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P057: HLA B27 transgenic rat: a new animal model of postsurgical ileitis in inflammatory bowel diseaseECCO '16 Amsterdam

Year: 2016

Authors:

A. Chau*¹, C. Chater¹, S. Speca², M. Djouina², C. Dubuquoy², L. Dubuquoy², C. Neut³, D. Koriche¹, P. Zerbib¹, F.R. Pruvot¹, P. Desreumaux⁴, B. Pariente⁴

¹Lille University North of France, INSERM U995, Department of Digestive Surgery and Transplantation, CHRU Lille, Lille, France, ²Lille University North of France, INSERM U995, CHRU Lille, Lille, France, ³Lille University North of France, INSERM U995, Department of Microbiology, Faculty of Pharmacy, Lille, France, ⁴Hepato-Gastroenterology Department, Claude Huriez Hospital, University of Lille 2, Inserm Unit 995, University of Lille 2, Lille, France

P058: Bacterial activation of thioguanine results in lymphocyte independent improvement in murine colitisECCO '16 Amsterdam

Year: 2016

Authors:

I. Oancea^{1, 2}, I. Das¹, D. Aguirre de Cárcer³, R. Movva^{1, 4}, V. Schreiber¹, Y. Yang^{1, 5}, M. Proctor¹, R. Wang¹, Y. Sheng¹, M. Lobb¹, P. Ó Cuiv⁶, J. A. Duley^{1, 4}, J. Begun*^{2, 7}, T. H. J. Florin^{1, 2}

¹University of Queensland, Mater Research Institute, Brisbane, Australia, ²University of Queensland, School of Medicine, Brisbane, Australia, ³CSIRO, Preventative Health National Research Flagship and Division of Livestock Industries, Brisbane, Australia, ⁴Griffith University, School of Pharmacy, Gold Coast, Australia, ⁵University of Queensland, School of Pharmacy, Brisbane, Australia, ⁶University of Queensland, Diamantina Institute, Brisbane, Australia, ⁷University of Queensland, Mater Research Institute, South Brisbane, Australia

P059: Two new genetic mouse models for ulcerative colitis based on lateral tight junction disruption.ECCO '16 Amsterdam

Year: 2016

Authors:

W. Stremmel*¹, S. Staffer², M. Schneider³, H. Gan-Schreier², A. Wannhoff², A. Gauss⁴, H. Wolburg⁵, M. Bach⁶, A. Swidsinski⁷, T. Efferth³

¹University Hospital of Heidelberg, Internal Medicine IV, Dept. of Gastroenterology, Heidelberg, Germany, ²University Hospital of Heidelberg, Internal Medicine IV, Div. of Gastroenterology, Heidelberg, Germany, ³Johannes Gutenberg University, Institute of Pharmacy & Biochemistry, Mainz, Germany, ⁴University Hospital of Heidelberg, Gastroenterology, Heidelberg, Germany, ⁵University Medical School Tuebingen, Pathology and Neuropathology, Tuebingen, Germany, ⁶Kirchhoff Institute of Physics, Physics, Heidelberg, Germany, ⁷Charité - University Hospital Berlin, Berlin, Germany

P060: Alterations of brain structure in Crohn’s disease with extraintestinal manifestationsECCO '16 Amsterdam

Year: 2016

Authors:

A. Thomann*¹, W. Reindl², P. Thomann³, C. Wolf⁴, D. Hirjak³, M. Griebe⁵

¹Universitätsmedizin Mannheim, Department of Medicine II, Mannheim, Germany, ²Universitätsmedizin Mannheim, Department of Medicine II, Mannheim, Germany, ³Universitätsklinik Heidelberg, Department of Psychiatry, Heidelberg, Germany, ⁴Universität des Saarlandes, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Homburg/Saar, Germany, ⁵Universitätsmedizin Mannheim, Department of Neurology, Mannheim, Germany

P061: Creeping fat contains a unique T-cell compartment with potential impact on intestinal inflammationECCO '16 Amsterdam

Year: 2016

Authors:

L. I. Kredel*¹, L. J. Jödicke¹, A. A. Kuehl¹, I. Freise¹, J. Gröne², B. Siegmund¹

¹Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, ²Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, General, Vascular and Thoracic Surgery, Berlin, Germany

P062: Critical role of the IL-33/ST2 axis in colitis-associated colorectal cancerECCO '16 Amsterdam

Year: 2016

Authors:

L. R. Lopetuso*^{1, 2, 3}, C. De Salvo³, L. Di Martino³, W. Goodman³, F. Scaldaferri², A. Gasbarrini², T. T. Pizarro³

¹Catholic University of the Sacread Hearth, Internal Medicine, Gastroenterology Division, Rome, Italy, ²Catholic University of Sacred Heart, Internal Medicine Department, Gastroenterology Division, Rome, Italy, ³Case Western Reserve University, Pathology, Cleveland, United States

P063: Dissecting the role of rage in intestinal fibrosisECCO '16 Amsterdam

Year: 2016

Authors:

S. Speca*¹, M. Body-Malapel¹, C. Fradin¹, M. Djouina¹, E. Boulanger¹, A.-M. Schmidt², P. Desreumaux¹, C. Vignal¹

¹Centre Hospitalier Régional Universitaire de Lille, Lille, France, ²NYU Langone Medical Centre, Departments of Medicine (Endocrinology Div), Biochemistry and Molecular Pharmacology and Pathology (Pathology) , New York, United States

P064: TOP1210 narrow spectrum kinase inhibitor demonstrates superior activity and improved safety profile potential compared with corticosteroid and immunomodulators in preclinical models of colitisECCO '16 Amsterdam

Year: 2016

Authors:

C. A. Walshe*, A. Rowley, M. R. Foster, Y. Solanke, S. Sirohi,  M. C. Fyfe, S. Webber

Topivert Pharma Ltd, London, United Kingdom

P065: Molecular landscape of early Crohn’s disease using an integrated approach of mRNA/miRNA profiling and genomicsECCO '16 Amsterdam

Year: 2016

Authors:

S. Verstockt*¹, J. Van der Goten², M. Vancamelbeke², B. Verstockt², F. Schuit³, P. Rutgeerts², M. Ferrante², S. Vermeire², I. Arijs², I. Cleynen¹

¹KU Leuven, Department of Human Genetics, Leuven, Belgium, ²KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Centre for Gastrointestinal Disorders, Leuven, Belgium, ³KU Leuven, Department of Cellular and Molecular Medicine, Gene Expression Unit, Leuven, Belgium

P066: CCR2-monocytes are essential for the resolution of inflammation and tissue repair in colitis.ECCO '16 Amsterdam

Year: 2016

Authors:

M. Stakenborg, G. Goverse, G. Farro, P. J. Gomez-Pinilla,  G. E. Boeckxstaens, G. Matteoli*

KU Leuven, P.O. Box 701, Department of Clinical and Experimental Medicine, Leuven, Belgium

P067: Angiogenic characterisation of Crohn’s disease mesenteric adipose tissueECCO '16 Amsterdam

Year: 2016

Authors:

M. Eddama*¹, R. Cohen¹, M. Rodriguez-Justo², I. Evans³, L. Shen⁴, L. Clapp⁴, M. Loizidou⁵

¹University College London Hospital, Colorectal Surgery, London, United Kingdom, ²University College London Hospital, Department of Pathology, London, United Kingdom, ³University College London, Centre for Cardiovascular Biology and Medicine, London, United Kingdom, ⁴University College London, Institute of Cardiovascular Science, London, United Kingdom, ⁵University College London, Academic Department of Surgery, London, United Kingdom

P068: Anti-fibrotic therapy for Crohn’s disease: in-vitro proof of concept with a selective ROCK2 inhibitor, LYC-53976, in the treatment of human intestinal myofibroblasts in stiffness and transforming growth factor β modelsECCO '16 Amsterdam

Year: 2016

Authors:

E. Rodansky¹, X. Liu², L. A. Johnson¹, K. Demock², A. J. Celeste², L. L. Carter², P. D. R. Higgins*¹

¹University of Michigan, Internal Medicine - Gastroenterology, Ann Arbor, Michigan, United States, ²Lycera, Inc., Ann Arbor, Michigan, United States

P069: TD-1473, a novel, potent, and orally administered, GI-targeted, pan-Janus kinase (JAK) inhibitorECCO '16 Amsterdam

Year: 2016

Authors:

D. Beattie*, P. Tsuruda, F. Shen, P. Brassil, C. Langrish, J. Janc, Z. Ren, R. Hudson, J. Smith, S. Hegde

Theravance Biopharma, South San Francisco, United States

P070: The influence of vitamin D on M1 and M2 macrophages in patients with Crohn’s diseaseECCO '16 Amsterdam

Year: 2016

Authors:

