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P106: Binding properties of human TLR-9 receptor to cobitolimod – a candidate for treatment of active ulcerative colitis in late stage of clinical developmentECCO '17 Barcelona
Year: 2017
Authors:

Zargari A., Admyre C., Knittel T.

Index Pharmaceuticals, Stockholm, Sweden

P107: Lactobacillus plantarum 06CC2 induces intestinal IL-10–producing dendritic cells to ameliorate acute experimental colitis in miceECCO '17 Barcelona
Year: 2017
Authors:

Tanaka A.*1,2, Kanmura S.1, Arima S.1, Sasaki F.1, Nasu Y.1, Tanoue S.1, Hashimoto S.1, Setoyama H.1, Ido A.1

1Kagoshima University Graduate School of Medical and Dental Sciences, Digestive and Lifestyle Diseases, Kagoshima, Japan 2Kagoshima Kosiren hospital, Kagoshima, Japan

P108: Oleuropein decreases interleukin-17 and attenuates inflammatory damage in colonic mucosa from ulcerative colitis patientsECCO '17 Barcelona
Year: 2017
Authors:

Larussa T.*1, Oliverio M.1, Suraci E.1, Greco M.1, Placida R.1, Gervasi S.1, Marasco R.1, Imeneo M.1, Paolino D.1, Tucci L.2, Gulletta E.1, Fresta M.1, Procopio A.1, Luzza F.1

1University of Catanzaro Magna Graecia, Health of Sciences, Catanzaro, Italy 2Azienda Ospedaliera Pugliese - Ciaccio, Catanzaro, Italy

P109: Profiling of receptor for advanced glycation end products expression in cases of primary sclerosing cholangitis with ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Udupa V.1, Baird A.2, Winter D.*3

1St Vincent's University Hospital, Dept of Surgery, Dublin, Ireland 2University College Dublin, Veterinary Science centre, School Of Veterinary Medicine, Dublin, Ireland 3St Vincent's University Hospital, Dept of Colorectal Surgery, Dublin, Ireland

P110: Characterization of human intestinal macrophage subsets in health and inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Bernardo D.*1, Mora-Gutierrez I.1, Marin A.c.1, Díaz-Guerra A.1, Caminero-Fernández R.2, Caldas M.2, De la Morena F.2, Jiménez M.2, Chaparro M.1, Gisbert J.P.1

1Hospital Universitario de La Princesa, CIBERehd, Madrid, Spain 2Hospital Universitario de La Princesa, Department of Gastroenterology, Madrid, Spain

P111: The anti-inflammatory effect of a serine protease inhibitor in a chronic colitis transfer model is mediated by the suppression of Th1 cell differentiationECCO '17 Barcelona
Year: 2017
Authors:

Van Spaendonk H.*1, Francque S.1,2, De Man J.1, De Winter B.1

1University of Antwerp, Laboratory of Experimental Medicine and Pediatrics, Antwerp, Belgium 2Antwerp University Hospital, Gastroenterology and Hepatology, Antwerp, Belgium

P112: Short-chain fatty acids administration is protective in colitis-associated colorectal cancer developmentECCO '17 Barcelona
Year: 2017
Authors:

Tian Y.*1, Wang K.1, Ji G.2

1The Second Affiliated Hospital of Nanjing Medical University, Department of Oncology, Nanjing, China 2The Second Affiliated Hospital of Nanjing Medical University, Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Nanjing, China

P113: Model based predictions of the PTG-100 pharmacodynamic responses in ulcerative colitis patientsECCO '17 Barcelona
Year: 2017
Authors:

Mattheakis L.*1, Fosser C.2, Saralaya R.2, Horsch K.2, Rao N.1, Bai L.1, Zhao L.1, Annamalai T.1, Liu D.1

1Protagonist Therapeutics, Milpitas, United States 2Cytel Inc., Cambridge, United States

P114: Fecal loss of infliximab is underestimated due to proteolysisECCO '17 Barcelona
Year: 2017
Authors:

Strik A.*1, Brandse J.1, Koelink P.2, Wildenberg M.2, De Vries A.3, Boshuizen R.3, van den Brink G.1, D'Haens G.1

1Academic Medical Center, Gastroenterology and Hepatology, Amsterdam, Netherlands 2Academic Medical Center (AMC), Tytgat Institute for Intestinal and Liver Research, Amsterdam, Netherlands 3Sanquin Blood Supply - Diagnostic Services, Biologicals Laboratory, Amsterdam, Netherlands

P115: Escherichia coli Nissle 1917 modulate gut microbiota composition in ulcerative colitis patientsECCO '17 Barcelona
Year: 2017
Authors:

Graziani C.1, Petito V.1, Del Chierico F.2, Mangiola F.1, Pecere S.1, Schiavoni E.1, Pizzoferrato M.1, Lopetuso L.R.1, Putignani L.2, Gasbarrini A.1, Scaldaferri F.*1

1Fondazione Policlinico Gemelli, Università Cattolica del Sacro Cuore, Gastroenterological Area, Gastroenterological and Endocrino-Metabolical Sciences Department, Rome, Italy 2Bambino Gesù Children Hospital, Department of Microbiology, Rome, Italy

P116: Escherichia coli Nissle 1917 distinctively regulates apoptosis and cell cycling of Caco-2 cellsECCO '17 Barcelona
Year: 2017
Authors:

Schirbel A.*1, Sturm A.2

1Charité Campus Virchow Klinikum, Berlin, Germany 2DRK Klinikum Westend, Gastroenterology, Berlin, Germany

P117: Functional implications of microRNAs in Crohn's disease revealed by integrating microRNA and messenger RNA expression profilingECCO '17 Barcelona
Year: 2017
Authors:

