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P060: Increased metabolic activity of faecal Sutterella Wadsworthensis at IBD onset is associated with an increased risk of escalation to biologic therapies - Results from the Birimingham Inception Cohort StudyECCO'24
Year: 2024
Authors: Rimmer, P.(1)*;Cheesbrough, J.(1);Horniblow, R.(2);Tull, S.(3);Sharma, N.(1);Cooney, R.(1);Beggs, A.(4);Regan-Komito, D.(5);Iqbal, A.(3);Iqbal, T.(1);Quraishi, M.N.(1);
(1)University Hospitals Birmingham NHS Foundation Trust, Gastroenterology, Birmingham, United Kingdom;(2)University of Birmingham, Institute of Immunology and Infection, Birmingham, United Kingdom;(3)University of Birmingham, Institute of Cardiovascular Sciences, Birmingham, United Kingdom;(4)University of Birmingham, Institute of Cancer and Genomic Science, Birmingham, United Kingdom;(5)F. Hoffman-La Roche, Immunology- Infectious Diseases and Ophthalmology, Basel, Switzerland;
P061: The macrophage-specific role of PTPN23 in Acute and Chronic ColitisECCO'24
Year: 2024
Authors: Linzmeier, L.(1)*;Matus, V.(1);Determann , M.(1);Wilmink, M.(1);Schwarzfischer, M.(1);Sanchez Alvarez, R.(1);Pöhlmann, D.(1);Scharl, M.(1);Spalinger, M.(1);
(1)University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland;
P062: Characterization of UC1 and UC2 patients: towards personalized medicine in Ulcerative ColitisECCO'24
Year: 2024
Authors: Castillo, F.(1)*;Selin, K.(2);Fransson , J.(2);Sorini, C.(3);Hedin, C.(1,4);Villablanca, E.(2,5);
(1)Karolinska Institutet, Department of Medicine Solna, Stockholm, Sweden;(2)Karolinska Institutet, Division of immunology and Allergy- Department of Medicine- Solna, Stockholm, Sweden;(3)Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden;(4)Karolinska University Hospital, Gastroenterology unit- Department of Gastroenterology- Dermatovenereology and Rheumatology, Stockholm, Sweden;(5)Karolinska Institutet, Center of Molecular Medicine, Stockholm, Sweden;
P063: Interleukin-8 mucosal transcript as predictor of response to Vedolizumab treatment in Ulcerative Colitis: preliminary results from a prospective studyECCO'24
Year: 2024
Authors: Bota, A.D.(1)*;Mușa, A.M.(1);Dinu, M.C.(1);Săftoiu, A.(1);Mușa, M.(1);Coman, S.(1);Dobre, M.(2);Milanesi, E.(2);Țieranu, C.G.(1);
(1)@D@Elias@D@ Emergency University Hospital, Gastroenterology, Bucharest, Romania;(2)@D@Victor Babeș@D@ National Institute of Pathology, Molecular Pathology, Bucharest, Romania;
P064: Investigating the genotoxic effect of reduced glutathione, n-acetylcysteine, human umbilical cord-derived mesenchymal stem cell exosomes and let-7 miRNA mimics in human lymphocytes and EpiIntestinal cellsECCO'24
Year: 2024
Authors: Adoul, Z.(1)*;Jafarinejed, S.(1);Baumgartner, A.(2);Isreb, M.(3);Liu, F.(4);Anderson, D.(1);Najafzadeh, M.(1);
(1)University of Bradford, School of Chemistry and Biosciences, Bradford, United Kingdom;(2)York St John University, School of Science- Technology and Health, York, United Kingdom;(3)University of Bradford, School of Pharmacy and Medical Sciences, Bradford, United Kingdom;(4)The Scottish Association for Marine Science, Ecotoxicology Group, Oban, United Kingdom;
P065: The evolution of inflammatory bowel disease can be monitored through multi-omics characterization of gut tissuesECCO'24
Year: 2024
Authors: Tout, I.(1)*;Toufiq, M.(2);Missous, G.N.(3);Chin-Smith, E.(1);Mathew, R.(4);Tomei, S.(4);Ibrahim, N.(5);Abunahia, N.S.(6);Mifsud, W.(7);Charles, A.(7);Ammar, A.(8);Al Kaabi, S.(6);Van Panhuys, N.(3);Al-Mohannadi, M.J.(6);Mamoun, E.(5);Maccalli, C.(1);
