liège, Hepato-gastroenterology and digestive oncology, Liège, Belgium;(7)INFINY Institute- INSERM NGERE- CHRU Nancy, Department of Gastroenterology, Nancy, France;(8)University of Liège, Laboratoty of translational gastroenterology, Liège, Belgium;(9)University Hospital of Liege, LTCG Division of Hematology, Liège, Belgium;(10)University Hopsital of Liège, LTCG Division of Hematology-, Liège, Belgium;(11)University Hopsital of Liège, LTCG Division of Hematology, Liège, Belgium;(12)University Hopsital of Liège, Department of Medicine- Abdominal- Senology- Endocrine surgery and Transplantation, Liège, Belgium;(13)University of Liège, Laboratory of translational gastroenterology, Liège, Belgium;
[1] C. G. C. McGregor, R. Tandon, and A. Simmons, "Pathogenesis of Fistulating Crohn’s Disease: A Review," Cell. Mol. Gastroenterol. Hepatol., vol. 15, no. 1, pp. 1–11, 2023, doi: 10.1016/j.jcmgh.2022.09.011.
[2] C. Reenaers et al., "Clinical and MRI Evolution After Local Injection of Bone Marrow-Derived Mesenchymal Stem Cells in Perianal Fistulae in Crohn’s Disease: Results From a Prospective Monocentric Study," J. Crohn’s Colitis, vol. 17, no. 5, pp. 728–737, May 2023, doi: 10.1093/ecco-jcc/jjac192.
[3] A.-M. Merli et al., "Solute Carrier Family 12 Member 2 as a Proteomic and Histological Biomarker of Dysplasia and Neoplasia in Ulcerative Colitis," J. Crohn’s Colitis, vol. 15, no. 2, pp. 287–298, 2021, doi: 10.1093/ecco-jcc/jjaa168.
P0039: Deletion of the autophagy-related gene 16 like 1 (Atg16l1) in the myeloid lineage induces systemic inflammationECCO'25Year: 2025
Authors: Wobbe, M.(1)*;Falk-Paulsen, M.(1);Luzius, A.(1);Pimenta Bernardes, J.(1);Kimmig, F.(1);Rosenstiel, P.(1);
(1)Kiel University and University Hospital Schleswig-Holstein, Institute of Clinical Molecular Biology, Kiel, Germany;
1. Dooley HC, Razi M, Polson HE, Girardin SE, Wilson MI, Tooze SA. WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol Cell. 2014;55(2):238-252. doi:10.1016/j.molcel.2014.05.021
2. Fujita N, Itoh T, Omori H, Fukuda M, Noda T, Yoshimori T. The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell. 2008;19(5):2092-2100. doi:10.1091/mbc.e07-12-1257
3. Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 2007;39(2):207-211. doi:10.1038/ng1954
P0040: Measurement of collagen concentration throughout the intestinal layers using Deep Learning: implications in Inflammatory Bowel Disease (IBD)ECCO'25Year: 2025
Authors: Tsounis, E.(1)*;Forlano, R.(2);Voulgaris, T.(3);Bosgana, P.(4);Tsakai, O.(5);Giannakeas, N.(5);Kalafateli, M.(1);Aggeletopoulou, I.(1);Pastras, P.(1);Diamantopoulou, G.(1);Tsolias, C.(1);Melachrinou, M.(4);Thomopoulos, K.(1);Theocharis, G.(1);Tzallas, A.(5);Goldin, R.(6);Manousou, P.(2);Triantos, C.(1);
(1)University Hospital of Patras, Division of Gastroenterology- Department of Internal Medicine, Patras, Greece;(2)Imperial College London, Liver Unit- Section of Hepatology and Gastroenterology- Division of Digestive Diseases- Department of Metabolism- Digestion and Reproduction- Faculty of Medicine, London, United Kingdom;(3)Medical School of National and Kapodistrian University of Athens- General Hospital of Athens "Laiko", Academic Department of Gastroenterology, Athens, Greece;(4)University Hospital of Patras, Department of Pathology, Patras, Greece;(5)University of Ioannina, Department of Informatics and Telecommunications, Ioannina, Greece;(6)Imperial College London, Section for Pathology- Division of Digestive Diseases- Department of Metabolism- Digestion and Reproduction- Faculty of Medicine, London, United Kingdom;
