¹Universitary Hospital A Coruna, Gastroenterology, A Coruna, Spain, ²Universitary Hospital A Coruna, A Coruna, Spain, ³Universitary Hospital A Coruna, Tuberculosis Unit, A Coruna, Spain

¹Servicio de Gastroenterología Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain, ²Instituto de Investigación Biomedica (IBI). SERGAS, Pontevedra, Spain, ³Hospital Universitario Virgen Macarena, Sevilla, Spain, ⁴Unitat de Malalties Digestives. Corporació Sanitaria Universitària Parc Taulí, Sabadell, Spain, ⁵Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain, ⁶Merck Sharp & Dohme, Spain, Medical Affairs, Madrid, Spain, ⁷Gastroenterology Section, Hospital Ramón y Cajal, Madrid, Spain

¹University Medical Centre Groningen, Gastroenterology, Groningen, The Netherlands, ²University Medical Centre Groningen, Epidemiology, Groningen, The Netherlands, ³University Medical Centre Groningen, Genetics, Groningen, The Netherlands, ⁴Wageningen University and Research, Food and Nutrition, Wageningen, The Netherlands

¹Vestre Viken Hospital Trust, Baerum Hospital Medical Division, Drammen, Norway, ²University of Oslo, Institute of Clinical Medicine, Oslo, Norway, ³Oslo University Hospital, Department of Gastroenterology, Oslo, Norway, ⁴Akershus University Hospital, Department of Gastroenterology, Lørenskog, Norway, ⁵Oslo University College of Applied Sciences, Oslo, Norway, ⁶Stavanger University Hospital, Department of Gastroenterology, Stavanger, Norway, ⁷Ålesund Hospital Trust, Department of Medicine, Ålesund, Norway, ⁸Telemark Hospital Trust, Department of Research and Development, Skien, Norway, ⁹Innlandet Hospital Trust, Department of Medicine, Gjøvik, Norway, ¹⁰Innlandet Hospital Trust, Department of Medicine, Hamar, Norway, ¹¹Vestfold Hospital Trust, Department of Research and Development, Tønsberg, Norway, ¹²Østfold Hospital Trust, Department of Gastroenterology, Grålum, Norway, ¹³Østfold University College, Department of Health Sciences, Fredrikstad, Norway

¹University of Wolverhampton, Psychology, Wolverhampton, UK, ²University of Bath, Department of Pharmacy and Pharmacology, Bath, UK, ³Kings College London, Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, London, UK, ⁴St James University Hospital, Gastroenterology, Leeds, UK, ⁵Royal Wolverhampton NHS Trust, Gastroenterology, Wolverhampton, UK

¹Clinical Hospital No.2 Rzeszow, Poland#8232;, Department of Internal Medicine, Endocrinology, Nephrology, Rzeszów, Poland, ²Clinical Hospital No.2 Rzeszow, Poland#8232;, Department of Gastroenterology with the Central Department of Endoscopy, Rzeszów, Poland, ³Faculty of Medicine, University of Rzeszow, Poland, Rzeszów, Poland, ⁴Steele Children's Research Center, Arizona Health Sciences Center, University of Arizona, Steele Children's Research Center, Departments of Pediatrics and Immunobiology, Arizona, USA

¹Inselspital, Bern, Department of Gastroenterology, Bern, Switzerland, ²Universitätsspital, Gastroenterology, Zürich, Switzerland, ³CHUV, Gastroenterology, Lausanne, Switzerland, ⁴Stadtspital Triemli, Gastroenterology, Zürich, Switzerland, ⁵CHUV, PMU, Lausanne, Switzerland, ⁶CHUV, Statistics, Lausanne, Switzerland, ⁷Hôpital Saint-Louis, Gastroenterology, Lausanne, France, ⁸Inselpital, Gastroenterology, Bern, Switzerland, ⁹Inselspital, Gastroenterology, Bern, Switzerland

¹IRCCS Policlinico S. Matteo, Pavia, Italy, ²AOU Policlinico, Messina, Italy, ³Azienda Ospedaliera di Padova, Padova, Italy, ⁴AUO S. Giovanni di Dio e Ruggi D’Aragona, Salerno, Italy, ⁵Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy, ⁶Università di Napoli Federico I, Napoli, Italy, ⁷Policlinico, Bari, Italy, ⁸Spedali Civili di Brescia, Brescia, Italy, ⁹Ospedale di Rivoli, Torino, Italy, ¹⁰AOU Careggi, Firenze, Italy, ¹¹AO S. Camillo Forlanini, Roma, Italy, ¹²AOU Seconda Università di Napoli, Napoli, Italy, ¹³IRCCS S. Martino, Genova, Italy, ¹⁴Università di Perugia, Perugia, Italy, ¹⁵AOU Trieste, Trieste, Italy, ¹⁶Policlinico Umberto I, Roma, Italy, ¹⁷AO S. Croce, Cuneo, Italy, ¹⁸Ospedale S. Maria del Prato, Feltre, Italy, ¹⁹Policlinico di Modena, Modena, Italy, ²⁰Ospedale SS Annunziata, Chieti, Italy, ²¹Ospedale Centrale di Bolzano, Bolzano, Italy

Yonsei University College of Medicine, Internal medicine, Seoul, South Korea

¹Chiba University, Department of Gastroenterology, Chiba, Japan, ²Chiba University, Kashiwanoha Clinic of East Asian Medicine, Kashiwa, Japan

