¹University Hospital of Nancy, Vandœuvre-lès-Nancy, France, ²Hospital Clinic of Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain, ³Virginia Mason Medical Center, Seattle, USA, ⁴Arena Pharmaceuticals, Inc., San Diego, USA, ⁵University Hospitals Leuven, Leuven, Flanders, Belgium, ⁶Western University, London, Ontario, Canada, ⁷Medical College of Wisconsin, Milwaukee, USA, ⁸University of California San Diego, La Jolla, USA

¹Norfolk and Norwich University Hospital, Gastroenterology, Norwich, UK, ²The Quadram Institute Bioscience, Gut Microbes and Health Programs, Norwich, UK, ³Centre for Molecular Science Informatics, Department of Chemistry University of Cambridge, Cambridge, UK, ⁴Earlham Institute, Norwich Research Park, Norwich, UK, ⁵KU Leuven,, Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium, ⁶Eötvös Loránd, Department of Genetics, Budapest, Hungary, ⁷University of East Anglia, Norwich Medical School, Norwich, UK, ⁸University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium

¹KU Leuven, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Leuven, Belgium, ²KU Leuven, Department of Development and Regeneration, Leuven, Belgium, ³KU Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium

¹Hospital of the Ludwig Maximilian University, General-, Visceral-, Vascular- and Transplantation Surgery, Munich, Germany, ²Hospital of the Ludwig Maximilian University, Laboratory Medicine, Munich, Germany, ³Hospital of the Ludwig Maximilian University, Medicine II, Munich, Germany

¹Janssen Research and Development, LLC, Spring House, USA

¹University of California San Diego, La Jolla, USA, ²University Hospital Schleswig-Holstein, Kiel, Germany, ³University of Washington, Seattle, USA, ⁴Centre for Immunobiology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK, ⁵Service de Gastroentérologie et Nutrition Clinique, Nice, France; Université de Nice-Sophia-Antipolis, Nice, France, ⁶AbbVie Inc., North Chicago, USA, ⁷Mayo Clinic, Rochester, USA

¹North Zealand University Hospital, Frederikssund, Denmark, ²Ben Gurion University of the Negev, Beer Sheva, Israel, ³Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel, ⁴University Hospital Center Zagreb, Zagreb, Croatia, ⁵Semmelweis University, Budapest, Hungary, ⁶Amiens University and Hospital, Amiens, France, ⁷Lithuanian University of Health Sciences, Kaunas, Lithuania, ⁸Hospital de São João, Porto, Portugal, ⁹Moscow Regional Research Clinical Institute, Moscow, Russian Federation, ¹⁰Tampere University Hospital, Tampere, Finland, ¹¹Imperial College London, London, UK, ¹²Herlev University Hospital, Herlev, Denmark, ¹³State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Moldova, Republic of, ¹⁴Azienda Ospedaliera di Padova, Padova, Italy, ¹⁵Complexo Hospitalario Universitario de Vigo, Vigo, Spain, ¹⁶Morgagni Hospital, Forli, Italy, ¹⁷Careggi Regional Referral Center for Inflammatory Bowel Disease, Florence, Italy, ¹⁸University Hospital, Ioannina, Greece, ¹⁹Charles University, Prague, Czech Republic, ²⁰National Hospital of the Faroe Islands, Torshavn, Faroe Islands, ²¹Herning Hospital, Herning, Denmark, ²²Mater Dei Hospital, Msida, Malta, ²³Tartu University Hospital, Tartu, Estonia, ²⁴University of Medicine ‘Victor Babes’, Timisoara, Romania, ²⁵American Gastroenterology center, Nicosia, Cyprus, ²⁶Slagelse Hospital, Department of medicine, Denmark, ²⁷Regional Hospital of Viborg, Viborg, Denmark, ²⁸Örebro University, Örebro, Sweden, ²⁹Hull and East Yorkshire NHS Trust, Hull, UK, ³⁰Aarhus University Hospital, Aarhus, Denmark

¹University College London Hospitals, London, UK, ²Queen Elizabeth Hospital Birmingham, Birmingham, UK, ³University Hospital Coventry and Warwickshire, Coventry, UK, ⁴Shrewsbury and Telford Hospital, Shrewsbury, UK, ⁵St Vincent’s University Hospital, Centre for Colorectal Disease, Dublin, Ireland, ⁶Sublimity Therapeutics, Solana Beach, USA

¹Icahn School at Mount Sinai, Department of Population, Health Science and Policy, New York, USA, ²University College of London, London, UK, ³Icahn School at Mount Sinai, Department of Genetics and Genomic Science, New York, USA, ⁴Icahn School at Mount Sinai, Department of Medicine, Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center, New York City, USA, ⁵Janssen Research and Development, Janssen Biotech, Johnson and Johnson, Spring House, USA

