Translational Gastroenterology Unit, Oxford, UK

St Mark's Hospital, London, UK

¹University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, IL, USA, ²Takeda Pharmaceuticals International AG, Zurich, Switzerland, ³Takeda Development Centre Europe Ltd., Evidence and Value Generation, London, UK

¹St John of God, Subiaco, IBD Center, Perth, Australia, ²Oxford University Hospitals, Oxford, UK, ³QIMR Berghofer Medical Research Institute, Brisbane, Australia, ⁴Mater Hospital, Brisbane, Australia, ⁵Austin Health, Melbourne, Australia, ⁶St Vincents Hospital, Melbourne, Australia, ⁷Eastern Health, Melbourne, Australia, ⁸St Vincents Hospital, Sydney, Australia, ⁹Flinders Medical centre, Adelaide, Australia, ¹⁰Liverpool Hospital, Sydney, Australia, ¹¹Royal Adelaide Hospital and University of Adelaide, Adelaide, Australia, ¹²The Alfred Hospital, Melbourne, Australia, ¹³The Chinese University of Hong Kong, Hong Kong, Hong Kong, ¹⁴Townsville Hospital, Townsville, Australia, ¹⁵Fiona Stanley Hospital, Perth, Australia, ¹⁶QIMR Berghofer Medical Research Institute, Brisbane, Australia, ¹⁷Flinders Medical Centre, Adelaide, Australia, ¹⁸The Chinese University of Hong Kong, Honk kong, Hong Kong

¹KU Leuven, Departement of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium, ²Hospital Haut-Lévêque, Bordeaux, France, ³Damiaan Hospital, Oostende, Belgium, ⁴Imelda Hospital, Bonheiden, Belgium, ⁵Hospital Estaing, Clermont-Ferrand, France, ⁶Hospital Archet, Nice, France, ⁷Sint-Lucas Hospital, Brugge, Belgium, ⁸Academic Medical Centre, Amsterdam, The Netherlands, ⁹University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, ¹⁰KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium

¹Lorraine University, Department of Gastroenterology and Inserm U954, Nancy, France, ²Arena Pharmaceuticals, Inc., San Diego, USA, ³Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain

¹Academic Medical Center (AMC) University of Amsterdam, Amsterdam, The Netherlands, ²School of Medicine, University of Osijek, Osijek, Croatia, ³Karolinska Institute, Stockholm, Sweden, ⁴Humanitas Clinical Institute, Milan, Italy, ⁵SetPoint Medical, Inc., Valencia, USA

¹Fondazione Policlinico A. Gemelli, Catholic University, Internal Medicine and Gastroenterology Unit, Presidio Columbus, Rome, Italy, ²Fondazione Policlinico A. Gemelli, Catholic University, Rheumatology Unit, Presidio Columbus, Rome, Italy, ³Fondazione Policlinico A. Gemelli, Catholic University, Internal Medicine and Gastroenterology Unit, Rome, Italy

¹Leeds Teaching Hospitals, Leeds, UK, ²Royal London Hospital, Barts Health, London, UK, ³Salisbury NHS Foundation Trust, Salisbury, UK, ⁴St Helens and Knowsley Foundation Trust, St Helens, UK, ⁵Kingston Hospital NHS Foundation Trust, Kingston upon Thames, UK, ⁶Bristol Royal Infirmary, Bristol, UK, ⁷Torbay and South Devon NHS Trust, Torbay, UK, ⁸Wirral University Teaching Hospital, Birkenhead, UK, ⁹Royal Bolton Hospital, Bolton, UK, ¹⁰North Manchester General Hospital, Manchester, UK, ¹¹University Hospital Llandough, Cardiff, UK, ¹²University College London Hospitals, London, UK, ¹³Epsom and St Helier University Hospitals NHS Trust, Epsom, UK, ¹⁴St George's University Hospitals NHS Foundation Trust, London, UK, ¹⁵Forth Valley Royal Hospital, Larbert, UK, ¹⁶Royal United Hospitals Bath NHS Foundation Trust, Bath, UK, ¹⁷East Kent Hospitals University NHS Foundation Trust, Margate, UK, ¹⁸Brighton and Sussex University Hospitals NHS Trust, Brighton, UK, ¹⁹Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