¹IBD Clinic, Instituto Nacional de Ciencias Medicas y Nutricion, Gastroenterology, Mexico, Mexico, ²Hospital San Jose Tec de Monterrey, Monterrey, Mexico, ³Hospital Universitario Dr. Jose e Gonzalez, Department of Gastroenterology, Monterrey, Mexico, ⁴Hospital de Especialidades Centro Medico Nacional General Manuel Avila Camacho IMSS, Gastroenterology, Puebla, Mexico, ⁵Hospital de Alta Especialidad ISSSTE, Gastroenterology, Morelia, Mexico, ⁶Hospital General Regional 110 IMSS, Gastroenterology, Guadalajara, Mexico, ⁷Centro Médico ISSEMyM, Gastroenterology, Toluca, Mexico, ⁸Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”, Colorectal Surgery, Guadalajara, Mexico, ⁹Hospital “Gomez Farias” ISSSTE, Endoscopy, Guadalajara, Mexico, ¹⁰Hospital General 450 Secretaría de Salud, Gastroenterology, Durango, Mexico, ¹¹Hospital Regional 25 IMSS, Gastroenterology, Mexico, Mexico, ¹²EPIMEX Study Group, Gastroenterology, Whole country, Mexico

¹University of Szeged, 1st Department of Medicine, Szeged, Hungary, ²St. Francis Hospital, Kalocsa, Hungary, ³Csolnoky Ferenc Veszprém County Hospital, Veszprém, Hungary, ⁴Semmelweis University, 2nd Department of Medicine, Budapest, Hungary, ⁵State Health Centre, Department of Gastroenterology, Budapest, Hungary, ⁶University of Pécs, 1st Department of Internal Medicine, Pécs, Hungary, ⁷Péterfy Sándor Hospital and Trauma Center, Budapest, Hungary, ⁸Bekes County Pandy Kalman Hospital, Gyula, Hungary, ⁹Tolna County Balassa Janos Hospital, Gastroenterology Department, Szekszárd, Hungary, ¹⁰Bács-Kiskun County University Teaching Hospital, Kecskemét, Hungary, ¹¹University of Pécs, 2nd Department of Internal Medicine and Nephrology Centre, Pécs, Hungary, ¹²University of Debrecen, Debrecen, Hungary, ¹³Budai Irgalmasrendi Hospital, Budapest, Hungary, ¹⁴University of Debrecen, 2nd Department of Internal Medicine, Debrecen, Hungary, ¹⁵Semmelweis University, 1st Department of Surgery, Budapest, Hungary, ¹⁶Semmelweis University, 1st Department of Medicine, Budapest, Hungary, ¹⁷Semmelweis University, Department of Pediatrics, Budapest, Hungary

¹Yokohama City University Medical Centre, Inflammatory Bowel Disease Centre, Yokohama, Japan, ²Yokohama City University Graduate School of Medicine, Department of Gastroenterology, Yokohama, Japan, ³Yokohama City University, Advanced Medical Research Centre, Yokohama, Japan, ⁴Niigata University Graduate School of Medical and Dental Sciences, Division of Molecular and Diagnostic Pathology, Niigata, Japan, ⁵Yokohama City University Medical Centre, Division of Endoscopy, Yokohama, Japan, ⁶Osaka City Juso Hospital, Department of Gastroenterology and Hepatology, Osaka, Japan, ⁷Yokohama City University Medical Centre, Department of Diagnostic Pathology, Yokohama, Japan

¹Wilhelmina Children’s Hospital, University Medical Center Utrecht (UMCU), Department of Pediatric Gastroenterology, Utrecht, The Netherlands, ²University Medical Center Utrecht (UMCU), Regenerative Medicine Center, Utrecht, The Netherlands, ³Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Boztug Laboratory, Vienna, Austria, ⁴CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, ⁵Ankara University, Department of Pediatric Gastroenterology, Ankara, Turkey, ⁶Medical University of Innsbruck, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck, Austria, ⁷Akdeniz University Medicine Hospital, Pediatric Gastroenterology Department, Antalya, Turkey, ⁸Başkent University, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, Ankara, Turkey, ⁹University Medical Center Groningen, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gronigen, The Netherlands, ¹⁰Medical University of Innsbruck, Department of Pediatrics I, Innsbruck, Austria, ¹¹University Medical Center Utrecht (UMCU), Department of Medical Genetics, Utrecht, The Netherlands, ¹²Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Vienna, Austria, ¹³Medical University of Vienna, St. Anna Kinderspital and Children’s Cancer Research Institute, Department of Pediatrics, Vienna, Austria

¹IDIBAPS-Hospital Clínic Barcelona, CIBER-EHD, Barcelona, Spain, ²AbbVie Inc., North Chicago, USA

¹IRCCS, Casa Sollievo della Sofferenza, Hospital, UOC Gastroenterology, San Giovanni Rotondo, Italy, ²IRCCS Casa Sollievo della Sofferenza, Unit of Bioinformatics, San Giovanni Rotondo, Italy

¹Institut für Klinische Molekularbiologie, Kiel, Germany, ²Yonsei University College of Medicine, Internal Medicine and Institute of Gastroenterology, Seoul, South Korea, ³Yonsei University College of Medicine, Pediatrics, Seoul, South Korea

University of Edinburgh, IGMM, EDINBURGH, UK

¹Ludwig Boltzmann Institute Rare and Undiagnosed Diseases, Vienna, Austria, ²CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, ³Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria, ⁴St. Anna Kinderspital and Childrens‘ Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, Vienna, Austria

¹Western University, Department of Gastroenterology, London, Canada, ²Western University, London, Canada, ³Western University, Department of Medicine, London, Canada