P0129: Distinct involvement of plasma cells and monocytes/macrophages in ileal and colonic ulcer formation in patients with Crohn's diseaseECCO'25Year: 2025
Authors: PierreDr., N.(1)*;Jacobs, N.(2);Fernández-Verdejo, R.(3);Louis, E.(1);Vieujean, S.(1);
(1)University of Liège, Laboratory of Translational Gastroenterology- GIGA-institute, Liège, Belgium;(2)University of Liège, Cellular and Molecular Immunology- GIGA-institute, Liège, Belgium;(3)Universidad Finis Terrae, Laboratorio de Fisiología del Ejercicio y Metabolismo LABFEM, Santiago, Chile;
- Pierre N, Salée C, Massot C, Blétard N, Mazzucchelli G, Smargiasso N, et al. Proteomics Highlights Common and Distinct Pathophysiological Processes Associated with Ileal and Colonic Ulcers in Crohn’s Disease. J Crohns Colitis 2020;14(2):205–15.
P0130: Assessment of macrophage types in the intestinal tissue of treatment naïve Inflammatory Bowel Disease patients in relation to their disease and activation of the CCL2/CCR2 pathwayECCO'25Year: 2025
Authors: Begum, J.(1)*;Fatima, A.(1);Rimmer, P.(2);Iqbal, T.(3);Stoica, V.(2);Owusu, M.(2);Lelios, I.(4);McGettrick, H.(5);Welford, R.(4);Iqbal, A.(1);
(1)University of Birmingham, Department of Cardiovascular Sciences, Birmingham, United Kingdom;(2)Queen Elizabeth Hospital Birmingham NHS Foundation Trust, Department of Gastroenterology, Birmingham, United Kingdom;(3)University of Birmingham, Department of Immunology and Immunotherapy, Birmingham, United Kingdom;(4)F Hoffmann-La Roche, Roche Pharma Research and Early Development, Basel, Switzerland;(5)University of Birmingham, Department of Inflammation and Ageing, Birmingham, United Kingdom;
P0131: Characterisation of a human multi-organ-on-chip model to unravel gut-blood-brain communicationECCO'25Year: 2025
Authors: Maes, L.(1,2,3)*;Van Welden, S.(1);Vandenbroucke, R.(2,3);Laukens, D.(1);
(1)Ghent University, Internal Medicine and Pediatrics, Gent, Belgium;(2)Flemish Institute for Biotechnology, VIB-UGent Center for Inflammation Research, Gent, Belgium;(3)Ghent University, Biomedical Molecular Biology, Gent, Belgium; IBD Research Unit
P0132: ACSS2 inhibition alleviates inflammatory signaling and improves epithelial integrity in Inflammatory Bowel Disease in vitro models.ECCO'25Year: 2025
Authors: Mezher, N.(1);El-Kurjieh, A.(1);Sobh, R.(2);Matar, M.(1);Nassr, S.(3);Kobeissy, P.H.(1)*;
(1)Lebanese American University, Natural Sciences, Beirut, Lebanon;(2)Lebanese American University, Medicine, Beirut, Lebanon;(3)Lebanese American University Medical Center, Pathology, Beirut, Lebanon;
1. Sairenji, T., Collins, K. L. & Evans, D. V. An Update on Inflammatory Bowel Disease. Prim. Care Clin. Off. Pract. 44, 673–692 (2017).
2. Ling, R. et al. Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development. Discov. Oncol. 13, 58 (2022).
3. Hao, F. et al. Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation. Proc. Natl. Acad. Sci. 118, e2014681118 (2021).
P0133: Activation of Adipose Tissue Browning as a Potential Therapeutic Approach to Reduce Inflammation in Crohn’s DiseaseECCO'25Year: 2025
Authors: Boronat-Toscano, A.(1)*;Monfort-Ferré, D.(1);Cepero, C.(2);Menacho, M.(2);Clua-Ferré, L.(1,3);Caro, A.(4);Lahoz, M.(4);Moline, A.(2);Valldosera, G.(2);Suau, R.(3);Mañas, M.J.(5);Manyé, J.(3,6);Serena, C.(1);
(1)Health Institute Pere Virgili IISPV, University Hospital Joan XXIII, Tarragona, Spain;(2)University Hospital Joan XXIII, Digestive Department, Tarragona, Spain;(3)Germans Trias i Pujol Research Institute IGTP, Inflammatory Bowel Diseases, Badalona, Spain;(4)University Hospital Joan XXIII, Surgery Department, Tarragona, Spain;(5)Hospital San Pau i Santa Tecla, Surgery Department, Tarragona, Spain;(6)Centro de Investigación Biomédica en Red, CIBERehd, Madrid, Spain;
1. Büning, C.; von Kraft, C.; Hermsdorf, M.; Gentz, E.; Wirth, E.K.; Valentini, L.; Haas, V. Visceral Adipose Tissue in Patients with Crohn’s Disease Correlates with Disease Activity, Inflammatory Markers, and Outcome. Inflamm. Bowel. Dis. 2015, 21, 2590–2597.
