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P077: The efficacy of tyrosine kinase inhibitor dasatinib on colonic mucosal damage in murine model of colitisECCO '16 Amsterdam

Year: 2016

Authors:

G. Can*¹, S. Ayvaz², H. Can³, I. Karaboğa⁴, S. Demirtaş⁴, H. Akşit⁵, B. Yilmaz⁶, U. Korkmaz⁷, M. Kurt⁷, T. Karaca⁴

¹Abant Izzet Baysal University, Faculty of Medicine, Department of Gastroenterology, Bolu, Turkey, ²Trakya University, Faculty of Medicine, Department of Paediatric Surgery, Edirne, Turkey, ³Abant Izzet Baysal University, Faculty of Medicine, Department of Internal Medicine, Bolu, Turkey, ⁴Trakya University, Faculty of Medicine, Department of Histology and Embryology, Edirne, Turkey, ⁵Balikesir University, Faculty of Veterinary, Balikesir, Turkey, ⁶Selcuk University, Faculty of Medicine, Department of Gastroenterology, Konya, Turkey, ⁷Abant Izzet Baysal University, Medical Faculty, Department of Gastroenterology, Bolu, Turkey

P078: Walnut extract ameliorates acute and chronic colitis in murine models of colitisECCO '16 Amsterdam

Year: 2016

Authors:

S.-J. Koh*, K. L. Lee, J.W. Kim, B. G. Kim, Y. J. Jung

Seoul National University Boramae Hospital, Seoul National University College of Medicine, Internal Medicine, Seoul, South Korea

P079: Trehalose ameliorates colitis by increasing mucosal autophagy and M2 polarisationECCO '16 Amsterdam

Year: 2016

Authors:

J. Cosin-Roger*¹, D. Ortiz-Masia¹, D. C. Macias-Ceja², P. Salvador¹, L. Gisbert-Ferrandiz¹, C. Hernandez², S. Calatayud¹, M. D. Barrachina¹

¹University of Valencia, Valencia, Spain, ²Fisabio Hospital Peset, Valencia, Spain

P080: Modulation of T-cell glycosylation and the control of intestinal inflammationECCO '16 Amsterdam

Year: 2016

Authors:

A. M. Dias*^{1, 2}, A. Correia³, M. Pereira¹, C. R. Almeida⁴, M. Lima^{5, 6}, R. Marcos-Pinto^{2, 7, 8}, M. Vilanova^{2, 3}, C. A. Reis^{1, 2, 9}, P. Lago⁸,  S. S. Pinho^{1, 2}

¹Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) & i3S – Instituto de Investigação e Inovação em Saúde, Glycobiology in Cancer, Porto, Portugal, ²Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Porto, Portugal, ³Instituto de Investigação e Inovação em Saude (I3S)/Institute for Molecular and Cell Biology (IBMC), Immunobiology Group, Porto, Portugal, ⁴Instituto de Investigação e Inovação em Saude (I3S)/ Institute of Biomedical Engineering (INEB), NEWTherapies Group, University of Porto, Porto, Portugal, ⁵Centro Hospitalar do Porto , Multidisciplinary Unit for Biomedical Research (UMIB), Porto, Portugal, ⁶Centro Hospitalar do Porto, Haematology Department, Porto, Portugal, ⁷Medical Faculty, Centre for Research in HealthTechnologies and Information Systems (CINTESIS), Porto, Portugal, ⁸Centro Hospitalar do Porto, Department of Gastroenterology, Porto, Portugal, ⁹University of Porto, Medical Faculty, Porto, Portugal

P081: Evaluation of intestinal permeability with a triple sugar test in inflammatory bowel diseaseECCO '16 Amsterdam

Year: 2016

Authors:

D. Mukhametova¹, D. Abdulganieva*¹, S. Koshkin², S. Abdulhakov¹, A. Odintsova³

¹Kazan State Medical University, Kazan, Russian Federation, ²Kazan (Volga region) Federal University, Kazan, Russian Federation, ³Republican Clinical Hospital, Kazan, Russian Federation

P082: Anti-TNF-alpha therapy and apoptosisECCO '16 Amsterdam

Year: 2016

Authors:

R. Zaharie¹, F. Zaharie², A. Tantau*³, B. Petrushev⁴, M. Tantau⁴

¹University of Medicine and Pharmacy, Third Medical Clinic, Cluj-Napoca, Romania, ²University of Medicine and Pharmacy, Third Surgery Clinic, Cluj-Napoca, Romania, ³University of Medicine and Pharmacy, Fourth Medical Clinic, Cluj-Napoca, Romania, ⁴University of Medicine and Pharmacy, Third Medical Clinic, Cluj-Napoca, Romania

