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P084: Intestinal organoids derived from patients with inflammatory bowel disease show unaltered transcriptional profiles when compared with healthy controlsECCO '16 Amsterdam

Year: 2016

Authors:

M. Noben*^{1, 2}, N. Hendriks^{1, 2}, G. Van Assche¹, S. Vermeire¹, C. Verfaillie², M. Ferrante¹

¹KU Leuven, Translational Research Centre for Gastrointestinal Disorders (Targid), Leuven, Belgium, ²KU Leuven, Stem Cell Institute Leuven, Leuven, Belgium

P085: Altered proportions of myeloid and plasmacytoid dendritic cells in children with inflammatory bowel diseaseECCO '16 Amsterdam

Year: 2016

Authors:

M. F. Elshal^{1, 2, 3, 4}, A. M. Aldahlawi^{2, 3, 5}, O. I. Saadah*^{6, 7}, J. P. McCoy⁸

¹Facuty of Sciences, King Abdulaziz Uinversity, Biochemistry Department, Jeddah, Saudi Arabia, ²Inflammatory Bowel Disease Research Group, King Abdulaziz University, Jeddah, Saudi Arabia, ³Immunology Unit, King Fahd Medical Research Centre, Jeddah, Saudi Arabia, ⁴Sadat City University, Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, Cairo, Egypt, ⁵Faculty of Sciences, KIng Abdulaziz University, Biological Sciences Department, Jeddah, Saudi Arabia, ⁶Faculty of Medicine, King Abdulaziz University, Paediatric Department, Jeddah, Saudi Arabia, ⁷Inflammatory Bowel Disease Research Group, King Abdulaziz Uinversity, Jeddah, Saudi Arabia, ⁸National Heart, Lung, and Blood Institute, National Institutes of Health, Flow Cytometry Core, Bethesda, MD, United States

P086: Glycosylation of T-cells as a new molecular biomarker in inflammatory bowel disease: an opportunity for new therapeutic strategiesECCO '16 Amsterdam

Year: 2016

Authors:

A. M. Dias¹, M. Pereira¹, R. Marcos-Pinto², A. Correia³, M. Vilanova³, C. Reis¹, P. Lago², S. S. Pinho*¹

¹IPATIMUP/i3S, University of Porto, Glycobiology in Cancer, Porto, Portugal, ²Porto Centre Hospital, Hospital Santo António, Gastrenterology department, Porto, Portugal, ³Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Immunology department, Porto, Portugal

P087: Contributions of monocytes to gut inflammation in acute and chronic colitis modelsECCO '16 Amsterdam

Year: 2016

Authors:

F. Becker*¹, F. N. Gavins², T. Vowinkel¹, I. Tsunoda³, E. Rijcken¹, D. V. Ostanin⁴, J. S. Alexander²

¹University Hospital Muenster, Department of General and Visceral Surgery, Muenster, Germany, ²Louisiana State University Health Sciences Centre-Shreveport, Department of Molecular & Cellular Physiology, Shreveport, Louisiana, United States, ³Louisiana State University Health Sciences Centre-Shreveport, Department of Microbiology and Immunology, Shreveport, Louisiana, United States, ⁴Louisiana State University Health Sciences Centre-Shreveport, Centre of Excellence for Arthritis and Rheumatology, Shreveport, Louisiana, United States

P088: Loss of intestinal Desmoglein 2 promotes chemically and pathogenic induced colitisECCO '16 Amsterdam

Year: 2016

Authors:

A. Gross*¹, L. Pack¹, S. Kant², C. Krusche², G. Sellge¹, C. Trautwein¹, R. Leube², P. Strnad¹

¹University Hospital Aachen, Medicine III, Aachen, Germany, ²University Hospital Aachen, Institute of Molecular and Cellular Anatomy, Aachen, Germany

P089: Stimulation of the ω-3 docosahexaenoic acid metabolism via MFSD2A as a novel therapy for inflammatory bowel disease.ECCO '16 Amsterdam

Year: 2016

Authors:

F. Ungaro*^{1, 2}, C. Correale¹, P. Corsetto³, L. Massimino⁴, P. Fonteyne¹, C. Tacconi¹, K. R. Maddipati⁵, A. Rizzo³, S. D’Alessio^{1, 2}, S. Danese¹

