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P064: TOP1210 narrow spectrum kinase inhibitor demonstrates superior activity and improved safety profile potential compared with corticosteroid and immunomodulators in preclinical models of colitisECCO '16 Amsterdam

Year: 2016

Authors:

C. A. Walshe*, A. Rowley, M. R. Foster, Y. Solanke, S. Sirohi,  M. C. Fyfe, S. Webber

Topivert Pharma Ltd, London, United Kingdom

P065: Molecular landscape of early Crohn’s disease using an integrated approach of mRNA/miRNA profiling and genomicsECCO '16 Amsterdam

Year: 2016

Authors:

S. Verstockt*¹, J. Van der Goten², M. Vancamelbeke², B. Verstockt², F. Schuit³, P. Rutgeerts², M. Ferrante², S. Vermeire², I. Arijs², I. Cleynen¹

¹KU Leuven, Department of Human Genetics, Leuven, Belgium, ²KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Centre for Gastrointestinal Disorders, Leuven, Belgium, ³KU Leuven, Department of Cellular and Molecular Medicine, Gene Expression Unit, Leuven, Belgium

P066: CCR2-monocytes are essential for the resolution of inflammation and tissue repair in colitis.ECCO '16 Amsterdam

Year: 2016

Authors:

M. Stakenborg, G. Goverse, G. Farro, P. J. Gomez-Pinilla,  G. E. Boeckxstaens, G. Matteoli*

KU Leuven, P.O. Box 701, Department of Clinical and Experimental Medicine, Leuven, Belgium

P067: Angiogenic characterisation of Crohn’s disease mesenteric adipose tissueECCO '16 Amsterdam

Year: 2016

Authors:

M. Eddama*¹, R. Cohen¹, M. Rodriguez-Justo², I. Evans³, L. Shen⁴, L. Clapp⁴, M. Loizidou⁵

¹University College London Hospital, Colorectal Surgery, London, United Kingdom, ²University College London Hospital, Department of Pathology, London, United Kingdom, ³University College London, Centre for Cardiovascular Biology and Medicine, London, United Kingdom, ⁴University College London, Institute of Cardiovascular Science, London, United Kingdom, ⁵University College London, Academic Department of Surgery, London, United Kingdom

P068: Anti-fibrotic therapy for Crohn’s disease: in-vitro proof of concept with a selective ROCK2 inhibitor, LYC-53976, in the treatment of human intestinal myofibroblasts in stiffness and transforming growth factor β modelsECCO '16 Amsterdam

Year: 2016

Authors:

E. Rodansky¹, X. Liu², L. A. Johnson¹, K. Demock², A. J. Celeste², L. L. Carter², P. D. R. Higgins*¹

¹University of Michigan, Internal Medicine - Gastroenterology, Ann Arbor, Michigan, United States, ²Lycera, Inc., Ann Arbor, Michigan, United States

P069: TD-1473, a novel, potent, and orally administered, GI-targeted, pan-Janus kinase (JAK) inhibitorECCO '16 Amsterdam

Year: 2016

Authors:

D. Beattie*, P. Tsuruda, F. Shen, P. Brassil, C. Langrish, J. Janc, Z. Ren, R. Hudson, J. Smith, S. Hegde

Theravance Biopharma, South San Francisco, United States

P070: The influence of vitamin D on M1 and M2 macrophages in patients with Crohn’s diseaseECCO '16 Amsterdam

Year: 2016

Authors:

E. Seidman*, S. Dionne

Research Institute of the McGill University Hospital, Gastroenterology, Montreal, Canada

P071: Improvement of experimental mouse models in inflammatory bowel diseases using flexible video endoscopic colon evaluationECCO '16 Amsterdam

Year: 2016

Authors:

C. Gay*¹, O. Martin Rodriguez², A. Daoui², S. Koch¹, P. Saas², S. Valmary Degano³, S. Perruche², L. Vuitton¹

¹CHU Jean Minjoz, Gastro-entérologie, besançon, France, ²UMR 1098 INSERM, Besançon, France, ³CHU Jean Minjoz, Anatomopathologie, besançon, France

P072: TREM-1 stimulation ameliorates colitis in miceECCO '16 Amsterdam

Year: 2016

Authors:

