P080: High faecal pH and low total microbial load associate with normalisation of faecal calprotectin in children with Crohn’s disease treated with exclusive enteral nutrition; results from iPENS, a multicentre, prospective studyECCO'24Year: 2024
Authors: Gkikas, K.(1)*;Lima, M.(1);McKirdy, S.(1);Nichols, B.(1);Kerbiriou, C.(1);Gervais, L.(2);Smith, G.(3);Armstrong, L.(4);Jordan, T.(3);Chalmers, I.(5,6);Barlow, H.(7);Al Hourani, G.(8);Muhammed, R.(9);Wands, D.(2);Narula, P.(10);Patel, M.(11);Ijaz, U.Z.(12);Milling, S.(13);Gasparetto, M.(14);Henderson, P.(15);Wilson, D.C.(15);Hansen, R.(2,16);Russell, R.K.(15);Gerasimidis, K.(1);
(1)University of Glasgow, School of Medicine- Dentistry and Nursing, Glasgow, United Kingdom;(2)Royal Hospital for Children, Department of Paediatric Gastroenterology- Hepatology and Nutrition, Glasgow, United Kingdom;(3)University Hospital Wishaw, Department of Paediatrics, Wishaw, United Kingdom;(4)University Crosshouse Hospital, Department of Paediatrics, Crosshouse, United Kingdom;(5)Aberdeen Children@E@s Hospital, Department of Paediatric Gastroenterology, Aberdeen, United Kingdom;(6)Tayside Children@E@s Hospital, Department of Paediatric Gastroenterology, Dundee, United Kingdom;(7)Royal Manchester Children@E@s Hospital, Department of Paediatrics, Manchester, United Kingdom;(8)Forth Valley Royal Hospital, Department of Paediatrics, Larbert, United Kingdom;(9)Birmingham Women@E@s and Children@E@s Hospital, Department of Paediatric Gastroenterology, Birmingham, United Kingdom;(10)Sheffield Children@E@s Hospital, Department of Paediatric Gastroenterology, Sheffield, United Kingdom;(11)Royal London Children@E@s Hospital, Department of Paediatric Gastroenterology, London, United Kingdom;(12)University of Glasgow, James Watt School of Engineering, Glasgow, United Kingdom;(13)University of Glasgow, School of Infection and Immunity, Glasgow, United Kingdom;(14)Norfolk and Norwich University Hospitals, Department of Paediatric Gastroenterology, Norwich, United Kingdom;(15)Royal Hospital for Children and Young People, Department of Paediatric Gastroenterology- Hepatology and Nutrition, Edinburgh, United Kingdom;(16)University of Dundee, Department of Child health- Division of Clinical and Molecular Medicine- School of Medicine, Dundee, United Kingdom;
P081: The integration of transcriptomic and microbiomic data links several intestinal bacterial families with key biological functions in the development of postoperative recurrence in Crohn@E@s disease.ECCO'24Year: 2024
Authors: Cabrer, M.(1);Suau, R.(1)*;Lopez-Siles, M.(2);Martinez-Medina, M.(2);Aterido, A.(3,4);Julià, T.(3);Zabana, Y.(5,6);Calafat, M.(1,6,7);Clua, L.(1);Lorén, V.(1);Domènech, E.(1,6,7);Mañosa, M.(1,6,7);Manyé, J.(1,6);
(1)Germans Trias i Pujol Research Institute IGTP, IBD Research Group, Badalona, Spain;(2)Biology Departament- University of Girona, Research Group in Microbiology of intestinal disease, Girona, Spain;(3)Vall d@E@Hebron Research Institute VHIR, Rheumatology Research Group, Barcelona, Spain;(4)Pompeu Fabra University, Department of Experimental and Health Sciences, Barcelona, Spain;(5)MútuaTerrassa University Hospital, Digestive Tract Service, Terrassa, Spain;(6)Centro de Investigación Biomédica en Red CIBER, Enfermedades Hepáticas y Digestivas CIBEREHD, Madrid, Spain;(7)Germans Trias i Pujol University Hospital HUGTP, Digestive Tract Service, Badalona, Spain;
P082: Downregulated apelin expression in T cells in the setting of Chronic ColitisECCO'24Year: 2024
Authors: Inoue, T.(1)*;Fushimi, M.(1);Yamada, D.(1);Watabe, T.(1);Watanabe, M.(1);Okamoto, R.(1);Nagaishi, T.(1);
(1)Tokyo Medical and Dental University, Gastroenterology, Tokyo, Japan;
P083: Dietary-derived ω-3 and ω-6 polyunsaturated fatty acids trigger an inflammatory response in intestinal epithelial cells with chemically inhibited GPX4 activityECCO'24Year: 2024