¹Humanitas Research Institute, Laboratory of Immunology in Gastroenterology, Milan, Italy, ²University of Milan, Department of Biotechnology and Translational Medicine, Milan, Italy, ³University of Milan, Department of Pharmacology and Biomolecular Science, Milan, Italy, ⁴San Raffaele Research Institute, Division of Neuroscience, Milan, Italy, ⁵Wayne State University, Department of Pathology, Detroit, Michigan, United States

P090: Differences in expression of G protein–coupled receptor 55 (GPR55) in patients with Crohn’s disease and ulcerative colitisECCO '16 Amsterdam

Year: 2016

Authors:

M. Wlodarczyk*¹, A. Sobolewska-Włodarczyk¹, A. Cygankiewicz², D. Jacenik², W. Krajewska³, K. Stec-Michalska¹, A. Piechota-Polanczyk⁴, J. Fichna⁴, M. Wisniewska-Jarosinska¹

¹Medical University of Lodz, Department of Gastroenterology, Lodz, Poland, ²University of Lodz, Department of Cytobiochemistry, Lodz, Poland, ³University of Lodz, Cytobiochemistry, Lodz, Poland, ⁴Medical University of Lodz, Department of Biochemistry, Lodz, Poland

P091: Sonic hedgehog inhibitor prevented colitis-associated cancer via stem inhibitionECCO '16 Amsterdam

Year: 2016

Authors:

K. B. Hahm*¹, Y. J. Kim²

¹CHA University, Gastroenterology, Seongnam, South Korea, ²Gachon University, Gastroenterology, Incheon, South Korea

P092: Characterisation of the lymphoid stress surveillance response performed by human colon resident γδ T-cellsECCO '16 Amsterdam

Year: 2016

Authors:

R. J. Dart*^{1, 2, 3}, R. Woolf², P. M. Irving³, A. C. Hayday^{1, 2}

¹Francis Crick Institute, Immunosurveillance Lab, London, United Kingdom, ²King’s College London, Immunobiology, DIIID, London, United Kingdom, ³Guy’s and St Thomas’ NHS Foundation Trust, IBD Centre, London, United Kingdom

P093: 15-d-PGJ2 – a possible regulator of iron homeostasisECCO '16 Amsterdam

Year: 2016

Authors:

J. Martin*^{1, 2}, S. Ulrich-Rueckert², J. Stein^{1, 3}

¹Interdisciplinary Crohn Colitis Centre Rhein-Main, Frankfurt/Main, Germany, ²Goethe University Frankfurt, Insitute of Pharmaceutical Chemistry, Frankfurt/Main, Germany, ³DGD Clinics Sachsenhausen, Frankfurt/Main, Germany

P094: Human neutrophil elastase shows increased elastinolytic activity in ulcerative colitis and contributes to loss of function of anti-TNF-alpha agents in ulcerative colitisECCO '16 Amsterdam

Year: 2016

Authors:

P. Giuffrida*¹, K. Kok², A. Di Sabatino¹, P. Biancheri², A. Vanoli³, G. Mazza⁴, R. Curciarello², A. Pasini¹, N. Aronico¹, M. Pinzani⁴, G. R. Corazza¹, T. T. MacDonald²

¹Fondazione IRCCS Policlinico San Matteo, University of Pavia, First Department of Medicine, Pavia, Italy, ²Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom, ³Fondazione IRCCS Policlinico San Matteo, University of Pavia, Department of Molecular Medicine, Pavia, Italy, ⁴Institute for Liver and Digestive Health, University College London, London, United Kingdom

P095: Immune compromised mice develop colitis upon denervation of the superior mesenteric nerve.ECCO '16 Amsterdam

Year: 2016

Authors:

R. Willemze*¹, L. Nijhuis¹, O. Welting¹, J. Folgering², H. Darwinkel², D. Chew³, A. Sridhar³, J. Witherington³, J. Seppen¹, S. Heinsbroek¹, W. de Jonge¹

¹Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, ²Brains On-line B.V., Groningen, Netherlands, ³Glaxo Smith Kline, Bioelectronics, Middlesex, United Kingdom

P096: Low-dose naltrexone reduces in-vitro endoplasmic reticulum stress and stimulates wound healing in intestinal epithelial cellsECCO '16 Amsterdam

Year: 2016

Authors:

G. Fuhler*, M. Lie, P. Dimitrijevic, C. J. van der Woude, M. Peppelenbosch

Erasmus MC University Medical Centre Rotterdam, Gastroenterology and Hepatology, Rotterdam, Netherlands

P097: MicroRNA23a is overexpressed in the colonic epithelium in Crohn’s diseaseECCO '16 Amsterdam

Year: 2016

Authors:

R. Felwick*¹, G. Dingley¹, T. Sanchez-Elsner¹, J. Collins¹, F. Cummings²

¹University of Southampton, Clinical and Experimental Sciences, Southampton, United Kingdom, ²University Hospital Southampton, Gastroenterology, Southampton, United Kingdom

P098: Anti-fibrotic effects of a novel small compound that promotes the nuclear translocation of YB-1 in a mouse model of colorectal fibrosisECCO '16 Amsterdam

Year: 2016

Authors:

J. Imai*¹, K. Hozumi², Y. Inagaki³, T. Mine¹

¹Tokai university School of Medicine, Gastroenterology, Isehara, Japan, ²Tokai university School of Medicine, Immunology, Isehara, Japan, ³Tokai university School of Medicine, Regenerative Medicine, Isehara, Japan

P099: Inhibitory effect of 6-aminopyridin-3-ol analogues on TNF-α-induced monocyte-colon epithelial cell adhesion and TNBS-induced rat colitisECCO '16 Amsterdam

Year: 2016

Authors:

B.-S. Jeong*¹, S. Banskota¹, P. Grung¹, T.-g. Nam², J.-A. Kim¹

¹Yeungnam University, College of Pharmacy, Gyeongsan, South Korea, ²Hanyang University, College of Pharmacy, Ansan, South Korea

P100: Effects of a narrow spectrum kinase inhibitor and selective kinase inhibitors on the intestinal pro-inflammatory immune response in ulcerative colitisECCO '16 Amsterdam

Year: 2016

Authors:

M. R. Foster*¹, P. Biancheri², Y. Solanke¹, S. Sirohi¹, M. C. Fyfe¹, A. Rowley¹, T. T. MacDonald², E. Wood³, S. Webber¹, C. A. Walshe¹

¹Topivert Pharma Ltd, London, United Kingdom, ²Barts and the London, School of medicine and dentistry, London, United Kingdom, ³Homerton University Hospital, Academic Department of Medical and Surgical Gastroenterology, London, United Kingdom

P101: Functional translation of IBD-associated genetic variation in patient-derived intestinal epithelial cellsECCO '16 Amsterdam

Year: 2016

Authors:

W. Vanhove*¹, K. Nys¹, I. Arijs¹, I. Cleynen², G. Van Assche¹, M. Ferrante¹, S. Vermeire¹

¹KU Leuven, Translational Research Centre for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, Leuven, Belgium, ²KU Leuven, Department of Human Genetics, Leuven, Belgium

P102: α-Defensins(αDef) 1-3 are specific plasmatic markers for Crohn’s disease (CD) at diagnosis and tissue α-Def 5 methylation is a pathogenic mechanism for αDef-5 down regulation in CD.ECCO '16 Amsterdam

Year: 2016

Authors:

E. Cerrillo¹, I. Moret-Tatay^2,3, M. Iborra^1,2, E. Sáez-González¹, E. Busó⁴, D. Ramos⁵, L. Tortosa¹, P. Nos^1,3, B. Beltrán*^1,3

¹Hospital Universitari La Fe, Gastroenterology, Valencia, Spain, ²Ciberehd, Gastroenterology, Valencia, Spain, ³IIS Hospital La Fe, Gastroenterology, Valencia, Spain, ⁴School of Medicine. Valencia University, Central Unit of Medical Research, Valencia, Spain, ⁵Hospital Universitari La Fe, Pathology, Valencia, Spain

P103: Selective M1 macrophage polarisation in Crohn’s disease in comparison to intestinal tuberculosis: a novel observationECCO '16 Amsterdam

Year: 2016

Authors:

P. Das¹, S. Pilli², T. Kumar¹, R. Rampal², I. A. Khan², A.K. Singh², D. Kumar³, V. Ahuja*²

¹All India Institute of Medical Sciences, Pathology, New Delhi, India, ²All India Institute of Medical Sciences, Gastroenterology, New Delhi, India, ³International Centre for Genetic Engineering and Biotechnology, Mammalian Biology, New Delhi, India