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P011: New insights into the pathogenic potential and signalling network of NKG2D+ CD4+ T-cells in Crohn’s DiseaseECCO'22
Year: 2022
Authors: Modos, D.(1,2);Gul, L.(1);Lo, J.(3,4);Madgwick, M.(1);Cozzetto, D.(3);Lord, G.(5,6);Korcsmaros, T.(1,2,3);Powell, N.(3,4);
(1)Earlham Institute, Organisms and Ecosystems, Norwich, United Kingdom;(2)Quadram Institute Bioscience, Gut Microbes and Health, Norwich, United Kingdom;(3)Imperial College-Faculty of Medicine, Department of Metabolism- Digestion and Reproduction, London, United Kingdom;(4)King's College, Centre for Inflammation Biology & Cancer Immunology, London, United Kingdom;(5)Manchester University, Faculty of Biology- Medicine and Health, Manchester, United Kingdom;(6)King's College, School of Immunology and Microbial Sciences, London, United Kingdom;
P012: The effect of Oncostatin M on human intestinal organoidsECCO'22
Year: 2022
Authors: Filidou, E.(1);Kandilogiannakis, L.(1);Kokkotis, G.(2);Tarapatzi, G.(1);Arvanitidis, K.(1);Drygiannakis, I.(3);Valatas, V.(3);Paspaliaris, V.(4);Kolios, G.(1);Bamias, G.(2);
(1)Laboratory of Pharmacology- Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;(2)GI Unit- 3rd Academic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece;(3)Laboratory of Gastroenterology, University of Crete, Herakleion, Greece;(4)Tithon Biotech, Inc, San Diego, United States;
P013: A single cell approach reveals immune cell dynamics in Inflammatory Bowel Disease (IBD) and highlights association of CD8 intraepithelial lymphocytes (IELs) with response to vedolizumab treatmentECCO'22
Year: 2022
Authors: Paraskevopoulou, M.(1);Mayer, L.(2);Krueger, A.(1);Pattekar, A.(3);Ramos, A.(3);Fulton, M.(3);Wai Lau, C.(3);Chau, L.(3);Ren, Y.(3);Tondon, R.(3);Al Garawi, A.(1);Bittinger, K.(4);Fogt, F.(3);Yajnik, V.(1);Lee, H.(3);Lewis, J.(3);Wu, G.(3);Bewtra, M.(3);Tomov, V.(3);Juarez, J.(1);
(1)Takeda Pharmaceuticals U.S.A., Inc., Lexington, United States;(2)Department of Medicine II- Gastroenterology- Hepatology- Endocrinology- and Infectious Diseases- Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany;(3)Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States;(4)The Children's Hospital of Philadelphia, Philadelphia, Philadelphia, United States;
P014: Impact of experimental ileitis and Toll-Like Receptor 4 signaling on enteric inhibitory neurotransmissionECCO'22
Year: 2022
Authors: Faggin, S.(1);Cerantola, S.(1);Dal Prà, A.(1);Caldana, G.(1);Bosi, A.(2);Banfi, D.(2);Giaroni, C.(2);Savarino, E.(3);Giron, M.C.(1);
(1)University of Padova, Department of Pharmaceutical and Pharmacological Sciences, Padova, Italy;(2)University of Insubria, Department of Medicine and Surgery, Varese, Italy;(3)University of Padova, Department of Surgery- Oncology and Gastroenterology, Padova, Italy;
P015: Detection of endoscopic lesions from limited quality annotations in colonoscopy videosECCO'22
Year: 2022
Authors: Alali, S.(1);Chaussard, J.(1);Li-Thiao-Té, S.(1);Ogier-Denis, É.(2);Percy-du-sert, A.(3);Treton, X.(3);Zaag, H.(1);
(1)Université sorbonne Paris Nord, Laboratoire Analyse- Géométrie et Applications, Villetaneuse, France;(2)Institut national de la santé et de la recherche médicale-INSERM, Paris, Paris, France;(3)Hôpital Beaujon Gastro-enterologie et assisstance nutritive, Hauts de seine, Clichy, France;
P016: Colonoids derived from UC patients retain higher transcriptional response to inflammatory triggers in-vitro, even after several passagesECCO'22