(1)Sidra Medicine, Laboratory of Immune and Biological Therapy, Doha, Qatar;(2)Sidra Medicine, System Biology, Doha, Qatar;(3)Sidra Medicine, Laboratory of Immunoregulation, Doha, Qatar;(4)Sidra Medicine, Omics core, Doha, Qatar;(5)Sidra Medicine, Department of Gastroenterology- Hepatology and Nutrition, Doha, Qatar;(6)Hamad Medical Corporation, Department of Gastroenterology- Ambulatory Care Center, Doha, Qatar;(7)Sidra Medicine, Anatomical Pathology, Doha, Qatar;(8)Hamad Medical Corporation, Pathology, Doha, Qatar;
P066: Serum amyloid A – A Novel Biomarker of Ulcerative Colitis Disease ActivityECCO'24
Year: 2024
Authors: McShane, C.(1)*;O@E@Connell, F.(2);Corcoran, R.(3);Buckley, C.(2);Lynam-Lennon, N.(2);Kevans, D.(3);O@E@Sullivan, J.(2);
(1)St James@E@s Hospital, Department of Gastroenterology, Dublin, Ireland;(2)St. James’s Hospital and Trinity College Dublin, Department of Surgery- Trinity St. James’s Cancer Institute and Trinity Translational Medicine Institute, Dublin, Ireland;(3)St. James’s Hospital, Department of Gastroenterology, Dublin, Ireland;
P067: Volumetric Assessment of Treatment Response in Newly Diagnosed Crohn Disease: A Pilot StudyECCO'24
Year: 2024
Authors: Derinkuyu, B.E.(1);Bard, A.(2);Naim, I.(2)*; A. Tkach, J.(1);A. Denson, L.(1);R. Dillman, J.(1);
(1)University of Cincinnati College of Medicine, Department of Radiology- Cincinnati Children’s Hospital Medical Center, Cincinnati- OH, United States;(2)Motilent, Research department, London, United Kingdom;
P068: Recapitulation of human colonocytes in situ by human colon organoids in vitro and after orthotopic transplantationECCO'24
Year: 2024
Authors: Hausmann, A.(1)*;Post, F.(2);Clement, D.L.(1);Skov, J.(1);Steenholdt, C.(3);Mund, A.(2);Nielsen, O.H.(3);Mann, M.(2);Jensen , K.B.(1);
(1)RENEW - NNF Center for Stem Cell Medicine, University of Copenhagen, Copenhagen, Denmark;(2)CPR - NNF Center for Proteome Research, University of Copenhagen, Copenhagen, Denmark;(3)Herlev Hospital, Gastroenterology, Copenhagen, Denmark;
P069: Ultra-processed food intake and dietary insufficiencies are common in adults with Crohn’s Disease in remission. The INTICO 2 StudyECCO'24
Year: 2024
Authors: Westoby, C.(1)*;Katarachia, V.(2);McDonnell , M.(3);Sartain, S.(4);Cummings , F.(5);Wootton , S.(6);
(1)University Hospital Southampton NHS Foundation Trust, Nutition and Dietetics, Southampton, United Kingdom;(2)University Hospital Southampton NHS Foundation Trust, Nutrition and Dietetics, Southampton, United Kingdom;(3)University Hospital Southampton NHS Foundation Trust, Gastroenterology, Southampton, United Kingdom;(4)University Hospital Southampton NHS Foundation Trust- Department of Nutrition and Dietetics- Southampton- United Kingdom, Gastroenterology, Southampton, United Kingdom;(5)University Hospital Southampton NHS Foundation Trust-, Gastroenterology, Southampton, United Kingdom;(6)University of Southampton, Faculty of Medicine, Southampton, United Kingdom;INTICO 2
P070: The influence of Crohn’s disease-derived blood plasma upon anabolic signaling responses to leucine stimulation in skeletal muscle cells in vitroECCO'24
Year: 2024
Authors: Fatani, H.(1)*;Kirkpatrick , E.(2);Atherton , P.(3);Moran, G.(4);Brook , M.(5);
