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P017 C86/CD16 macrophages accumulate in the mucosa of B3 patients and could mediate EMT in Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

A. Boronat-Muñoz1, A. Cejudo-Garces1, P. Lledo-Gil1, J. Cosín-Roger2, S. Coll3, F. Navarro-Vicente4, R. Alos5, S. Calatayud6, M.D. Barrachina6, D. Ortiz-Masiá7

1Department of Medicine, Universidad de Valencia, Valencia, Spain, 2FISABIO, Hospital Dr Peset, Valencia, Spain, 3Department of Pharmacy, Universidad de Valencia, Valencia, Spain, 4Hospital de Manises, Cirugía General y Digestiva, Manises, Spain, 5Hospital la Fe, Cirugía General y Digestiva, Valencia, Spain, 6Department of Pharmacy and CIBERehd, Universidad de Valencia, Valencia, Spain, 7Department of Medicine and CIBERehd, Universidad de Valencia, Valencia, Spain

P018 Per- and polyfluoroalkyl substances (PFAS) are significantly increased in patients with late-onset of ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

F. Fart1, S. Salihovic1,2, A. McGlinchey1, M. Orešič1,3, J. Halfvarson4, T. Hyötyläinen2, I. Schoultz1

1School of Medical Sciences, Örebro University, Örebro, Sweden, 2School of Science and Technology, Örebro University, Örebro, Sweden, 3Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland, 4Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

P019 Colonic mucosal kinase activity, cytokine and chemokine profiles in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

E. Brand1, B. Roosenboom2, B. Malvar Fernandez3, L. Lutter1, E. van Koolwijk4, E.G. van Lochem4, C.S. Horjus Talabur Horje2, K.A. Reedquist3, F. van Wijk3, B. Oldenburg5

1Department of Gastroenterology and Hepatology and Centre for Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands, 2Department of Gastroenterology and Hepatology, Rijnstate Crohn and Colitis Centre, Arnhem, The Netherlands, 3Centre for Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands, 4Department of Microbiology and Immunology, Rijnstate Hospital, Arnhem, The Netherlands, 5Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands

P020 MAM, an anti-inflammatory protein derived from Faecalibacterium prausnitzii as a biomarker in Crohn’s disease?

ECCO'20 Vienna

Year: 2020
Authors:

P. McLellan1, A. Lavelle1, L. Brot1, M. Straube1, L. de Sordi1, J.P. Grill1, A. Bourrier2, J. Kirchgesner2, J.M. Chatel3, L. Beaugerie2, H. Sokol1, P. Seksik1

1INSERM, Pierre and Marie Curie University, CRSA UMRS_938 Team Microbiota Intestine and Inflammation, Paris, France, 2Saint Antoine Hospital, Department of Gastroenterology, Paris, France, 3INRA, Micalis, Jouy-enJosas, France

P021 The influence of short-chain fatty acids produced by commensal bacteria on macrophage phenotype

ECCO'20 Vienna

Year: 2020
Authors:

C. Jukes1,2, L. Ricci3, E. von Coburg1,2, M. Nasr4, A.W. Walker3, S.H. Duncan3, A.N. Hegazy MD, PhD1,2

1Charité, University Medicine Berlin, CBF and German Rheumatism Research Center-Berlin, Department of Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, 2Deutsches Rheuma-Forschungszentrum- ein Institut der Leibniz-Gemeinschaft, Inflammatory Mechanisms Group, Berlin, Germany, 3Rowett Institute, University of Aberdeen, Gut Health Group, Aberdeen, UK, 4Department of Pharmaceutics and Industrial Pharmacy, Ain Shams University, Faculty of Pharmacy, Cairo, Egypt

P022 Impact of increasing disease symptom concordance between patients with inflammatory bowel disease and their physicians: insights from US, France, Germany, Italy, Spain and UK (5EU)

ECCO'20 Vienna

Year: 2020
Authors:

J. Kershaw1, R. Wild1, R. Lukanova1, S. Bruce Wirta2, M. Sikirica3

1Adelphi Real World, Adelphi, Manchester, UK, 2Janssen-Cilag, Janssen, Solna, Sweden, 3Janssen Scientific Affairs, LLC, Janssen, Horsham- PA, USA

P023 Identification of regulated mechanistic pathways and genes to protect intestinal barrier injury by larazotide acetate in an IBD microenvironment

