P169: Circulating eNAMPT predicts anti-TNF response in IBD patients: possible place in therapy of anti-eNAMPT antibodyECCO'24Year: 2024
Authors: TravelliPh.D, C.(1)*;Cascetta, G.(2);colombo, G.(3);Alessi, A.(2);Caputo, E.(2);Lenti, M.V.(4);Pasini, A.(4);Porta , C.(3);Ribaldone, D.(5);Pastorelli, L.(6);Di Sabatino, A.(7);Genazzani, A.(3);Caviglia, G.P.(8);Stocco, G.(9);
(1)Università degli Studi di Pavia, Dipartimento di Scienze del Farmaco, pavia, Italy;(2)Università di Pavia, Scienze del Farmaco, Pavia, Italy;(3)Università del Piemonte Orientale, scienze farmaceutiche, Novara, Italy;(4)Università di Pavia, Medicina Interna, Pavia, Italy;(5)Università di Torino, Surgical Sciences, Torino, Italy;(6)IRCCS Policlinico San Donato, San Donato, Milano, Italy;(7)IRCCS San Matteo, Medicina Interna, Pavia, Italy;(8)Università di Torino, Scienze Mediche, Torino, Italy;(9)Università di Trieste, Life Sciences, Trieste, Italy;
P169: Multimorbidity and Disease Trajectories in Patients with INFLAMMATORY BOWEL DISEASES: Insights from Observational and Genetic AnalysesECCO'24Year: 2024
Authors: Jiang, F.(1)*;Zhao, J.(1);Chen, J.(1);Wang, L.(2);Yuan, S.(3);Kalla, R.(4);Wellens, J.(5);Nowak, J.(6);Larrson, S.(3);Ludvigsson, J.(7);Satsangi, J.(8);Theodoratou, E.(2);Li, X.(1);
(1)Zhejiang University School of Medicine, Department of Big Data in Health Science School of Public Health and The Second Affiliated Hospital, Hangzhou, China;(2)University of Edinburgh, Centre for Population Health Sciences- Usher Institute, Edinburgh, United Kingdom;(3)Karolinska Institutet, Unit of Cardiovascular and Nutritional Epidemiology- Institute of Environmental Medicine, Stockholm, Sweden;(4)University of Edinburgh, Department of Gastroenterology- Royal Infirmary of Edinburgh, Edinburgh, United Kingdom;(5)Translational Research Center for Gastrointestinal Disorders TARGID, KU Leuven Department of Chronic Diseases and Metabolism, Leuven, Belgium;(6)Poznan University of Medical Sciences, Department of Paediatric Gastroenterology and Metabolic Diseases, Poznan, Poland;(7)Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden;(8)University of Oxford, Translational Gastroenterology Unit- Nuffield Department of Medicine- Experimental Medicine Division, Oxford, United Kingdom;
P170: SLC7A5 promotes the progression of Ulcerative Colitis by regulating amino acid transport and intestinal epithelial autophagyECCO'24Year: 2024
Authors: Shi, Y.(1)*;Wang, F.(1);Hou, L.(1);Zhou, H.(1);Wu, T.(1);Li, R.(1);Li, X.(1);Liu, X.(1);Fan, Z.(1);Zhang, T.(1);Da, Y.(1);Liang, J.(1);
(1)Fourth Military Medical University, Xijing Hospital of Digestive Diseases, Xi@E@an, China;
P171: Rescuing Intestinal Stem Cells via TMEM219 inhibition promotes mucosal healing in Crohn’s diseaseECCO'24Year: 2024
Authors: D@E@Addio , F.(1);Canducci , F.(2)*;Marin , V.(2);Assi , E.(3);Maestroni , A.(4);Nardini , M.(4);Petrazzuolo , A.(4);Loretelli , C.(5);Usuelli , V.(4);Moufida , B.N.(4);Sampietro , G.(6);Ardizzone , S.(7);Fiorina , P.(8);
(1)University of Milan, Pediatric Clinical Research Center - Biomedical and Clinical Science, Milan, Italy;(2)Enthera, Enthera, Milan, Italy;(3)University of Milan, Pediatric Clinical Research Center Invernizzi- Biomedical and Clinical Science, Milan, Italy;(4)University of Milan, Pediatric Clinical Research Center Invernizzi- Biomedical and Clinical Sciences, Milan, Italy;(5)University of Milan, Pediatric Clinical Research Center- Biomedical and Clinical Sciences, Milan, Italy;(6)Rho Memorial Hospital- ASST Rhodense, Division of General and HBP Surgery, Rho, Italy;(7)ASST Fatebenefratelli-Sacco, Gastroenterology Division, Milan, Italy;(8)Pediatric Clinical and Research Center, Biomedical and Clinical Sciences, Milan, Italy;
