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OP28: Host–microbial crosstalk in the pathogenesis of inflammation and cancer in primary sclerosing cholangitis

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Neyazi1, N. Ilott2, Oxford IBD Cohort Study Investigators1, S. Travis1, C. Arancibia1, F. Powrie2, A. Geremia*1

1Translational Gastroenterology Unit, University of Oxford, Oxford, UK, 2Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK

OP29: ST2+/IL-33 responsive cells promote tumorigenesis in colitis-associated colorectal cancer

ECCO '19 Copenhagen

Year: 2019
Authors:

L. R. Lopetuso*1, C. De Salvo2, L. Di Martino2, W. Goodman2, F. Scaldaferri1, A. Armuzzi1, A. Gasbarrini1, T. T. Pizarro2

1Fondazione Policlinico Universitario A. Gemelli IRCCS – Università Cattolica del Sacro Cuore, UOC Internal Medicine, Gastroenterology and Hepatology Gastroenterological and Oncological Area, Gastroenterological and Endocrino-Metabolical Sciences Department, Roma, Italy, 2Case Western Reserve University, Cleveland, USA

OP30: Serum proteomic profiling predicts and diagnoses pouchitis in ulcerative colitis patients undergoing ileal pouch-anal anastomosis

ECCO '19 Copenhagen

Year: 2019
Authors:

K. Machiels*1, M. Ferrante1,2, N. Davani1, A. Wolthuis3, A. D’Hoore3, S. Vermeire1,2

1KU Leuven, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, 2University Hospitals Leuven, Department of gastroenterology and hepatology, Leuven, Belgium, 3University Hospitals Leuven, Abdominal surgery, Leuven, Belgium

OP31: TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation

ECCO '19 Copenhagen

Year: 2019
Authors:

K. Tsuchiya*1, S. Watanabe1, T. Shirasaki1, R. Nishimura1, N. Katsukura1, S. Hibiya1, R. Okamoto1, T. Nakamura1, M. Watanabe1

1Tokyo Medical and Dental Universityl and Dental Universityl and, Tokyo, Japan

OP32: A novel mechanism of colonic epithelial-T-cell cross-talk is dysregulated in IBD

ECCO '19 Copenhagen

Year: 2019
Authors:

R. J. Dart*1,2,3, P. Vantourout1,2, P. M. Irving3, A. Hayday1,2

1King’s College London, Peter Gorer Department of Immunobiology, London, UK, 2Francis Crick Institute, Immunosurveillance Lab, London, UK, 3Guy’s and St Thomas Hospital, Department of Gastroenterology, London, UK

OP33: BUB1: a new player in the development of Crohn’s disease (CD)-associated fibrosisECCO '19 Copenhagen
Year: 2019
Authors:

V. Garlatti*1, F. Ungaro1, S. Spanò1, S. D’Alessio1,2, S. Danese1,2

1Humanitas University, Pieve Emanuele, Italy, 2Humanitas Research Hospital, Rozzano, Italy

Files: 1
OP34: VARSITY: A double-blind, double-dummy, randomised, controlled trial of vedolizumab versus adalimumab in patients with active ulcerative colitisECCO '19 Copenhagen
Year: 2019
Authors:

Stefan. Schreiber1, Laurent. Peyrin-Biroulet2, Edward. V. LoftusJr.3, Silvio. Danese4, Jean-Frederic. Colombel5, Brihad. Abhyankar6, Jingjing. Chen7, Raquel. Rogers7, Richard. A. Lirio7, Jeffrey. D. Bornstein7, Bruce. E. Sands5

1University-Hospital Schleswig-Holstein, Kiel, Germany, 2Nancy University Hospital, Nancy, France, 3Mayo Clinic College of Medicine, Rochester, MN, USA, 4Humanitas University, Milan, Italy, 5Icahn School of Medicine at Mount Sinai, NY, USA, 6Formerly Takeda Development Centre Europe Ltd, London, UK, 7Takeda Development Center Americas, Inc., Cambridge, MA, USA