Year: 2022
Authors: Abbas Egbariya, H.(1);Ben-Shoshan, M.(2);Braun, Z.(2);Berger, T.(2);granot, M.(2);Loberman-Nachum, N.(2);Vais, B.(2);Gal Mor, O.(1);Amir, A.(2);Haberman, Y.(2);
(1)Tel Aviv university - faculty of medicine, microbiology, tel aviv, Israel;(2)Sheba medical center, pediatric gastroenterology, Ramat Gan, Israel;
P017: Transcriptional characterization of lymphocytic colitis and comparison to collagenous colitisECCO'22
Year: 2022
Authors: Koch, S.(1);Münch, A.(2);Escudero-Hernández, C.(1,3);
(1)Linköping University, Department of Biomedical and Clinical Sciences BKV, Linköping, Sweden;(2)Linköping University, Department of Biomedical and Clinical Sciences BKV- Department of Gastroenterology and Hepatology- and Department of Health- Medicine- and Caring Sciences, Linköping, Sweden;(3)Current address: Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein- Kiel- Germany, Institute for Clinical Molecular Biology- IKMB, Kiel, Germany;
P018: Proteomic profile of serum and urine in newly diagnosed patients with Inflammatory Bowel Disease: new approach for biomarker discoveryECCO'22
Year: 2022
Authors: Baldan-Martin, M.(1);Azkargorta , M.(2);Iloro , I.(2);Ortega Moreno , L.(1);Aldars Garcia , L.(1);Soleto Fernández , I.(1);Ramirez , C.(1);Riestra , S.(3);Rivero , M.(4);Gutierrez , A.(5);Rodríguez-Lago , I.(6);Fernández-Salazar , L.(7);Ceballos , D.(8);Benítez , J.M.(9);Aguas , M.(10);Bastón-Rey , I.(11);Bermejo , F.(12);Casanova , M.J.(1);Llorente , R.(13);Ber , Y.(14);Royo , V.(15);Esteve , M.(16);Elortza , F.(2);Chaparro , M.(1);Gisbert , J.P.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-IP- Universidad Autónoma de Madrid and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Unit, Madrid, Spain;(2)Proteomics Platform- CIC bioGUNE- BRTA Basque Research & Technology Alliance- CIBERehd- ProteoRed-ISCIII, Proteomics Platform, Derio, Spain;(3)Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias ISPA, Gastroenterology Unit, Oviedo, Spain;(4)Hospital Universitario Marqués de Valdecilla and IDIVAL, Gastroenterology Unit, Santander, Spain;(5)Hospital General Universitario de Alicante- ISABIAL and CIBERehd, Gastroenterology Unit, Alicante, Spain;(6)Hospital Galdakao-Usansolo, Gastroenterology Unit, Vizcaya, Spain;(7)Hospital Clínico Universitario de Valladolid, Gastroenterology Unit, Valladolid, Spain;(8)Hospital Universitario de Gran Canaria Dr. Negrín, Gastroenterology Unit, Las Palmas de Gran Canaria, Spain;(9)Hospital Universitario Reina Sofía and IMIBIC, Gastroenterology Unit, Córdoba, Spain;(10)Hospital Universitari i Politecnic La Fe and CIBERehd, Gastroenterology Unit, Valencia, Spain;(11)Hospital Clínico Universitario de Santiago de Compostela, Gastroenterology Unit, Santiago de Compostela, Spain;(12)Hospital Universitario de Fuenlabrada and IDIPAZ, Gastroenterology Unit, Madrid, Spain;(13)Hospital General Universitario de Ciudad Real, Gastroenterology Unit, Ciudad Real, Spain;(14)Hospital San Jorge, Gastroenterology Unit, Huesca, Spain;(15)Hospital Universitari Son Espases, Gastroenterology Unit, Palma de Mallorca, Spain;(16)Hospital Universitari Mutua Terrasa and CIBERehd, Gastroenterology Unit, Terrasa, Spain;
P019: GS-1069518 is a potent and selective small molecule α4β7 inhibitorECCO'22
Year: 2022
Authors: Wang, Y.(1);Zhou, J.(2);Chang, C.(3);Roedder, S.(3);Bonne-Annee, S.(1);Marchand, B.(4);Hung, K.(4);Currie, K.(5);Clarke, A.(1);