P083: Intestinal fatty acid binding protein as a biomarker of intestinal damage in children with coeliac and Crohn’s diseaseECCO '16 Amsterdam

Year: 2016

Authors:

C. M. Clark*¹, A. Kountouri¹, M. MacKinder¹, R. Hansen², R. K. Russell², K. Gerasimidis¹

¹University of Glasgow, Human Nutrition, School of Medicine, Glasgow, United Kingdom, ²Royal Hospital for Children, Department of Paediatric Gastroenterology, Glasgow, United Kingdom

P084: Intestinal organoids derived from patients with inflammatory bowel disease show unaltered transcriptional profiles when compared with healthy controlsECCO '16 Amsterdam

Year: 2016

Authors:

M. Noben*^{1, 2}, N. Hendriks^{1, 2}, G. Van Assche¹, S. Vermeire¹, C. Verfaillie², M. Ferrante¹

¹KU Leuven, Translational Research Centre for Gastrointestinal Disorders (Targid), Leuven, Belgium, ²KU Leuven, Stem Cell Institute Leuven, Leuven, Belgium

P085: Altered proportions of myeloid and plasmacytoid dendritic cells in children with inflammatory bowel diseaseECCO '16 Amsterdam

Year: 2016

Authors:

M. F. Elshal^{1, 2, 3, 4}, A. M. Aldahlawi^{2, 3, 5}, O. I. Saadah*^{6, 7}, J. P. McCoy⁸

¹Facuty of Sciences, King Abdulaziz Uinversity, Biochemistry Department, Jeddah, Saudi Arabia, ²Inflammatory Bowel Disease Research Group, King Abdulaziz University, Jeddah, Saudi Arabia, ³Immunology Unit, King Fahd Medical Research Centre, Jeddah, Saudi Arabia, ⁴Sadat City University, Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, Cairo, Egypt, ⁵Faculty of Sciences, KIng Abdulaziz University, Biological Sciences Department, Jeddah, Saudi Arabia, ⁶Faculty of Medicine, King Abdulaziz University, Paediatric Department, Jeddah, Saudi Arabia, ⁷Inflammatory Bowel Disease Research Group, King Abdulaziz Uinversity, Jeddah, Saudi Arabia, ⁸National Heart, Lung, and Blood Institute, National Institutes of Health, Flow Cytometry Core, Bethesda, MD, United States

P086: Glycosylation of T-cells as a new molecular biomarker in inflammatory bowel disease: an opportunity for new therapeutic strategiesECCO '16 Amsterdam

Year: 2016

Authors:

A. M. Dias¹, M. Pereira¹, R. Marcos-Pinto², A. Correia³, M. Vilanova³, C. Reis¹, P. Lago², S. S. Pinho*¹

¹IPATIMUP/i3S, University of Porto, Glycobiology in Cancer, Porto, Portugal, ²Porto Centre Hospital, Hospital Santo António, Gastrenterology department, Porto, Portugal, ³Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Immunology department, Porto, Portugal

P087: Contributions of monocytes to gut inflammation in acute and chronic colitis modelsECCO '16 Amsterdam

Year: 2016

Authors:

F. Becker*¹, F. N. Gavins², T. Vowinkel¹, I. Tsunoda³, E. Rijcken¹, D. V. Ostanin⁴, J. S. Alexander²

¹University Hospital Muenster, Department of General and Visceral Surgery, Muenster, Germany, ²Louisiana State University Health Sciences Centre-Shreveport, Department of Molecular & Cellular Physiology, Shreveport, Louisiana, United States, ³Louisiana State University Health Sciences Centre-Shreveport, Department of Microbiology and Immunology, Shreveport, Louisiana, United States, ⁴Louisiana State University Health Sciences Centre-Shreveport, Centre of Excellence for Arthritis and Rheumatology, Shreveport, Louisiana, United States

P088: Loss of intestinal Desmoglein 2 promotes chemically and pathogenic induced colitisECCO '16 Amsterdam

Year: 2016

Authors:

A. Gross*¹, L. Pack¹, S. Kant², C. Krusche², G. Sellge¹, C. Trautwein¹, R. Leube², P. Strnad¹

¹University Hospital Aachen, Medicine III, Aachen, Germany, ²University Hospital Aachen, Institute of Molecular and Cellular Anatomy, Aachen, Germany

P089: Stimulation of the ω-3 docosahexaenoic acid metabolism via MFSD2A as a novel therapy for inflammatory bowel disease.ECCO '16 Amsterdam

Year: 2016

Authors:

F. Ungaro*^{1, 2}, C. Correale¹, P. Corsetto³, L. Massimino⁴, P. Fonteyne¹, C. Tacconi¹, K. R. Maddipati⁵, A. Rizzo³, S. D’Alessio^{1, 2}, S. Danese¹

