¹Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) & Institute for Research and Innovation in Health (i3S), Porto, Portugal, ²Centro Hospitalar do Porto, Department of Gastroenterology, Porto, Portugal, ³Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Porto, Portugal

¹Nordic Bioscience, Biomarkers & Research, Herlev, Denmark, ²Odense University Hospital, Department of Gastroenterology, Odense, Denmark

¹University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France, ²UMR 1071 Inserm/Université d’Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the host, Clermont-Ferrand, France, ³University Hospital G. Montpied, Biochemistry laboratory, Clermont-Ferrand, France, ⁴GM – Clermont-Ferrand University and Medical Centre, Biostatistics Unit, Clermont-Ferrand, France

¹University of Groningen, Department of Pharmaceutical Technology and Biopharmacy, Groningen, Netherlands, ²University Medical Centre Groningen, Department of Gastro-enterology and Hepatology, Groningen, Netherlands, ³Nordic Bioscience, Biomarkers and Research, Herlev, Denmark

¹Örebro University, Faculty of Medicine and Health, Örebro, Sweden, ²Karolinska Institutet, Department of Medicine, Solna, Sweden

¹Akershus University Hospital, Department of Gastroenterology, Lørenskog/Nordbyhagen, Norway, ²Genetic Analysis AS, Oslo, Norway

Janssen R & D, LLC, Spring House, Pennsylvania, United States

¹Hospital Clinic Barcelona, Barcelona, Spain, ²Hospital U. Fundación Jiménez-Díaz, Madrid, Spain, ³University Hospitals Leuven, KU Leuven, Leuven, Belgium, ⁴Icahn School of Medicine at Mount Sinai, New York, New York, United States, ⁵Medical University of Vienna, Vienna, Austria, ⁶Charité Medical School - Humboldt-University of Berlin, Berlin, Germany, ⁷CHU Lille, Lille, France, ⁸Hôpital Nord, Marseille, France, ⁹Hospital Virgen del Rocío, Sevilla, Spain, ¹⁰Sharee Zedek MC, Jerusalem, Israel, ¹¹TiGenix, Madrid, Spain, ¹²Istituto Clinico Humanitas, Milano, Italy

¹University of Erlangen-Nuernberg, Department of Medicine 1, Erlangen, Germany, ²Aleris Medilab, Department of Pathology and Cytology, Täby, Sweden, ³Index Pharmaceuticals, Stockholm, Sweden, ⁴Catholic University of Rome, Internal Medicine Department / Gastroenterology Division, Rome, Italy, ⁵Nottingham University Hospitals, Department of Gastroenterology, Nottingham, United Kingdom

¹Semmelweis University, First Department of Medicine, Budapest, Hungary, ²University of Szeged, First Department of Medicine, Szeged, Hungary, ³Military Hospital, State Health Centre, Department of Gastroenterology, Budapest, Hungary, ⁴Peterfy Hospital, First Department of Medicine, Budapest, Hungary, ⁵Zala County Hospital, Second Department of Medicine, Zalaegerszeg, Hungary, ⁶B-A-Z County and University Teaching Hospital, Second Department of Medicine, Miskolc, Hungary, ⁷Csolnoky F. Province Hospital, Department of Medicine, Veszprem, Hungary, ⁸Semmelweis University, Second Department of Medicine, Budapest, Hungary, ⁹University of Debrecen, Institute of Medicine, Department of Gastroenterology, Debrecen, Hungary, ¹⁰Markusovszky Hospital, First Department of Medicine and Gastroenterology, Szombathely, Iceland, ¹¹Tolna County Teaching Hospital, First Department of Gastroenterology, Szekszard, Hungary, ¹²University of Szeged, First Department of Internal Medicine, Szeged, Hungary, ¹³Janos Hospital, Department of Gastroenterology, Budapest, Hungary, ¹⁴University of Pécs, First Department of Medicine, Pécs, Hungary, ¹⁵Semmelweis University, Department of Laboratory Medicine, Budapest, Hungary

Janssen R & D, LLC, Spring House, Pennsylvania, United States

¹Department of Clinical and Experimental Medicine, KU Leuven, Translational Research in Gastrointestinal Disorders (TARGID), Leuven, Belgium, ²University Hospitals Leuven, Gastroenterology - 
Translational Research Centre for Gastrointestinal Disorders (TARGID), Leuven, Belgium, ³KU Leuven, Laboratory for Therapeutic and Diagnostic Antibodies, Leuven, Belgium