H. W. Ma*^{1, 2}, X. Che^{1, 2}, D. H. Seo^{1, 2}, J. H. Kim^{1, 2}, D. H. Kim¹,  T. I. Kim¹, W. H. Kim¹, S. W. Kim^{1, 2, 3}, J. H. Cheon^{1, 2, 3}

¹Yonsei University College of Medicine, Department of Internal Medicine and Institute of Gastroenterology, Seoul, South Korea, ²Yonsei University College of Medicine, Brain Korea 21 PLUS Project for Medical Science, Seoul, South Korea, ³Yonsei University College of Medicine, Severance Biomedical Science Institute, Seoul, South Korea

P073: TNF-alpha activity in plasma from patients with inflammatory bowel disease under adalimumab and infliximab treatment evaluated in a cell-based assayECCO '16 Amsterdam

Year: 2016

Authors:

P. M. Linares*¹, H. De la Fuente², M. Chaparro¹, I. Guerra³, P. L. Majano⁴, M. Iborra⁵, J. L. Cabriada⁶, L. Bujanda⁷, M. Barreiro-de Acosta⁸, V. García-Sánchez⁹, I. Marín-Jiménez¹⁰, D. Bernardo¹,  J. P. Gisbert¹

¹Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Gastroenterology Unit, Madrid, Spain, ²Hospital Universitario de La Princesa, IIS-IP, Immunology Unit, Madrid, Spain, ³Hospital Universitario de Fuenlabrada, Gastroenterology Unit, Madrid, Spain, ⁴Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Molecular Biology Unit, Madrid, Spain, ⁵Hospital Universitario La Fe and CIBERehd, Gastroenterology Unit, Valencia, Spain, ⁶Hospital Galdakao, Gastroenterology Unit, Vizcaya, Spain, ⁷Hospital de Donostia, Instituto Biodonostia, UPV/EHU and CIBEREHD, Gastroenterology Unit, Guipuzcoa, Spain, ⁸Hospital Clínico Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain, ⁹Hospital Universitario Reina Sofía, Gastroenterology Unit, Córdoba, Spain, ¹⁰Hospital Gregorio Marañón and IiSGM, Gastroenterology Unit, Madrid, Spain

P074: Association of colonic mucosal infiltration of IgG4 plasma cells with ulcerative colitis activity and presence of primary sclerosing cholangitisECCO '16 Amsterdam

Year: 2016

Authors:

F. Alborzi*¹, Z. Azizi², N. Ebrahimi Daryani³, F. Azmude Ardalan³, N. Aletaha³, R. Taslimi³, N. Roshan³

¹Tehran University of Medical Science, Gastrenterology, Tehran, Iran, Islamic Republic of, ²Iran University of Medical Science, Tehran, Iran, Islamic Republic of, ³Tehran University of Medical Science, Tehran, Iran, Islamic Republic of

P075: Innate immunity in inflammatory bowel disease and colon cancerECCO '16 Amsterdam

Year: 2016

Authors:

E. Lo Presti*¹, R. Di Mitri², F. Dieli¹, F. Mocciaro², G. Pecoraro², G. Russo², S. Meraviglia¹

¹University of Palermo, Central Laboratory of Advanced Diagnosis & Biomedical Research (CLADIBIOR), Department of Biopathology, Palermo, Italy, ²ARNAS Civico-Di Cristina-Benfratelli Hospital, Department of Gastroenterology and Endoscopy, Palermo, Italy

P076: The role for T-cells in the pathogenesis of Crohn’s disease–associated fistulaeECCO '16 Amsterdam

Year: 2016

Authors:

R. Bruckner*, M. Spalinger, G. Rogler, M. Scharl

University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland

P077: The efficacy of tyrosine kinase inhibitor dasatinib on colonic mucosal damage in murine model of colitisECCO '16 Amsterdam

Year: 2016

Authors:

G. Can*¹, S. Ayvaz², H. Can³, I. Karaboğa⁴, S. Demirtaş⁴, H. Akşit⁵, B. Yilmaz⁶, U. Korkmaz⁷, M. Kurt⁷, T. Karaca⁴

¹Abant Izzet Baysal University, Faculty of Medicine, Department of Gastroenterology, Bolu, Turkey, ²Trakya University, Faculty of Medicine, Department of Paediatric Surgery, Edirne, Turkey, ³Abant Izzet Baysal University, Faculty of Medicine, Department of Internal Medicine, Bolu, Turkey, ⁴Trakya University, Faculty of Medicine, Department of Histology and Embryology, Edirne, Turkey, ⁵Balikesir University, Faculty of Veterinary, Balikesir, Turkey, ⁶Selcuk University, Faculty of Medicine, Department of Gastroenterology, Konya, Turkey, ⁷Abant Izzet Baysal University, Medical Faculty, Department of Gastroenterology, Bolu, Turkey