ECCO'20 Vienna

Year: 2020
Authors:

Y. Jin1, J. Madan2, K. Radha B2, B. Anthony3

1Department of Animal and Avian Sciences, University of Maryland College Park, College Park, MD, USA, 2Innovate Biopharmaceuticals Inc., Innovate Biopharmaceuticals Inc., Raleigh, NC, USA, 3North Carolina State University, Department of Clinical Sciences, Raleigh, NC, USA

P024 Evaluation of the clinical course of patients diagnosed with primary sclerosing cholangitis: single centre study

ECCO'20 Vienna

Year: 2020
Authors:

S. Wiecek1, A. Wojtyniak2, B. Pindur2, U. Grzybowska-Chlebowczyk1

1Department of Pediatrics, Department of Pediatrics, Medical University of Silesia, Katowice, Poland, 2Student Scientific Club, Department of Pediatrics, Medical University of Silesia, Katowice, Poland

P025 Evaluation of endoplasmic reticulum stress in intestinal mucosa from patients with Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

B. Rodrigues1, L.B. Pascoal1, A. Coope1, M.L.S. Ayrizono1, M.G. Camargo1, L.A. Velloso2, J.J. Fagundes1, R.F. Leal1

1Department of Surgery, University of Campinas, Campinas, Brazil, 2Department of Internal Medicine, University of Campinas, Campinas, Brazil

P026 The impact of different dietary factors in the etiopathogenesis of inflammatory bowel disease: a retrospective case–control study

ECCO'20 Vienna

Year: 2020
Authors:

C.M. Preda1, T. Manuc1, A.E. Chifulescu1, D. Istratescu1, E. Louis2, M. Diculescu1, T. Cristian3, L.S. Gheorghe1, M. Manuc1

1Department of Gastroenterology, Department of Digestive Diseases and Liver Transplantation, Clinical Institute Fundeni, Bucharest, Romania, 2Department of Gastroenterology, University Hospital CHU Liège, Liège, Belgium, 3Department of Gastroenterology and Hepatology, Elias Emergency Hospital, Bucharest, Romania

P027 Repertoire analysis of memory T-cell receptors in Japanese patients with inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

N. Takeru, Y. Kakuta, Y. Izumiyama, R. Ichikawa, D. Okamoto, R. Moroi, M. Kuroha, Y. Kanazawa, Y. Kinouchi, A. Masamune

Tohoku University, Gastroenterology, Miyagiken Sendai City, Japan

P028 The anti-inflammatory effects of a poly-probiotic on the oral mucosa

ECCO'20 Vienna

Year: 2020
Authors:

E. Marlina1, B. Hirani2, V. Mercadante1, M. Shephard3, S. Kishida4, G. Sebepos-Rogers5, R. McMillan3, T. Hodgson3, R. Leeson1, S. Porter1, J. Barber6, S. Fedele1, A. Smith1

1Eastman Dental Institute, University College London, London, UK, 2UCLH Biomedical Research Centre, National Institute for Health Research, London, UK, 3Eastman Dental Hospital, University College London Hospital, London, UK, 4Biochemical Genetic Department, Kagoshima University, Kagoshima, Japan, 5Department of Gastroenterology, University College Hospital, London, UK, 6Department of Statistical Science, University College London, London, UK

P029 TRIM 21 protects against ulcerative colitis and colitic cancer via smad7 inhibition

ECCO'20 Vienna

Year: 2020
Authors:

K.B. Hahm

CHA University, Gastroenterology, Seongnam-Si, Korea Republic of

P030 Dynamics of intestinal inflammation and microbial dysbiosis in pregnant women with IBD and their infants

ECCO'20 Vienna

Year: 2020
Authors:

L. Tarassishin PhD1, E. Kim2, C. Eisele1, A. Barre3, A. Thjømøe4, E. Mørk4, M. Dubinsky5, J. Stone6, N. Nair1, A. Debebe1, K. Hawkins1, A. Rendon1, J. Sabino7, J. Torres8, J.F. Colombel9, I. Peter1, J. Hu1