OP35: Endoscopic and deep remission at 1 year prevents disease progression in early Crohn’s disease: long-term data from CALM

ECCO '19 Copenhagen

Year: 2019
Authors:

C. Yzet1, R. Ungaro*2, P. Bossuyt3, F. Baert4, T. Vanasek5, G. D’Haens6, V. Joustra6, R. Panaccione7, G. Novacek8, A. Armuzzi9, O. Golovchenko10, O. Prymak10, A. Goldis11, S. Travis12, X. Hébuterne13, M. Ferrante14, G. Rogler15, M. Fumery1, S. Danese16, G. Rydzewska17, B. Pariente18, E. Hertervig19, C. Stanciu20, J-C. Grimaud21, M-M. Diculescu22, L. Peyrin-Biroulet23, D. Laharie24, J. P. Wright25, F. Gomollón26, I. Gubonina27, S. Schreiber28, S. Motoya29, P. Hellström30, J. Halfvarson31, J-F. Colombel2

1Amiens University Hospital, Amiens, France, 2Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, USA, 3IBD Clinic, Department of Gastroenterology, Imelda General Hospital, Bonheiden, Belgium, 4AZ Delta Roeselare, Roeselare, Belgium, 52nd Department of Internal Medicine, University Hospital Hradec Králové, Hradec Králové, Czech Republic, 6Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands, 7Cumming School of Medicine, University of Calgary, Calgary, Canada, 8Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria, 9Presidio Columbus Fondazione Policlinico A. Gemelli IRCCS – Università Cattolica del Sacro Cuore, Rome, Italy, 10Medical Clinical Investigational Center of Medical Center Health Clinic LLC, Vinnytsia, Ukraine, 11Universitatea de Medicina si Farmacie, Timisoara, Romania, 12Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK, 13Gastro-Entérologie and Nutrition Clinique, Hopital de l’Archet 2, Nice, France, 14University Hospitals Leuven, Leuven, Belgium, 15Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland, 16Humanitas University, Istituto Clinico Humanitas, Milan, Italy, 17Central Clinical Hospital of the Ministry of Interior in Warsaw, Warsaw, Poland, 18Claude Huriez Hospital, Lille University, Lille, France, 19Skane University Hospital, Lund, Sweden, 20Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania, 21Hepato-Gastroenterology Department, North Hospital, University of Mediterranean, Marseille, France, 22University of Medicine and Pharmacy ‘Carol Davila’, Bucharest, Romania, 23Hépato Gastro-Entérologie, Hôpital de Brabois, Nancy, France, 24Hépato-gastroentérologie et d’Oncologie Digestive, Hôpital Haut-Lévêque, Pessac, France, 25Kingsbury Hospital, Cape Town, South Africa, 26Hospital Clínico de Zaragoza, IIS Aragón, Zaragoza, Spain, 27Military Medical Academy Named After S.M.Kirov, Saint-Petersburg, Russian Federation, 28Department of Internal Medicine I, Kiel University, Kiel, Germany, 29IBD Center, Sapporo Kosei General Hospital, Sapporo, Japan, 30Uppsala University Hospital, Uppsala, Sweden, 31Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

OP36: A colonic gene expression signature predicts non-response to anti-inflammatory therapies in inflammatory bowel disease

ECCO '19 Copenhagen

Year: 2019
Authors:

T. Sato*1, K. Li1, K. Hayden1, L. Tomsho1, F. Baribaud1, C. Brodmerkel1, L. E. Greenbaum1, J. R. Friedman1, M. Curran1, Y. Imai2, S. Plevy1, S. E. Telesco1

1Janssen Research and Development, LLC, Spring House, USA, 2Janssen Pharmaceutical K.K., Tokyo, Japan

OP37: Efficacy and safety of ustekinumab as maintenance therapy in ulcerative colitis: Week 44 results from UNIFI

ECCO '19 Copenhagen

Year: 2019
Authors:

W. J. Sandborn*1, B. E. Sands2, R. Panaccione3, C. D. O’Brien4, H. Zhang4, J. Johanns4, L. Peyrin-Biroulet5, G. Van Assche6, S. Danese7, S. R. Targan8, M. T. Abreu9, T. Hisamatsu10, P. Szapary4, C. Marano4

1University of California San Diego, La Jolla, USA, 2Icahn School of Medicine at Mount Sinai, New York, USA, 3University of Calgary, Calgary, Canada, 4Janssen Research and Development, LLC, Spring House, USA, 5Nancy University Hospital, Université de Lorraine, Nancy, France, 6University of Leuven, Leuven, Belgium, 7Humanitas Research Hospital, Milan, Italy, 8Cedars-Sinai Medical Center, Los Angeles, USA, 9University of Miami Miller School of Medicine, Miami, USA, 10Kyorin University, Tokyo, Japan

OP38: Maintenance treatment with mirikizumab, a p19-directed IL-23 antibody: 52-week results in patients with moderately-to-severely active ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Geert. R. D’Haens*1, W. J. Sandborn2, M. Ferrante3, B. R. Bhandari4, E. Berliba5, T. Hibi6, J. Tuttle7, J. B. Canavan8, S. Friedrich8, M. Durante8, V. Arora8, B. Feagan9

1Amsterdam University Medical Centers, Amsterdam, The Netherlands, 2University California San Diego, La Jolla, California, USA, 3UZ Leuven, KU Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, 4Delta Research Partners, LLC, Bastrop, LA, USA, 5Nicolae Testemițanu State University of Medicine and Pharmacy, Chisinau, Moldova, Republic of, 6Kitasato Institute Hospital Center for Advanced IBD Research and Treatment, Minato-ku, Tokyo, Japan, 7Eli Lilly and Company, Lilly Biotechnology Center, San Diego, California, USA, 8Eli Lilly and Company, Indianapolis, Indiana, USA, 9Western University, Robarts Clinical Trials Inc., London, Ontario, Canada

P001: Multi-omic data integration assisted identification of molecular features contributing to disease heterogeneity in Crohn's disease

ECCO '19 Copenhagen

Year: 2019
Authors:

P. Sudhakar*1,2,3, B. Verstockt1,4, B. Creyns5, J. Cremer5, G. van Assche1,4, T. Korcsmaros2,3, M. Ferrante1,4, S. Vermeire1,4

1KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, 2Earlham Institute, Norwich, UK, 3Quadram Institute, Norwich, UK, 4University Hospitals Leuven, Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium, 5KU Leuven Department of Microbiology and Immunology, Laboratory of Clinical Immunology, Leuven, Belgium

P002: Endoscopic placement of a drug-eluting platform with monoclonal antibodies in an animal model of experimental colitis by TNBS: effect on disease outcome and anti-drug antibodies (ADA’s) formation

ECCO '19 Copenhagen

Year: 2019
Authors:

I. Bon-Romero1,2, R. Bartolí1,2,3, N. De la Ossa4, V. Moreno de Vega2, I. Marín2, E. Domènech1,2,3, V. Lorenzo-Zúñiga1,2,3

1Health Research Institute Germans Trias i Pujol, Digestive System, Badalona, Spain, 2Germans Trias i Pujol Hospital, Endoscopy Unit, Badalona, Spain, 3CIBERehd, Madrid, Spain, 4Germans Trias i Pujol Hospital, Pathology Service, Badalona, Spain

P003: C86/CD16 macrophages may act as a source of WNT2b in intestinal tissue from B3 Crohn’s disease patients

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Ortiz-Masia1,2, J. Cosin-Roger2,3, M. Rodriguez-Antequera1, D. Macias-Ceja3, S. Coll4, P. Salvador4, L. Gisbert-Ferrándiz4, R. Alós5, J. Manyé6, F. Navarro-Vicente7, S. Calatayud2,4, M. D. Barrachina2,4

