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P046: Starch consumption is associated with serologic responses in patients with ulcerative colitis and an ileo-anal pouchECCO '17 Barcelona
Year: 2017
Authors:

Goren I.1,2, Godny L.2,3, Maharshak N.3,4, Tulchinsky H.4,5, Dotan I.*2,5

1Tel Aviv Medical Center, IBD unit, Department of Gastroenterology and hepatology, Tel Aviv, Israel 2Sackler Faculty of Medicine, Tel Aviv Israel, IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 3Tel Aviv Medical Center, IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 4Sackler Faculty of Medicine, Tel Aviv Israel, Department of Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 5Tel Aviv Medical Center, Tel Aviv Israel, Pouch Clinic, IBD Center, Tel Aviv, Israel

P047: Therapeutic dosing of filgotinib (GS-6034, GLPG0634) is efficacious in the mouse DSS model of colitisECCO '17 Barcelona
Year: 2017
Authors:

Kim S., Zheng J., Lu B., Alonzo D., Kanwar B., Smith V.

Gilead Sciences, Inc, Foster City, United States

P048: Decreased expression of aquaporins in colonic biopsies from collagenous colitis patients. A novel diarrhoeal pathomechanism?ECCO '17 Barcelona
Year: 2017
Authors:

Holm A.1, Mancebo Giménez A.1, Loitto V.1, Vikström E.1, Magnusson K.-E.1, Münch A.*2

1Linköping University, Department of Clinical and Experimental Medicine, Linköping, Sweden 2University Hospital, Dept of Gastroenterology, Linköping, Sweden

P049: Lewis score: a useful tool for the diagnosis but not for the definition of prognosis in suspected Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Silva M., Cardoso H., Peixoto A., Marques M., Rodrigues-Pinto E., Nunes A.C.-R., Lopes S., Magro F., Macedo G.

Centro Hospitalar São João, Department of Gastroenterology, Porto, Portugal

P050: Centrally-determined standardization of flow cytometry methods reduces inter-laboratory variation in a prospective multicenter studyECCO '17 Barcelona
Year: 2017
Authors:

Westera L.1, van Viegen T.2, Jeyarajah J.3, Azad A.4, Bilsborough J.5, van den Brink G.1, Danese S.6, D'Haens G.2,7, Eckmann L.8, Faubion W.9, Korf H.10, McGovern D.5, Panes J.11, Salas A.11, Sandborn W.8,12, Silverberg M.4, Smith M.4, Vermeire S.10, Vetrano S.6, Shackelton L.3, Stitt L.3, Jairath V.3,13, Levesque B.8,12, Spencer D.3, Feagan B.3,13, Vande Casteele N.*8,12

1Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Robarts Clinical Trials, Inc., Amsterdam, Netherlands 3Robarts Clinical Trials, Inc., London, Canada 4Mount Sinai Hospital, Toronto, Canada 5F. Widjaja Foundation Inflammatory Bowel and Immunobiology Institute, Los Angeles, United States 6Humanitas University, Milan, Italy 7Academic Medical Center, Amsterdam, Canada 8University of California, San Diego, United States 9Mayo Clinic, Rochester, United States 10University of Leuven, Leuven, Belgium 11Hospital Clínic Barcelona, Barcelona, Spain 12Robarts Clinical Trials, Inc., San Diego, United States 13University of Western Ontario, London, Canada

P051: Use of digital technology to boost patient recruitment in inflammatory bowel disease clinical trialsECCO '17 Barcelona
Year: 2017
Authors:

Bouhnik Y.*1, Amiot A.2, Alexandre N.1, Attar A.1, Kondamudi P.K.3, Stéfanescu C.1

1Beaujon Hospital, Gastroenterology, Clichy, France 2University Paris, Paris, France 3CTMA- Clinical Trials Mobile Application, Paris, France

P052: The role of TDAG8 in intestinal inflammationECCO '17 Barcelona
Year: 2017
Authors:

Tcymbarevich I.1, de Vallière C.*1, Spalinger M.1, Cosin-Roger J.1, Atrott K.1, Richards S.2, Seuwen K.2, Frey-Wagner I.1, Rogler G.1,3

1University of Zurich, Zurich, Switzerland 2Novartis Institute for Biomedical Research, Basel, Switzerland 3University Hospital Zürich, Department of Gastroenterology and Hepatology, Zurich, Switzerland

P053: Circulating non-classical monocytes are reduced in patients with active IBD but increase after vedolizumab: a role for α4β7 in myeloid cell recruitment to the inflamed intestineECCO '17 Barcelona
Year: 2017
Authors:

Gordon H.*1, Hoti I.2, Lindsay J.O.1,3, Stagg A.2

1Royal London Hospital, Gastroenterology, London, United Kingdom 2The Blizard Institute, Centre for Immunobiology, Barts and the London School of Medicine, London, United Kingdom 3The Blizard Institute, Centre for Immunology, Barts and the London School of Medicine, London, United Kingdom

P054: Metformin protects against intestinal barrier disruption via AMPKα1-dependent inhibition of JNK signaling pathwayECCO '17 Barcelona
Year: 2017
Authors:

Deng J., Chen Y., Zeng L.

Nanfang Hospital, Southern Medical Universit, Department of Gastroenterology, Guangzhou, China

P055: Mitochondrial DNA is a damage-associated molecular pattern released during active IBD promoting TLR9-mediated inflammationECCO '17 Barcelona
Year: 2017
Authors:

Boyapati R., Dorward D., Tamborska A., Kalla R., Ventham N., Rossi A., Satsangi J., Ho G.-T.

