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P086: MMP-12, a novel mediator of nociception in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Tranter M., Barakat F., Dogra H., Lindsay J., Croft N., Bulmer D.

Queen Mary University of London, London, United Kingdom

P087: Increased wnt ligands expression in M2c macrophages is associated with fibrosis in Stat6 knockout miceECCO '17 Barcelona
Year: 2017
Authors:

Ortiz-Masia D.*1,2, Salvador P.3, Macias-Ceja D.C.4, Gisbert-Ferrándiz L.3, Hernandez C.4, Calatayud S.3, Esplugues J.V.3,4, Barrachina D.3

1Universidad de Valencia-CIBERehd, Pharmacology, Valencia, Spain 2Universidad de Valencia, Medicine, Valencia, Spain 3Universidad de Valencia, Pharmacology, Valencia, Spain 4FISABIO Hospital Peset, Pharmacology, Valencia, Spain

P088: Evaluation of Free Vitamin D levels in IBD pediatric patients: the role of inflammationECCO '17 Barcelona
Year: 2017
Authors:

Strisciuglio C.*1, Cenni S.2, Giugliano F.P.2, Miele E.2, Cirillo G.1, Martinelli M.2, Vitale A.1, Staiano A.2, Miraglia del Giudice E.1, Perrone L.1

1Second University of Naples, Department of Woman, Child and General and Specialistic Surgery, Naples, Italy 2University Federico II of Naples, Department of Translational Medical Science, Section of Pediatrics, Naples, Italy

P089: Extracellular matrix fragments as markers of cytokine driven intestinal damage or protection; test in a novel intestinal ex vivo modelECCO '17 Barcelona
Year: 2017
Authors:

Olesen M.L.*1,2, Krag A.2, Karsdal M.1, Kjeldsen J.2, Bay-Jensen A.-C.1, Mortensen J.H.1

1Nordic Bioscience A/S, Biomarkers and Research, Herlev, Denmark 2University of Southern Denmark and Odense University Hospital, Department of Medical Gastroenterology, Odense, Denmark

P090: Metformin induces late Apoptosis and modulates dysbiosis in western-style diet induced colitic cancerECCO '17 Barcelona
Year: 2017
Authors:

Chung E.J.*1, Do E.J.2, Myung S.-J.1,2

1Asan Medical Center, Seoul, South Korea 2Asan Institute for Life Science, Seoul, South Korea

P091: Usefulness of transcriptional whole blood biomarkers as a non-invasive surrogate marker of mucosal healing and endoscopic response in ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Planell N.*1,2, Masamunt M.C.1, Franco Leal R.3, Rodríguez L.4, Esteller M.1, Lozano J.J.2, Ramírez A.1, Setsuko Ayrizono M.d.L.3, Saddy Rodrigues Coy C.3, Alfaro I.1, Ordás I.1, Visvanathan S.5, Ricart E.1, Guardiola J.4, Panés J.1, Salas A.1

1IDIBAPS, Hospital Clínic, CIBER-EHD, Gastroenterology, Barcelona, Spain 2CIBER-EHD, Bioinformatics Platform, Barcelona, Spain 3IBD Research Laboratory, University of Campinas, Surgery, Sao Paulo, Brazil 4Hospital Universitari de Bellvitge - Institut d'Investigaciό Biomèdica de Bellvitge, Gastroenterology, Barcelona, Spain 5Boehringer-Ingelheim Pharmaceuticals Inc, Ridgefield, United States

P092: Exogenous administration of IL-4-treated macrophages prevents intestinal fibrosis in Stat6 knockout miceECCO '17 Barcelona
Year: 2017
Authors:

Salvador P.*1, Ortiz-Masià D.1, Macias-Ceja D.C.2, Gisbert-Ferrándiz L.1, Hernández C.2,3, Esplugues J.V.1,2,3, Barrachina-Sancho M.D.1,3, Calatayud S.1,3

1University of Valencia, Valencia, Spain 2Fisabio Hospital Peset, Valencia, Spain 3CIBERehd, Valencia, Spain

