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P031: Impact of nutritional antigens in inflammatory bowel disease patients

ECCO '19 Copenhagen

Year: 2019
Authors:

Y. Rodríguez Sillke*1, M. Schumann1, D. Lissner1, F. Branchi1, R. Glauben1, B. Siegmund1

1Charité Universitätsmedizin Berlin, Medical Department (Gastroenterology, Infectious Diseases, Rheumatology), Berlin, Germany

P032: Hepatocyte growth factor and MET in ulcerative colitis, novel drug targets impairing neutrophil recruitment?

ECCO '19 Copenhagen

Year: 2019
Authors:

B. Verstockt*1,2, M. Stakenborg2, W-J. Wollants2, G. Van Assche1,2, M. Ferrante1,2, S. Vermeire1,2, G. Matteoli2

1University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, 2KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium

P033: Periostin regulates ER-stress mediated intestinal subepithelial myofibroblasts function to promote fibrosis in Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

C. Li*1, J. Kuemmerle1

1Virginia Commonwealth University, Internal Medicine, Richmond, USA

P034: A dietary fibre intervention shapes the microbiome towards an anti-inflammatory tone

ECCO '19 Copenhagen

Year: 2019
Authors:

S. J. Reider*1,2, S. Moosmang3, J. Tragust1, L. Trgovec-Greif4, S. Tragust5, N. Przysiecki1, S. Sturm3, H. Tilg2, T. Rattei4, H. Stuppner3, A. R. Moschen1,2

1Medical University Innsbruck, Christian Doppler Laboratory for Mucosal Immunology, Innsbruck, Austria, 2Medical University Innsbruck, Department for Internal Medicine I – Gastroenterology, Hepatology, Endocrinology and Metabolism, Innsbruck, Austria, 3University of Innsbruck, Institute of Pharmacy / Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), Innsbruck, Austria, 4University of Vienna, Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, Vienna, Austria, 5University Halle, Institute of Biology – General Zoology, Halle (Saale), Germany

P035: Pharmacological inhibition of the canonical WNT signalling pathway represents a potential novel therapy for fibrosis in Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Lewis*1, A. Nijhuis1, G. Berti1, C. L. Bishop2, R. Feakins3, J. O. Lindsay4, A. Silver1

1Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Genomics and Child Health, London, UK, 2Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Cell Biology and Cutaneous Research, London, UK, 3Department of Histopathology, The Royal London Hospital, London, UK, 4Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Immunobiology, London, UK

P036: Expression of CD69 on peripheral lymphocytes predicts treatment response in Acute Severe ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

M. C. Choy*1,2,3, J. Yu2, M. Congiu2, P. Pelpola2, J. Nigro2, R. Burder1, K. Boyd1, M. McGuckin4, A. J. Corbett5, L. Kjer-Nielsen5, J. McCluskey5, K. Visvanathan2, P. De Cruz1,3

1Austin Health, Gastroenterology, Heidelberg, Australia, 2St Vincent's Hospital, Immunology Research Centre, Fitzroy, Australia, 3Austin Academic Centre, University of Melbourne, Medicine, Heidelberg, Australia, 4University of Melbourne, Department of Medicine, Dentistry and Health Sciences, Parkville, Australia, 5The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Department of Microbiology and Immunology, Parkville, Australia

P037: USP16-mediated deubiquitination of calcineurin A controls peripheral T cells maintenance and attenuates intestinal inflammation

ECCO '19 Copenhagen

Year: 2019
Authors:

Y. Zhang*1,2, R. Liu1,2, K. Fan3, L. Huang1,2, Z. Gao3, T. Huang3, J. Zhong3, X. Mao3, X. Mao3, F. Wang3, P. Xiao1,2, Y. Zhao1,2, Y. Li3, X. Feng3, J. Jin3, Q. Cao1,2

1Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Gastroenterology, Hangzhou, China, 2Inflammatory Bowel Disease Center of Sir Run Run Shaw Hospital, Hangzhou, China, 3MOE Laboratory of Biosystem Homeostasis and Protection, and Life Sciences Institute, Zhejiang University, Hangzhou, China

P038: Expression analysis in colitis-associated carcinoma: a role for osteopontin?