P172: Spatial Transcriptomics Characterization of S1P Pathway Genes in Ulcerative Colitis and Crohn’s Disease Colon TissuesECCO'24Year: 2024
Authors: Zhang, J.(1)*;Maddux, R.(1);Petersen, A.(2);Mehandru, S.(3);Stauffer, W.(4);Baichwal, V.(4);Harris, S.(1);
(1)Bristol Myers Squibb, Translational Medicine, Princeton NJ, United States;(2)Bristol Myers Squibb, Clinical Development Gastroenterology, Princeton NJ, United States;(3)Icahn School of Medicine at Mount Sinai, Henry D. Janowitz Division of Gastroenterology- Susan and Leonard Feinstein Inflammatory Bowel Disease Center, New York, United States;(4)Canopy Biosciences, Canopy Biosciences, Hayward CA, United States;
P173: Characterization of the gut microbiota and the colonic immune response in acute severe ulcerative colitis : the multi-omics ITAC project.ECCO'24Year: 2024
Authors: Riviere, P.(1,2,3)*;Dallmann-Sauer, M.(3);Enaud, R.(4);Bessissow, T.(5);Treton, X.(6);Uzzan, M.(7);Poullenot, F.(8);Zerbib, F.(8);Laharie, D.(8);Schurr, E.(9,10);
(1)Bordeaux University Hospital, Gastroenterology unit, Pessac, France;(2)McGill University, Microbiology and Immunology Department, Montréal, Canada;(3)Research Institute of the McGill University Health Centre, Program in Infectious Diseases and Immunity in Global Health, Montréal, Canada;(4)Bordeaux University Hospitals, CRCM Pediatrique, Bordeaux, France;(5)McGill University Health Centre, Division of Gastroenterology and hepatology, Montréal, Canada;(6)Groupe Hospitalier Privé Ambroise Paré-Hartmann, Paris IBD Center, Neuilly/Seine, France;(7)Paris Est Créteil University UPEC- Assistance Publique-Hôpitaux de Paris AP-HP- Henri Mondor Hospital, Gastroenterology department- Fédération Hospitalo-Universitaire TRUE InnovaTive theRapy for immUne disordErs, Créteil, France;(8)Bordeaux University Hospitals, Gastroenterology department, Bordeaux, France;(9)Research Institute of McGill University Health Centre, Program in Infectious Diseases and Immunity in Global Health, Montréal, Canada;(10)McGill University, Mirobiology and Immunology department, Montréal, Canada;
P175: HucMSC-Exo ameliorate experimental colitis via modulating gut microbiota and metabolitesECCO'24Year: 2024
Authors: Wang, C.(1);Wang, D.(1);Luo, Y.(1);Guo, J.(1);Ma, Z.(2);Liang, X.(1);Sun, D.(1);Li, C.(1);Zhang, X.(1)*;
(1)The Second Hospital of Hebei Medical University, Gastroenterology, Shijiazhuang, China;(2)The Second Hospital of Hebei Medical University, respirology, Shijiazhuang, China;
P176: TYK2 inhibition attenuates the stimulation of sensory neurons with hyper-IL-6ECCO'24Year: 2024
Authors: Pritchard, T.(1);Meng, M.(1);Higham, J.(1);Bulmer, D.(2)*;
(1)University of Cambridge, Pharmacology, Cambridge, United Kingdom;(2)University of Cambridge, Department of Pharmacology, Cambridge, United Kingdom;
P177: Beta-CGRP in inflammatory bowel disease: a protective neuropeptide of the gutECCO'24Year: 2024
Authors: Pascual, M.(1)*;Gárate, G.(2);Serrano, M.S.(1);González-Quintanilla, V.(2);García, M.J.(1);Castro Senosiain, B.(1);Crespo, J.(1);Pascual, J.(2);Rivero Tirado, M.(1);
(1)Valdecilla Research Institute IDIVAL- Universidad de Cantabria UC- Marqués de Valdecilla University Hospital, Gastroenterology and Hepatology Department- Clinical and Translational Research in Digestive Diseases, Santander, Spain;(2)Valdecilla Research Institute IDIVAL- Universidad de Cantabria UC- Marqués de Valdecilla University Hospital, Neurology, Santander, Spain;
P178: Changes in composition and structure of ileal mucus in Crohn’s disease patients compared to healthy controlsECCO'24Year: 2024
