P139: A potential protective rule of Mannose Binding lectin (MBL) against SARS-COV2 infection in IBD patientsECCO'24Year: 2024
Authors: Albertini, G.(1)*;Pisani, L.F.(2);Bolzoni, A.(3);Annunziata, M.L.(1);Porta, C.(4);Pastorelli, L.(5);
(1)IRCCS Policlinico San Donato, Gastroenterology and Digestive Endoscopy, Milan, Italy;(2)Centro Cardiologico Monzino IRCCS, Immunology and Functional Genomics Unit, Milan, Italy;(3)Università degli Studi di Milano, Department of Health Sciences, Milan, Italy;(4)University of Piemonte Orientale, Center for Translational Research on Autoimmune and Allergic Diseases, Novara, Italy;(5)ASST Santi Paolo e Carlo, Gastroenterology and Liver Unit, Milan, Italy;
P140: Serum Metabolomic Biomarkers Can Identify and Characterize Associated Subtypes and Phenotypes in Inflammatory Bowel DiseaseECCO'24Year: 2024
Authors: Kim, J.(1)*;Suh, D.H.(2);Park, Y.J.(2);Oh, S.J.(1);Kang, H.(2);Ji, Y.(2);Jung, E.S.(2);Lee, C.K.(1);
(1)Kyung Hee University College of Medicine, Gastroenterology, Seoul, Korea- Republic Of;(2)HEM Pharma Inc, Multi-Omics Center, Suwon- Gyeonggi, Korea- Republic Of;
P142: Genetic ablation of DNA methyltransferase 3A in myeloid cells impairs M1/M2 polarization and leads to pro-inflammatory macrophagesECCO'24Year: 2024
Authors: Bordoni, D.(1);Escudero-Hernández, C.(1)*;Kimmig, F.(1);Mishra, N.(1);Fazio, A.(1);Tran, F.(1);Imm, S.(1);Hinrichsen, F.(1);Weber-Stiehl, S.(1);Stengel, S.(1);Sommer, F.(1);Falk-Paulsen, M.(1);Rosenstiel, P.(1);
(1)University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology IKMB, Kiel, Germany;
P143: Efficacy of the oral tyrosine kinase 2 (TYK2) inhibitor TAK-279 in two preclinical mouse models of colitisECCO'24Year: 2024
Authors: Kong, K.F.(1)*;Khan, M.A.W.(1);Singh, N.(2);Nguyen, V.A.(3);Wilson, E.(1);Tang, J.(1);Marusic, S.(4);Xia, G.(1);Petrakis, I.(5);Nguyen, D.G.(1);
(1)Takeda Development Center Americas- Inc., Gastroenterology Drug Discovery Unit, Lexington- MA, United States;(2)Takeda Development Center Americas- Inc., Clinical Sciences, Lexington- MA, United States;(3)Takeda Development Center Americas- Inc., Quantitative Clinical Pharmacology, Lexington- MA, United States;(4)Hooke Laboratories, President, Lawrence- MA, United States;(5)Takeda Development Center Americas- Inc., Gastroenterology Therapeutic Area Unit, Lexington- MA, United States;
P144: Modulation of Immunometabolism via NLRX1 or PLXDC2: Novel Bimodal Mechanisms for the Treatment of Inflammatory Bowel DiseasesECCO'24Year: 2024
Authors: Danese, S.(1)*;Colombel, J.F.(2);Rieder, F.(3);Peyrin-Biroulet, L.(4);Siegmund, B.(5);Vermeire, S.(6);Dubinsky, M.(7);Schreiber, S.(8);Yarur, A.(9);Panaccione, R.(10);Feagan, B.(11);Mosig, R.(12);Cataldi, F.(13);Verstockt, B.(14);
(1)IRCCS San Raffaele Scientific Institute- Vita-Salute San Raffaele University, Gastroenterology and Gastrointestinal Endoscopy Unit, Milan, Italy;(2)Icahn School of Medicine at Mount Sinai, The Dr. Henry D. Janowitz Division of Gastroenterology, New York, United States;(3)Cleveland Clinic, Department of Inflammation and Immunity- Lerner Research Institute- Department of Gastroenterology- Hepatology and Nutrition- Digestive Disease Institute, Cleveland, United States;(4)Nancy University Hospital- University of