1. Mak JWY, Ng SC. Epidemiology of fibrostenosing inflammatory bowel disease. J Dig Dis. 2020;21(6):332-335. doi:10.1111/1751-2980.12853
2. Rieder F, Mukherjee PK, Massey WJ, Wang Y, Fiocchi C. Fibrosis in IBD: from pathogenesis to therapeutic targets. Gut. 2024;73(5):854-866. Published 2024 Apr 5. doi:10.1136/gutjnl-2023-329963
P0041: Assessment of real-world effectiveness of risankizumab in patients with moderate-severe Crohn’s disease in a global settingECCO'25Year: 2025
Authors: Dignass, A.(1)*;Joshi, N.(2);Lukanova, R.(3);Dawod, F.(3);Jones, W.(3);Kligys, K.(2);Zambrano, J.A.(2);Song, A.(2); Griffith, J.(2);Jairath, V.(4);Bossuyt, P.(5);
(1)Agaplesion Markus Hospital- Goethe-University, Department of Medicine I, Frankfurt am Main, Germany;(2)AbbVie Inc., Gastroenterology, North Chicago, United States;(3)Adelphi Real World, Gastroenterology, Bollington, United Kingdom;(4)Western University, Department of Medicine, London, Canada;(5)Imelda General Hospital, Department of Gastroenterology, Bonheiden, Belgium;
P0042: Hydrogel-integrated millifluidic system enhances function in primary small intestinal epithelial cellsECCO'25Year: 2025
Authors: Alzain, N.(1)*;Almalla, A.(2);Gerbeth, L.(1);Ziegler, J.(1);Kramer, C.(1);Glauben, R.(1);Weinhart, M.(2);Siegmund, B.(1);
(1)Charité—Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;(2)Freie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany;
P0043: Fecal extracellular vesicles from healthy individuals: A novel therapeutic approach for patients with Inflammatory Bowel DiseaseECCO'25Year: 2025
Authors: Ghandian, A.(1)*;Heydari, R.(2);Shahrokh, S.(3);Meyfour, A.(2);
(1)Farzanegan 1 High School, Experimental Sciences, Tehran, Iran- Islamic Republic Of;(2)Research Institute for Gastroenterology and Liver Diseases- Shahid Beheshti University of Medical Sciences, Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Tehran, Iran- Islamic Republic Of;(3)Research Institute for Gastroenterology and Liver Diseases- Shahid Beheshti University of Medical Sciences, Gastroenterology and Liver Diseases Research Center, Tehran, Iran- Islamic Republic Of;
P0044: What are the similarities between primary immunodeficiency states and ulcerative colitis: damage to the microbiome, impaired mucosal secretion of proteins and short-chain fatty acids, or something else?ECCO'25Year: 2025
Authors: Iakovlev, A.A.(1);Bashtovaya, O.(2)*;Volkov, A.(2);Tarasova, G.(2);Nukhova, S.(2);Zubova, A.(2);Piskovets, V.(2);
(1)Rostov State Medical University, Department of Gastroenterology, Rostov-on-Don, Russian Federation;(2)Federal State Budgetary Educational Institution of Higher Education- Rostov State Medical University of the Ministry of Health of Russia, Gastroenterology, Rostov-on-Don, Russian Federation;
1.Jørgensen SF, Trøseid M, Kummen M, et al. Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunol. 2016; 9:1455-1465.