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Cardoso da Silva*1, M. Sehn2, S. Elezkurtaj3, A. Kühl4, B. Siegmund1, M. Kreis2, C. Holmer2, M. Hummel3, J. Gröne5, M. Schumann1

1Charité Universitätsmedizin Berlin, Department for Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, 2Charité Universitätsmedizin Berlin, Department for General and Visceral Surgery, Berlin, Germany, 3Charité Universitätsmedizin Berlin, Department for Pathology, Berlin, Germany, 4Charité Universitätsmedizin Berlin, Department for Immunopathology, Berlin, Germany, 5Rotes Kreuz Krankenhaus, Department for General and Visceral Surgery, Bremen, Germany

P039: Tracking intestinal epithelial cells with fluorescent dyes

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Seidelin*1, F. H. Bergenheim1, O. H. Nielsen1

1Herlev Hospital, University of Copenhagen, Department of Gastroenterology, Herlev, Denmark

P040: The cytokine milieu in patients with inflammatory bowel disease impacts the phenotype of mesenchymal stromal cells

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Barnhoorn*1, K. Schepers2, H. Verspaget1, W. Fibbe2, L. Hawinkels1, M. van Pel2, A. van der Meulen - de Jong1

1Leiden University Medical Center, Gastroenterology and Hepatology, Leiden, The Netherlands, 2Leiden University Medical Center, Immunohematology and Blood Transfusion, Leiden, The Netherlands

P041: Differences in NOTCH signalling between stricturing and penetrating behaviour in Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Rodriguez-Antequera1, J. Cosin-Roger2,3, D. Macias-Ceja3, P. Salvador4, L. Gisbert-Ferrándiz4, S. Coll4, J. Manyé5, R. Alós6, F. Navarro-Vicente7, S. Calatayud2,4, M. D. Barrachina2,4, D. Ortiz-Masia1,2

1Universidad de Valencia, Medicine, Valencia, Spain, 2CIBERehd, Valencia, Spain, 3Fisabio, Valencia, Spain, 4Universidad de Valencia, Pharmacology, Valencia, Spain, 5CIBERehd, Badalona, Spain, 6Hospital de Sagunto, Sagunto, Spain, 7Hospital de Manises, Manises, Spain

P042: APL expression is down-regulated in an animal model of chronic colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

T. Nagaishi*1, Y. Kojima1, D. Yamada1, T. Watabe1, N. Tsugawa1, N. Jose1, M. Onizawa1, M. Watanabe1

1Tokyo Medical and Dental University, Gastroenterology, Tokyo, Japan

P043: Secretome modulation of Caco-2 cell line induced by a multi-strain probiotic

ECCO '19 Copenhagen

Year: 2019
Authors:

V. Petito*1, V. Greco2,3, L. Laterza4, C. Graziani4, L. Lopetuso1,4, F. Scaldaferri1,4, A. Urbani2,3, A. Gasbarrini1,4

1Universita' Cattolica del Sacro Cuore, Institute of Medical Pathology, Rome, Italy, 2Università cattolica del Sacro Cuore, Institute of Biochemistry and Clinical Biochemistry, Rome, Italy, 3Fondazione Policlinico A. Gemelli IRCCS, Department of Laboratory Diagnostic and Infectious Diseases, Rome, Italy, 4Fondazione Policlinico Universitario Gemelli IRCCS, Gastroenterological Area, Gastroenterological, Endocrino-Metabolical and Nefro-urological Sciences Department, Rome, Italy

P044: A novel porcine model of Crohn’s disease anastomotic stricture

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Lukas*1, M. Kolar1, O. Ryska2,3, S. Juhas3, J. Juhasova3, J. Kalvach3,4, J. Pazin3,4, J. Hadac3,4, I. Vitkova5, M. Bortlik1,6,7, M. Lukas1,8