¹Academic Medical Centre, Gastroenterology and Hepatology, Amsterdam, Netherlands, ²Academic Medical Centre, Tytgat Institute, Amsterdam, Netherlands, ³Erasmus Medical Centre, Department of Gastroenterology and Hepatology, Rotterdam, Netherlands, ⁴Beatson Institute for Cancer Research, Glasgow, United Kingdom

¹University of Edinburgh, CGEM, Edinburgh, United Kingdom, ²Centro Nacional de Análisis Genómico, Barcelona, Spain, ³University Of Edinburgh, Department of Child Life and Health, Edinburgh, United Kingdom

¹University of Groningen and University Medical Centre Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands, ²Academic Medical Centre, Department of Gastroenterology and Hepatology, Amsterdam, Netherlands, ³University of Cambridge, Department of Medicine, Division of Hepatology, Cambridge, United Kingdom, ⁴Sapienza University of Rome, Department of Clinical Medicine, Division of Gastroenterology, Rome, Italy, ⁵Karolinska University Hospital Huddinge, Karolinska Institutet, Department of Gastroenterology and Hepatology, Stockholm, Sweden, ⁶Landspitali University Hospital, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Reykjavik, Iceland, ⁷Oslo University Hospital, Rikshospitalet, Norwegian PSC Research Centre, Division of Cancer Medicine, Surgery and Transplantation, Oslo, Norway, ⁸University of California Davis, Division of Gastroenterology and Hepatology, Davis, California, United States, ⁹John Radcliffe University Hospitals NHS Trust, Department of Hepatology, Oxford, United Kingdom, ¹⁰Hôpital Saint Antoine and U.P.M.C. Univ Paris 06, AP-HP and Department of Hepatology, Paris, France, ¹¹University Health Network - Toronto General Hospital, Gen. Internal Medicine, Toronto, Canada, ¹²Medical School, University of Thessaly, Department of Medicine and Research Laboratory of Internal Medicine, Larissa, Greece, ¹³University of Calgary, Snyder Institute of Chronic Diseases, Department of Medicine, Calgary, Canada, ¹⁴Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany, ¹⁵Helsinki University Hospital, Division of Gastroenterology, Department of Medicine, Helsinki, Finland, ¹⁶University of Padova, Dept. of Surgical, Oncological and Gastroenterological Sciences, Padova, Italy, ¹⁷Norfolk and Norwich University Hospital, Department of Gastroenterology, Norwich, United Kingdom, ¹⁸University Hospital of Heidelberg, Department of Medicine, Heidelberg, Germany, ¹⁹University of Toronto, Division of Gastroenterology, Department of Medicine, Toronto, Canada, ²⁰Leiden University Medical Centre, Department of Gastroenterology and Hepatology, Leiden, Netherlands, ²¹University of Munich, Department of Medicine II, Munich, Germany, ²²Humanitas Clinical and Research Centre, Centre for Autoimmune Liver Diseases, Rozzano, Italy, ²³Mayo Clinic, Division of Gastroenterology and Hepatology, Rochester, Minnesota, United States, ²⁴Mayo Clinic, College of Medicine, Centre for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Rochester, Minnesota, United States, ²⁵Institute for Molecular Medicine Finland F.I.M.M., University of Helsinki and National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland, ²⁶Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, ²⁷Karolinska Institute, Department of, Stockholm, Sweden, ²⁸Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany, ²⁹Institute of Medicine, Sahlgrenska Academy and University Hospital, Department of Internal Medicine, Gothenburg, Sweden, ³⁰Università Politecnica delle Marche, Ospedali Riuniti University Hospital, Department of Gastroenterology, Ancona, Italy, ³¹University of Alberta, Division of Gastroenterology and Hepatology, Edmonton, Alberta, Canada, ³²Medical University of Warsaw, Liver and Internal Medicine Unit, Warsaw, Poland, ³³Charité Universitätsmedizin Berlin, Department of Internal Medicine, Hepatology and Gastroenterology, Berlin, Germany, ³⁴University of Barcelona, Liver Unit, Hospital Clinic, I.D.I.B.A.P.S., C.I.B.E.R.ehd, Barcelona, Spain, ³⁵University Hospital of Heidelberg, Department of Internal Medicine IV, Heidelberg, Germany, ³⁶University Hospitals NHS Trust, Department of Gastroenterology and Hepatology, Norfolk and Norwich, Norwich, United Kingdom, ³⁷University of Munich, Department of Medicine 2, Grosshadern, Munich, Germany, ³⁸Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory, Cambridge, United Kingdom, ³⁹University of Cambridge, Academic Department of Medical Genetics, Cambridge, United Kingdom, ⁴⁰University Medical Centre Hamburg-Eppendorf, 1st Department of Medicine, Hamburg, Germany, ⁴¹Mount Sinai Hospital Toronto, Inflammatory Bowel Disease Group, Zane Cohen Centre for Digestive Diseases, Toronto, Ontario, Canada, ⁴²University Medical Centre Hamburg-Eppendorf, Department of Hepatobiliary Surgery and Transplantation, Hamburg, Germany, ⁴³University of Mainz, First Department of Medicine, Mainz, Germany, ⁴⁴Christian-Albrechts-University of Kiel, Institute for Epidemiology, Kiel, Germany, ⁴⁵University of Groningen and University Medical Centre Groningen, Department of Genetics, Groningen, Netherlands, ⁴⁶University of Thessaly, Department of Internal Medicine, Larissa, Greece, ⁴⁷Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, Massachusetts, United States