Authors: Schwärzler, J.P.(1)*;Mayr, L.(1);Grabherr, F.(1);Meyer, M.(1);Jukic, A.(1);Tilg, H.(1);Adolph, T.E.(1);
(1)Medical University of Innsbruck, Department of Internal Medicine I- Gastroenterology- Hepatology- Endocrinology & Metabolism, Innsbruck, Austria;
P084: Natural extracts and omega-3 derived molecule: role in resolution of intestinal inflammationECCO'24Year: 2024
Authors: Camba Gómez, M.(1)*;Arosa, L.(1); Ait Eldjoudi, D.(2);Gonzalez-Rodríguez , M.(2);Gualillo, O.(2);Conde-Aranda, J.(1);
(1)Health Research Institute of Santiago de Compostela IDIS, Molecular and Cellular Gastroenterology, Santiago de Compostela, Spain;(2)Health Research Institute of Santiago de Compostela IDIS, Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases NEIRID, Santiago de Compostela, Spain;
P085: Tc17 cells with a distinct immune signature do not correlate with response to therapy with ustekinumab or TNF antibodies in active Crohn’s DiseaseECCO'24Year: 2024
Authors: Szentandrasi, J.(1)*;Hockenjos, B.(1);Reinscheid, M.(1);Thimme, R.(1);Bengsch, B.(1);Hasselblatt, P.(1);Mayer, L.S.(1);
(1)University Medical Center and Faculty of Medicine- University of Freiburg, Department of Medicine II: Gastroenterology- Hepatology- Endocrinology- and Infectious Disease, Freiburg, Germany;
P086: Identification of a Novel Immunometabolic Target and Agonist for PLXDC2 for Amelioration of DSS Colitis Model in MiceECCO'24Year: 2024
Authors: Abdurahiman, S.(1);Mosig, R.(2);Cataldi, F.(3);Vermeire, S.(1);Verstockt, B.(1)*;
(1)University Hospitals Leuven- KU Leuven-, Department of Gastroenterology and Hepatology- Department of Chronic Diseases and Metabolism, Leuven, Belgium;(2)Landos Biopharma- Inc, Corporate Development, Blacksburg, United States;(3)Landos Biopharma- Inc, Clinical, Boston, United States;
P087: IFN-γ-Induced Intestinal Epithelial Cell Type-Specific Cytotoxic Responses of Human Enteroids: PANoptosis and The Protective Role of Selective JAK1 Inhibitors.ECCO'24Year: 2024
Authors: Hong, S.N.(1)*;Chansu , L.(1);Minjee, K.(1);Yujin , L.(1);Songee, B.(1);Ji Eun , K.(1);Young-Ho , K.(1);
(1)Samsung Medical Center- Sungkyunkwan University School of Medicine, Department of Medicine, Seoul, Korea- Republic Of;
P088: Single-cell transcriptomic analysis identifies early immune disturbances in preclinical Crohn@E@s diseaseECCO'24Year: 2024
Authors: Kioroglou, D.(1);Egia-Mendikute, L.(2);Palazon, A.(2,3);Barreiro-de Acosta, M.(4);Rodríguez-Lago, I.(5);Martinez Marigorta, U.(1,3)*;
(1)Center for Cooperative Research in Biosciences CIC bioGUNE- Basque Research and Technology Alliance BRTA- Bizkaia Technology Park, Integrative Genomics Lab, Derio, Spain;(2)Center for Cooperative Research in Biosciences CIC bioGUNE- Basque Research and Technology Alliance BRTA- Bizkaia Technology Park, Cancer Immunology and Immunotherapy Lab, Derio, Spain;(3)IKERBASQUE, Basque Foundation for Sciences, Bilbao, Spain;(4)Hospital Clínico Universitario de Santiago, Gastroenterology Department, Santiago de Compostela, Spain;(5)Hospital Universitario de Galdakao, Gastroenterology Department, Galdakao, Spain;
P089: Development and preliminary evaluation of a suicidal risk assessment protocol in a research trial using the Patient Health Questionnaire (PHQ-9).ECCO'24Year: 2024
Authors: Wileman, V.(1);McGuinness, S.(1);Sweeney , L.(1);Miller, L.(2);Stagg, I.(3);O@E@Carroll, R.(4);Moss-Morris, R.(1);Norton, C.(5)*;
(1)King@E@s College London, Psychology, London, United Kingdom;(2)Queen Mary University of London, Barts and the London Pragmatic Clinical Trials Unit PCTU, London, United Kingdom;(3)London North West Hospitals NHS Trust, St Mark@E@s Hospital The National Bowel Hospital and Academic Institute, London, United Kingdom;(4)University of Stirling, Psychology, Stirling, United Kingdom;(5)King@E@s College London, Florence Nightingale Faculty of Nursing- Midwifery & Palliative Care, London, United Kingdom;