Authors: Kramer, C.(1)*;Rulff, H.(2);Kuppe, A.(3);Addante, A.(3);Fentker, K.(4);Ziegler, J.(1);Bischoff, P.(5);Gradzielski, M.(2);Mertins, P.(4);Mall, M.(3);Glauben, R.(1);Siegmund, B.(1);
(1)Charité - Universitätsmedizin Berlin, Medical Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Institut für Chemie, Stranski-Laboratorium für Physikalische und Theoretische Chemie, Berlin, Germany;(3)Charité - Universitätsmedizin Berlin, Department of Pediatric Respiratory Medicine- Immunology and Critical Care Medicine, Berlin, Germany;(4)Max Delbrück Center for Molecular Medicine in the Helmholtz Society and Berlin Institute of Health, Proteomics, Berlin, Germany;(5)Charité - Universitätsmedizin Berlin, Institute of Pathology, Berlin, Germany;
P179: Decrease in Butyric Acid in fecal matter in patients with Inflammatory Bowel Disease is associated with the levels of secretory Immunoglobulin A and fecal calprotectinECCO'24Year: 2024
Authors: Parra Izquierdo, L.V.(1)*;de Avila, J.(1);Ramos, A.(1);Chila-Moreno, L.(2);Bello-Gualtero, J.M.(2);Valdes, A.(3);Morantes, S.(4);Madroñero, J.(5);Bautista-Molano, W.(6);Delgado, F.(5);Florez-Sarmiento, C.(7);Romero-Sanchez, C.(8);
(1)Universidad El Bosque- Cellular and Molecular Immunology Group/INMUBO- Bogotá-Colombia., Immunology, Bogota, Colombia;(2)Universidad Militar Nueva Granada- Faculty of Medicine- Applied Clinical Immunology Group- Bogota-Colombia., Immunology, Bogota, Colombia;(3)Instituto de Investigación en Ciencias de la Alimentación- CIAL CSIC-UAM- Madrid- Spain., Research, Madrid, Spain;(4)Universidad El Bosque- Pharmaceutical Chemistry Programme- Applied Chemistry Research Group-INQA- Bogota- Colombia., Pharmaceutical Chemistry, Bogota, Colombia;(5)Universidad El Bosque- Instituto de Virología- Vicerrectoría de Investigaciones- Bogotá- Colombia, Virology, Bogota, Colombia;(6)Universidad Militar Nueva Granada- Faculty of Medicine- Applied Clinical Immunology Group- Bogota-Colombia, Immunology, Bogota, Colombia;(7)Hospital Internacional de Colombia- Bucaramanga- Colombia., Gastroenterology, Bogota, Colombia;(8)Universidad El Bosque- Cellular and Molecular Immunology Group/INMUBO- Bogotá-Colombia, Immunology, Bogota, Colombia;
P180: Novel biomarkers associated with inflammatory bowel diseaseECCO'24Year: 2024
Authors: Baldan-Martin, M.(1)*;lloro, I.(2);Azkargorta, M.(2);Orejudo, M.(1);Ramírez, C.(1);Soleto, I.(1);Mercado, J.(1);Suárez-Trujillo, F.(1);Sánchez-Sánchez, C.(1);Gordillo-Vélez, C.H.(3);Riestra, S.(4);Rivero, M.(5);Gutiérrez, A.(6);Rodríguez-Lago, I.(7);Fernández-Salazar, L.(8);Ceballos, D.(9);Benítez, J.M.(10);Aguas , M.(11);Bastón Rey, I.(12);Bermejo, F.(13);Casanova, M.J.(1);Lorente, R.(14);Ber, Y.(15);Royo, V.(16);Esteve, M.(17);Elortza, F.(2);Gisbert*, J.P.(1);Chaparro*, M.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd- Madrid. Spain, Gastroenterology Unit, Madrid Madrid, Spain;(2)CIC bioGUNE- BRTA Basque Research & Technology Alliance- CIBERehd, Proteomics Platform, Derio, Spain;(3)Hospital Universitario de La Princesa, Anatomía Patológica, Madrid, Spain;(4)Hospital Universitario Central de Asturias and Instituto de Investigación sanitaria del Principado de Asturias ISPA, Gastroenterology Unit, Oviedo, Spain;(5)Hospital Universitario Marqués de Valdecilla and IDIVAL, Gastroenterology Unit, Santander, Spain;(6)Hospital General Universitario de Alicante- ISABIAL and CIBERehd, Gastroenterology Unit, Alicante, Spain;(7)Hospital Galdakao-Usansolo, Gastroenterology Unit, Vizcaya, Spain;(8)Hospital Clínico Universitario de Valladolid, Gastroenterology Unit, Valladolid, Spain;(9)Hospital Universitario de Gran Canaria