University of Edinburgh, MRC Centre for Inflammation Research, Edinburgh, United Kingdom

P056: Gut microbiota characterisation in South Asian IBD patients resident in the UKECCO '17 Barcelona
Year: 2017
Authors:

Quraishi M.N.*1,2, Rossiter A.3, Bhala N.2, Beaumont M.4, Pathmakanthan S.2, Ghosh S.2,5, Iqbal T.H.1,2

1University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, United Kingdom 2University Hospital Birmingham, Department of Gastroenterology, Birmingham, United Kingdom 3University of Birmingham, Institute of Microbiology and Infection, Birmingham, United Kingdom 4Kings College London, Twin Research & Genetic Epidemiology, London, United Kingdom 5University Hospital Birmingham, Institute of Translational Medicine, Birmingham, United Kingdom

P057: IL-6 induces NLRP3 inflammasome activation through JAK/STAT3-dependent NOX2 induction in colon epithelial cellsECCO '17 Barcelona
Year: 2017
Authors:

Kim J.-A.*1, Grung P.1, Banskota S.1, Jeong B.-S.1, Nam T.-g.2

1Yeungnam University, College of Pharmacy, Gyeongsan, South Korea 2Hanyang University, College of Pharmacy, Ansan, South Korea

P058: Comparison of Calprotectin levels in stool and rectal mucus in subjects with suspected or confirmed inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

McLaughlin J.*1, Hedley A.D.2, Treasure P.3, Collins C.M.2, Craven R.A.2

1University of Manchester, School of Medical Sciences, Manchester, United Kingdom 2Origin Sciences, Cambridge, United Kingdom 3statistics@petertreasure.com, King's Lynn, United Kingdom

P059: Mucosal inflammation promotes activation of circulating Vδ2+ T-cells in Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

McCarthy N.*1, Gordon H.1, Rahman S.1, Harrow P.1,2, Stagg A.1, Lindsay J.1,2

1The Blizard Institute, Queen Mary University of London, Centre for Immunobiology, London, United Kingdom 2Barts Health NHS Trust, Department of Gastroenterology, London, United Kingdom

P060: Role of innate lymphoid cells in the chronic colitis under anti-il-17a therapyECCO '17 Barcelona
Year: 2017
Authors:

Eun C.S., Han D.S., Park C.H., Lee A.R., Lee Y.R.

Hanyang University Guri Hospital, Gastroenterology, Guri, South Korea

P061: Epigenetic alterations at diagnosis predict susceptibility, prognosis and treatment escalation in inflammatory bowel disease – IBD CharacterECCO '17 Barcelona
Year: 2017
Authors:

Adams A.*1, Kalla R.1, Vatn S.2, Bonfiglio F.3, Nimmo E.1, Kennedy N.1, Ventham N.1, Vatn M.2, Ricanek P.4, Bergemalm D.5, Halfvarson J.5, Söderholm J.6, Pierik M.7, Törkvist L.8, Gomollόn F.9, Gut I.10, Jahnsen J.2, Satsangi J.1 IBD Character Consortium

1University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom 2University of Oslo, Institute of Clinical Medicine, EpiGen, Campus Ahus, Oslo, Norway 3BioCruces Health Research Institue, Bilbao, Spain 4Akershus University, Department of Gastroenterology, Akershus, Norway 5Örebro University, Department of Gastroenterology, Faculty of Medicine and Health, Örebro, Sweden 6Linköping University Hospital, Department of Surgery, Linköping, Sweden 7Maastricht University Medical Center (MUMC), Department of Gastroenterology and Hepatology, Maastricht, Netherlands 8Karolinska Institute, Department of Clinical Science, Intervention and Technology, Stockholm, Sweden 9University Hospital Clinic Lozano Blesa, Zaragoza, Spain 10CNAG-CRG Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain

P062: The narrow spectrum kinase inhibitor TOP1288 demonstrates potent anti-inflammatory effects in a T cell adoptive transfer colitis model through a topical mode of actionECCO '17 Barcelona
Year: 2017
Authors:

Solanke Y., Foster M., Fyfe M., Rowley A., Sirohi S., Webber S., Walshe C.

Topivert Pharma Ltd, London, United Kingdom

P063: HDAC as versatile regulators of the intestinal epithelial barrier in inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Friedrich M., Ganther J., Breiderhoff T., Rosenthal R., Glauben R., Siegmund B.

Charité - Universitätsmedizin Berlin, Medical department for Gastroenterology, Infectious Diseases and Rheumatology, Berlin, Germany

P064: EBI2 and oxysterols in the development of intestinal lymphoid structures and colitisECCO '17 Barcelona
Year: 2017
Authors:

Wyss A.*1, Raselli T.1, Schmelczer G.1, Spalinger M.1, Atrott K.1, Frey-Wagner I.1, Sailer A.W.2, Rogler G.1, Misselwitz B.1

1University of Zurich, Zurich, Switzerland 2Novartis Institutes for BioMedical Research, Basel, Switzerland

P065: Effects of gut bacteria on the intestinal immune cell composition and barrier functionECCO '17 Barcelona
Year: 2017
Authors:

Schmidt F.*1, Dahlke K.2, Batra A.1,3, Ring C.2, Keye J.1, Loh G.2,4, Schumann M.1, Kühl A.1, Blaut M.2, Siegmund B.1

1Charité - Universitätsmedizin Berlin, Medical Department for Gastroenterology, Infectious Diseases and Rheumatology, Berlin, Germany 2German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Gastrointestinal Microbiology, Nuthetal, Germany 3Takeda Pharma Vertrieb GmbH & Co. KG, Berlin, Germany 4Max Rubner-Institute, Institute of Physiology and Biochemistry of Nutrition, Nutrition and Intestinal Microbiota, Karlsruhe, Germany