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P024: Therapeutic potential of the human amniotic fluid mesenchymal stem cells/stroma cells secreted molecules in a mice model of colitisECCO '16 Amsterdam
Year: 2016
Authors:

M. Gazouli*1, E. Legaki1, M. Roubelakis1, A. Lazaris2, G. Karamanolis3, E. Marinos1, G. Theodoropoulos4

1School of Medicine, University of Athens, Biology, Athens, Greece, 2School of Medicine, University of Athens, Pathology, Athens, Greece, 3School of Medicine, University of Athens, Gastroenterology, Athens, Greece, 4School of Medicine, University of Athens, Surgery, Athens, Greece

P025: Tonsil-derived mesenchymal stem cell ameliorate intestinal fibrosis in chronic murine colitis modelECCO '16 Amsterdam
Year: 2016
Authors:

E. M. Song*1, S.-A. Jung1, S.-E. Kim1, K. E. Lee1, J. Y. Chang1, H. M. Son1, M. S. Ryu1, Y. H. Joo1, C. H. Tae1, C. M. Moon1, H.-K. Jung1, K.-N. Shim1, I. H. Jo2, Y. S. Yu2

1Ewha Woman’s University School of Medicine, Department of Internal Medicine, Ewha Medical Research Institute, Seoul, South Korea, 2Ewha Woman’ University School of Medicine, Department of Molecular Medicine, Ewha Medical Research Institute, Seoul, South Korea

P026: Characterisation of mucosal CD4+ T-cells in peripheral blood of healthy controls and paediatric inflammatory bowel disease patientsECCO '16 Amsterdam
Year: 2016
Authors:

M. Joosse*1, C. Menckeberg1, L. de Ruiter1, H. Raatgeep1, L. van Berkel1, F. Muskens2, R. Hendriks2, R. Hoogenboezem3, T. Cupedo3, L. de Ridder4, H. Escher4, S. Veenbergen1, J. Samsom1

1Erasmus MC, Laboratory of Paediatrics, division Gastroenterology and Nutrition, Rotterdam, Netherlands, 2Erasmus MC, Department of Pulmonary Medicine, Rotterdam, Netherlands, 3Erasmus MC, Department of Haematology, Rotterdam, Netherlands, 4Erasmus MC, Department of Paediatric Gastroenterology, Rotterdam, Netherlands

P027: Characterisation of human intestinal dendritic cells and macrophages through the lower gastrointestinal tract.ECCO '16 Amsterdam
Year: 2016
Authors:

D. Bernardo*, A. C. Marín, P. M. Linares, M. Jiménez, M. Chaparro, J. P. Gisbert

Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Gastroenterology Unit, Madrid, Spain

P028: Inflammatory bowel disease is associated with cytoskeleton rearrangement in the epithelial cellsECCO '16 Amsterdam
Year: 2016
Authors:

A. Portyanko1, P. Perevoschikov1, K. Ruksha1, J. Gorgun*2

1Belarusian State Medical University, Department of Pathology, Minsk, Belarus, 2Belarusian Medical Academy of Postgraduate Education, Department of Gastroenterology and Nutrition, Minsk, Belarus

P029: Intestinal mesenchymal-specific IKK2 promotes initiation of colitis and colitis-associated cancerECCO '16 Amsterdam
Year: 2016
Authors:

V. Koliaraki*1, M. Pasparakis2, G. Kollias1, 3

1BSRC "Alexander Fleming", Vari, Greece, 2University of Cologne, Institute of Genetics, Cologne, Germany, 3University of Athens, Department of Physiology, Athens, Greece

P030: Development of small bowel tissue phantom for microultrasound 
investigationECCO '16 Amsterdam
Year: 2016
Authors:

T. Anbarasan*1, C. E. M. Démoré1, H. Lay2, M. R. S. Sunoqrot1, R. Poltarjonoks1, S. Cochran2, B. F. Cox1

1University of Dundee, Dundee, United Kingdom, 2University of Glasgow, Glasgow, United Kingdom

