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P010: Synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Kawamoto*1, S. Nagata1, S. Anzai1, J. Takahashi1, M. Kawai1, M. Hama1, D. Nogawa2, K. Yamamoto2, R. Kuno1, K. Suzuki1, H. Shimizu1, Y. Hiraguri1, S. Yui3, S. Oshima1, K. Tsuchiya1, T. Nakamura1,4, K. Ohtsuka1, M. Kitagawa2, R. Okamoto1,3, M. Watanabe1

1Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan, 2Department of Comprehensive Pathology, Tokyo Medical and Dental University, Tokyo, Japan, 3Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan, 4Tokyo Medical and Dental University, Department of Advanced Therapeutics in GI Diseases, Tokyo, Japan

P011: Signalling and transcriptional network propagation uncovers novel ulcerative colitis pathogenetic pathways from single-nucleotide polymorphisms

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Modos*1, J. Brooks2,3,4,5, P. Sudhakar2,4,6, B. Verstockt6,7, B. Alexander-Dann1, A. Zoufir1, D. Fazekas4,8, S. Vermeire6,7, T. Korcsmaros2,4, A. Bender1

1University of Cambridge, Chemistry, Cambridge, UK, 2The Quadram Institute Bioscience, Gut Microbes and Health Programme, Norwich, UK, 3Norfolk and Norwich University Hospitals, Norwich Medical School, Norwich, UK, 4Earlham Institute, Norwich, UK, 5University Hospitals, Department of Gastroenterology Norfolk and Norwich, Norwich, UK, 6KU Leuven, Department of Chronic Diseases, Leuven, The Netherlands, 7University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, The Netherlands, 8Eötvös Loránd University, Department of Genetics, Budapest, Hungary

P012: IL22 expression in intestinal immune cells is not augmented by AHR activation in health or Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

P. Harrow*1,2, R. Datta1, A. Stagg1, J. O. Lindsay1,2

1Blizard Institute, QMUL, Immunobiology, London, UK, 2Royal London Hospital, Barts Health NHS Trust, London, UK

P013: Novel immunomodulatory role of food bioactive peptide lunasin in the healthy human intestinal mucosa

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Fernández-Tomé1, L. Pérez-Rodríguez2, A. C. Marin1, P. Indiano-Romacho2, L. Ortega-Moreno1,3, M. J. Casanova1, J. A. Moreno-Monteagudo1, C. Santander1, M. Chaparro1, J. P. Gisbert1, B. Hernández-Ledesma2, D. Bernardo1

1Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain, 2Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM, CEI UAM+CSIC), Madrid, Spain, 3Universidad Autónoma de Madrid, Madrid, Spain

P014: Disruption of epithelial barrier function by coeliac peripheral blood mononuclear cells

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Delbue da Silva1, A. Itzlinger1, B. Jessen1, H. Pfeiffert1, C. Heldt1, F. Branchi1, D. Lissner1, W. Dieterich1, B. Siegmund1, M. Schumann1

1Charité Universitätsmedizin, Department of Gastroenterology, Berlin, Germany

P015: PNAd+ and MAdCAM+ high endothelial venules correlate with disease activity in ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

B. Roosenboom*1, P. Wahab1, J. Meijer2, C. Smids1, M. Groenen1, E. Van Lochem3, C. Horjus Talabur Horje1

1Rijnstate Crohn and Colitis Centre, Gastroenterology and Hepatology, Arnhem, The Netherlands, 2Rijnstate Hospital, Department of Pathology, Arnhem, The Netherlands, 3Rijnstate Hospital, Department of Microbiology and Immunology, Arnhem, The Netherlands

P016: Constitutive activity of the cation channel TRPM8 regulates monocyte to macrophage transition in humans to control intestinal inflammation

ECCO '19 Copenhagen

Year: 2019
Authors:

E. Hornsby*1, M. Peiris1, M. Peiris1, H. W. King1, E. S. Wing1, J. O. Lindsay1, L. A. Blackshaw1, A. J. Stagg1

1QMUL, Blizard Institute, London, UK

P017: Transcriptional reprogramming of the HIF pathway is associated with inflammation and mucosal hypoxia in ulcerative colitis patients

ECCO '19 Copenhagen

Year: 2019
Authors:

C. R. Rowan*1, E. Brown2,3, M. J. Strowitzki2,3, R. R. Fagundes2,3,4, A. Guntsch2,3, D. N. Halligan2,3, G. A. Doherty1,3, C. T. Taylor2,3

1St.Vincent's University Hospital, Center for Colorectal Disease, Dublin, Ireland, 2University College Dublin, Conway Institute, Dublin, Ireland, 3University College Dublin, School of Medicine and Medical Science, Dublin, Ireland, 4University of Groningen, Graduate School of Medical Sciences, Groningen, The Netherlands