(1)Gilead Sciences- Inc., Inflammation Biology, Seattle, United States;(2)Gilead Sciences- Inc., Oncology Biology, Seattle, United States;(3)Gilead Sciences- Inc., Biomarkers, Foster City, United States;(4)Gilead Sciences- Inc., Discovery Sciences, Foster City, United States;(5)Gilead Sciences- Inc., Medicinal Chemistry, Seattle, United States;
P020: Differential expression of miR-424-5p and miR-378c in stenotic and penetrating lessions of Crohn’s Disease associates with altered transcription of genes involved in vascular regulationECCO'22
Year: 2022
Authors: Coll, S.(1);Seco, M.(1);Bauset, C.(1);Lis, L.(1);Cosín-Roger, J.(2);Ortiz-Masia, D.(3);Gisbert-Ferrandiz, L.(1);Barrachina, D.(1);Calatayud, S.(1);
(1)Faculty of Medicine - University of Valencia, Pharmacology, Valencia, Spain;(2)FISABIO, Unidad Mixta Facultad de Medicina-Hospital Dr Peset, Valencia, Spain;(3)Faculty of Medicine - University of Valencia, Medicine, Valencia, Spain;
P021: Vitamin D receptor-dependent protective effect of moderate hypoxia in a mouse colitis model Running title: Hypoxia prevents mouse colitis through VDRECCO'22
Year: 2022
Authors: Wang, Z.(1);Hong, Y.(2);Hong, L.(3);Changzhi, H.(4);Jiaming, Q.(3);
(1)Peking Union Medical College Hospital, Gastroenterology, Beijing- China, China;(2)Peking Union Medical College Hospital, Gastroenterology, Beijng, China;(3)Peking Union Medical College Hospital, Gastroenterology, Beijing, China;(4)Cancer Hospital- CAMS and PUMC, State Key Laboratory of Molecular Oncology, Beijing, China;
P022: Transcriptional biomarkers for vedolizumab therapy response in patients with moderate to severe Ulcerative Colitis.ECCO'22
Year: 2022
Authors: Arosa García, L.(1);Camba-Gómez, M.(1);Calviño-Suárez, C.(2);Bastón-Rey, I.(2);Ferreiro-Iglesias, R.(2);Porto , M.(2);Nieto-García , L.(2);Domínguez-Muñoz, J.E.(2);Barreiro-de Acosta , M.(2);Conde-Aranda, J.(1);
(1)Health Research Institute of Santiago de Compostela IDIS, Molecular and Cellular Gastroenterology, Santiago de Compostela, Spain;(2)University Hospital of Santiago de Compostela, Department of Gastroenterology and Hepatology, Santiago de Compostela, Spain;Molecular and Cellular Gastroenterology
P023: Prevalence of malnutrition, risk of malnutrition and quality of life among patients with Inflammatory Bowel Disease.ECCO'22
Year: 2022
Authors: Korwel, K.M.(1);Hjortswang , H.(1);Eberhardson , M.(1);Pihl Lesnovska, K.(1);
(1)Linköping University, Department of Gastroenterology and Department of Medical and Health Sciences, Linköping, Sweden;
P024: CD40 and key CD40/CD154 pathway members are significantly upregulated in inflamed lesional IBD biopsies as shown by whole transcriptome AmpliSeq gene expression profiling and corresponding immunohistochemistry.ECCO'22
Year: 2022
Authors: Raulf, F.(1);Delucis-Bronn, C.(1);Angevaare, E.(1);Caesar, N.(1);Marcantonio, A.(1);Ceci, M.(1);Regnier, C.(1);Bonal, C.(2);Siegel, R.(2);Niess, J.H.(3);Wieczorek, G.(1);Hrúz, P.(3);
(1)Novartis Pharma AG / Novartis Institutes for BioMedical Research, Autoimmunity- Transplantation and Inflammation Disease Area, Basel, Switzerland;(2)Novartis Pharma AG / Novartis Institutes for BioMedical Research, Translational Medicine, Basel, Switzerland;(3)Clarunis AG, University Center for Gastrointestinal and Liver Diseases, Basel, Switzerland;
P025: A review of the newly implemented Inflammatory Bowel Disease dietetic serviceECCO'22