Dr. Negrín, Gastroenterology Unit, Las Palmas de Gran Canaria, Spain;(10)Hospital Universitario Reina Sofía and IMIBIC, Gastroenterology Unit, Córdoba, Spain;(11)Hospital Universitari i Politecnic La Fe and Health Research Institute IISLaFe, Gastroenterology Unit, Valencia, Spain;(12)Hospital Clínico Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain;(13)Hospital Universitario de Fuenlabrada, Gastroenterology Unit, Madrid, Spain;(14)Hospital General Universitario de Ciudad Real, Gastroenterology Unit, Ciudad Real, Spain;(15)Hospital San Jorge- Huesca, Gastroenterology Unit, Huesca, Spain;(16)Hospital Universitari Son Espases, Gastroenterology Unit, Palma de Mallorca, Spain;(17)Hospital Universitari Mutua Terrasa- Terrasa- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Unit, Madrid, Spain;* Authors share co-senior authorship
P181: Combination of EPIC-CD epigenetic signatures accurately identifies non-response to multiple biologics in patients with active Crohn’s diseaseECCO'24Year: 2024
Authors: JoustraMD., V.(1)*;Li Yim, A.(2,3);Henneman, P.(3);Ishtu, H.(1,2);de Waard, T.(4);Evgeni, L.(4);Noble, A.(5);van Zon, S.(1);Chapman, T.(5,6);McGregor, C.(5);Adams, A.(5);Satsangi, J.(5);de Jonge, W.(2,7);D@E@Haens, G.(1);
(1)Amsterdam UMC - University of Amsterdam, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands;(2)Amsterdam UMC - University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(3)Amsterdam UMC - University of Amsterdam- Genome Diagnostics Laboratory, Department of Human Genetics, Amsterdam, The Netherlands;(4)Horaizon BV, Horaizon, Delft, The Netherlands;(5)Oxford University Hospitals NHS Foundation Trust - John Radcliffe Hospital, Translational Gastroenterology Unit & NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom;(6)St Richard’s and Worthing Hospitals- University Hospitals Sussex NHS Foundation Trust, Department of Gastroenterology, West Sussex, United Kingdom;(7)University of Bonn, Department of Surgery, Bonn, Germany;EPIC-CD Consortium
P182: Hepatic lesions in chronic inflammatory bowel disease revealed by liver biopsy during surgery.ECCO'24Year: 2024
Authors: Siham, B.(1)*;zazour, A.(2);koulali, H.(2);Ismaili, Z.(2);Kharrasse, G.(3);
(1)service d@E@hépato-gastro-entérologie, CHU mohamed VI, oujda, Morocco;(2)service d@E@hépato-gastro-entérologie, CHU mohammed VI, oujda, Morocco;(3)service d@E@hépato-gastro-entérologie, oujda, oujda, Morocco;
P183: Therapeutic Effects of Curcumin and Ginsenoside Combination in a Animal Model of Radiation ProctitisECCO'24Year: 2024
Authors: Kim, S.E.(1)*;Kim, M.S.(2);Lee, R.A.(3);Yang, S.J.(2);Lim, H.(4);Lee, T.Y.(2);Woo, S.Y.(5);
(1)EWHA Womans University- Mokdong Hospital, Department of Internal Medicine, Seoul, Korea- Republic Of;(2)CORESTEMCHEMON Inc., Central Research Center, Seoul, Korea- Republic Of;(3)Ewha Womans University- College of Medicine- Seoul- South Korea, Department of Surgery, Seoul, Korea- Republic Of;(4)Ewha Womans University- College of Medicine, Department of Internal Medicine, Seoul, Korea- Republic Of;(5)Ewha Womans University- College of Medicine, Department of Microbiology, Seoul, Korea- Republic Of;
P186: Comparative Analysis of Clinical Phenotypes and Pathogenic Features between Late-Onset and Infantile-Onset Monogenic Inflammatory Bowel DiseaseECCO'24Year: 2024
Authors: Xiao, F.(1)*;Liu, H.(2);Xu, J.(2);Shen, Y.(2);Liao, J.(2);
(1)Tongji Hospital- Tongji Medical College- Huazhong University of Science and Technology, Department of Gastroenterology-, Wuhan, China;(2)Tongji Hospital- Tongji Medical College- Huazhong University of Science and Technology, Department of Gastroenterology, Wuhan, China;