E. Seidman*, S. Dionne

Research Institute of the McGill University Hospital, Gastroenterology, Montreal, Canada

P071: Improvement of experimental mouse models in inflammatory bowel diseases using flexible video endoscopic colon evaluationECCO '16 Amsterdam

Year: 2016

Authors:

C. Gay*¹, O. Martin Rodriguez², A. Daoui², S. Koch¹, P. Saas², S. Valmary Degano³, S. Perruche², L. Vuitton¹

¹CHU Jean Minjoz, Gastro-entérologie, besançon, France, ²UMR 1098 INSERM, Besançon, France, ³CHU Jean Minjoz, Anatomopathologie, besançon, France

P072: TREM-1 stimulation ameliorates colitis in miceECCO '16 Amsterdam

Year: 2016

Authors:

H. W. Ma*^{1, 2}, X. Che^{1, 2}, D. H. Seo^{1, 2}, J. H. Kim^{1, 2}, D. H. Kim¹,  T. I. Kim¹, W. H. Kim¹, S. W. Kim^{1, 2, 3}, J. H. Cheon^{1, 2, 3}

¹Yonsei University College of Medicine, Department of Internal Medicine and Institute of Gastroenterology, Seoul, South Korea, ²Yonsei University College of Medicine, Brain Korea 21 PLUS Project for Medical Science, Seoul, South Korea, ³Yonsei University College of Medicine, Severance Biomedical Science Institute, Seoul, South Korea

P073: TNF-alpha activity in plasma from patients with inflammatory bowel disease under adalimumab and infliximab treatment evaluated in a cell-based assayECCO '16 Amsterdam

Year: 2016

Authors:

P. M. Linares*¹, H. De la Fuente², M. Chaparro¹, I. Guerra³, P. L. Majano⁴, M. Iborra⁵, J. L. Cabriada⁶, L. Bujanda⁷, M. Barreiro-de Acosta⁸, V. García-Sánchez⁹, I. Marín-Jiménez¹⁰, D. Bernardo¹,  J. P. Gisbert¹

¹Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Gastroenterology Unit, Madrid, Spain, ²Hospital Universitario de La Princesa, IIS-IP, Immunology Unit, Madrid, Spain, ³Hospital Universitario de Fuenlabrada, Gastroenterology Unit, Madrid, Spain, ⁴Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Molecular Biology Unit, Madrid, Spain, ⁵Hospital Universitario La Fe and CIBERehd, Gastroenterology Unit, Valencia, Spain, ⁶Hospital Galdakao, Gastroenterology Unit, Vizcaya, Spain, ⁷Hospital de Donostia, Instituto Biodonostia, UPV/EHU and CIBEREHD, Gastroenterology Unit, Guipuzcoa, Spain, ⁸Hospital Clínico Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain, ⁹Hospital Universitario Reina Sofía, Gastroenterology Unit, Córdoba, Spain, ¹⁰Hospital Gregorio Marañón and IiSGM, Gastroenterology Unit, Madrid, Spain

P074: Association of colonic mucosal infiltration of IgG4 plasma cells with ulcerative colitis activity and presence of primary sclerosing cholangitisECCO '16 Amsterdam

Year: 2016

Authors:

F. Alborzi*¹, Z. Azizi², N. Ebrahimi Daryani³, F. Azmude Ardalan³, N. Aletaha³, R. Taslimi³, N. Roshan³

¹Tehran University of Medical Science, Gastrenterology, Tehran, Iran, Islamic Republic of, ²Iran University of Medical Science, Tehran, Iran, Islamic Republic of, ³Tehran University of Medical Science, Tehran, Iran, Islamic Republic of

P075: Innate immunity in inflammatory bowel disease and colon cancerECCO '16 Amsterdam

Year: 2016

Authors:

E. Lo Presti*¹, R. Di Mitri², F. Dieli¹, F. Mocciaro², G. Pecoraro², G. Russo², S. Meraviglia¹

¹University of Palermo, Central Laboratory of Advanced Diagnosis & Biomedical Research (CLADIBIOR), Department of Biopathology, Palermo, Italy, ²ARNAS Civico-Di Cristina-Benfratelli Hospital, Department of Gastroenterology and Endoscopy, Palermo, Italy

P076: The role for T-cells in the pathogenesis of Crohn’s disease–associated fistulaeECCO '16 Amsterdam

Year: 2016

Authors:

R. Bruckner*, M. Spalinger, G. Rogler, M. Scharl

University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland