¹University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland, ²University of Lausanne, Institute of Social and Preventive Medicine, Lausanne, Switzerland, ³Center of Gastroenterology Klinik Hirslanden, Zurich, Switzerland, ⁴Gastroenterology Bethanien, Zurich, Switzerland, ⁵Center of Gastroenterology and Hepatology, Zurich, Zurich, Switzerland, ⁶University of Lausanne, Lausanne, Switzerland, ⁷University Hospital Zurich, Department of Medical Oncology and Hematology, Zurich, Switzerland, ⁸Inselspital Bern University Hospital, Department of Visceral Surgery and Medicine, Bern, Switzerland, ⁹University Hospital Zurich, Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, Zurich, Switzerland

¹Eli Lilly and Company, Indianapolis, USA

¹Evangelismos General Hospital of Athens, Gastroenterology Department, Athens, Greece, ²University Hospital of Heraklion, Gastroenterology Department, Heraklion, Greece, ³First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece, ⁴School of Health Science and Education, Harokopio University, Athens, Greece

¹Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, South Korea, ²The Catholic University of Korea College of Medicine, Department of Medical Statistics, Seoul, South Korea

¹Azienda Ospedaliero Universitaria Pisana, Department of Surgery and Gastroenterology, Pisa, Italy, ²Istituto di Tecnologie Biomediche, CNR, Pisa, Italy, ³University of Pisa, Department of New Technologies and Translational Research in Medicine and Surgery, Pisa, Italy

¹Shaare Tzedek Medical Center, The Juliet Keiden Institute of Pediatric Gastroenterology and Nutrition, Jerusalem, Israel, ²Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel, Department of Gastroenterology and Hepatology, Beer Sheva, Israel, ³The Hebrew University- Hadassah Medical Center, Unit of Epidemiology, Jerusalem, Israel, ⁴Clalit Research Institute, Chief’s Office, Clalit Health Services, Tel-Aviv, Israel, ⁵Maccabi Healthcare Services, Tel-Aviv, Israel, ⁶Meuhedet Health Services, Tel-Aviv, Israel, ⁷Leumit Health Services, Tel-Aviv, Israel, ⁸Icahn Institute for Genomics and Multiscale Biology at Mount Sinai, Department of Genetics and Genomics, New York City, Israel

¹Hospital Universitario Gregorio Marañón, Gastroenterology, Madrid, Spain, ²Hospital Universitari Vall d'Hebron, Crohn-Colitis Care Unit, Barcelona, Spain, ³Elche University Hospital, Gastroenterology, Elche, Spain, ⁴Medical Affairs, Merck Sharp and Dohme, Madrid, Spain, ⁵Medical Affairs, Merck Sharp and Dohme, Spain, Madrid, Spain

¹IBD Unit, "Villa Sofia-Cervello" Hospital, Palermo, Italy, ²Department of Sciences for Health Promotion ‘ G. D’Alessandro’, University of Palermo, Palermo, Italy, ³Gastroenterology of Pediatric Unit, Maggiore Hospital, Bologna, Italy, ⁴Infectious Disease Unit, Department of Biomedical and Clinical Sciences, ‘Luigi Sacco’ University Hospital, Milan, Italy, ⁵IBD Unit, Presidio Columbus Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy, ⁶Department of Biochemical and Clinical Science "L. Sacco" - University of Milan, ASST Fatebenefratelli Sacco, Milan, Italy