Palmieri O.*1, Creanza T.2, Bossa F.1, Latiano T.1, Corritore G.1, Palumbo O.3, Martino G.1, Biscaglia G.1, Scimeca D.1, Carella M.3, Ancona N.2, Andriulli A.1, Latiano A.1

1IRCCS, Casa Sollievo della Sofferenza, Hospital, UOC Gastroenterology, San Giovanni Rotondo, Italy 2CNR, Institute of Intelligent Systems for Automation, Bari, Italy 3IRCCS, Casa Sollievo della Sofferenza, Hospital, Medical Genetics, San Giovanni Rotondo, Italy

P118: Balancing JAK/STAT-signaling with Tofacitinib in monocytes of healthy controls and IBD patientsECCO '17 Barcelona
Year: 2017
Authors:

Cordes A.F.*1, Lenker E.2, Weinhage T.2, Varga G.2, Foell D.2

1University Hospital Münster, Department of Gastroenterology, Münster, Germany 2University Children's Hospital Münster, Department of Pediatric Rheumatology and Immunology, Münster, Germany

P119: Higher levels of infliximab may alleviate the need of azathioprine comedication in the treatment of patients with Crohn's disease: a SONIC post hoc analysisECCO '17 Barcelona
Year: 2017
Authors:

Colombel J.-F.*1, Adedokun O.J.2, Gasink C.2, Tang K.2, Cornillie F.3, D'Haens G.4, Rutgeerts P.5, Reinisch W.6, Sandborn W.7, Hanauer S.8

1Icahn School of Medicine at Mt Sinai, New York, United States 2Janssen Research & Development, LLC, Spring House, United States 3MSD International GmbH, Kriens, Switzerland 4Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands 5University Hospital, Gasthuisberg, Leuven, Belgium 6Universitätsklinik für Innere Medizin III and McMaster University, Vienna and Hamilton, Austria 7University of California San Diego, La Jolla, United States 8Northwestern University Feinberg School of Medicine, Chicago, United States

P120: A single-nucleotide polymorphism in the vitamin D receptor gene is associated with a B3-penetrating phenotype in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Gisbert-Ferrándiz L.*1, Salvador P.1, Ortiz-Masiá D.1, Macias-Ceja D.C.2, Calatayud S.1,3, Hinojosa J.4, Oltra-Camps L.4, Barrachina M.D.1,3, Hernández C.2

1University of Valencia, Valencia, Spain 2Fisabio Hospital Dr Peset, Valencia, Spain 3CIBERehd, Valencia, Spain 4Hospital of Manises, Valencia, Spain

P121: Antimicrobial antibodies and inflammatory markers are present in the serum of patients with IBD years before diagnosis and can predict diseaseECCO '17 Barcelona
Year: 2017
Authors:

Torres J.*1, Wang P.2, Princen F.3, Stockfisch T.3, Petralia F.2, Choung R.S.4, Telesco S.5, Strauss R.5, Porter C.6, Murray J.4, Riddle M.6, Colombel J.-F.1

1Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, United States 2Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York, United States 3Prometheus Lab Inc., San Diego, United States 4Mayo Clinic, Gastroenterology, Rochester, United States 5Janssen R&D, Spring House, United States 6Naval Medical Research Center, Silver Spring, United States

P122: Magnetic resonance index of activity (MaRIA) and Clermont score are two MRI indices which are highly and equally effective in detecting mucosal healing in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Buisson A.*1,2, Pereira B.3, Goutte M.1,2, Reymond M.1, Allimant C.1, Bommelaer G.1,2, Hordonneau C.4

1University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France 2UMR 1071 Inserm/Université d'Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the host, Clermont-Ferrand, France 3University Hospital, Biostatistics Unit, DRCI, Clermont-Ferrand, France 4University Hospital Estaing, Radiology Department, Clermont-Ferrand, France

P123: MRI remission after therapeutic intervention is associated with more time spent in clinical corticosteroids-free remission and decreased risk of surgery in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Buisson A.*1,2, Hordonneau C.3, Goutorbe F.1,4, Allimant C.1, Goutte M.1,2, Reymond M.1, Pereira B.5, Bommelaer G.1,2

1University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France 2UMR 1071 Inserm/Université d'Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the host, Clermont-Ferrand, France 3University Hospital Estaing, Radiology Department, Clermont-Ferrand, France 4Hospital of Bayonne, Gastroenterology Department, Bayonne, France 5University Hospital, Biostatistics Unit, DRCI, Clermont-Ferrand, France

P124: Disagreement among gastroenterologists in the endoscopic evaluation using the Mayo endoscopic score and the Rutgeerts postoperative scoreECCO '17 Barcelona
Year: 2017
Authors:

Raimundo Fernandes S.*1, Pinto J.2, Marques da Costa P.1, Correia L.1 Grupo de Estudos de Doença Inflamatόria Intestinal

1Hospital de Santa Maria, Serviço de Gastrenterologia e Hepatologia, Lisboa, Portugal 2Hospital Amato Lusitano, Serviço de Gastrenterologia, Castelo Branco, Portugal

P125: Rapid increase in pan-treatment refractory Crohn's disease after transition to adult services: a regional cohort studyECCO '17 Barcelona
Year: 2017
Authors:

Merrick V.*1, Henderson P.1, Rogers P.2, Arnott I.3, Satsangi J.4, Wilson D.1

1University of Edinburgh, Child Life and Health, Edinburgh, United Kingdom 2Royal Hospital for Sick Children, Paediatric Gastroenterology, Edinburgh, United Kingdom 3Western General Hospital, Gastrointestinal Unit, Edinburgh, United Kingdom 4University of Edinburgh, Gastrointestinal Unit, Centre for Genomic and Experimental Medicine, Edinburgh, United Kingdom