P091: Single-cell metabolic phenotyping of monocytes and macrophages in Crohn’s diseaseECCO'24Year: 2024
Authors: Haag, L.M.(1)*;Lehmann, M.(1);Walling, S.(1);Kunkel, D.(2);Hecker, J.(1);Huck, A.(1);Glauben, R.(1);Weidinger, C.(1);Kuehl, A.A.(3);TRR241 IBDome Consortium, T.(1);Siegmund, B.(1);
(1)Charité - Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;(2)Berlin Institute of Health BIH at Charité - Universitätsmedizin Berlin, BIH Flow & Mass Cytometry Core Facility, Berlin, Germany;(3)Charité - Universitätsmedizin Berlin, iPATH.Berlin – Core Unit Immunpathologie für Experimentelle Modelle, Berlin, Germany;
P093: Innovating in IBD care: what do patients and informal caregivers value? Preliminary results of a narrative inquiryECCO'24Year: 2024
Authors: Thomassen, B.J.M.(1,2,3)*;Hendrix, E.M.B.(1,3);Mujagic, Z.(1,3);Smeets, F.G.M.(1,4);de Jong, M.J.(5);Gevers, T.J.G.(1,3);Veldhuijzen, G.(6,7);Scherpenzeel, M.(8);Dijkstra, G.(9);Ament, S.M.C.(10);Pierik, M.J.(1,3);
(1)Maastricht University Medical Centre+, Department of Gastroenterology and Hepatology, Maastricht, The Netherlands;(2)Maastricht University Medical Centre+, Department of Surgery, Maastricht, The Netherlands;(3)Maastricht University, Research Institute for Nutrition and Translational Research in Metabolism NUTRIM, Maastricht, The Netherlands;(4)St. Jans Gasthuis, Department of Gastroenterology and Hepatology, Weert, The Netherlands;(5)Erasmus Medical Centre, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands;(6)Gelre Hospitals, Department of Gastroenterology and Hepatology, Apeldoorn, The Netherlands;(7)Radboud University Medical Centre, Department of Gastroenterology and Hepatology, Nijmegen, The Netherlands;(8)Crohn & Colitis Netherlands, crohn-colitis.nl, Woerden, The Netherlands;(9)University Medical Centre Groningen- University of Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands;(10)Maastricht University Medical Centre+, Department of Innovation - Centre of Expertise Quality- Innovation & Research, Maastricht, The Netherlands;
P095: Accelerated degradation of gut barrier-protecting 3-aminobenzoic acid exacerbate colitis in Inflammatory Bowel DiseaseECCO'24Year: 2024
Authors: Tanaka, M.(1)*;Toyonaga, T.(1);Nakagawa, F.(1);Sumiyoshi, N.(1);Shibuya, N.(1);Iwamoto, T.(2);Minemura, A.(3);Ariyoshi, T.(3);Matsumoto, A.(3);Oka, K.(3);Shimoda, M.(4);Saruta, M.(1);
(1)The Jikei University School of Medicine, Division of Gastroenterology and Hepatology- Department of Intenal Medicine, Tokyo, Japan;(2)The Jikei University School of Medicine, Division of Molecular Cell Biology- Core Research Facilities for Basic Science, Tokyo, Japan;(3)Miyarisan Pharmaceutical Co.- Ltd., Central Research Institute, Tokyo, Japan;(4)The Jikei University School of Medicine, Department of Pathology, Tokyo, Japan;
P096: Human extrachromosomal circular DNA is an emerging biomarker in Inflammatory Bowel DiseaseECCO'24Year: 2024
Authors: Petito, V.(1);DI VINCENZO, F.(1)*;Gerovska, D.(2);Piazzesi, A.(3);Russo, A.(4);Turchini, L.(1);Masi, L.(1);Lopetuso, L.R.(1);Abreu, M.T.(5);Regenberg, B.(6);Gasbarrini, A.(1);Putignani, L.(4);Bravo Araúzo, M.J.(7);Scaldaferri, F.(1);
(1)Fondazione Policlinico Universitario @D@A. Gemelli@D@ IRCCS- Università Cattolica del Sacro Cuore, Dipartimento di Medicina Interna e Gastroenterologia, Roma, Italy;(2)Biodonostia Health Research Institute, Computational Biology and Systems Biomedicine, San Sebastian, Spain;(3)Bambino Gesù Children’s Hospital- IRCCS, Multimodal Laboratory Medicine Research Area- Unit of Human Microbiome, Roma, Italy;(4)Bambino Gesù Children’s Hospital- IRCCS, Department of Diagnostic and Laboratory Medicine- Unit of Microbiology and Diagnostic Immunology- Unit of Microbiomics, Roma, Italy;(5)Miller School of Medicine- University of Miami, Division of Gastroenterology- Department of Medicine, Miami, United States;(6)University of Copenhagen, Department of Biology- SECTION FOR ECOLOGY AND EVOLUTION- Universitet sparken, Copenhagen, Denmark;(7)University of Basque Country UPV/EHU, Department of Cell Biology and Histology- Faculty of Medicine and Nursing, San Sebastian, Spain;