Year: 2022
Authors: Norman, E.(1);Hoque, S.(1);Mudege, T.(1);
(1)Whipps Cross Hospital- Barts Trust, Gastroenterology, London, United Kingdom;
P026: Inflammatory bowel disease does not preclude the presence of environmental enteropathy in Zambian adultsECCO'22
Year: 2022
Authors: Hodges, P.(1);Mulenga, C.(2);Banda, R.(2);Kelly, P.(1);
(1)Queen Mary University of London, Blizard Institute- Barts and the London School of Medicine and Dentistry, London, United Kingdom;(2)University of Zambia School of Medicine, Tropical Gastroenterology and Nutrition Group, Lusaka, Zambia;
P027: Effects of anti-TNF and anti-α4β7 drugs on circulating monocytes migratory capacity in inflammatory bowel diseaseECCO'22
Year: 2022
Authors: Soleto, I.(1);Fernández-Tomé, S.(2);Mora-Gutiérrez, I.(3);Baldan-Martin, M.(1);Ramirez, C.(1);Santander, C.(1);Moreno-Monteagudo, J.A.(1);Casanova, M.J.(1);Casals, F.(1);Casabona, S.(1);Becerro, I.(1);Chaparro, M.(1);Bernardo, D.(4);Gisbert, J.P.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria IIS-IP and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Unidad de Enfermedad Inflamatoria Intestinal, Madrid, Spain;(2)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria IIS-IP and Departamento de Nutrición y Ciencia de los Alimentos- Facultad de Farmacia- Universidad Complutense de Madrid, Unidad de Enfermedad Inflamatoria Intestinal, Madrid, Spain;(3)Biobanco del sistema de salud de Aragón, Biobanco, Zaragoza, Spain;(4)Mucosal Immunology Lab- Instituto de Biología y Genética Molecular IBGM- Universidad de Valladolid-CISC, Mucosal Immunology, Valladolid, Spain;
P028: Inhibition of stromal glycolysis by targeting PFKFB3 decreases experimental colitisECCO'22
Year: 2022
Authors: Zhou, Z.(1);Plug, L.G.(1);de Jonge-Muller, E.S.M.(1);Abou Elmagd , A.(1);van der Meulen-de Jong, A.E.(1);Barnhoorn , M.C.(1);Hawinkels, L.J.A.C.(1);
(1)Leiden University Medical Center, Department of Gastroenterology and Hepatology, Leiden, The Netherlands;
P029: Expression of miR-21 in mucosal biopsies give clues to anti-TNF treatment non-response in IBD children and adultsECCO'22
Year: 2022
Authors: Pallikkunnath James, J.(1);Schnack Nielsen, B.(2);Langholz, E.(3,4);Mikkel , M.(5,6,7);Estrid , H.(1);Buhl Riis, L.(8);
(1)Herlev University Hospital, Department of Pathology, 2730- Herlev, Denmark;(2)Bioneer A/S, Molecular histology and detection, 2970 Hørsholm, Denmark;(3)Herlev University Hospital, Gastroenheden D, 2730 Herlev, Denmark;(4)University of Copenhagen, Institute for Clinical Medicine, 2200 Copenhagen, Denmark;(5)Hvidovre Hospital- Universty of Copenhagen, The Pediatric Department, 2650 Hvidovre, Denmark;(6)Hvidovre Hospital- University of Copenhagen, Copenhagen Center for Inflammatory Bowel Disease in Children- Adolescents and Adults, 2650 Hvidovre, Denmark;(7)Holbæk Sygehus, The Pediatric Department, 4300 Holbæk, Denmark;(8)Herlev University Hospital, Department of Pathology-, 2730- Herlev, Denmark;
P030: Distinct molecular profiles between idiopathic cryptoglandular and Crohn-related perianal fistulasECCO'22
Year: 2022
Authors: Verstockt., B.(1,2);Verstockt, S.(2);Bislenghi, G.(3);Sabino, J.(1,2);Ferrante, M.(1,2);D'Hoore, A.(3);Vermeire, S.(1,2);
(1)University Hospitals Leuven, Dpt. Gastroenterology and Hepatology, Leuven, Belgium;(2)KU Leuven, Dpt. Chronic Diseases and Metabolism, Leuven, Belgium;(3)University Hospitals Leuven, Dpt. Abdominal Surgery, Leuven, Belgium;