2. Boronat-Toscano A, Monfort-Ferré D, Menacho M, Caro A, Bosch R, Espina B, Algaba-Chueca F, Saera-Vila A, Moliné A, Marti M, Espin E, Millan M, Serena C. Anti-TNF Therapies Suppress Adipose Tissue Inflammation in Crohn's Disease. Int J Mol Sci. 2022 Sep 22;23(19):11170.
3. Monfort-Ferré D, Caro A, Menacho M, Martí M, Espina B, Boronat-Toscano A, Nuñez-Roa C, Seco J, Bautista M, Espín E, Megía A, Vendrell J, Fernández-Veledo S, Serena C. The Gut Microbiota Metabolite Succinate Promotes Adipose Tissue Browning in Crohn's Disease. J Crohns Colitis. 2022 Nov 1;16(10):1571-1583.
4. Zuo L, Geng Z, Song X, Li J, Wang Y, Zhang X, Ge S, Wang L, Liu G, Zhang L, Xu M, Zhao Y, Shen L, Ge Y, Wu R, Hu J. Browning of Mesenteric White Adipose Tissue in Crohn's Disease: A New Pathological Change and Therapeutic Target. J Crohns Colitis. 2023 Aug 21;17(8):1179-1192.
P0134: Human umbilical cord-derived mesenchymal stem cells promote intestinal mucosal repair by activating fibroblasts-epithelial interactionsECCO'25Year: 2025
Authors: Huang, Z.(1,2)*;Yang, H.(1,2);Chao, K.(1,2);Gao, X.(1,2);
(1)The Sixth Affiliated Hospital- Sun Yat-sen University, Department of Gastroenterology, Guangzhou, China;(2)The Sixth Affiliated Hospital- Sun Yat-sen University, Biomedical Innovation Center, Guangzhou, China;
P0135: Effect of human recombinant IL-33 on fibrosis markers in colonic fibroblastsECCO'25Year: 2025
Authors: Ratel, L.(1)*;Leboutte, M.(1);Hermoso, M.A.(2);Savoye, G.(3);Marion-Letellier, R.(1);
(1)Univ Rouen Normandie- INSERM- Normandie Univ- ADEN UMR1073- Nutrition- Inflammation and the Microbiota-Gut-Brain Axis- F-76000 Rouen- France / Institute for Research and Innovation in Biomedicine IRIB- University of Rouen- CEDEX- 76183 Rouen- France, UFR santé - Université Rouen Normandie, Rouen, France;(2)Laboratory of Innate Immunity- Program of Immunology- Institute of Biomedical Sciences- Faculty of Medicine- Universidad de Chile- Santiago- Chile / Department of Gastroenterology and Hepatology- University of Groningen- University Medical Center Groningen- Groningen- The Netherlands, Universidad de Chile- Santiago- Chile, Santiago, Chile;(3)Univ Rouen Normandie- INSERM- Normandie Univ- ADEN UMR1073- Nutrition- Inflammation and the Microbiota-Gut-Brain Axis- F-76000 Rouen- France / Institute for Research and Innovation in Biomedicine IRIB- University of Rouen- CEDEX- 76183 Rouen- France / Gastroenterology Department- Rouen University Hospital- CEDEX- 76031 Rouen- France, Gastroenterology Department- Rouen University Hospital- CEDEX- 76031 Rouen- France, Rouen, France;
1. Amamou A, Yaker L, Leboutte M, Bôle-Feysot C, Savoye G, Marion-Letellier R. Dietary AhR Ligands Have No Anti-Fibrotic Properties in TGF-β1-Stimulated Human Colonic Fibroblasts. Nutrients. 2022;14(16):3253. doi:10.3390/nu14163253
2. Schmitz J, Owyang A, Oldham E, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005;23(5):479-490. doi:10.1016/j.immuni.2005.09.015
3. Beltrán CJ, Núñez LE, Díaz-Jiménez D, et al. Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2010;16(7):1097-1107. doi:10.1002/ibd.21175 4.
