P031: Intestinal lymphoepithelial interactions in Crohn's disease: modeling alphaE-beta7 and NKG2D blockadeECCO'22Year: 2022
Authors: Hammoudi, N.(1);Hamoudi, S.(2);Bonnereau, J.(2);Bottois, H.(2);Perez, K.(2);Bezault, M.(2);Hassid, D.(1);Chardiny, V.(2);Celine, G.(2);Gergaud, B.(2);Bonnet, J.(1);Chedouba, L.(1);Tran Minh, M.L.(1);Gornet, J.M.(1);Baudry, C.(1);Corte, H.(3);Maggiori, L.(3);Toubert, A.(2);McBride, J.(4);Brochier, C.(5);Neighbors, M.(4);Le Bourhis, L.(2);Allez, M.(1);
(1)APHP Saint Louis, Gastroenterology, Paris, France;(2)Inserm, Unit 1160, Paris, France;(3)APHP Saint Louis, Digestive Surgery, Paris, France;(4)Genentech, OMNI Biomarker Development, San Francisco, United States;(5)Roche, Roche, Boulogne-Billancourt, France;
P032: Host transcriptome signatures in human fecal-washes predict histological remission in IBD patientsECCO'22Year: 2022
Authors: Ungar, B.(1);Yavzori, M.(1);Fudim, E.(1);Picard, O.(1);Kopylov, U.(1);Eliakim, R.(1);Shouval, D.(2);Levin, Y.(3);Savidor, A.(3);Ben-Moshe, S.(4);Manco, R.(4);Dan, S.(4);Egozi, A.(4);Bahar Halpern, K.(4);Mayer, C.(5);Barshak, I.(5);Ben-Horin, S.(1);Itzkovitz, S.(4);
(1)Tel-HaShomer Sheba Medical Center, Department of Gastroenterology, Ramat Gan, Israel;(2)Schneider Children’s Medical Center, Gastroentreology- Nutrition and Liver Diseases, Petah Tikva, Israel;(3)The Nancy and Stephen Grand Israel National Center for Personalized Medicine, The De Botton Institute for Protein Profiling, Rehovot, Israel;(4)Weizmann Institute of Science- Rehovot- Israel, Molecular Cell Biology, Rehovot, Israel;(5)Sheba Medical Center Tel Hashomer, Pathology Institute, Ramat Gan, Israel;
P033: Single-cell analysis of gut mucosal- and peripheral blood cells in ulcerative colitis patients undergoing vedolizumab treatmentECCO'22Year: 2022
Authors: Karmi, N.(1);Sun, S.(1);de Jong, S.(1);Bangma, A.(1);Teunis, J.(2);Paraskevopoulou, M.(3);Juarez, J.(3);Bleck, B.(3);Farahmand, S.(3);Weersma, R.(1);Bigaeva, E.(1);Festen, E.(1);
(1)University Medical Center Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(2)University Medical Center Groningen, Flow Cytometry Unit, Groningen, The Netherlands;(3)Takeda Pharmaceuticals, GI Drug Discovery Unit, Cambridge MA, United States;
P034: DISRUPTive liquid biopsies in Inflammatory Bowel Disease (DISRUPT-IBD): Release of exosomal and molecular tissue signals by transabdominal ultrasound?ECCO'22Year: 2022
Authors: Tran, F.(1,2);Scharmacher, A.(1);Mishra, N.(1);Barann, N.(1);Sievers, L.K.(1,2);Juzenas, S.(1);Bernardes, J.P.(1);Lessing, M.(2);Lassen, A.(2);Rosenstiel, P.(1);Schreiber, S.(1,2);
(1)University Medical Center- Schleswig-Holstein- Kiel Campus, Institute of Clinical Molecular Biology, Kiel, Germany;(2)University Medical Center- Schleswig-Holstein- Kiel Campus, Department of Internal Medicine I, Kiel, Germany;
P035: An examination of resting state functional connectivity in patients with active Crohn’s diseaseECCO'22Year: 2022
Authors: Thapaliya, G.(1);Eldeghaidy, S.(2);Radford, S.(3);Francis, S.(2);Moran, G.(3);
(1)Johns Hopkins- School of Medicine, Department of Psychiatry, Baltimore, United States;(2)University of Nottingham, Sir Peter Mansfield Imaging Centre- School of Physics and Astronomy, Nottingham, United Kingdom;(3)University of Nottingham, NIHR Nottingham Biomedical Research Centre- Nottingham University Hospitals NHS Trust and School of Medicine, Nottingham, United Kingdom;