¹Humanitas Research Institute, Laboratory of Immunology in Gastroenterology, Milan, Italy, ²University of Milan, Department of Biotechnology and Translational Medicine, Milan, Italy, ³University of Milan, Department of Pharmacology and Biomolecular Science, Milan, Italy, ⁴San Raffaele Research Institute, Division of Neuroscience, Milan, Italy, ⁵Wayne State University, Department of Pathology, Detroit, Michigan, United States

P090: Differences in expression of G protein–coupled receptor 55 (GPR55) in patients with Crohn’s disease and ulcerative colitisECCO '16 Amsterdam

Year: 2016

Authors:

M. Wlodarczyk*¹, A. Sobolewska-Włodarczyk¹, A. Cygankiewicz², D. Jacenik², W. Krajewska³, K. Stec-Michalska¹, A. Piechota-Polanczyk⁴, J. Fichna⁴, M. Wisniewska-Jarosinska¹

¹Medical University of Lodz, Department of Gastroenterology, Lodz, Poland, ²University of Lodz, Department of Cytobiochemistry, Lodz, Poland, ³University of Lodz, Cytobiochemistry, Lodz, Poland, ⁴Medical University of Lodz, Department of Biochemistry, Lodz, Poland

P091: Sonic hedgehog inhibitor prevented colitis-associated cancer via stem inhibitionECCO '16 Amsterdam

Year: 2016

Authors:

K. B. Hahm*¹, Y. J. Kim²

¹CHA University, Gastroenterology, Seongnam, South Korea, ²Gachon University, Gastroenterology, Incheon, South Korea

P092: Characterisation of the lymphoid stress surveillance response performed by human colon resident γδ T-cellsECCO '16 Amsterdam

Year: 2016

Authors:

R. J. Dart*^{1, 2, 3}, R. Woolf², P. M. Irving³, A. C. Hayday^{1, 2}

¹Francis Crick Institute, Immunosurveillance Lab, London, United Kingdom, ²King’s College London, Immunobiology, DIIID, London, United Kingdom, ³Guy’s and St Thomas’ NHS Foundation Trust, IBD Centre, London, United Kingdom

P093: 15-d-PGJ2 – a possible regulator of iron homeostasisECCO '16 Amsterdam

Year: 2016

Authors:

J. Martin*^{1, 2}, S. Ulrich-Rueckert², J. Stein^{1, 3}

¹Interdisciplinary Crohn Colitis Centre Rhein-Main, Frankfurt/Main, Germany, ²Goethe University Frankfurt, Insitute of Pharmaceutical Chemistry, Frankfurt/Main, Germany, ³DGD Clinics Sachsenhausen, Frankfurt/Main, Germany

P094: Human neutrophil elastase shows increased elastinolytic activity in ulcerative colitis and contributes to loss of function of anti-TNF-alpha agents in ulcerative colitisECCO '16 Amsterdam

Year: 2016

Authors:

P. Giuffrida*¹, K. Kok², A. Di Sabatino¹, P. Biancheri², A. Vanoli³, G. Mazza⁴, R. Curciarello², A. Pasini¹, N. Aronico¹, M. Pinzani⁴, G. R. Corazza¹, T. T. MacDonald²

¹Fondazione IRCCS Policlinico San Matteo, University of Pavia, First Department of Medicine, Pavia, Italy, ²Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom, ³Fondazione IRCCS Policlinico San Matteo, University of Pavia, Department of Molecular Medicine, Pavia, Italy, ⁴Institute for Liver and Digestive Health, University College London, London, United Kingdom

P095: Immune compromised mice develop colitis upon denervation of the superior mesenteric nerve.ECCO '16 Amsterdam

Year: 2016

Authors:

R. Willemze*¹, L. Nijhuis¹, O. Welting¹, J. Folgering², H. Darwinkel², D. Chew³, A. Sridhar³, J. Witherington³, J. Seppen¹, S. Heinsbroek¹, W. de Jonge¹

¹Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, ²Brains On-line B.V., Groningen, Netherlands, ³Glaxo Smith Kline, Bioelectronics, Middlesex, United Kingdom

P096: Low-dose naltrexone reduces in-vitro endoplasmic reticulum stress and stimulates wound healing in intestinal epithelial cellsECCO '16 Amsterdam

Year: 2016

Authors:

G. Fuhler*, M. Lie, P. Dimitrijevic, C. J. van der Woude, M. Peppelenbosch

Erasmus MC University Medical Centre Rotterdam, Gastroenterology and Hepatology, Rotterdam, Netherlands