Lorraine- Paris IBD Center- and McGill University Health Centre, Department of Gastroenterology- INSERM- NGERE- INFINY Institute- FHU-CURE- Groupe Hospitalier privé Ambroise Paré - Hartmann- Division of Gastroenterology and Hepatology, Vandoeuvre-les-Nancy, France;(5)Charité - Universitätsmedizin Berlin- corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Division of Gastroenterology, Berlin, Germany;(6)University Hospitals Leuven- KU Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(7)Mount Sinai Kravis Children@E@s Hospital- Icahn School of Medicine Mount Sinai, Division of Pediatric Gastroenterology and Nutrition, New York, United States;(8)Christian-Albrechts-University and University Hospital Schleswig-Holstein- Campus Kiel, Institute of Clinical Molecular Biology- Department of Internal Medicine, Kiel, Germany;(9)Cedars Sinai Medical Center, Division of Gastroenterology and Hepatology- Center for Inflammatory Bowel Diseases, Los Angeles, United States;(10)Cumming School of Medicine- University of Calgary, Division of Gastroenterology & Hepatology- Department of Medicine, Calgary, Canada;(11)Western University, Department of Medicine- Division of Gastroenterology and Department of Epidemiology and Biostatistics, London, Canada;(12)Landos Biopharma- Inc, Corporate Development, Blacksburg, United States;(13)Landos Biopharma- Inc, Medicine, Boston, United States;(14)University Hospitals Leuven- KU Leuven, Department of Gastroenterology and Hepatology- Department of Chronic Diseases and Metabolism, Leuven, Belgium;
P145: Phagocyte responses to gut-derived C. albicans are modified in inflammatory bowel diseaseECCO'24Year: 2024
Authors: Mathew, L.(1)*;Carlson, S.(2);Savage, M.(1);Pardieu, C.(1);Sze, N.(3);Munro, C.(4);Naglik, J.(5);Stagg, A.(1);Kok, K.(2);O. Lindsay, J.(2);McCarthy, N.(1);
(1)Queen Mary University of London, Centre for Immunobiology, London, United Kingdom;(2)Barts and the London School of Medicine and Dentistry, Gastroenterology, London, United Kingdom;(3)Brock University, Health Sciences, Ontario, Canada;(4)University of Aberdeen, Medical Sciences, Aberden, United Kingdom;(5)Kings College London, Fungal Pathogenesis and Immunology, London, United Kingdom;
P146: Latent activation of the extrinsic coagulation pathway in patients with ulcerative colitisECCO'24Year: 2024
Authors: Drygiannakis, I.(1)*;Valatas, V.(1);Filidou, E.(2);Tzenaki, N.(1);Archontoulaki, E.(1);Dovrolis, N.(2);Kandilogiannakis, L.(2);Kefalogiannis, G.(3);Sidiropoulos, P.(1);Kolios, G.(2);Koutroubakis, I.E.(1);
(1)University of Crete, School of Medicine, Heraklion, Greece;(2)Democritus University of Thrace, Department of Medicine, Alexandroupolis, Greece;(3)Heraklion University Hospital, Laboratory of Clinical Immunology, Heraklion, Greece;
P147: IBD relevant pathways are upregulated in Paneth cells in a murine model of dietary induced intestinal inflammationECCO'24Year: 2024
Authors: Grabherr, F.(1)*;Meyer, M.(1);Christina, P.(2);Marteau, V.(2);Schwärzler, J.(1);Mayr, L.(1);Enrich, B.(1);Jukic, A.(1);Grander, C.(1);Trajanoski, Z.(2);Tilg, H.(1);Adolph, T.E.(1);
(1)Medical University Innsbruck, Internal Medicine I - Gastroenterology- Hepatology & Endocrinology, Innsbruck, Austria;(2)Medical University Innsbruck, Biocenter- Institute of Bioinformatics, Innsbruck, Austria;