P078: Walnut extract ameliorates acute and chronic colitis in murine models of colitisECCO '16 Amsterdam

Year: 2016

Authors:

S.-J. Koh*, K. L. Lee, J.W. Kim, B. G. Kim, Y. J. Jung

Seoul National University Boramae Hospital, Seoul National University College of Medicine, Internal Medicine, Seoul, South Korea

P079: Trehalose ameliorates colitis by increasing mucosal autophagy and M2 polarisationECCO '16 Amsterdam

Year: 2016

Authors:

J. Cosin-Roger*¹, D. Ortiz-Masia¹, D. C. Macias-Ceja², P. Salvador¹, L. Gisbert-Ferrandiz¹, C. Hernandez², S. Calatayud¹, M. D. Barrachina¹

¹University of Valencia, Valencia, Spain, ²Fisabio Hospital Peset, Valencia, Spain

P080: Modulation of T-cell glycosylation and the control of intestinal inflammationECCO '16 Amsterdam

Year: 2016

Authors:

A. M. Dias*^{1, 2}, A. Correia³, M. Pereira¹, C. R. Almeida⁴, M. Lima^{5, 6}, R. Marcos-Pinto^{2, 7, 8}, M. Vilanova^{2, 3}, C. A. Reis^{1, 2, 9}, P. Lago⁸,  S. S. Pinho^{1, 2}

¹Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) & i3S – Instituto de Investigação e Inovação em Saúde, Glycobiology in Cancer, Porto, Portugal, ²Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Porto, Portugal, ³Instituto de Investigação e Inovação em Saude (I3S)/Institute for Molecular and Cell Biology (IBMC), Immunobiology Group, Porto, Portugal, ⁴Instituto de Investigação e Inovação em Saude (I3S)/ Institute of Biomedical Engineering (INEB), NEWTherapies Group, University of Porto, Porto, Portugal, ⁵Centro Hospitalar do Porto , Multidisciplinary Unit for Biomedical Research (UMIB), Porto, Portugal, ⁶Centro Hospitalar do Porto, Haematology Department, Porto, Portugal, ⁷Medical Faculty, Centre for Research in HealthTechnologies and Information Systems (CINTESIS), Porto, Portugal, ⁸Centro Hospitalar do Porto, Department of Gastroenterology, Porto, Portugal, ⁹University of Porto, Medical Faculty, Porto, Portugal

P081: Evaluation of intestinal permeability with a triple sugar test in inflammatory bowel diseaseECCO '16 Amsterdam

Year: 2016

Authors:

D. Mukhametova¹, D. Abdulganieva*¹, S. Koshkin², S. Abdulhakov¹, A. Odintsova³

¹Kazan State Medical University, Kazan, Russian Federation, ²Kazan (Volga region) Federal University, Kazan, Russian Federation, ³Republican Clinical Hospital, Kazan, Russian Federation

P082: Anti-TNF-alpha therapy and apoptosisECCO '16 Amsterdam

Year: 2016

Authors:

R. Zaharie¹, F. Zaharie², A. Tantau*³, B. Petrushev⁴, M. Tantau⁴

¹University of Medicine and Pharmacy, Third Medical Clinic, Cluj-Napoca, Romania, ²University of Medicine and Pharmacy, Third Surgery Clinic, Cluj-Napoca, Romania, ³University of Medicine and Pharmacy, Fourth Medical Clinic, Cluj-Napoca, Romania, ⁴University of Medicine and Pharmacy, Third Medical Clinic, Cluj-Napoca, Romania

P083: Intestinal fatty acid binding protein as a biomarker of intestinal damage in children with coeliac and Crohn’s diseaseECCO '16 Amsterdam

Year: 2016

Authors:

C. M. Clark*¹, A. Kountouri¹, M. MacKinder¹, R. Hansen², R. K. Russell², K. Gerasimidis¹

¹University of Glasgow, Human Nutrition, School of Medicine, Glasgow, United Kingdom, ²Royal Hospital for Children, Department of Paediatric Gastroenterology, Glasgow, United Kingdom