P018: Macrophage targeting contributes to the inhibitory effects of dihydroartemisinin on DSS-induced colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Teng*1, W. Ting1, W. Huahong1

1Peking University First Hospital, Gastroenterology, Beijing, China

P020: Regulation of intestinal epithelial homeostasis by the IBD risk gene CCNY

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Heil1, A. Molinas1, S. Koch*1

1Linköping University, Clinical and Experimental Medicine, Linköping, Sweden

P022: Galectin-3, galectin-9, and galectin-3 binding protein in patients with inflammatory bowel diseases

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Cibor*1, K. Szczeklik2, D. Owczarek1, T. Mach1

1Jagiellonian University Medical College, Gastroenterology, Hepatology and Infectious Diseases, Cracow, Poland, 2Jagiellonian University Medical College, Integrated Dentistry, Cracow, Poland

P023: A resting state fMRI study in patients with active Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Thapaliya1, S. Eldeghaidy2, S. J. Radford1, S. Francis2, G. Moran*1

1The University of Nottingham, NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and School of Medicine, Nottingham, UK, 2The University of Nottingham, Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, Nottingham, UK

P024: Plasma acetic acid, propanoic acid, and isobutyric acid are associated with treatment response in pouchitis patients treated with antibiotics

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Segal*1, M. Sarafian2, J. I. Serrano Contreras2, A. Pechlivanis2, Y. Siaw3, S. Clark1,2, L. Braz1,2, E. Holmes2, A. Hart1,2

1St Marks Hospital, Gastroenterology, Harrow, UK, 2Imperial College London, London, UK, 3Hillingdon Hospital, Gastroenterology, Hillingdon, UK

P025: Comparison of abdominal lymph nodes between healthy volunteers and patients with Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

H. Williams1, C. Hoad1, R. Scott2, G. Aithal2, L. Marciani2, G. Moran*2, P. Gowland1

1University of Nottingham, Sir Peter Mansfield Imaging Centre, Nottingham, UK, 2University of Nottingham, Nottingham Digestive Diseases Biomedical Research Centre, Nottingham, UK

P026: Establishment of an in vitro system to evaluate the therapeutic effect of the investigational drug on ulcerative colitis using human colonic organoids

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Hibiya*1, K. Tsuchiya1, R. Nishimura1, T. Shirasaki1, S. Watanabe1, N. Katsukura1, T. Nakamura2, M. Watanabe1

1Tokyo Medical and Dental University, Gastroenterology and Hepatology, Tokyo, Japan, 2Tokyo Medical and Dental University, Advanced Therapeutics for Gastrointestinal Diseases, Tokyo, Japan

P027: Machine learning approaches to identify prognosis indicators from microbiome data

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Madgwick*1,2, P. Sudhakar1,2,3, T. Korcsmáros1,2

1Earlham Institute, Norwich, UK, 2Quadram Institute, Norwich, UK, 3KU Leuven Department of Chronic Diseases, Leuven, Belgium

P028: Telomere shortening and genetic anticipation in IBD

ECCO '19 Copenhagen

Year: 2019
Authors:

B. Truta*1, S. Brant1, M. Armani1, L. Datta1, T. Bayless1

1Johns Hopkins University, Baltimore, USA

P029: Serum bile acids profiling in IBD patients treated with anti-TNFs

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Roda*1, E. Porru2, K. Katsanos3, A. Skamnelos3, K. Kyriakidi3, D. K. Christodoulou3, C. Caliceti2, G. Fiorino1, S. Danese1, A. Roda2

1Humanitas Research Hospital, IBD Centre, Milan, Italy, 2Department of Chemistry ‘Giacomo Ciamician’, Alma Mater Studiorum, Bologna, Italy, 3Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece

P030: Myeloid calcineurin in the control of immune checkpoint inhibition in intestinal tumour development

ECCO '19 Copenhagen

Year: 2019
Authors:

K. Peuker*1, A. Strigli1, L. Južnić1, L. Matthiesen1, M. Koch1, S. Krüger2, D. Tauriello3, E. Batlle3, C. Röcken2, J. Hampe1,4, S. Zeissig1,4

1TU Dresden, Center for Regenerative Therapies, Dresden, Germany, 2University Medical Center Schleswig-Holstein, Institute of Pathology, Kiel, Germany, 3The Barcelona Institute of Science and Technology, Institute for Research in Biomedicine, Barcelona, Spain, 4University Hospital Carl-Gustav Carus, Department of Internal Medicine I, Dresden, Germany

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