P031: STAT6 deficiency alters macrophage polarisation and promotes fibrosis in a murine model of chronic inflammationECCO '16 Amsterdam
Year: 2016
Authors:

P. Salvador*1, D. Ortiz-Masiá1, D. C. Macias-Ceja1, 2, J. Cosín-Roger1, L. Gisbert-Ferrándiz1, C. Hernández2, S. Calatayud1, M. D. Barrachina-Sancho1

1University of Valencia, Valencia, Spain, 2Fisabio Hospital Peset, Valencia, Spain

P032: IFN-γ controls the immunomodulatory properties of bone marrow mesenchymal stem cells via a microRNA29a/STAT-3 dependent mechanismECCO '16 Amsterdam
Year: 2016
Authors:

A. Oikonomopoulos*1, P. Lacey1, T. Tomakili1, D. Iliopoulos2, 
D. W. Hommes1

1UCLA Centre for Inflammatory Bowel Diseases, Division of Digestive Diseases, Los Angeles, California, United States, 2UCLA Centre for Systems Biomedicine, Division of Digestive Diseases, Los Angeles, California, United States

P033: Anti-TNF-α therapy normalises aberrant cytokine production and homing profile of circulating dendritic cells in Crohn’s diseaseECCO '16 Amsterdam
Year: 2016
Authors:

P. Hendy*1, 2, D. Reddi2, D. Bernardo3, L. Durant2, A. Noble2, N. English2, S. Knight2, A. Hart1

1St Mark’s Hospital, Gastroenterology, LONDON, United Kingdom, 2Imperial College, Antigen Presentation Research Group, London, United Kingdom, 3Hospital Universitario de La Princesa, Department of Immunology, Madrid, Spain

P034: Immunoregulatory properties of human adipose–derived stem cells in inflammatory diseases: differences between Crohn´s disease and obesityECCO '16 Amsterdam
Year: 2016
Authors:

C. Serena*1, 2, N. Keiran2, M. Millan2, M. Ejarque1, 2, R. Fradera3, E. Espin4, K. Roche1, 2, J. Vendrell1, 2, S. Fernandez-Veledo1, 2

1Health Institute Pere Virgili, Research Unit, Tarragona, Spain, 2Hospital Joan XXIII, Tarragona, Spain, 3Hospital St. Pau i Sta Tecla, Tarragona, Spain, 4Hospital Vall d’Hebron, Barcelona, Spain

P035: Lamina propria CD4+LAP+ Foxp3- regulatory cells are involved in limiting the disease extension in Ulcerative ColitisECCO '16 Amsterdam
Year: 2016
Authors:

A. Butera1, A. Amendola1, M. Sanchez2, S. Piroli3, A. Pronio3, D. De Nitto4, R. Pica4, M. Boirivant*1

1Istituto Superiore di Sanità, Dept Infectious, Parasitic and Immune-mediated Diseases, Roma, Italy, 2Istituto Superiore di Sanità, Dept Cell Biology and Neurosciences, Rome, Italy, 3University ‘Sapienza’, Dept General Surgery, ‘P. Stefanini’, Roma, Italy, 4Sandro Pertini Hospital, IBD, GE Unit, Roma, Italy

P036: Colon targeted delivery of tofacitinib inhibits oxazolone-induced colitis in mice, despite low systemic exposureECCO '16 Amsterdam
Year: 2016
Authors:

F. Shen*, P. Brassil, S. Hegde, D. Beattie

Theravance Biopharma, South San Francisco, California, United States

P037: Remodelling events preceding clinical onset of intestinal inflammation reveal the predictive power of the extracellular matrix ECCO '16 Amsterdam
Year: 2016
Authors:

E. Shimshoni*1, R. Afik1, L. Puricelli2, A. Shenoy3, T. Geiger3, A. Podestà2, I. Sagi1

1Weizmann Institute of Science, Biological Regulation, Rehovot, Israel, 2University of Milan, Physics, Milan, Italy, 3Tel Aviv University, Human Genetics, Tel Aviv, Israel

P038: Revised roles of matrix metalloproteinase/MMP-9 in inflammatory bowel diseases: from target to biomarkerECCO '16 Amsterdam
Year: 2016
Authors:

M. de Bruyn*1, 2, C. Breynaert3, I. Arijs2, G. De Hertogh4, K. Geboes4, G. Thijs1, J. Hu5, J. Van Damme1, B. Arnold6, M. Ferrante7, S. Vermeire7, G. Van Assche7, J. Ceuppens3, G. Opdenakker1

1Rega Institute for Medical Research, KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium, 2Translational Research Centre for Gastrointestinal Disorders (TARGID), KU Leuven, Department of Clinical and Experimental Medicine, Leuven, Belgium, 3Laboratory of Clinical Immunology, KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium, 4Translational Cell and Tissue Research, KU Leuven, Department of Imaging and Pathology, Leuven, Belgium, 5Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Ministry of Education, Nanjing, China, 6German Cancer Research Centre (DKFZ), Department of Molecular Immunology, Heidelberg, Germany, 7University Hospitals Leuven, KU Leuven, Department of Gastroenterology, Leuven, Belgium

P039: Expression of the liver homing receptor CXCR3+ on colonic CD8+ T lymphocytes in patients with primary sclerosing cholangitis provides a possible link between colonic and biliary duct inflammation.ECCO '16 Amsterdam
Year: 2016
Authors:

M. Lampinen*1, A. Fredricsson1, J. Vessby1, A. Wanders2, F. Rorsman1, M. Carlson1

1Uppsala University, Medical Sciences, Uppsala, Sweden, 2Umeå University, Medical Biosciences, Umeå, Sweden

P040: Sonic hedgehog inhibitor prevented colitis-associated cancer via concerted mechanisms of IL-6/gp130 inhibition, 15-prostaglandin dehydrogenase induction, Bcl-2 abrogation, and tumour sphere inhibitionECCO '16 Amsterdam
Year: 2016
Authors:

K. B. Hahm*1, N. Kangwan1, Y. J. Kim2

1CHA University, Gastroenterology, Seongnam, South Korea, 2Gachon University, Gastroenterology, Incheon, South Korea

P041: Automated image analysis as a diagnostic tool in discriminating between subgroups of microscopic colitisECCO '16 Amsterdam
Year: 2016
Authors:

A.-M. Kanstrup-Fiehn1, M. Kristensson2, U. H. Engel3, L. K. Munck4, 5, 
S. Holck3, P. J. H. Engel*1, 5

1Roskilde Hospital, Department of Pathology, Roskilde, Denmark, 2Visiopharm, Hoersholm, Denmark, 3Copenhagen University Hospital, Department of Pathology, Hvidovre, Denmark, 4Koege Sygehus, Department of Gastroenterology, Koege, Denmark, 5University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark

P042: Circulating IL9 in inflammatory bowel disease: possible marker of mucosal non-healingECCO '16 Amsterdam
Year: 2016
Authors:

K. Neubauer*1, M. Krzystek-Korpacka2, M. Matusiewicz2, M. Zawadzki3, I. Bednarz-Misa2, S. Górska4, W. Witkiewicz5, A. Gamian6, 7

1Wroclaw Medical University, Gastroenterology and Hepatology, Wroclaw, Poland, 2Wroclaw Medical University, Medical Biochemistry, Wroclaw, Poland, 3Regional Specialist Hospital, Vascular Surgery, Wroclaw, Poland, 4LudwikHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Laboratory of Medical Microbiology, Wroclaw, Poland, 5Research and Development Centre at Regional Specialist Hospital, Wroclaw, Poland, 6Medical Wroclaw University, Medical Biochemistry, Wroclaw, Poland, 7LudwikHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

P043: Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitisECCO '16 Amsterdam
Year: 2016
Authors:

N. Duijvis*1, C. Kunne1, M. Slaman1, F. van Dooren1, E. Vogels1, S. Meijer2, K. Fluiter3, P. Moerland3, A. te Velde1

1Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 2Academic Medical Centre (AMC), Department of Pathology, Amsterdam, Netherlands, 3Academic Medical Centre (AMC), Department of Clinical Epidemiology, Amsterdam, Netherlands