4. England E, Rees DG, Scott IC, et al. Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction. Sci Rep. 2023;13(1):9825. doi:10.1038/s41598-023-36642-y
P0136: The role of FDG PET/CT in the and identification of fibrosis related to Crohn’s diseaseECCO'25Year: 2025
Authors: Élthes, Z.(1)*;Sándor, K.(1);Galuska, L.(2);Farkas, B.(3);Pető, S.(4);Palatka, K.(1);
(1)University of Debrecen- Clinical Center- Institute of Gastroenterology, Gastroenterology, Debrecen, Hungary;(2)University of Debrecen, Scaomed Ltd., Debrecen, Hungary;(3)University of Debrecen, Scanomed Ltd., Debrecen, Hungary;(4)BAZ County Central and Teaching Hospital, Second Department of Internal Medicine, Miskolc, Hungary;
P0137: Primary bile acids promote epithelial necroptosis via Stat1 signalingECCO'25Year: 2025
Authors: Hu, K.(1)*;Leistl, S.(1);Wieser, L.(1);Chiriac, M.(1);Rauh, M.(2);Neurath, M.(1,3,4);Günther, C.(1,3,4);
(1)Universitätsklinikum Erlangen, Department of Medicine 1, Erlangen, Germany;(2)Universitätsklinikum Erlangen, Clinical laboratory, Erlangen, Germany;(3)Universitätsklinikum Erlangen, Deutsches Zentrum Immuntherapie DZI, Erlangen, Germany;(4)Friedrich-Alexander-Universität Erlangen-Nürnberg, FAU Profile Center Immunomedicine FAU I-MED, Erlangen, Germany;
1.Liso M,De Santis S,Verna G, et al. A Specific Mutation in Muc2 Determines Early Dysbiosis in Colitis-Prone Winnie Mice. Inflamm Bowel Dis. 2020;26 (4):546-556. doi:10.1093/ibd/izz279
2.Franzosa EA,Sirota-Madi A,Avila-Pacheco J, et al. Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nat Microbiol. 2019;4 (2):293-305. doi:10.1038/s41564-018-0306-4
P0140: Estrogen Related Receptor Alpha Contributes to Intestinal Homeostasis by Modulating the Gut Microbiota and activating autophagyECCO'25Year: 2025
Authors: Lee, J.Y.(1)*;Kim, S.(2);Shin, S.G.(3);Kim, J.K.(3);Silwal, P.(3);Kim, Y.J.(3);Shin, N.R.(4);Kim, P.S.(1);Won, M.(5);Lee, S.H.(6);Kim, S.Y.(7);Sasai, M.(8);Yamamoto, M.(8);Kim, J.M.(9);Jo, E.K.(3);Bae, J.W.(1);
(1)KyungHee University, Department of Biology, Seoul, Korea- Republic Of;(2)Chungnam National University Hospital, Department of Radiation Oncology, Daejeon, Korea- Republic Of;(3)Chungnam National University School of Medicine, Department of Microbiology, Daejeon, Korea- Republic Of;(4)Biological Resource Center, Korean Collection for Type Cultures, Jeongeup, Korea- Republic Of;(5)Korea Research Institute of Bioscience & Biotechnology KRIBB, Biotechnology Process Engineering Center, Cheongju, Korea- Republic Of;(6)Korea Basic Science Institute, Center for Research Equipment, Cheongju, Korea- Republic Of;(7)Korea Institute of Oriental Medicine, Future Medicine Division, Daejeon, Korea- Republic Of;(8)WPI Immunology Frontier Research Center, Department of Immunoparasitology, Osaka, Japan;(9)Chungnam National University School of Medicine, Pathology and Department of Medical Science, Daejeon, Korea- Republic Of;
- 1. Kim S, Lee JY, Shin SG, Kim JK, Silwal P, Kim YJ, et al. ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota. Autophagy 2021; 17:2856-75.