P148: Longitudinal single-cell data informs deterministic modelling of inflammatory bowel disease.ECCO'24Year: 2024
Authors: Kilian, C.(1)*;Ulrich, H.(1);Zouboulis, V.(1);Sprezyna, P.(1);Büttner, M.(2);Biton, M.(3);Villablanca, E.J.(4);Huber, S.(1);Adlung, L.(1);
(1)University Medical Center Hamburg-Eppendorf, I. Department of Medicine, Hamburg, Germany;(2)LLC, Calico Life Sciences, South San Francisco, United States;(3)Weizmann Institute of Science, Department of Immunology and Regenerative Biology, Rehovot, Israel;(4)Karolinska Institutet, Division of Immunology and Allergy & Center of Molecular Medicine, Stockholm, Sweden;
P149: Bacteroides uniformis ameliorates pro-inflammatory diet-exacerbated colitis by targeting endoplasmic reticulum stress-mediated ferroptosisECCO'24Year: 2024
Authors: Liu, C.(1)*;Zhuang, X.(1);Zhan, S.(1);Tian, Z.(1);Mao, R.(1);Zhang, S.(1);Chen, M.(1);Zeng, Z.(1);
(1)The First Affiliated Hospital- Sun Yat-sen University, Department of Gastroenterology, Guangzhou, China;
P150: Ulcerative Colitis Patients’ Luminal Zinc Induces Clostridioides difficile Virulence and Exacerbates Inflammatory ResponsesECCO'24Year: 2024
Authors: Wu, T.(1)*;Zhou, H.(1);Li, X.(1);Lin, J.(1);Wang, F.(1);Da, Y.(1);Liang, J.(1);
(1)Fourth Military Medical University, Xijing Hospital of Digestive Diseases, Xi@E@an, China;
P151: Characterization of platelet activation profile in Inflammatory Bowel DiseaseECCO'24Year: 2024
Authors: Rueda Garcia, J.L.(1,2)*;Martín Arranz, E.(1,2);Ramírez García, L.(1,2);Suárez Ferrer, C.(1,2);Sánchez Azofra, M.(1,2);Poza Cordón, J.(1,2);Amiama Roig, C.(1);Noci Belda, J.(1,2);Perosanz, L.(1,2);Cubillo García, C.(1,2);García-Rojas, C.(2);Silva, K.(2);Monzón Manzano, E.(2,3);G. Arias-Salgado, E.(2,3);Acuña, P.(2,3);Butta, N.(2,3);Martín Arranz, M.D.(1,2,4);
(1)La Paz University Hospital, Gastroenterology, Madrid, Spain;(2)La Paz Institute for Health Research, IdiPAZ, Madrid, Spain;(3)La Paz University Hospital, Hematology and Hemotherapy Unit, Madrid, Spain;(4)Universidad Autónoma de Madrid, Facultad de Medicina, Madrid, Spain;Immune-mediated Gastrointestinal Diseases.
P152: Longitudinal immune profiling of peripheral blood in patients with Ulcerative Colitis.ECCO'24Year: 2024
Authors: Wider-Eberspächer, E.(1)*;Garza, A.P.(1);Albrecht, T.(1);Rosania, R.(2);Dunay, I.R.(1);
(1)Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Hospital, Magdeburg, Germany;(2)Department of Gastroenterology Hepatology and Infectious Disease, Otto-von Guericke University Hospital, Magdeburg, Germany;
P153: Artificial Intelligence to predict interleukin-23 signalling activity from H&E stained whole slide images of Inflammatory Bowel DiseaseECCO'24Year: 2024
Authors: Qaiser , T.(1)*;Hamidinekoo , A.(1);Daniel , S.(1);Zhang , I.(1);Kekic , M.(2);Lewis , A.(1);Angermann , B.(3);Bourke , L.(4);Gehrmann , U.(5);Neisen , J.(4);Tian , S.(4);Corridoni , D.(6);Marks , D.(6);Adissu , H.(7);Burlutskiy , N.(1);