1ISCARE I.V.F. a.s., IBD Clinical and Research Centre, Prague, Czech Republic, 2University Hospitals of Morecambe Bay NHS Foundation Trust, Royal Lancaster Infirmary, Lancaster, UK, 3Institute of Animal Physiology and Genetics, Czech Academy of Sciences, PIGMOD Centre, Laboratory of Cell Regeneration and Plasticity, Libechov, Czech Republic, 4Military University Hospital and 2nd Faculty of Medicine, Charles University, Department of Surgery, Prague, Czech Republic, 5Institute of Pathology of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic, 6Military University Hospital and First Faculty of Medicine, Charles University, Department of Internal Medicine, Prague, Czech Republic, 7Institute of Pharmacology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 8Institute of Medical Biochemistry and Laboratory Medicine, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic

P045: Local inflammation modulates vitamin D receptor protein levels in fibroblasts

ECCO '19 Copenhagen

Year: 2019
Authors:

L. Gisbert-Ferrándiz1, J. Cosin-Roger2, P. Salvador1, D. C. Macias-Ceja2, F. Navarro-Vicente3, R. Alos4, S. Calatayud1, M. D. Barrachina1

1Universitat de Valencia and CIBERehd, Pharmacology, Valencia, Spain, 2Fisabio, Hospital Dr. Peset, Valencia, Spain, 3Hospital Manises, Valencia, Spain, 4Hospital La Fe, Valencia, Spain

P046: Iron mobilisation into the intestinal epithelium prevents hypoxia-associated autophagy and reduces inflammation through the inhibition of NF-κB

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Simmen1, J. Cosin-Roger1, H. Melhem1, N. Maliachovas1, M. Maane1, K. Baebler1, B. Weder1, C. Maeyashiki1, K. Spanaus1, M. Scharl1, C. de Vallière1, J. Zeitz1, S. R. Vavricka1, M. Hausmann1, G. Rogler1, P. A. Ruiz-Castro1

1University of Zurich / University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland

P047: Neuroendocrine cells densities alterations in colonic mucosa of patients with inflammatory bowel disease

ECCO '19 Copenhagen

Year: 2019
Authors:

C. Meianu*1, G. Becheanu1, C-M. Preda1, D. Istratescu1, C-A. Ciora1, M. Manuc1, L. Tugui1, A-C. Andrei1, M. Diculescu1

1Clinic Fundeni Institute- Gastroenterology and Hepatology, Bucuresti, Romania

P048: Exploring mucosal function as a clinical endpoint in ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Kjaergaard*1,2, M. M. B. Damm1, J. Chang3, L. B. Riis4, R. Hytting-Andreasen5, S. Krug6, J. D. Schulzke6, N. Bindslev2, M. B. Hansen1

1Bispebjerg Hospital, Digestive Disease Center, Copenhagen, Denmark, 2Faculty of Health and Medical Sciences, Department of Biomedical Sciences, Copenhagen, Denmark, 3University of Manchester, Wellcome Trust Centre for Cell-Matrix Research, Manchester, UK, 4Herlev Hospital, Department of Pathology, Copenhagen, Denmark, 5NNF Center of Basic Metabolic Research, University of Copenhagen, Department of Biomedical Sciences, Copenhagen, Denmark, 6Institute of Clinical Physiology, Charité, Berlin, Germany

P049: Dietary walnus to prevent indomethacin-induced intestinal damages

ECCO '19 Copenhagen

Year: 2019
Authors:

K. B. Hahm*1, Y. W. Shin2

1CHA University, Gastroenterology, Seongnam, South Korea, 2Inha University Hospital, Incheon, South Korea

P050: Serum adropin levels in patients with Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

P. M. Zivkovic*1, I. Tadin Hadjina1, D. Rusic2, M. Vilovic3, D. Supe-Domic4, D. Martinovic3, Z. Puljiz1, A. Tonkic1, J. Bozic3

1University Hospital of Split, Department of Gastroenterology and Hepatology, Split, Croatia, 2University of Split School of Medicine, Department of Pharmacy, Split, Croatia, 3University of Split School of Medicine, Department of Pathophysiology, Split, Croatia, 4University Hospital of Split, Department of Laboratory Diagnostics, Split, Croatia

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