¹Division of Internal Medicine, ''Villa Sofia-Cervello'' Hospital, Palermo, Italy, ²Inflammatory Bowel Disease Unit, A.O.U. Policlinico "G. Martino”, Messina, Italy, ³IBD Unit, A.O. "Cannizzaro”, Catania, Italy, ⁴Gastroenterology and Hepatology Unit, A.O.U. Policlinico “G. Giaccone”, Palermo, Italy, ⁵Gastroenterology Unit, A.R.N.A.S. “Garibaldi”, Catania, Italy, ⁶Internal Medicine Unit, A.O.U. Policlinico “Vittorio Emanuele”, Catania, Italy, ⁷Gastroenterology Unit, A.O.U. Policlinico “Vittorio Emanuele”, Catania, Italy, ⁸Gastroenterology and Endoscopy Unit, A.R.N.A.S. “Civico Di Cristina Benfratelli”, Palermo, Italy, ⁹Gastroenterology Unit, A.O. “Guzzardi”, Vittoria, Italy, ¹⁰Gastroenterology Unit, A.O.O.R. “S. Elia- M. Raimondi”, Caltanissetta, Italy, ¹¹Gastroenterology Unit, A.O. “Santa Marta e S. Venera”, Acireale, Italy, ¹²Surgery Unit, A.O. “Umberto I”, Siracusa, Italy, ¹³Internal Medicine Unit, A.O. “Giovanni Paolo II”, Sciacca, Italy, ¹⁴Gastroenterology and Endoscopy Unit, A.O. “S. Antonio Abate”, Trapani, Italy, ¹⁵Gastroenterology Unit, A.O.O.R. “Papardo Piemonte”, Messina, Italy, Messina, Italy, ¹⁶Gastroenterology and Endoscopy Unit, A.O. “Buccheri La Ferla Fatebenefratelli”, Palermo, Italy

¹Academic Medical Center (AMC), Department of Surgery, Amsterdam, The Netherlands, ²St Vincent's University Hospital, Department of Colorectal Disease, Dublin, Ireland, ³Academic Medical Center (AMC), Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands

¹CHU UCL Namur, Catholic University of Louvain, Gastroenterology and Hepatology, Yvoir, Belgium, ²University of Saint Etienne, Department of Gastroenterology, Saint Etienne, France, ³Faculty of Medicine of Saint-Etienne, University of Lyon, EA-3064, Groupe Immunité des Muqueuses et Agents Pathogènes (GIMAP), Lyon, France, ⁴CHU UCL Namur, Scientific Support Unit, Yvoir, Belgium, ⁵University of Saint Etienne, Laboratory of Infectious Agents and Hygiene, Saint Etienne, France

¹Bata Regional Hospital, Internal Clinic, Zlin, Czech Republic, ²Third Faculty of Medicine, Charles University in Prague, 2nd Department of Internal Medicine, Prague, Czech Republic, ³Third Faculty of Medicine, Charles University in Prague, 2nd Department of Internal Medicine, Prague, Czech Republic, ⁴Thomayer Hospital, 2nd Department of Internal Medicine, Prague, Czech Republic

¹Institute of Social and Preventive Medicine, Healthcare Evaluation Unit, Lausanne, Switzerland, ²Lausanne University Hospital, Department of Gastroenterology and Hepatology, Lausanne, Switzerland, ³Lindenhof Spital, Division of Gastroenterology, Bern, Switzerland, ⁴Institute of Social and Preventive Medicine, Centre for Integrative and Complementary Medicines, Lausanne, Switzerland

St Vincents University Hospital and School of Medicine, University College Dublin, Centre for Colorectal Disease, Dublin 4, Ireland

¹Gastro-entérologie La Source-Beaulieu and Division of Gastroenterology, Centre Hospitalier Universitaire Vaudois, Crohn and Colitis Center, Lausanne, Switzerland, ²Takeda Pharmaceuticals International AG, Zurich, Switzerland, ³Hôpital Saint-Louis, APHP, INSERM UMRS 1160, Université Denis Diderot, Gastroenterology and Hepatology, Paris, France

¹Erasmus MC, Sophia Children's Hospital, Paediatric Gastroenterology, Rotterdam, The Netherlands, ²Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, Paediatric Gastroenterology, London, UK, ³Université Paris Descartes, Sorbonne Paris Cité, APHP, Hopital Necker Enfants Malades, Department of Paediatric Gastroenterology, Paris, France

¹Gangnam Severance Hospital, Yonsei University College of Medicine, Internal Medicine, Seoul, South Korea, ²Seoul National University College of Medicine, Preventive Medicine, Seoul, South Korea, ³Severance Hospital, Yonsei University College of Medicine, Internal Medicine, Seoul, South Korea

University of Chicago Medicine, Inflammatory Bowel Disease Center, Chicago, USA

¹Radboudumc, Nijmegen, The Netherlands, ²Maastricht University Medical Center (MUMC), Maastricht, The Netherlands, ³Erasmus Medical Center, Rotterdam, The Netherlands, ⁴University Medical Center Groningen, Groningen, The Netherlands, ⁵Leiden University Medical Center (LUMC), Department of Gastroenterology and Hepatology, Leiden, The Netherlands, ⁶University Medical Centre Utrecht, Utrecht, The Netherlands, ⁷VU University Medical Centre Institute of Education, Department of Gastroenterology and Hepatology, Room J393, Amsterdam, The Netherlands, ⁸Academic Medical Center (AMC), Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands, ⁹Radboudumc, Department of Gastroenterology and Hepatology, Nijmegen, The Netherlands