P093: Dysregulation of cellular vs humoral immunity to the intestinal microbiota in inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Noble A.*1, Durant L.2, Hoyles L.2, McCartney A.L.3, Man R.4, Costello S.P.5, Hendy P.4, Reddi D.2, Segal J.4, Lim D.4, Bolton M.4, Hart A.L.4, Carding S.R.6, Knight S.C.2

1Imperial College London, Antigen Presentation Research Group, Harrow, United Kingdom 2Imperial College London, London, United Kingdom 3University of Reading, Reading, United Kingdom 4Northwick Park & St Mark's Hospital, Harrow, United Kingdom 5Queen Elizabeth Hospital, Adelaide, Australia 6Institute of Food Research, Norwich, United Kingdom

P094: DNA methylation patterns in Crohn's disease mucosal-derived fibroblastsECCO '17 Barcelona
Year: 2017
Authors:

te Velde A.A.*1, Li Yim A.Y.2,3, de Bruyn J.R.1,4, Duijvis N.W.1, de Jonge W.J.1, Wildenberg M.E.1, Mannens M.M.2, D'Haens G.R.4, Henneman P.2

1Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Academic Medical Center, Department of Clinical Genetics, Genome Diagnostics Laboratory, Amsterdam, Netherlands 3GlaxoSmithKline, Epinova Discovery Performance Unit, Stevenage, United Kingdom 4Academic Medical Center, Department of Gastroenterology, Amsterdam, Netherlands

P095: The genetic risk in ER stress and autophagy translates into quantifiable epithelial ER stress levels in IBD patientsECCO '17 Barcelona
Year: 2017
Authors:

Vanhove W.*1, Nys K.1, Arijs I.1,2, Cleynen I.3, de Bruyn M.1,4, Korf H.1,5, Ferrante M.1,6, Van Assche G.1,6, Vermeire S.1,6

1KU Leuven, Translational Research in Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, Leuven, Belgium 2Hasselt University, Faculty of Medicine and Life Sciences, Hasselt, Belgium 3KU Leuven, Laboratory for Complex Genetics, Department of Human Genetics, Leuven, Belgium 4KU Leuven, Laboratory of Immunobiology, Department of Microbiology and Immunology, Rega Institute for Medical Research, Leuven, Belgium 5KU Leuven, Hepatology, Department of Clinical and Experimental Medicine, Leuven, Belgium 6University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium

P096: Combined detection variants of NUDT15 could highly predict thiopurine-induced leukopenia in Chinese patients with inflammatory bowel disease: a multi-center analysisECCO '17 Barcelona
Year: 2017
Authors:

Chao K.*1, Zhu X.1, Cao Q.2, Yang H.3, Liang J.4, Lin L.1, Huang Z.1, Zhang Y.2, Huang Y.2, Sun Y.3, Xue X.4, Huang M.5, Hu P.1, Wu K.4, Lan P.6, Wang X.5, Qian J.3, Gao X.1

1The Sixth Affiliated Hospital, Sun Yat-sen University, Department of Gastroenterology, Guangzhou, China 2Sir Run Run Shaw Hospital, Department of Gastroenterology, Hangzhou, China 3Peking Union Medical College Hospital, Department of Gastroenterology, Beijing, China 4Xijing Hospital, Department of Gastroenterology, Xi'an, China 5School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China 6The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

P097: Th2 cytokines are potent stimulators of pro-fibrotic responses by human intestinal subepithelial myofibroblastsECCO '17 Barcelona
Year: 2017
Authors:

Filidou E.*1, Valatas V.2, Drygiannakis I.2, Arvanitidis K.1, Vradelis S.3, Kolios G.1

1Democritus University of Thrace, Laboratory of Pharmacology, Faculty of Medicine, Alexandroupolis, Greece 2University of Crete, Laboratory of Gastroenterology, Faculty of Medicine, Heraklion, Greece 3Democritus University of Thrace, 2nd Department of Internal Medicine of University Hospital of Alexandroupolis, Alexandroupolis, Greece

P098: Oregonin inhibits intestinal epithelial injury by modulating heme oxygenase-1ECCO '17 Barcelona
Year: 2017
Authors:

