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OP37 Fibrogenesis in chronic DSS colitis is driven by an innate lymphoid cell-independent innate immune response

ECCO'20 Vienna

Year: 2020
Authors:

B. Creyns1,2, J. Cremer1,2, G. De Hertogh3, L. Boon4, M. Ferrante2,5, S. Vermeire2,5, G. Van Assche2,5, J. Ceuppens1, C. Breynaert1,6, Allergy and Clinical Immunology Research Group

1Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium, 2Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders TARGID, KU Leuven, Leuven, Belgium, 3Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium, 4Bioceros, Utrecht, The Netherlands, 5Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium, 6Department of General Internal Medicine, KU Leuven, University Hospitals Leuven, Leuven, Belgium

OP38 Top-down infliximab superior to step-up in children with Moderate-to-Severe Crohn’s disease: A multicentre randomised controlled trial

ECCO'20 Vienna

Year: 2020
Authors:

M. Jongsma MSc1, M. Aardoom1, M. Cozijnsen1, M. van Pieterson1, T. de Meij2, O. Norbruis3, M. Groeneweg4, V. Wolters5, H. van Wering6, I. Hojsak7, K.L. Kolho8, T. Hummel9, J. Stapelbroek10, C. van der Feen11, P. Rheenen12, M. van Wijk2, S. Teklenburg-Roord3, J. Escher1, J. Samsom13, L. Ridder1

1Department of Pediatric Gastroenterology, Erasmus MC - Sophia Children’s Hospital, Rotterdam, The Netherlands, 2Department of Paediatric Gastroenterology, Amsterdam UMC/Emma Children’s Hospital, Amsterdam, The Netherlands, 3Department of Paediatric Gastroenterology, Isala Hospital, Zwolle, The Netherlands, 4Department of Paediatrics, Maasstad Hospital, Rotterdam, The Netherlands, 5Department of Paediatric Gastroenterology, Utrecht UMC/Wilhelmina Children’s Hospital, Utrecht, The Netherlands, 6Department of Paediatric Gastroenterology, Amphia Hospital, Breda, The Netherlands, 7Department of Paediatric Gastroenterology, Zagreb Children’s Hospital, Zagreb, The Netherlands, 8Department of Paediatric Gastroenterology, Tampere University Hospital and University of Tampere, Helsinki, Finland, 9Department of Paediatric Gastroenterology, Medical Spectrum Twente, Enschede, The Netherlands, 10Department of Paediatric Gastroenterology, Catharina Hospital, Eindhoven, The Netherlands, 11Department of Paediatric Gastroenterology, Jeroen Bosch Hospital, Den Bosch, The Netherlands, 12Department of Paediatric Gastroenterology, UMCG, Groningen, The Netherlands, 13Laboratory of Paediatrics, Erasmus MC - Sophia Children’s Hospital, Rotterdam, The Netherlands

OP39 Treatment of ulcerative colitis With AMT-101, a novel oral interleukin-10 immunomodulatory fusion biologic that traffics across the intestinal epithelium

ECCO'20 Vienna

Year: 2020
Authors:

R. Mrsny1, B. Kanwar2, T. Mahmood3

1Applied Molecular Transport, Platform and Biology, South San Francisco, USA, 2Applied Molecular Transport, Clinical Development, South San Francisco, USA, 3Applied Molecular Transport, CEO, South San Francisco, USA

OP40 A core transferable microbiota in responders to faecal microbiota transplant for ulcerative colitis shape mucosal T-cell immunity

ECCO'20 Vienna

Year: 2020
Authors:

L. Gogokhia1, S. Lima1, M. Viladomiu1, Y. Gerardin2, C. Crawford1, V. Jacob1, E. Scherl1, M. Rosenthal3, S.E. Brown3, J. Hambor3, R. LONGMAN1

1Department of Medicine, Weill Cornell Medicine, New York, USA, 2Department of Finch Therapeutics, Finch Therapeutics, Somerville, USA, 3SHINE Program, Boehringer Ingelheim, Ridgefield, USA

P001 The novel DYRK1a inhibitor VRN024219 alleviates disease severity on the IBD mouse models by modulating T-cell differentiation

ECCO'20 Vienna

Year: 2020
Authors:

D.H. Seo1, H.W. Ma2,3, S. Kim1, D.H. Kim2, H.K. Kim4, S.H. Lee1, S. Kim1, J.Y. Ahn5, S.H. Yoon5, D.K. Kim1, J.H. Cheon2,3,6

1Bio Lab, Voronoi Inc., Incheon, Korea Republic of, 2Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea Republic of, 3Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea Republic of, 4VoronoiBio Inc., In Vitro Efficacy Assessment, Incheon, Korea Republic of, 5Department of Business Development, Voronoi Inc., Incheon, Korea Republic of, 6Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea Republic of

P002 Specific genome editing to model hypermethylation of the SP140 gene that associates to Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