P097: Spatially resolved insights into fistulating Crohn@E@s disease pathogenesis: Unveiling molecular heterogeneityECCO'24Year: 2024
Authors: Mcgregor, C.(1,2)*;Yin, Z.(1);Bridges, E.(1);Gupta, T.(1,2);Aulicino, A.(1);Siejka-Zielinska, P.(1);Lee, C.H.J.(1,3);Bornschein, J.(1,2);Bignell, M.(2,4);George, B.(2,4);Vieth, M.(5,6);Tandon, R.(7);Fryer, E.(7);Antanaviciute, A.(1,3);Simmons, A.(1,2);
(1)University of Oxford, MRC Translational Immune Discovery Unit, Oxford, United Kingdom;(2)University of Oxford, Translational Gastroenterology Unit, Oxford, United Kingdom;(3)University of Oxford, MRC WIMM Centre for Computational Biology, Oxford, United Kingdom;(4)Oxford University Hospitals NHS Trust- John Radcliffe Hospital, Department of Colorectal Surgery, Oxford, United Kingdom;(5)Klinikum Bayreuth, Department of Pathology, Bayreuth, Germany;(6)Friedrich-Alexander University Erlangen-Nuremberg, Institute of Pathology, Oberfranken, Germany;(7)Oxford University Hospitals NHS Trust- John Radcliffe Hospital, Department of Cellular Pathology, Oxford, United Kingdom;
P098: The Endoscopic Severity Score Map (ESSM): An Artificial Intelligence scoring system providing accurate, objective and localised measurements of endoscopic disease severity in ulcerative colitis.ECCO'24Year: 2024
Authors: Gutierrez Becker, B.(1)*;Fraessle, S.(1);Yao, H.(2);Lüscher , J.(2);Girycki, R.(3);Machura, B.(4);Gośliński, J.(4);Czornik, J.(4);Pitura, M.(4);Arús-Pous, J.(1);Fisher, E.(5);Bojic, D.(6);Richmond, D.(2);Bigorgne, A.(5);Prunotto, M.(5);
(1)Roche, Pharma Research & Early Development. Data and Analytics, Basel, Switzerland;(2)Genentech Research and Early Development, Biological Research - AI Development, South San Francisco, United States;(3)Future Processing S.A., Future Processing S.A., Gliwice, Poland;(4)Graylight Imaging, Graylight Imaging, Gliwice, Poland;(5)Roche, Technology and Translational Research Product Development Immunology Infectious Diseases and Ophthalmology, Basel, Switzerland;(6)Roche, Product Development Clinical, Basel, Switzerland;
P099: Neutrophil extracellular traps enhance profibrotic activity of intestinal fibroblasts in Crohn@E@s disease through TLR2/NF-kB pathwayECCO'24Year: 2024
Authors: Dragoni, G.(1)*;Ke, B.J.(2);Picariello, L.(3);Ceni, E.(3);Mello, T.(3);Verstockt, B.(4);Abdurahiman, S.(2);Biscu, F.(2);Innocenti, T.(1);De Hertogh, G.(5);Martinod, K.(6);Galli, A.(3);Matteoli, G.(2);Vermeire, S.(4);
(1)Careggi University Hospital, Department of Gastroenterology- IBD Referral Centre, Firenze, Italy;(2)Translational Research Center for Gastrointestinal Disorders- Department of Chronic Diseases- Metabolism and Ageing- KU Leuven, Laboratory for Mucosal Immunology, Leuven, Belgium;(3)University of Florence, Gastroenterology Research Unit- Department of Experimental and Clinical Biochemical Sciences @D@Mario Serio@D@, Firenze, Italy;(4)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(5)KU Leuven- Faculty of Medicine, Laboratory of Translational Cell and Tissue Research- Department of Imaging and Pathology, Leuven, Belgium;(6)KU Leuven, Center for Molecular and Vascular Biology- Department of Cardiovascular Sciences, Leuven, Belgium;
P1000: A meta-analysis and systematic review of 5-aminosalicylates withdrawal in Inflammatory Bowel DiseaseECCO'24Year: 2024
Authors: Arzivian, A.(1);Kerkham, A.(2);Tran, Y.(3);Rubin, D.(4);Leong, R.(1)*;
(1)Macquarie University Hospital, Gastroenterology and Hepatology Department, Sydney, Australia;(2)Nepean Hospital, Gastroenterology and Hepatology Department, Sydney, Australia;(3)Macquarie University, Department of Health Sciences, Sydney, Australia;(4)University of Chicago, Inflammatory Bowel Disease Center, Chicago, United States;