1Universidad de Valencia, Medicine, Valencia, Spain, 2CIBERehd, Valencia, Spain, 3Fisabio, Valencia, Spain, 4Universidad de Valencia, Pharmacology, Valencia, Spain, 5Hospital de Sagunto, Sagunto, Spain, 6CIBERehd, Badalona, Spain, 7Hospital de Manises, Manises, Spain

P004: IL-22 affects barrier function and cell polarity by MAPK/PI3 kinase signal transduction

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Delbue da Silva*1, L. Lebenheim1, C. Heldt1, B. Siegmund1, M. Schumann1

1Charité Universitätsmedizin, Department of Gastroenterology, Berlin, Germany

P005: Persistent transcriptional reprogramming in the choroid plexus during chronic colitis: towards understanding persistent fatigue in patients with quiescent inflammatory bowel disease?

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Bruggeman1,2, C. Vandendriessche1,2, M. De Vos3,4, R. Vandenbroucke1,2, D. Laukens*3,4

1Vlaams Instituut voor Biotechnologie, Center for Inflammation Research, Zwijnaarde, Belgium, 2Department of Biomedical Molecular Biology, Ghent University, Gent, Belgium, 3Department of Gastroenterology, Ghent University Hospital, Gent, Belgium, 4Ghent Gut Inflammation Group (GGIG), Ghent University, Gent, Belgium

P006: Loss of protein tyrosine phosphatase non-receptor type 23 (PTPN23) in intestinal epithelial cells induces inflammation and epithelial hyperproliferation

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Montalban-Arques1, C. Gottier1, I. Olivares-Rivas1, M. Scharl1,2, M. Spalinger1

1University Hospital Zurich/ University of Zurich, Gastroenterology and Hepatology, Zurich, Switzerland, 2Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland

P007: Faecal protease activity as a predictor marker of disease recurrence in patients with Crohn's disease following ileocecectomy

ECCO '19 Copenhagen

Year: 2019
Authors:

R. Golovey*1,2, S. Hoffman1,2, E. Scapa2,3, N. Fliss4,3, H. Tulchinski2,6, I. Dotan2,7, N. Maharshak1,3,8,9

1Tel Aviv medical Center, The Research Center for Digestive Tract and Liver Diseases, Tel Aviv, Israel, 2Tel-Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel, 3Tel Aviv medical Center, Department of Gastroenterology and Liver Diseases, Tel Aviv, Israel, 4Tel Aviv medical Center, IBD center, Tel Aviv, Israel, 6Tel Aviv medical Center, Division of Surgery Colorectal Unit, Tel Aviv, Israel, 7Rabin Medical Center, Division of Gastroenterology, Petah Tikva, Israel, 8Tel Aviv Medical Center, IBD Center, Tel Aviv, Israel, 9Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel

P008: Proteomic markers of response to anti-TNF drugs in patients with Crohn's disease

ECCO '19 Copenhagen

Year: 2019
Authors:

R. Medina-Medina1, E. Iglesias-Flores1, J. M. Benítez1, S. Marín-Pedrosa1, I. Salgueiro1, G. Ferrín1, C. I. Linares1, S. González-Rubio1, P. Soto1, B. Gros1, C. Moral1, F. Alvarez1, M. Rodríguez-Perálvarez1, E. Chicano-Gálvez1, I. Ortea1, V. García-Sánchez1, P. Aguilar-Melero1

1IMIBIC/Hospital Universitario Reina Sofia/Córdoba University, CÓRDOBA, Spain

P009: Fluorescence mediated tomography detects and quantifies early intestinal neutrophil infiltration in experimental colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

T. M. Nowacki*1,2, P. Lenz3, D. Bettenworth2, M. Brückner2, P. Tepasse2, A. Becker4, M. Wildgruber4, M. Eisenblätter4

1Josephs-Hospital Warendorf, Department of Medicine I, Warendorf, Germany, 2University Hospital Münster, Department of Medicine B, Gastroenterology and Hepatology, Münster, Germany, 3University Hospital Münster, Institute of Palliative Care, Münster, Germany, 4University Hospital Münster, Translational Research Imaging Center, Department of Clinical Radiology, Münster, Germany

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