I. Hageman1, A. Li Yim2, V. Joustra3, M. Ghiboub1, K. Gecse3, A. Te Velde1, G. D’Haens3, C. Paulusma1, P. Henneman2, W. De Jonge1

1Academic Medical Center AMC University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands, 2Department of Clinical Genetics, Academic Medical Center AMC University of Amsterdam, Amsterdam, The Netherlands, 3Department of Gastroenterology and Hepatology, Academic Medical Center AMC University of Amsterdam, Amsterdam, The Netherlands

P003 Metabolomics for improved patient stratification in inflammatory bowel disease: Characterisation of the ulcerative colitis metabolome

ECCO'20 Vienna

Year: 2020
Authors:

J. Diab1, T. Hansen1, R. Goll2,3, H. Stenlund4, E. Jensen1, T. Moritz4,5, J. Florholmen2,3, G. Forsdahl1

1Department of Pharmacy, Faculty of Health Sciences, University of Tromsø The Arctic University of Norway, Tromsø, Norway, 2Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø The Arctic University of Norway, Tromsø, Norway, 3Department of Medical Gastroenterology, University Hospital of North Norway, Tromsø, Norway, 4Department of Molecular Biology, Swedish Metabolomics Center, Umeå University, Umeå, Sweden, 5The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

P004 PN-943, an oral α4β7 integrin antagonist, inhibits MAdCAM1-mediated proliferation and cytokine release from CD4+ T cells independent of trafficking

ECCO'20 Vienna

Year: 2020
Authors:

L. CHENG, S. Venkataraman, L. Zhao, L. Lee, T. Tang, D. Liu, L. Mattheakis

Department of Biology, Protagonist Therapeutics, Newark, USA

P005 Regulators of the guanylate cyclase pathway are potential novel markers of mucosal healing in IBD

ECCO'20 Vienna

Year: 2020
Authors:

L.E. Jeffery1, U.N. Shivaji1, D. Zardo2, A. Acharjee3, O.M. Nardone4, S.C. Smith4, G. Gkoutos3, S.S. Visweswariah5, S. Ghosh1, M. Iacucci1

1NIHR Birmingham Biomedical Research Centre, University of Birmingham, Gastroenterology, Birmingham, UK, 2University Hospitals Birmingham, Pathology, Birmingham, UK, 3Department of Gastroenterology, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK, 4Department of Gastroenterology, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK, 5Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India

P006 3D Multicellular intestine-on-a-chip model for disease modelling and drug discovery

ECCO'20 Vienna

Year: 2020
Authors:

G. Lo Sasso1, L. Gijzen2, D. Marescotti1, E. Naumovska2, E. Raineri2, A. Nicolas2, H. Lanz2, D. Guerrera1, R. van Vught2, J. Joore2, P. Vulto2, M.C. Peitsch1, J. Hoeng1, D. Kurek2

1Department of System Toxicology, Philip Morris Products SA, Neuchâtel, Switzerland, 2Mimetas BV, Leiden, The Netherlands

P007 GC1qR driven oxidative phosphorylation is essential for intestinal goblet cell differentiation

ECCO'20 Vienna

Year: 2020
Authors:

A. SÜNDERHAUF1, M. Hicken1, K. Skibbe1, H. Schlichting1, M. Hirose2, S. Perner3, S. Ibrahim2, S. Derer1, C. Sina1

1Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Lübeck, Germany, 2Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany, 3Institute of Pathology, University Hospital Schleswig-Holstein, Lübeck, Germany

P008 Whole-genome RNA sequencing in collagenous colitis: a subgroup analysis

ECCO'20 Vienna

Year: 2020
Authors:

C. Escudero-Hernández1, A. van Beelen Granlund2, T. Bruland3, A.K. Sandvik4, S. Koch5, A.E. Østvik3, A. Münch6

1Department of Biomedical and Clinical Sciences BKV, Linköping University, Linköping, Sweden, 2Centre of Molecular Inflammation Research and Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway, 3Department of Clinical and Molecular Medicine and Department of Gastroenterology and Hepatology, Norwegian University of Science and Technology NTNU, Trondheim, Norway, 4Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine and Department of Gastroenterology and Hepatology, Norwegian University of Science and Technology NTNU, Trondheim, Norway, 5Department of Biomedical and Clinical Sciences BKV and Wallenberg Center for Molecular Medicine WCMM, Linköping University, Linköping, Sweden, 6Division of Gastroenterology and Hepatology, Department of Biomedical and Clinical Sciences BKV, Linköping University, Linköping, Sweden

P009 The innate cytokines IL-1α and TNF-α induce the expression of Oncostatin M and its type II receptor in human colonic subepithelial myofibroblasts

ECCO'20 Vienna

Year: 2020
Authors:

E. Filidou1, G. Kokkotis2, G. Tarapatzi1, M. Boulkou3, K. Arvanitidis1, I. Drygiannakis3, V. Valatas3, I. Koutroubakis3, S. Vradelis4, G. Kolios1, G. Bamias2

1Laboratory of Pharmacology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece, 2GI Unit, 3rd Academic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece, 3Laboratory of Gastroenterology, Department of Medicine, University of Crete, Heraklion, Greece, 4University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece

P010 Measurement of colonic mucosal content of biologics with the use of magnetic resonance imaging (MRI): A pilot study in patients with ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

R. Filip1, P. Bar2, D. Bartusik-Aebisher3, D. Aebisher3

1Kliniczny Szpital Wojewodzki Nr 2 im. Sw. Krolowej Jadwigi w Rzeszowie, Klinika Gastroenterologii i Centralna Pracownia Endoskopii, Rzeszow, Poland, 2Department of Gastroenterology with IBD Unit, Clinical Hospital 2- Rzeszów- Poland, Rzeszow, Poland, 3University of Rzeszow, Medical Faculty, Rzeszow, Poland

P011 Dysbiosis and Goblet cells depletion triggers early intestinal barrier dysfunction that precedes gut inflammation in IL-10 deficient mice (IL-10−/−)

ECCO'20 Vienna

Year: 2020
Authors:

B. López Cauce1, M. Puerto1, J.J. García2, J. Miranda-Bautista1, J. Vaquero1, R. Bañares1, L. Menchén1

1Department of Gastroenterology and Digestive System Medicine, General University Hospital Gregorio Marañón, Madrid, Spain, 2Department of Microbiology and Parasitology, Pharmacy Faculty of Complutense University of Madrid, Madrid, Spain

P012 α4β7 Receptor occupancy by vedolizumab at trough time-point occurs at the membranal level and is not associated with endoscopic healing in inflammatory bowel disease patients

ECCO'20 Vienna

Year: 2020
Authors:

B. Ungar1,2, Z. Ben-Shatach1,2, O. Haj-Natour1,2, M. Yavzori1,2, E. Fudim1,2, O. Picard1,2, D. Coscas1,2, A. Lahat1,2, M. Lidar2,3, R. Eliakim1,2, U. Kopylov1,2, S. Ben-Horin1,2

1Sheba Medical Center Tel Hashomer, Gastroenterology Institute, Ramat gan, Israel, 2Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, 3Sheba Medical Center Tel Hashomer, Rheumatology Institute, Ramat gan, Israel

P013 The JAK-3 and TYK-2 / STAT pathways are activated in moderate to severe ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

M. Loza1, J.M. Brea1, C. Calviño-Suarez2, I. Baston-Rey2, R. Ferreiro-Iglesias2, J.E. Dominguez-Munoz2, M. Barreiro-de Acosta2

1BioFarma Research Group, CIMUS Research Center and IDIS Health Research Institute, Department of Pharmacology, Santiago de Compostela, Spain, 2Department of Gastroenterology, IBD Unit, University Hospital Santiago De Compostela CHUS, Santiago De Compostela, Spain

P014 Identification of Crohn’s disease immunopathotypes

ECCO'20 Vienna

Year: 2020
Authors:

H.M. Baer1, E. MacDonald2, A. Ferguson1, A.M. Scott3, M.I. Khan3, K.A. Bain1, U.Z. Ijaz4, J. Cole1, M. Ramanujam5, R.J.B. Nibbs1, D.R. Gaya3, S.W.F. Milling1

1Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Immunobiology, Glasgow, UK, 2Medical Research Institute, QIMR Berghofer, Immunology in Cancer and Infection, Brisbane, Australia, 3Gastroenterology Unit, Glasgow Royal Infirmary, Gastroenterology, Glasgow, UK, 4Rankine Building,- School of Engineering, University of Glasgow, Microbial Informatics, Glasgow, UK, 5Boehringer Ingelheim Pharmaceuticals Inc., Immunology and Respiratory Diseases Research, Ridgefield, USA

P015 Tricellulin overexpression protects against elevated macromolecule uptake in DSS colitis mice

ECCO'20 Vienna

Year: 2020
Authors:

F. WEIß1, I.F.M. Lee1, A. Fromm1, J.C.E. Hu1, T. Breiderhoff2, M. Fromm1, J.D. Schulzke1, S.M. Krug1

1Charité, Universitätsmedizin Berlin, Institute of Clinical Physiology, Berlin, Germany, 2Charité, Department of Pediatrics, Division of Nephrology, Universitätsmedizin Berlin, Berlin, Germany

P016 Efficiency of evaluating the expression of Toll-like receptors 2, 4, 6 and proteins proteomic profiling as integral indicators for predicting the risk of early relapse of ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

G. Tarasova, A. Volkov, A. Iakovlev, T. Ghazudin, I. Shcherbakova

Department of Gastroenterology, Rostov State Medical University, Rostov-on-Don, Russian Federation