P0141: Estrogen receptor β alleviates colitis in intestinal epithelial cells by activating HIF-1α and ATG-9a mediated autophagyECCO'25Year: 2025
Authors: Li, J.(1,2)*;Chen, Y.(1);Zhu, L.(1);
(1)Union Hospital- Tongji Medical College- Huazhong University of Science and Technology, Division of Gastroenterology, Wuhan, China;(2)Chongqing Hospital Union Hospital- Tongji Medical College- Huazhong University of Science and Technology, Division of Gastroenterology, Chongqing, China;
P0143: Isotretinoin treatment protects against Crohn’s disease development and suppresses pro-inflammatory cytokines that drive experimental enteritisECCO'25Year: 2025
Authors: Meyer, M.(1)*;Grabherr, F.(1);Hadjihannas, M.V.(2);Schwärzler, J.(1);Mayr, L.(1);Jukic, A.(1);Enrich, B.(1);Scheffauer, L.(1);Zundel, L.(1);Zollner, A.(1);Grander, C.(1);Franke, A.(2);Tilg, H.(1);Adolph, T.E.(1);
(1)Medical University of Innsbruck, Department of Internal Medicine I- Gastroenterology- Hepatology- Endocrinology & Metabolism, Innsbruck, Austria;(2)Christian-Albrechts-University Kiel and Schleswig-Holstein University Hospital, Institute of Clinical Molecular Biology, Kiel, Germany;
1. Schwärzler J, Mayr L, Vila AV, et al. PUFA-induced metabolic enteritis as a fuel for Crohn's disease. Gastroenterology. Jan 11 2022;doi:10.1053/j.gastro.2022.01.004
2. Mayr L, Grabherr F, Schwarzler J, et al. Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease. Nat Commun. Apr 14 2020;11(1):1775. doi:10.1038/s41467-020-15646-6
3. Allenby G, Bocquel MT, Saunders M, et al. Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. Jan 1 1993;90(1):30-4. doi:10.1073/pnas.90.1.30
4. Palchuk MB, London JW, Perez-Rey D, et al. A global federated real-world data and analytics platform for research. JAMIA Open. Jul 2023;6(2):ooad035. doi:10.1093/jamiaopen/ooad035
P0144: Unveiling the role of the MFSD2A protein in contributing to the resolution of colitis-associated cancer inflammationECCO'25Year: 2025
Authors: Cagliani, S.(1,2)*;Massimino, L.(1);Facoetti, A.(1);Spanò, S.(1);Maddipati, K.(3);Errico, C.(1);Nicolò, S.(1);Colasante, G.(4);Danese, S.(2,5);Ungaro, F.(1);
(1)San Raffaele Research Institute, Laboratory of Experimental Gastroenterology- Division of Immunology- Transplantation and Infectious Disease, Milan, Italy;(2)Vita-Salute San Raffaele University, Faculty of Medicine, Milan, Italy;(3)Wayne State University, Lipidomics Core Facility, Detroit, United States;(4)San Raffaele Research Institute, Stem Cell and Neurogenesis Unit- Division of Neuroscience, Milan, Italy;(5)San Raffaele Hospital, Gastro Center- Gastroenterology and Digestive Endoscopy, Milan, Italy;
1. Ungaro F, D'Alessio S, Danese S. The Role of Pro-Resolving Lipid Mediators in Colorectal Cancer-Associated Inflammation: Implications for Therapeutic Strategies. Cancers (Basel). 2020;12(8):2060. Published 2020 Jul 26. doi:10.3390/cancers12082060
2. Ungaro F, Tacconi C, Massimino L, et al. MFSD2A Promotes Endothelial Generation of Inflammation-Resolving Lipid Mediators and Reduces Colitis in Mice. Gastroenterology. 2017;153(5):1363-1377.e6. doi:10.1053/j.gastro.2017.07.048
3. Massimino L, Bulbarelli A, Corsetto PA, et al. LSEA Evaluation of Lipid Mediators of Inflammation in Lung and Cortex of Mice Exposed to Diesel Air Pollution. Biomedicines. 2022;10(3):712. Published 2022 Mar 19. doi:10.3390/biomedicines10030712
P0146: Phosphoglycerate dehydrogenase plays a vital role in ER-stress-related intestinal inflammationECCO'25Year: 2025
Authors: Yang, G.(1)*;Xiang, H.(1);Welz, L.(1);Bhardwaj, A.(1);Treitz, C.(2);Sima, K.(3);Koncina, E.(4);Kim, N.M.(1);Kugler, J.(1);Tran, F.(1); Nikolaus, S.(5);Sievers, L.K.(1);Liu, Z.(6);He, Q.(6);Schreiber, S.(5);Rosenstiel, P.(1);Aden, K.(1);