¹University "Tor Vergata" of Rome, Department of Systems Medicine, Rome, Italy, ²Internal Medicine and Gastroenterology - Complesso Integrato Columbus Catholic University, Complesso Integrato Columbus, Internal Medicine and Gastroenterology, Rome, Italy, ³Azienda Ospedaliera S.Camillo-Forlanini, Gastroenterology Unit, Rome, Italy, ⁴Federico II University, Gastroenterologia AOU, Gastroenterologia AOU, Naples, Naples, Italy, ⁵University of Padua, Department of Surgical, Oncological and Gastroenterological Sciences, Padua, Italy, ⁶A.O. Mauriziano, Gastroenterology Unit, Turin, Italy, ⁷S. Filippo Neri Hospital, Gastroenterology Unit, Rome, Italy, ⁸IRCCS ca' Granda, Ospedale Maggiore Policlinico Foundation University of Milan della Carita, Gastroenterology and Endoscopy Unit, Milan, Italy, ⁹University of Messina, Department of Clinical and Experimental Medicine, Clinical Unit for Chroric Bowel Disorders, Messina, Italy, ¹⁰University della Campania ‘Luigi Vanvitelli’, U.O. of Gastroenterology C.S., Naples, Italy, ¹¹Ospedale Maggiore, Unit PEDIATRIA, Bologna, Italy, ¹²Hospital Civico, Gastroenterology, Palermo, Italy, ¹³University "Tor Vergata" of Rome, GI Unit, Department of Systems Medicine, Rome, Italy, ¹⁴Federico II University, Gastroenterologia AOU, Naples, Italy, ¹⁵University, Department of Systems Medicine, Rome, Italy, ¹⁶Hospital Civico, Gastroenterology Unit, Palermo, Italy, ¹⁷IRCCS Policlinico S. Donato, San Donato Milanese, Gi Unit, Milan, Italy, ¹⁸AOU Careggi Univesrity Hospital, Gi Unit, Florence, Italy, ¹⁹Hospital ‘Riuniti Villa Sofia-Cervello’, Di.Bi.Mis., C.O.U. Of Internal Medicine, Palermo, Italy, ²⁰SOFAR Ospedale San Giuseppe, Gi Unit, Milan, Italy, ²¹Complesso Integrato Columbus Catholic University, Complesso Integrato Columbus, Internal Medicine and Gastroenterology, Rome, Italy

¹University Hospital Galway, Galway, Ireland, ²Univeristy Hospital Galway, Galway, Ireland

¹IRCCS Sacro Cuore Don Calabria, IBD Unit, Negrar, Italy, ²IRCCS Sacro Cuore Don Calabria, Rheumatology, Negrar, Italy

¹General Hospital of Nikea and Piraeus "Agios Panteleimon", Gastroenterology, Athens, Greece, ²General Hospital of Heraklion "Venizeleio", Gastroenterology, Heraklion, Greece, ³University General Hospital of Heraklion, Nephrology, Heraklion, Greece

¹Connolly Hospital and RCSI, Blanchardstown, Dublin 15, Department of Gastroenterology, Dublin, Ireland

¹GlaxoSmithKline, Stevenage, UK, ²GlaxoSmithKline, Upper Providence, USA, ³GlaxoSmithKline, London, UK, ⁴Adelphi Real World, Cheshire, UK

¹University Hospital Bratislava, 5th Department of Internal Medicine, Bratislava, Slovakia

¹Hospital Universitario de La Princesa, IIS-IP , Universidad Autónoma de Madrid and CIBEREHD, Gastroenterology Unit, Madrid, Spain, ²Ekineo Business Intelligence / www.in-pacient.es Barcelona, Spain

¹Brotzu Hospital, Gastroenterology Unit, Cagliari, Italy, ²San Martino Hospital, Endoscopy, Oristano, Italy, ³University of Sassari, Clinica Medica, Sassari, Italy, ⁴Territorial Gastroenterology, Sassari, Italy, ⁵Santissima Annunziata Hospital, Gastroenterology Unit, Sassari, Italy, ⁶University of Cagliari, Gastroenterology Unit, Cagliari, Italy, ⁷NS di Bonaria Hospital, Endoscopy, San Gavino, Italy

¹The Catholic University of Korea, Seoul, South Korea, ²Inje University Haeundae Paik, Pusan, South Korea, ³Hanyang University College of Medicine, Seoul, South Korea, ⁴Pusan National University School of Medicine, Pusan, South Korea, ⁵Seoul National University Hospital, Healthcare System Gangnam Center, Seoul, South Korea, ⁶Inje University Ilsan Paik Hospital, Gyeonggi, South Korea, ⁷Ewha Womans University School of Medicine, Seoul, South Korea

¹Sahloul Sousse, Gastroenterology, Sousse, Tunisia, ²Sahloul Sousse, Sousse, Tunisia

¹Hospital Universitario San Cecilio, UGC Aparato Digestivo, Granada, Spain