(1)University of Nottingham, The Nottingham Digestive Diseases Centre NDDC- MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research & NIHR Nottingham- School of Medicine, Nottingham, United Kingdom;(2)University of Nottingham, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research & NIHR Nottingham- School of Life Sciences, Nottingham, United Kingdom;(3)University of Nottingham, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research & NIHR Nottingham- Centre Of Metabolism- Ageing & Physiology COMAP-School of Medicine-, Nottingham, United Kingdom;(4)University of Nottingham, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research & NIHR Nottingham- The Nottingham Digestive Diseases Centre NDDC- School of Medicine, Nottingham, United Kingdom;(5)University of Nottingham, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research & NIHR Nottingham- Centre Of Metabolism- Ageing & Physiology COMAP- School of Life Sciences, Nottingham, United Kingdom;
P071: Neonatal levels of inflammatory markers in individuals who later develop early onset Inflammatory Bowel Disease.ECCO'24
Year: 2024
Authors: Rudbæk, J.(1,2)*;Borbye-Lorenzen, N.(2);Poulsen, G.J.(1);Skogstrand, K.(2);Jess, T.(1,3);
(1)Aalborg University, Center for Molecular Prediction of Inflammatory Bowel Disease- Department of Clinical Medicine, Copenhagen, Denmark;(2)Statens Serum Institut, Section for Biomarkers- Immunology and Antibodies- Department for Congenital Disorders, Copenhagen, Denmark;(3)Aalborg University Hospital, Department of Gastroenterology & Hepatology, Aalborg, Denmark;
P072: LDN-071, a novel first-in-class amino acid-based PAI-1 inhibitor, significantly reduces the severity of experimental colitis in miceECCO'24
Year: 2024
Authors: Jójárt, B.(1,2,3,4)*;Csákány-Papp, N.(2,3,4);Laub, H.(1,4);Vasas, B.(5);Barta, B.(6);Szabó, V.(2,3,4);Bagyánszki, M.(6);Mándity, I.(1,7);Heltovics, G.(1);Pallagi, P.(1,2,3,4);Maléth, J.(1,2,3,4);
(1)Ladon Therapeutics Ltd, Ladon Therapeutics Ltd, Szeged, Hungary;(2)HCEMM-USz, Molecular Gastroenterology Research Group, Szeged, Hungary;(3)University of Szeged, ELKH-USz Momentum Epithelial Cell Signaling and Secretion Research Group, Szeged, Hungary;(4)University of Szeged, Szent-Györgyi Albert Medical School- Department of Medicine, Szeged, Hungary;(5)University of Szeged, Szent-Györgyi Albert Medical School- Department of Pathology, Szeged, Hungary;(6)University of Szeged, Faculty of Science and Informatics- Department of Physiology- Anatomy and Neuroscience, Szeged, Hungary;(7)Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry- Artificial transporters Research Group, Budapest, Hungary;Ladon Therapeutics Ltd
P073: Enhancing the MFSD2A protein for the treatment of colitis-associated cancer: novel insights for pathogenesis and treatmentECCO'24
Year: 2024
Authors: Cagliani, S.(1,2)*;Massimino, L.(1,3);Facoetti, A.(1);Spanò, S.(1,3);Errico, C.(1);Parigi, T.L.(1,2,3);Colasante, G.(4);Danese, S.(2,3);Ungaro, F.(1,3);
(1)San Raffaele Research Institute, Laboratory of Experimental Gastroenterology- Division of Immunology- Transplantation and Infectious Disease, Milan, Italy;(2)Vita-Salute San Raffaele University, Faculty of Medicine, Milan, Italy;(3)San Raffaele Hospital, Gastro Center- Gastroenterology and Digestive Endoscopy, Milan, Italy;(4)San Raffaele Research Institute, Stem Cell and Neurogenesis Unit- Division of Neuroscience, Milan, Italy;
P074: Inflammatory Environment-Induced Transcriptomic Alterations in Crohn@E@s Disease Adipose Stem CellsECCO'24
Year: 2024
Authors: Montfort-Ferré, D.(1)*;Boronat-Toscano, A.(1);Sánchez-Herrero, J.F.(2);Caro, A.(3);Menacho, M.(4);Vañó-Segarra, I.(1);Martí, M.(5);Espina, B.(3);Pluvinet, R.(2);Cabrinety, L.(4);Abadia, C.(4);Ejarque, M.(1);Nuñez-Roa, C.(1);Maymo-Masip, E.(1);Sumoy, L.(2);Vendrell, J.(1);Fernández-Veledo, S.(1);Serena, C.(1);