¹University of Groningen and University Medical Centre Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands, ²University of Groningen and University Medical Centre Groningen, Department of Genetics, Groningen, Netherlands, ³The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States, ⁴Harvard School of Public Health, Biostatistics Department, Boston, Massachusetts, United States

¹University Hospital, Gastroenterology, Saint-Etienne, France, ²University of Saint-Etienne, Immunology, Saint-Etienne, France, ³University Hospital, Rheumatology, Saint-Etienne, France, ⁴CHU Saint-Etienne, Saint-Etienne, France, ⁵CHU de Nancy, Department of Gastroenterology, Vandoeuvre-lès-nancy, France, ⁶Mount Sinai Hospital, New York, New York, United States

¹Iwate Medical University, Division of Gastroenterology, Department of Medicine, Morioka, Japan, ²Sapporo Kosei General Hospital, Inflammatory Bowel Disease Centre, Sapporo, Japan, ³Osaka City General Hospital, Division of Gastroenterology, Osaka, Japan, ⁴Kyorin University School of Medicine, The Third Department of Internal Medicine, Tokyo, Japan, ⁵Kyoto University, Department of Gastroenterology and Hepatology, Endoscopic Medicine, Kyoto, Japan, ⁶Tokyo Yamate Medical Centre, Department of Medicine, Division of Gastroenterology, Tokyo, Japan, ⁷Oita Red Cross Hospital, Department of Gastroenterology, Oita, Japan, ⁸Saitama Medical Centre, Saitama Medical University, Department of Gastroenterology and Hepatology, Kawagoe, Japan, ⁹Chiba University, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba, Japan, ¹⁰Kyushu University, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Fukuoka, Japan, ¹¹Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Tokyo, Japan, ¹²Fukuoka University Chikushi Hospital, Department of Gastroenterology, Chikushino, Japan, ¹³Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Department of Molecular Gastroenterology and Hepatology, Kyoto, Japan, ¹⁴Keio University, Department of Internal Medicine, School of Medicine, Tokyo, Japan, ¹⁵Toho University Sakura Medical Centre, Department of Internal Medicine, Sakura, Japan, ¹⁶The Institute of Medical Science Hospital, The University of Tokyo, Centre for Translational Research, Tokyo, Japan, ¹⁷Kitasato University Kitasato Institute Hospital, Centre for Advanced IBD Research and Treatment, Tokyo, Japan

¹St. Mark’s Hospital, London, United Kingdom, ²Barts Cancer Institute, Tumour Biology, London, United Kingdom, ³University Hospital of North Tees, Department of Gastroenterology, Stockton-on-Tees, Teesside, United Kingdom

¹Maastricht University Medical Centre, Internal Medicine - Division of Gastroenterology and Hepatology, Maastricht, Netherlands, ²Maastricht University Medical Centre, NUTRIM - School for Nutrition and Translational Research in Metabolism, Maastricht, Netherlands, ³Maastricht University Medical Centre, Complex Genetics - School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht, Netherlands, ⁴Maastricht University Medical Centre, CAPHRI - School for Public Health and Primary Care, Maastricht, Netherlands, ⁵Zuyderland Medical Centre, Internal Medicine and Gastroenterology-Hepatology, Sittard-Geleen, Netherlands, ⁶Zuyderland Medical Centre, Internal Medicine and Gastroenterology-Hepatology, Heerlen, Netherlands