P036: Identification and functional analysis of stromal subsets in experimental IBD mouse modelsECCO'22Year: 2022
Authors: Zhou, Z.(1);Plug, L.G.(1);de Jonge-Muller, E.S.M.(1);van de Beek, L.M.(1);Brands, L.(1);van der Meulen-de Jong, A.E.(1);Hawinkels, L.J.A.C.(1);Barnhoorn, M.C.(1);
(1)Leiden University Medical Center, Department of Gastroenterology and Hepatology, Leiden, The Netherlands;
P037: MicroRNA-31 and microRNA-200 family reflect disease activity in Crohn’s disease: results from the BIOMIR studyECCO'22Year: 2022
Authors: Cristina, T.(1);Mateescu, B.(2);Mitroi, A.(3);Cozaru, G.(3);Brinzan, C.(3);State, M.(2);Dumitru, A.(1);Rafti, R.(1);Dina, E.(1);Alexandrescu, L.(1);Dumitru, E.(1);
(1)County Clinical Emergency Hospital of Constanta, Gastroenterology, Constanta, Romania;(2)Colentina Hospital Bucharest, Gastroenterology, Bucharest, Romania;(3)County Clinical Emergency Hospital of Constanta, Genetics, Constanta, Romania;
P038: Targeting the hepcidin-ferroportin axis with Nrf2 agonists to treat iron deficiency anaemia in Inflammatory Bowel DiseaseECCO'22Year: 2022
Authors: Martin, J.(1,2);Aksan, A.(1,2,3);Steinhilber, D.(2);Ulrich-Rückert, S.(1,2);Stein, J.M.(1,2,4);
(1)Interdisciplinary Crohn-Colitis Centre Rhein-Main, Clinical Research, Frankfurt am Main, Germany;(2)Goethe University Frankfurt, Institute of Pharmaceutical Chemistry, Frankfurt am Main, Germany;(3)Justus-Liebig University Giessen, Institute of Nutritional Science, Giessen, Germany;(4)DGD Clinics Sachsenhausen, Department of Gastroenterology and Clinical Nutrition, Frankfurt am Main, Germany;
P039: The role of α4β7+CLA+ ‘dual tropic’ T cells in inflammatory bowel diseaseECCO'22Year: 2022
Authors: Gordon, H.(1);Rodger, B.(2);Hornsby, E.(2);McGuire, J.(1);Kok, K.B.(1);Lindsay, J.O.(1);Stagg, A.J.(2);
(1)Royal London Hospital, Department of Gastroenterology- Barts Health NHS Trust, London, United Kingdom;(2)The Blizard Institute, Department of Immunobiology, London, United Kingdom;
P040: Reduced serological response to COVID-19 vaccines in patients with IBD is further diminished by TNF inhibitor therapy; Early results of the VARIATION study (VAriability in Response in IBD Against SARS-COV-2 ImmunisatiON)ECCO'22Year: 2022
Authors: Doherty, J.(1);Stack, R.(1);O' Morain, N.(1);Girod, P.(1);Tosetto, M.(1);Inzitari, R.(2);Sheridan, J.(1);Cullen, G.(1);Buckley, M.(3);Mulcahy, H.(1);Ryan, E.J.(4);Daghfal, D.(5);Doran, P.(2);O Morain, C.(6);Doherty, G.(1);
(1)Centre for Colorectal Disease- St Vincent's University Hospital, Gastroenterology, Dublin, Ireland;(2)School of Medicine- University College Dublin, School of Medicine- University College Dublin, Dublin, Ireland;(3)St Michaels Hospital- Dun Laoighre, Gastroenterology, Dublin, Ireland;(4)University of Limerick, Department of Biological Sciences- Health Research Institute, Limerick, Ireland;(5)Abbot Diagnostics, Lake Forest, Illinois, United States;(6)Beacon Hospital, Gastroenterology, Dublin, Ireland;INITIative IBD research network (www.initiativeibd.ie)