P0045: Serologic levels of fatty acids as promising biomarkers for the severity of Inflammatory Bowel DiseaseECCO'25Year: 2025
Authors: Cejudo-Garcés, A.(1)*;Patel, J.(1);Jarén, A.(1);Macias-Ceja, D.(1);Boscá-Watts, M.M.(2);Boronat, L.(2);Calatayud, S.(1,3);Barrachina, M.D.(1,3);Ortiz-Masiá, D.(3,4,5);Cosín-Roger, J.(1,3);
(1)Universitat de València, Pharmacology department, Valencia, Spain;(2)Hospital Clínico Universitario de Valencia, Gastroenterology department, Valencia, Spain;(3)Centro de investigaciones en red CIBER, Enfermedades Hepáticas y Digestivas, Valencia, Spain;(4)Universitat de València, Medicine department, Valencia, Spain;(5)Grupo español de trabajo en enfermedad de Crohn y Colitis GETECCU, Grupo de investigación básica y translacional, Madrid, Spain;
P0046: Proteomic Profiles Associated with Residual Ultrastructural Anomalies in the Epithelium of IBD patients in Endoscopic RemissionECCO'25Year: 2025
Authors: Meuwis, M.A.(1,2)*;Loly, J.P.(3);Salée, C.(2);Massot, C.(2,4);Baiwir, D.(5);Fléron, M.(6);Mazzucchelli, G.(7);Vieujean, S.(2,8,9);Somja, J.(10);Louis, E.(2,11);
(1)University hospital if Liège CHU, Hepato-gastroenterology and digestive oncology, Liege, Belgium;(2)GIGA institute- University of Liège, Translational Gastroenterology laboratory, Liège, Belgium;(3)University hopsital of Liège CHU, Hepato-gastroenterology and digestive oncology, Liège, Belgium;(4)University Hospital of Liège- CHU, Hepato-gastroenterology and digestive oncology, Liège, Belgium;(5)University of Liège- ULiège, GIGA Proteomics Facility, Liège, Belgium;(6)Univesrity of Liège- Uliège, GIGA Proteomics Facility, Liège, Belgium;(7)University of Liège- Uliège, Laboratory of Mass spectrometry LSM, Liège, Belgium;(8)University Hopsital of Liège- CHU, Hepato-gastroenterology and digestive oncology, Liège, Belgium;(9)INFINY Institute- CHRU Nancy, INSERM NGERE - Dep. of Gastroenterology, Nancy, France;(10)University hospital of Liège- CHU Liège, Anatomo-pathology, Liège, Belgium;(11)University Hopistal of Liège- CHU, Hepato-gastroenterology and digestive oncology, Liège, Belgium;
1 Jean-Philippe Loly, Sophie Vieujean, Catherine Reenaers, Catherine Van Kemseke, Laurence Seidel ScD, Edouard Louis, Joan Somja In-Depth Assessment of Endoscopic Remission in Inflammatory Bowel Disease Treated by Anti-TNF or Vedolizumab Inflamm Bowel Dis. 2024 Feb 1;30(2):240-246. doi: 10.1093/ibd/izad066. DOI: 10.1093/ibd/izad066 2. Angela-Maria Merli, Sophie Vieujean, Charlotte Massot, Noella Blétard, Florence Quesada Calvo, Dominique Baiwir, Gabriel Mazzucchelli, Laurence Servais, Odile Wéra, Cécile Oury, Laurence de Leval, Christine Sempoux, Roberto Manzini, Sena Bluemel, Michael Scharl, Gerhard Rogler, Edwin De Pauw, C Coimbra Marques, Arnaud Colard, Anne Vijverman, Philippe Delvenne, Edouard Louis, Marie-Alice Meuwis Solute carrier family 12 member 2 as a proteomic and histological biomarker of dysplasia and neoplasia in ulcerative colitis J Crohns Colitis 2020 Sep 13:jjaa168. doi: 10.1093/ecco-jcc/jjaa168.