1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA, 2School of Medicine, Department of Internal Medicine, Kyungpook National University- Daegu, Korea- Republic of, 3Gastroenterology Division, Cochin University Hospital, Paris, France, 4Calpro AS, Calpro AS, Lysaker, Norway, 5Division of Pediatric Gastroenterology and Hepatology, Icahn School of Medicine at Mount Sinai, New York, USA, 6Department of Obstetrics, Gynecology and Reproductive Sciences, Icahn School of Medicine at Mount Sinai, New York, USA, 7Department of Gastroenterology, University Hospital of Leuven, Leuven, Belgium, 8Gastroenterology Division, Hospital Beatriz Angelo, Loures, Portugal, 9Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA

P031 Therapeutic effect of OPS-2071 in a murine model of Crohn’s disease and in in vitro anti-inflammatory assays

ECCO'20 Vienna

Year: 2020
Authors:

H. Takagi1, M. Sato1, F. Kazuyuki1, I. Shibuya2, D. Oka1, N. Yamaya3, K. Inagaki1

1Department of Medical Innovations, New Drug Research Division, Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan, 2Pharmaceutical Planning Group, Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan, 3Medical Regulatory Affairs Department, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan

P032 Increased endoplasmic reticulum stress-specific chaperones characterise CD fibrosis epithelium tissues and participate to in vitro induction of intestinal fibrobast differentiation

ECCO'20 Vienna

Year: 2020
Authors:

S. Vieujean1, S. Hu1, E. Bequet1, C. Salee1, C. Massot1, N. Bletard2, N. Pierre1, F. Quesada calvo1, D. Baiwir3, G. Mazzucchelli4, E. De Pauw4, P. Delvenne2, M.A. Meuwis1, E. Louis1

1CHU of Liège and Laboratory of Translational Gastroenterology, GIGA-R, ULiège, Hepato-Gastroenterology and Digestive Oncology, Liège, Belgium, 2CHU of Liège, Anatomy and Pathology, Liège, Belgium, 3ULiège, Proteomics Facility of GIGA, Liège, Belgium, 4ULiège, Laboratory of Mass Spectrometry, CART, Liège, Belgium

P033 Combination of vedolizumab with tacrolimus is more efficient in reducing intestinal inflammation than vedolizumab alone in the DSS-induced acute colitis mouse model

ECCO'20 Vienna

Year: 2020
Authors:

R. Manzini, K. Atrott, M. Schwarzfischer, A. Laimbacher, S. Lang, G. Rogler, M. Scharl, M.R. Spalinger

Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland

P034 GB004, a novel gut-targeted prolyl hydroxylase inhibitor, induces HIF-1α target genes and is efficacious in mouse colitis

ECCO'20 Vienna

Year: 2020
Authors:

K. Taylor Meadows1, M. Kennedy2, Z. Naiman1, M. Sergeeva2, B. Paulson2, G. Opiteck3, D. Slee4, L. Carter1, L. Salter-Cid4

1Department of Biology, Gossamer Bio Inc., San Diego, USA, 2Department of Preclinical Research, Gossamer Bio Inc., San Diego, USA, 3Department of Clinical Development, Gossamer Bio Inc., San Diego, USA, 4Department of Research and Development, Gossamer Bio Inc., San Diego, USA

P035 NUDT15 variance increases DNA-incorporated thiopurine metabolites and lymphocyte apoptosis in patients with inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

H. Kiyohara1, T. Toyonaga1, S. Kuronuma2, A. Ueno3, S. Okabayashi3, R. Ozaki1, O. Takeuchi2, S.A. Coulthard4, C.P.F. Redfern4, H. Terai5, Y. Tanaka6, M. Nakano1, T. Hibi3, T. Kobayashi3

1Department of Gastroenterology/Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan, 2Department of Research, Kitasato University Kitasato Institute Hospital, Tokyo, Japan, 3Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan, 4The Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK, 5Department of Respiratory Medicine, Kitasato University Kitasato Institute Hospital, Tokyo, Japan, 6Department of Clinical Pharmacy, Center for Clinical Pharmacy and Sciences, Kitasato University School of Pharmacy, Tokyo, Japan

P036 A novel p53-mediated mouse model of inflammatory bowel disease-associated colorectal cancer

ECCO'20 Vienna

Year: 2020
Authors:

A.M. Churchhouse1, C.V. Billard1, M.J. Arends2, K.B. Myant1

1The Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK, 2Division of Pathology, Centre for Comparative Pathology, Cancer Research UK Edinburgh Centre, The Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK