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DOP81 Time to loss of efficacy among patients in remission following induction treatment with tofacitinib 10 mg BID who reduced tofacitinib dose or discontinued tofacitinib in OCTAVE sustain

ECCO'20 Vienna

Year: 2020
Authors:

M.C. Dubinsky1, J.W. Chou2, C. Su3, W. Wang3, I. Modesto4, X. Guo3, S. Vermeire5

1Icahn School of Medicine at Mount Sinai, New York, NY, USA, 2Division of Gastroenterology and Hepatology, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan, Province of China, 3Pfizer Inc., Collegeville, PA, USA, 4Pfizer Inc., New York, NY, USA, 5Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium

DOP82 Macrophages in Crohn’s disease mesentery are predominantly inflammatory and produce calprotectin

ECCO'20 Vienna

Year: 2020
Authors:

F.M. Bloemendaal1, M. Becker1, P.J. Koelink1, J.D. van der Bilt2,3, W.A. Bemelman2, G.R.A.M. D’Haens4, C.J. Buskens2, M.E. Wildenberg1,4

1Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Amsterdam, The Netherlands, 2Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands, 3Department of Surgery, Flevoziekenhuis, Almere, The Netherlands, 4Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam, The Netherlands

DOP83 Intestinal fibrosis in Crohn’s disease patients is marked by up-regulation of innate immune cells and mucosal B cells

ECCO'20 Vienna

Year: 2020
Authors:

B. Creyns1,2, D. Gabriele3, C. Jonathan1,2, B. Verstockt2, G. Bislenghi4, F. Marc2,4, S. Vermeire2,4, G. Van Assche2,4, J. Ceuppens1, A. D’Hoore4, G. De Hertogh5, C. Breynaert1,6, Allergy and Clinical Immunology Research Group

1KU Leuven, Department of Microbiology, Immunology and Transplantation- Allergy and Clinical Immunology Research Group,Leuven, Belgium, 2KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders TARGID, Leuven, Belgium, 3Clinical Gastroenterology Unit, Department of Biomedical Clinical and Experimental Sciences Mario Serio, University of Florence, Florence, Italy, 4Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium, 5Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium, 6Department of General Internal Medicine, University Hospitals Leuven, KU Leuven, Leuven, Belgium

DOP84 Crohn’s disease modifies the DNA methylome of human adipose-stem cells, which is only partially re-established in remission

ECCO'20 Vienna

Year: 2020
Authors:

C. Serena1, M. Millan2, M. Ejarque1, A. Saera-Vila1, D. Monfort-Ferré1, M. Bautista3, M. Menacho3, M. Martí4, E. Espin4, J. Vendrell1, S. Fernández-Veledo1

1Health Institute Pere Virgili IISPV, Hospital Joan XXIII of Tarragona, Tarragona, Spain, 2General Surgery Service, Hospital Joan XXIII, Tarragona, Spain, 3Digestive Unit, Hospital Joan XXIIII, Tarragona, Spain, 4General Surgery Service, Hospital University Vall d’Hebron, Barcelona, Spain

DOP85 The role of fibroblasts in the pathogenesis of Crohn’s disease-associated fistulas and in mesenchymal stem cell therapy

ECCO'20 Vienna

Year: 2020
Authors:

R.S. Bruckner1, M.C. Barnhoorn1, H. Mei2, S.M. Kiełbasa2, T.J. Harrijvan1, S.K. Hakuno1, J.J. van der Reijden1, A.E. van der Meulen-de Jong1, L.J.A.C. Hawinkels1

1Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands, 2Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands

DOP86 An IFN-STAT1-MLKL axis drives programmed necrosis of Paneth cells in Crohn’s ileitis

ECCO'20 Vienna

Year: 2020
Authors:

L. HARTMANN1, B. Siegmund2, C. Weidinger2, C. Becker1, M.F. Neurath1, C. Günther1

1University Clinic Erlangen, Department of Medicine 1, Erlangen, Germany, 2Charité, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Berlin, Germany

DOP87 SUCNR1 a novel key protagonist in fistula development

ECCO'20 Vienna

Year: 2020
Authors:

C. Bauset1, L. Gisbert-Ferrandiz1, D. Ortiz-Masia2, S. Coll1, C. Mamie3, M. Scharl3, S. Calatayud1, M.D. Barrachina1, J. Cosín-Roger4

1Department of Pharmacology, Universidad de Valencia, Valencia, Spain, 2Department of Medicine, Universidad de Valencia, Valencia, Spain, 3Department of Gastroenterology, UniversitatsSpital Zurich, Zurich, Switzerland, 4Department of Endocrinology and Metabolism, Hospital Dr. Peset, Valencia, Spain

DOP88 Visceral fat area correlates well with anti-TNFα drug levels and secondary loss of response in Crohn’s disease patients

ECCO'20 Vienna

Year: 2020
Authors:

Z. Lim1, C. Welman2, W. Raymond3, L. Thin1,3

1Department of Gastroenterology, Fiona Stanley Hospital, Perth, Australia, 2Department of Radiology, Fiona Stanley Hospital, Perth, Australia, 3School of Medicine and Pharmacology, University of Western Australia, Perth, Australia

DOP89 Pre-treatment mucosal inflammatory and wound healing gene programmes reveal mechanisms associated with future stricturing behaviour during 5-year follow-up in paediatric Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

Y. Haberman Ziv1, P. Minar1, R. Karns1, P. Dexheimer1, S. Ghandikota1, S. Tegge1, D. Shapiro1, B. Shuler1, S. Venkateswaran2, T. Braun3, B. Aronow1, G. Gibson4, J. Hyams5, S. Kugathasan2, A. Jegga1, L. Denson1, CCF sponsored RISK Study

1Department of Gastroenterology, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, USA, 2Department of Gastroenterology, Emory University, Atlanta, USA, 3Department of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel, 4Institute of Technology, Georgia Institute of Technology, Atlanta, USA, 5Department of Gastroenterology, Connecticut Children’s Medical Center, Hartford, USA

DOP90 The role of Nlrp9b, a novel NLR member in regulating experimental colitis

ECCO'20 Vienna

Year: 2020
Authors:

D. Zheng1,2, M. Levy1, E. Elinav1

1Immunology Department, Weizmann Institute of Science, Rehovot, Israel, 2Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

N01 Factors related to self-medication with corticosteroids, aminosalicylates or analgesics and reasons given by patients with ulcerative colitis from Spain

ECCO'20 Vienna

Year: 2020
Authors:

M. Cañas1, F. Mesonero2, I. Rodriguez-Lago3, C. Savini4, R. Saldaña4, L. Feo-Luca5, S. FERNANDEZ5, L. Cea-Calvo5, B. Juliá5

1Hospital Clínico San Carlos, Gastroenterology Department, Madrid, Spain, 2Hospital Ramón y Cajal, Gastroenterology Department- IBD Unit, Madrid, Spain, 3Hospital de Galdakao, Gastroenterology Department- IBD Unit, Madrid, Spain, 4Spanish confederation of associations of patients with Crohn′s disease and Ulcerative colitis ACCU, accu, Madrid, Spain, 5Merck Sharp & Dohme of Spain, Medical Affairs Department, Madrid, Spain

N02 The IBD-BOOST programme: developing a digital self-management intervention for symptoms of fatigue, pain and urgency in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

S. Windgassen1, M. Artom2, C. Norton3, L. Sweeney3, R. Moss-Morris2

1King’s College London, Psychological Medicine, London, UK, 2King’s College London, Health Psychology Section, London, UK, 3King’s College London, Florence Nightingale Faculty of Nursing-Midwifery and Palliative Care, London, UK

N03 Disease burden of patients with inflammatory bowel disease from the viewpoint of QOL and depression

ECCO'20 Vienna

Year: 2020
Authors:

M. Takahashi1, N. Aoyama2, M. Nunotani3

1Mukogawa Women’s University- Graduate School of Nursing, Department of nursing, Nishinomiya, Japan, 2Aoyama Clinic GI endoscopy & IBD, Gastroenterology, Kobe, Japan, 3Mukogawa Women’s University, Department of nursing, Nishinomiya, Japan

N05 IBDoc® Faecal calprotectin self-test retrospective audit in a District General Hospital (DGH)

ECCO'20 Vienna

Year: 2020
Authors:

P. Avery, K. Blackmore, C. Angel

Dorset County Hospital, inflammatory bowel disease, Dorchester, UK

N06 Help-seeking behaviours for fatigue in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

D. NI DHALAIGH, G. Anna Marie, D. Farrell

Institute of Technology Tralee, Nursing, Kerry, Ireland

N07 Patient reported outcome measures collected from patients using a digital tablet: early benefits

ECCO'20 Vienna

Year: 2020
Authors:

P. Avery1, K. Blackmore2, C. Angel1

1Dorset County Hospital, Inflammatory Bowel Disease Nursing, Dorchester, UK, 2Dorset County Hospital, inflammatory bowel disease, Dorchester, UK