(1)Health Institute Pere Virgili IISPV, Hospital Joan XXIII of Tarragona- Universitat Rovira i Virgili URV., Tarragona, Spain;(2)Germans Trias i Pujol Research Institute IGTP, High Content Genomics and Bioinformatics, Badalona, Spain;(3)Hospital Joan XXIII of Tarragona, Surgery Service, Tarragona, Spain;(4)Hospital Joan XXIII of Tarragona, Gastroenterology Service, Tarragona, Spain;(5)Hospital Vall d@E@Hebron of Barcelona, Surgery Service, Barcelona, Spain;
P075: Early intestinal ultrasound non-response is a prediction tool of complicated disease outcome in Crohn’s disease patients treated with infliximabECCO'24
Year: 2024
Authors: Bárbara, A.(1)*;Bravo, C.(1);Reves, J.(1);Nascimento, C.(1);Gomes, C.(1);Torres, J.(1);Palmela, C.(1);
(1)Hospital Beatriz Ângelo, Gastroenterology, Lisbon, Portugal;
P076: Dock2 acts as a tumour suppressor via immune cell regulation of IDO1 in Inflammatory Bowel Disease–associated colorectal cancerECCO'24
Year: 2024
Authors: ChurchhouseMD, A.(1)*;Billard, C.V.(1);Pohl, S.Ö.(1);Donnelly, K.(1);Suzuki, T.(2);Von Kriegsheim, A.(1);Arends, M.J.(1);Coffelt, S.B.(2);Myant, K.B.(1);
(1)The University of Edinburgh, The Institute of Genetics and Cancer, Edinburgh, United Kingdom;(2)University of Glasgow, School of Cancer Sciences, Glasgow, United Kingdom;
P077: The Immunometabolic Bimodal Mechanism of NLRX1 Agonist NX-13 in a Pig Model of Ulcerative ColitisECCO'24
Year: 2024
Authors: Verstockt, B.(1)*;Mosig, R.(2);Dubinsky, M.(3);Cataldi, F.(4);Danese, S.(5);
(1)University Hospitals Leuven- KU Leuven-, Department of Gastroenterology and Hepatology- Department of Chronic Diseases and Metabolism, Leuven, Belgium;(2)Landos Biopharma- Inc, Corporate Development, Blacksburg, United States;(3)Mount Sinai Kravis Children@E@s Hospital- Icahn School of Medicine Mount Sinai, Division of Pediatric Gastroenterology and Nutrition, New York, United States;(4)Landos Biopharma- Inc, Medicine, Boston, United States;(5)IRCCS San Raffaele Scientific Institute- Vita-Salute San Raffaele University, Gastroenterology and Gastrointestinal Endoscopy Unit, Milan, Italy;
P078: Inflammatory transcriptomic signatures and cell type compositions in colonic mucosa of ulcerative colitisECCO'24
Year: 2024
Authors: Song, E.M.(1)*;Jung, S.A.(1);Joo, Y.H.(1);Moon, C.M.(2);Kim, J.(3);
(1)College of Medicine- Ewha Womans University, Departments of Internal Medicine, Seoul, Korea- Republic Of;(2)College of Medicine- Ewha Womans University, Departments of Internal Medicine-, Seoul, Korea- Republic Of;(3)Soongsil University, School of Systems Biomedical Science, Seoul, Korea- Republic Of;
P079: Low-intensity Pulsed Ultrasound reflects the status of mucosal injury and repair through stage-specific miRNAs in experimental model of Ulcerative ColitisECCO'24
Year: 2024
Authors: Pineda Chavez, S.E.(1)*;Carriles Linares, A.(1);Rizzo, G.(2);Wozny, M.(1);Cafarelli, A.(3,4);Mori, G.(2);Sorriento, A.(3,4);Loy, L.(5);Dal Buono, A.(5);Gabbiadini, R.(5);Bezzio, C.(5);Lucchetti, D.(6);Sgambato, A.(6);Ricotti, L.(3,4);Repici, A.(1,7);Armuzzi, A.(1,5);Vetrano, S.(1,2);
(1)Humanitas University, Biomedical Sciences, Pieve Emanuele- Milan, Italy;(2)IRCCS Humanitas Research Hospital, Laboratory of Gastrointestinal Immunopathology- Department of Gastroenterology, Rozzano- Milan, Italy;(3)Scuola Superiore Sant’Anna, The BioRobotics Institute, Pisa, Italy;(4)Scuola Superiore Sant’Anna, Department of Excellence in Robotics & AI, Pisa, Italy;(5)Humanitas Clinical and Research Center - IRCCS -, IBD Unit- Department of Gastroenterology, Rozzano- Milan, Italy;(6)Università Cattolica del Sacro Cuore, Institute of General Pathology, Rome, Italy;(7)Humanitas Clinical and Research Center-IRCCS, Endoscopy Unit, Rozzano- Milan, Italy;