(1)Kiel University, Institute of Clinical Molecular Biology IKMB, Kiel, Germany;(2)Kiel University, Institute for Experimental Medicine IEM, Kiel, Germany;(3)University of Lübeck, Department of Infectious Diseases and Microbiology, Lübeck, Germany;(4)University of Luxembourg, Department of Life Sciences and Medicine, Luxembourg, Luxembourg;(5)University Hospital Schleswig-Holstein, Department of Internal Medicine I, Kiel, Germany;(6)Shanghai Tenth People's Hospital- Tongji University School of Medicine- Shanghai- China, Center for IBD Research- Department of Gastroenterology, Shanghai, China;
P0147: Regulation of Inflammatory Pathways by miR-338-3p and miR-378a-3p: A Novel Approach for Crohn’s Disease TreatmentECCO'25Year: 2025
Authors: Choi, C.H.(1)*;Moon, J.M.(1);Kim, K.U.(2);Lim, E.(2);Hwang, H.W.(3);Kyuwon, K.(1);Seo, J.(1);Shin, S.Y.(1);Lim, H.(1);Min, H.(2);
(1)Chung-Ang University College of Medicine, Department of Internal Medicine, Seoul, Korea- Republic Of;(2)Chung-Ang University, College of Pharmacy, Seoul, Korea- Republic Of;(3)Chung-Ang University College of Medicine, Department of Pathology, Seoul, Korea- Republic Of;
P0148: Studying the role of adipose tissue in intestinal inflammation using acquired generalized lipodystrophyECCO'25Year: 2025
Authors: Letizia , M.(1);Omar, T.(1)*;Weidner, P.(2);Siegmund, B.(1);Weidinger , C.(1);
(1)Charité – Universitätsmedizin Berlin- corporate member of Freie Universität Berlin and Humboldt -Universität zu Berlin, Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Max-Delbrück-Centrum für Molekulare Medizin MDC, Berlin Institute for medical system biology, Berlin, Germany;
(1) Coffey JC, O'Leary DP. The mesentery: structure, function, and role in disease. Lancet Gastroenterol Hepatol 2016;1:238-247.
P0149: Deep functional analysis of a defined sulphide-reducing diet (4-SURE diet) as a novel therapy for ulcerative colitis (UC) demonstrates all specific luminal micro environmental objectives were achievedECCO'25Year: 2025
Authors: Day, A.(1,2,3)*;Slater, R.(4);Marcelino, V.(5,6);Wheeler, R.(7);Young, R.(5,8);Maddigan, N.(2,3);Forster, S.(5);Costello, S.(2,3,9);Uylaki, W.(3,10);Probert, C.(4);Andrews, J.(2,11);Yao, C.(12);Gibson, P.(12);Bryant, R.(2,3,9);
(1)The Queen Elizabeth Hospital, Gastroenterology, Woodville South- Adelaide, Australia;(2)University of Adelaide, Faculty of Health and Medical Sciences, Adelaide- South Australia, Australia;(3)Basil Hetzel Institute, IBD Research Group, Adelaide- South Australia, Australia;(4)University of Liverpool, Institute of Systems- Molecular and Integrative Biology- Department of Molecular and Clinical Cancer, Liverpool, United Kingdom;(5)Hudson Institute of Medical Research, Centre for Innate Immunity and Infectious Diseases, Clayton- Victoria, Australia;(6)The Peter Doherty Institute- University of Melbourne, Melbourne Integrative Genomics- School of BioSciences & Department of Microbiology and Immunology, Melbourne- Victoria, Australia;(7)Flinders University, College of Science and Engineering, Adelaide- South Australia, Australia;(8)Monash University, Department of Molecular and Translational Sciences, Clayton- Victoria, Australia;(9)The Queen Elizabeth Hospital, Gastroenterology, Adelaide- South Australia, Australia;(10)The Queen Elizabeth Hospital, Department of Gastroenterology, Adelaide- South Australia, Australia;(11)Royal Adelaide Hospital, Gastroenterology, Adelaide- South Australia, Australia;(12)Monash University & Alfred Health, Department of Gastroenterology- School of Translational Research, Melbourne- Victoria, Australia;