Seo G.S.*1, Chi J.-H.2, Jin H.3, Lee S.H.2

1Wonkwang University Hospital, Digestive Disease Research Institute, Department of Gastroenterology, Iksan, South Korea 2Wonkwang University, Institute of Pharmaceutical Research and Development, Department of Pharmacy, Iksan, South Korea 3Institute of Pharmaceutical Research and Development, Wonkwang University, Department of Pharmacy, Iksan, South Korea

P099: Altered intrinsic brain function in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Thomann A.*1, Griebe M.2, Thomann P.3, Reindl W.4, Wolf C.3

1Universitätsmedizin Mannheim, Department of Medicine II, Mannheim, Germany 2Universitätsmedizin Mannheim, Department of Neurology, Mannheim, Germany 3Universitätsklinik Heidelberg, Department of Psychiatry, Heidelberg, Germany 4Universitätsmedizin Mannheim, Department of Medicine II, Mannheim, Germany

P100: Intestinal epithelial cells under endoplasmic reticulum stress boosts serine proteolytic activity and modulates barrier functionECCO '17 Barcelona
Year: 2017
Authors:

Solà Tapias N., Denadai-Souza A., Rolland-Fourcade C., Blanpied C., Dietrich G., Bonnart C., Edir A., Rolland C., Deraison C., Vergnolle N., Barreau F.

Institut de Recherche en Santé Digestive (IRSD), Toulouse, France

P101: Interleukin-13 induces polarity defects in the intestinal epitheliaECCO '17 Barcelona
Year: 2017
Authors:

Lebenheim L., Kühnel A., Hering N., Bojarski C., Schulzke J.-D., Siegmund B., Schumann M.

Charité - University Hospital Berlin, Campus Benjamin Franklin, Department of Gastroenterology and Medicine I, Berlin, Germany

P102: Hypoxia reduces inflammation through the downregulation of NLRP3/mTOR signaling and the activation of autophagyECCO '17 Barcelona
Year: 2017
Authors:

Cosin-Roger J.*1, Simmen S.1, Melhem H.1, Atrott K.1, Frey-Wagner I.1, Hausmann M.1, de Vallière C.1, Spalinger M.R.1, Spielmann P.2,3, Wagner R.H.2,3, Zeitz J.1, Vavricka S.R.1, Rogler G.1, Ruiz P.A.1

1University of Zurich, Gastroenterology, Zurich, Switzerland 2Institute of Physiology, University of Zurich, Zurich, Switzerland 3Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland

P103: Evaluation of efficacy of new vectors for siRNA CYCLIN D1 and E2F1 delivery in control of cancer progression in inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Russo I.*1, Bochicchio S.2, Piazza O.3, Barba A.A.2, Lamberti G.4, Carrizzo A.5, Zeppa P.6, Vecchione C.6, Iovino P.6, Ciacci C.6

1University of Salerno, Department of Medicine and Surgery, Baronissi Campus (Salerno), Italy 2University of Salerno, Department of Pharmacy, Fisciano, Italy 3Department of Medicine and Surgery, Department of Medicine and Surgery, Baronissi, Italy 4University of Salerno, Department of Industrial Engineering, Fisciano, Italy 5University of Salerno, Department of Medicine and Surgery, Fisciano, Italy 6University of Salerno, Department of Medicine and Surgery, Baronissi, Italy

P104: Rebamipide, sucralfate, and rifaximin have the suppressive effects on radiation-induced inflammation in the intestine of mouseECCO '17 Barcelona
Year: 2017
Authors:

Moon W., Park S.J., Kim J.H., Park M.I., Kim S.E., Jung K.W.

Kosin University College of Medicine, Department of Internal Medicine, Busan, South Korea

P105: An experimental examination of appetite and disordered eating in Crohn's disease patientsECCO '17 Barcelona
Year: 2017
Authors:

Wardle R.1, Thapaliya G.1, Nowak A.1, Dalton M.2, Finlayson G.2, Moran G.*1

1University Hospitals Nottingham, NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham, United Kingdom 2University of Leeds, Institute of Psychological Sciences, Leeds, United Kingdom