P041: Characterization of cytokine and drug concentrations in serum, mucosa and faeces during induction treatment of moderate-to-severe ulcerative colitis with anti-TNF monoclonal antibodiesECCO'22Year: 2022
Authors: Van Oostrom, J.(1);Hanzel, J.(1,2);Verstockt, B.(3,4);Singh, S.(5);Smith, J.(5);Stylli, J.(5);Vermeire, S.(3);D'Haens, G.(1);
(1)Amsterdam UMC- Meibergdreef 9- 1105 AZ Amsterdam- The Netherlands, Gastroenterology, Amsterdam, The Netherlands;(2)UMC Ljubljana- Japljeva ul. 2- 1000 Ljubljana- Slovenia, Gastroenterology, Lubljana, Slovenia;(3)University Hospitals Leuven- KU Leuven- Leuven- Belgium, Department of Gastroenterology and Hepatology, Leuven, Belgium;(4)KU Leuven- Leuven- Belgium, Department of Chronic Diseases and Metabolism-, Leuven, Belgium;(5)Progenity Inc, Progenity laboratories, San Diego, United States;
P042: Succinate promotes the conversion from white to beige adipose tissue in Crohn’s DiseaseECCO'22Year: 2022
Authors: Montfort-Ferré, D.(1);Menacho, M.(2);Caro, A.(3);Espina, B.(3);Boronat-Toscano, A.(1);Nuñez-Roa, C.(1);Martí, M.(4);Espin, E.(4);Vendrell, J.(1);Fernández-Veledo, S.(1);Serena, C.(1);
(1)Health Institute Pere Virgili IISPV, Hospital Joan XXIII of Tarragona, Tarragona, Spain;(2)Hospital Joan XXIII of tarragona, Gastroenterology Service, Tarragona, Spain;(3)Hospital Joan XXIII of Tarragona, Surgery Service, Tarragona, Spain;(4)Hospital Universitari Vall Hebron, Surgery Service, Barcelona, Spain;
P043: 3-oxo-C12:2, a Quorum Sensing molecule from the gut, exerts anti-inflammatory effects through a bitter taste receptorECCO'22Year: 2022
Authors: Coquant, G.(1);Aguanno, D.(2);Brot, L.(1);Belloir, C.(3);Briand, L.(3);Grill, J.P.(1);De Sordi, L.(1);Thenet, S.(4);Seksik, P.(1);
(1)Sorbonne Université, Medecine Faculty, Paris, France;(2)Technische Universität München, Lehrstuhl für Ernährung und Immunologie, Freising, Germany;(3)INRAE, Centre des Sciences du Goût et de l'Alimentation, Dijon, France;(4)PSL university, Ecole Pratique des Hautes Etudes, Paris, France;
P044: Enteric dopaminergic pathways in mouse and human intestinal inflammationECCO'22Year: 2022
Authors: Cerantola, S.(1);Faggin, S.(1);Caputi, V.(2);Cortese, V.(1);Bosi, A.(3);Banfi, D.(3);Rambaldo, A.(4);Porzionato, A.(4);Giaroni, C.(3);Savarino, E.V.(5);Giron, M.C.(1);
(1)University of Padova, Department of Pharmaceutical and Pharmacological Sciences, Padova, Italy;(2)University of Arkansas, Department of Poultry Science, Fayetteville, United States;(3)University of Insubria, Department of Clinical and Experimental Medicine, Varese, Italy;(4)University of Padova, Department of Neuroscience, Padova, Italy;(5)University of Padova, Department of Surgery- Oncology and Gastroenterology, Padova, Italy;
P045: TIGIT expression differentiates regulatory from inflammatory Th1* gut-homing effector CD4+ T cells in inflammatory bowel disease patientsECCO'22Year: 2022
Authors: Heredia, M.(1);Costes, L.M.M.(1);Tindemans, I.(1);Aardoom, M.A.(2);Klomberg, R.C.W.(2);Kemos, P.(3);Joosse, M.E.(1);van Haaften, D.H.(1);Tuk, B.(1);Ruemmele, F.(4);Croft, N.M.(3);Escher, J.C.(2);de Ridder, L.(2);Samsom, J.N.(1);
(1)Erasmus University Medical Center-Sophia Children’s Hospital, Laboratory of Pediatric Gastroenterology, Rotterdam, The Netherlands;(2)Erasmus University Medical Center-Sophia Children’s Hospital, Pediatric Gastroenterology, Rotterdam, The Netherlands;(3)Blizard Institute- Queen Mary University of London, Centre for Immunobiology, London, United Kingdom;(4)Hôpital Necker-Enfants Malades- Institut Imagine- AP-HP- Université de Paris, Pediatric Gastroenterology, Paris, France;
P046: Effects of CB2 and TRPV1 stimulation on osteoclast overactivity induced by iron in pediatric inflammatory bowel diseaseECCO'22Year: 2022
Authors: Strisciuglio, C.(1);Tortora, C.(1);Di Paola, A.(2);Creoli, M.(2);Cenni, S.(3);Argenziano, M.(1);Martinelli, M.(3);Miele, E.(3);Rossi, F.(1);
(1)Department of pediatrics- University of Campania @Vanvitelli@, Department of Woman- Child and General and Specialist Surgery, Naples, Italy;(2)University of Campania “Luigi Vanvitelli”, Department of Experimental Medicine, Naples, Italy;(3)University of Naples @Federico II@, Department of Translational Medical Science- Section of Pediatrics, Naples, Italy;
P047: Effect of infliximab and vedolizumab on M1 and M2 macrophages derived from THP-1 cells.ECCO'22Year: 2022
Authors: Notararigo, S.(1);Viñuela-Roldán, J.(1);Zurita-Gonzalez, M.J.(1);Dominguez Medina, E.(2);Dominguez-Munos, J.E.(1);Barreiro-de Acosta, M.(1);
(1)Fundacion IDIS, Digestive, Santiago de Compostela, Spain;(2)Fundacion IDIS, BioPharma, Santiago de Compostela, Spain;Fundación IDIS Complejo Hospitalario Santiago de Compostela A Coruña 15706 Spain
P048: Bridging the Gap Between Body and Soul: A Pilot Study Examining Inflammation and Depression / Anxiety in Inflammatory Bowel Disease PatientsECCO'22Year: 2022
Authors: Mekori - Domachevsky, E..(1);Avinir, A.(2);Dar, S.(3);Haj, O.(1);Ben - Horin, S.(1);Gothelf, D.(4);Kopylov, U.(1);Taler, M.(3);
(1)Sheba Medical Center, Gastroenterology Department, Ramat Gan, Israel;(2)Sheba Medical Center, Child and Adolescent Psychiatry Clinic, Ramat Gan, Israel;(3)Sheba Medical Center, Laboratory of Pediatric Molecular Psychiatry, Ramat Gan, Israel;(4)Sheba Medical Center, Child and Adolescent Psychiatry Division, Ramat Gan, Israel;
P049: The treatment effect of tonsil-derived mesenchymal stem cells (T-MSCs) via regulating programmed death-1/programmed death ligand-1 (PD-1/PD-L1) in ulcerative colitisECCO'22Year: 2022
Authors: Song, E.M.(1);Joo, Y.H.(1);Park, Y.(1);Choe, A.R.(1);Tae, C.H.(1);Moon, C.M.(1);Kim, S.E.(1);Jung, H.K.(1);Shim, K.N.(1);Jung, S.A.(1);
(1)EWHA Womans University- School of Medicine, Department of Internal Medicine- Department of Gastroenterology, Seoul, Korea- Republic Of;
P050: A comparison of the Gut Microbiota in Pregnant Women with and without Inflammatory Bowel Disease and Their Offspring in Hong Kong and United StatesECCO'22Year: 2022
Authors: Hu, J.(1);Agrawal, M.(2);Tarassishin, L.(1);Rendon, A.(1);Picker, M.(1);Kalash, O.(1);Eisele, C.(1);Ching, J.Y.(3);Wong, A.(3);Zhan, H.(3);Ng, S.C.(3);Colombel, J.F.(2);Peter, I.(1);
(1)Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York City, United States;(2)Icahn School of Medicine at Mount Sinai, The Henry D. Janowitz Division of Gastroenterology- Department of Medicine, New York City, United States;(3)The Chinese University of Hong Kong, Department of Medicine and Therapeutics- Microbiota I-Center MagIC, Hong Kong, China;