(1)AstraZeneca, Imaging and Data Analytics- Clinical Pharmacology & Safety Sciences- R&D, Cambridge, United Kingdom;(2)AstraZeneca, Imaging and Data Analytics- Clinical Pharmacology & Safety Sciences- R&D, Barcelona, Spain;(3)AstraZeneca, Translational Science and Experimental Medicine, Gothenburg, Sweden;(4)AstraZeneca, Translational Science and Experimental Medicine, Cambridge, United Kingdom;(5)AstraZeneca, Translational Science and Experimental Medicin, Gothenburg, Sweden;(6)AstraZeneca, Research and Early Development- Respiratory and Immunology R&I, Cambridge, United Kingdom;(7)AstraZeneca, Respiratory and Immunology Safety Pathology, Gaithersburg, United States;
P154: Histological disease progression and ALK5i therapeutic efficacy in a chronic DSS-induced mouse model of IBD with intestinal fibrosisECCO'24Year: 2024
Authors: Nielsen, M.H.(1)*;Zachariassen, L.(1);Sárvári, A.K.(2);Madsen, M.R.(2);Hansen, H.B.(3);Fink, L.N.(4);Fuchs, B.C.(5);Papazyan, R.(5);Aymeric , R.(6);Feigh, M.(7);
(1)Gubra A/S, Pharmacology research, Hørsholm, Denmark;(2)Gubra A/S, Histology & NGS, Hørsholm, Denmark;(3)Gubra A/S, Sales & Marketing, Hørsholm, Denmark;(4)Ferring Pharmaceuticals A/S, Discovery Biotherapeutics, Copenhagen, Denmark;(5)Ferring Pharmaceuticals A/S, Ferring Research Institute, San Diego, United States;(6)Ferring Pharmaceuticals A/S, Clinical and Translational Sciences, Copenhagen, Denmark;(7)Gubra A/S, Sales and Marketing, Hørsholm, Denmark;
P156: Gut microbiota composition in Patients with Chron@E@s Disease in Saudi ArabiaECCO'24Year: 2024
Authors: Alahdal, H.(1)*;Almuneef, G.(2); Alkhulaifi, M.M.(3);Aldibasi, O.(4);Aljouie, A.(5);Alharbi, O.(6);Rejili, M.(7);
(1)Department of Biology- Collage of Science- Princes Nourah Bint Abdulrahman University, Biology, Riyadh, Saudi Arabia;(2)Princess Nourah university, Biology, Riyadh, Saudi Arabia;(3)King Saud bin Abdulaziz university, Biology, Riyadh, Saudi Arabia;(4)King Abdullah international medical research center, Biostatistics section, Riyadh, Saudi Arabia;(5)King Abdullah international medical research center, Bioinformatics, Riyadh, Saudi Arabia;(6)King Khalid university hospital- King Saud University, medicine, Riyadh, Saudi Arabia;(7)Imam Mohammad ibn Saud Islamic University, Biology, Riyadh, Saudi Arabia;
P157: Differentiation of Tonsil-derived mesenchymal stem cells to intestinal stem cells-like cells for cell therapy of inflammatory bowel diseaseECCO'24Year: 2024
Authors: Song, E.M.(1)*;Joo, Y.H.(1);Byeon, J.(1);Choe, A.R.(1);Park, Y.(1);Moon, C.M.(1);Kim, S.E.(1);Jung, S.A.(1);
(1)EWHA Womans University- School of Medicine, Department of Internal Medicine- Department of Gastroenterology, Seoul, Korea- Republic Of;
P158: Expression of IL-19 and IL-24 in intestinal mucosa of inflammatory bowel disease: An immunohistochemical study.ECCO'24Year: 2024
Authors: ToskasMD, A.(1)*;Milias, S.(2);Papamitsou, T.(3);Meditskou, S.(4);Dellis, G.(5);Sioga, A.(4);
(1)1.St Mark@E@s Hospital- London- UK. 2.Aristotle University of Thessaloniki- Thessaloniki- Greece., Gastroenterology, Harrow, United Kingdom;(2)Private Histopathology Laboratory, n/a, Thessaloniki, Greece;(3)Aristotle University of Thessaloniki- Thessaloniki- Greece., Laboratory of Histology and Embryology- Medical School-, Thessaloniki, Greece;(4)Aristotle University of Thessaloniki- Thessaloniki- Greece, Laboratory of Histology and Embryology- Medical School, Thessaloniki, Greece;(5)Aristotle University of Thessaloniki, Veterinary School of Medicine, Thessaloniki, Greece;