P0047: Understanding the pathogenic role of inflammatory fibroblasts in Inflammatory Bowel DiseaseECCO'25Year: 2025
Authors: Matellan, C.(1);Nwaezeigwe, M.(2)*;Doherty, G.(3);Manresa, M.(4);
(1)School of Medicine- Conway Institute- University College Dublin- Ireland, School of Biomolecular and Biomedical Sciences- Conway Institute- University College Dublin- Ireland, Dublin, Ireland;(2)St Vincents University Hospital/ School of Medicine- University College Dublin, Gastroenterology, Dublin, Ireland;(3)St Vincents University Hospital/School of Medicine- University College Dublin., Gastroenterology, Dublin, Ireland;(4)School of Biomolecular and Biomedical Sciences- Conway Institute., School of Biomolecular and Biomedical Sciences- Conway Institute- University College Dublin, Dublin, Ireland;
P0048: Alterations in circulating T-cell subpopulations reflect disease activity in Ulcerative ColitisECCO'25Year: 2025
Authors: Profeta, F.(1)*;Rumi, G.(1);Notarnicola, D.(1);Capobianco, I.(1);Masi, L.(1);Emoli, V.(1);Troisi, S.(1);Varuolo, M.M.(1);Turchini, L.(1);Lopetuso, L.R.(2);Laterza, L.(1);Pugliese, D.(3);Papa, A.(4);Gasbarrini, A.(4);Petito, V.(1);Scaldaferri, F.(1);
(1)CeMAD Translational Research Laboratory- Digestive Disease center- Department of Medical and Surgical sciences- Fondazione Policlinico Universitario “A. Gemelli”- IRCSS- Rome- Italy., Department of Medical and Surgical, Rome, Italy;(2)Center of Advanced Studies and Technology CAST- “G. D’Annunzio” University of Chieti-Pescara- Chieti- Italy, Center of Advanced Studies and Technology CAST, Chieti, Italy;(3)IBD Unit- Digestive Disease center- Department of Medical and Surgical Sciences- Fondazione Policlinico Universitario “A.Gemelli”- IRCSS- Rome- Italy, Department of Medical and Surgical, Rome, Italy;(4)Department of Translational Medicine and Surgery- Catholic University of the Secred Heart Rome- Italy, Department of Translational Medicine and Surgery, Rome, Italy;
Casalegno Garduño R, Däbritz J. New Insights on CD8+ T Cells in Inflammatory Bowel Disease and Therapeutic Approaches. Front Immunol. 2021 Oct 11;12:738762. doi: 10.3389/fimmu.2021.738762. PMID: 34707610; PMCID: PMC8542854.
P0049: Bile acid profiling of ileal fluid in Crohn’s disease using metabolomicsECCO'25Year: 2025
Authors: De Greef, I.(1)*;Loopmans, S.(2);Bislenghi, G.(3);D'Hoore, A.(3);Terrasson, I.(3);Verstockt, B.(4);Sabino, J.(4);Ferrante, M.(4);Ghesquière, B.(2);Vermeire, S.(4);Verstockt, S.(1);
(1)KU Leuven, Department of Chronic Diseases and Metabolism, Leuven, Belgium;(2)KU Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium;(3)University Hospitals Leuven, Department of Abdominal Surgery, Leuven, Belgium;(4)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;
(1) Vitek L. Bile acid malabsorption in inflammatory bowel disease. Inflamm Bowel Dis. 2015;21(2):476-83
P0050: 4-Octyl Itaconate Protects Against Colitis by Modulating Neutrophil Function and Enhancing Intestinal Epithelial Barrier IntegrityECCO'25Year: 2025
Authors: Guo, M.(1)*;Lingjuan, J.(2);Ruan, G.(1);Runing, Z.(1);Yiqun, G.(3);Hong, Y.(1);
(1)Peking Union Medical College Hospital, Gastroenterology, Beijing, China;(2)Peking Union Medical College Hospital, Biomarker Discovery and Validation Facility, Beijing, China;(3)State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery of Active Substances Discovery and Druggability Evaluation- Institute of Materia Medica- Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
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