¹Schneider Children’s Hospital, Gastroenterology, Nutrition and Liver Diseases, Petach Tikva, Israel, ²Schneider Children’s medical Center, Gastroenterology, Nutrition and Liver Diseases, Petach Tikva, Israel, ³Shaare Zedek Medical Center, Gastroenterology, Nutrition and Liver Diseases, Jerusalem, Israel, ⁴Assaf Harofeh, Pediatric Gastroenterology, Zerifin, Israel, ⁵Sheba Medical Center, Pediatric Gastroenterology, Ramat Gan, Israel, ⁶Shaare Zedek Medical Center, Pediatric Gastroenterology, Nutrition and Liver Diseases, Jerusalem, Israel, ⁷Tel Aviv Medical Center, Pediatric Gastroenterology, Tel-Aviv, Israel, ⁸Kaplan Medical Center, Pediatric Gastroenterology, Rehovot, Israel, ⁹Rambam Medical center, Pediatric Gastroenterology, Haifa, Israel, ¹⁰Soroka Medical Center, Pediatric Gastroenterology, Beer Sheva, Israel

¹Sheba Medical Center, Tel Hashomer, Israel, ²Cincinnati Children Hospital Medical Center, Cincinnati, USA, ³Broad Institute of MIT and Harvard University, Cambridge, USA, ⁴Georgia Institute of Technology, Atlanta, USA, ⁵University of North Carolina, Chapel Hill, USA, ⁶Emory University, Atlanta, USA, ⁷Hospital For Sick Children, Toronto, Canada, ⁸Harvard School of Public Health, Boston, USA, ⁹Broad Institute of MIT and Harvard University, Boston, USA, ¹⁰Connecticut Children’s Medical Center, Hartford, USA

¹Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Genomics and Child Health, London, UK, ²Centre for Digestive Diseases, Queens Medical Centre, Nottingham, UK, ³Department of Gastroenterology, Hôpital Saint Louis, APHP, INSERM UMRS 1160, Paris Diderot, Sorbonne Paris-Cité Unversity, Paris, France, ⁴Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK, ⁵Department of Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland, ⁶Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Immunobiology, London, UK

¹University Hospitals Leuven, Leuven, Belgium, ²CHU Nice Hopital Archet 2, Nice, France, ³Piotr Napora Centrum Badań Klinicznych Lekarze Sp.p., Wroclaw, Poland, ⁴SANTA FAMILIA, Centrum Badań, Profilaktyki i Leczenia, Lodz, Poland, ⁵Vasútegészségügyi Nonprofit Közhasznú Kft, Debrecen, Hungary, ⁶CHU Nantes Hotel Dieu, Nantes, France, ⁷KO-Med, Lublin, Poland, ⁸Abivax, Paris, France

¹Leiden University Medical Center, Gastroenterology and Hepatology, Leiden, The Netherlands, ²Leiden University Medical Center, Cell and Chemical Biology, Leiden, The Netherlands

¹Research Institute, Chong Kun Dang Pharmaceutical Corporation, Yongin, South Korea, ²Hallym University, Department of Biomedical Science, Chuncheon, South Korea, ³Inje University College of Medicine, Department of Microbiology and Immunology, Gimhae, South Korea, ⁴Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, South Korea, ⁵Seoul National University Hospital Healthcare System Gangnam Center, Department of Internal Medicine and Healthcare Research Institute, Seoul, South Korea

¹Amiens University Hospital, Gastroenterology, AMIENS (80000), France, ²Nancy University Hospital, Gastroenterology, Nancy, France, ³Lyon University Hospital, Lyon, France, ⁴Montpellier University Hospital, Gastroenterology, Montpellier, France, ⁵Saint Etienne University Hospital, Gastroenterology, Saint Etienne, France, ⁶Rennes University Hospital, Gastroenterology, Rennes, France, ⁷Caen University Hospital, Gastroenterology, Caen, France, ⁸Bordeaux University Hospital, Gastroenterology, Bordeaux, France, ⁹Nice University Hospital, Gastroenterology, Nice, France, ¹⁰Clermont-Ferrand, Gastroenterology, Clermont-Ferrand, France, ¹¹Hopital Beaujon, Gastroenterology, Clichy, France, ¹²Toulouse University Hospital, Gastroenterology, Toulouse, France, ¹³Amiens University Hospital, Gastroenterology, Amiens, France, ¹⁴Lyon University Hospital, Gastroenterology, Lyon, France, ¹⁵Saint Etienne University Hospital, Gastroenterology, Saint-Etienne, France

¹University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium, ²AZ Delta, Department of Gastroenterology, Roeselare, Belgium, ³Hôpital Haut-Lévêque, Service d’Hépato-gastroentérologie et Oncologie Digestive, Bordeaux, France, ⁴Imelda General Hospital, IBD Clinic, Bonheiden, Belgium, ⁵Beaujon Hospital, APHP, Paris Diderot University, Department of Gastroenterology, Clichy, France, ⁶Estaing University Hospital, Department of Gastroenterology, Clermont-Ferrand, France, ⁷AZ Damiaan, Department of Gastroenterology, Oostende, Belgium, ⁸Liège University Hospital, Department of Gastroenterology, Liège, Belgium, ⁹University Medical Centre, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands, ¹⁰Huriez Hospital, Lille 2 University, Department of Gastroenterology and Hepatology, Lille, France, ¹¹University Medical Centre, Department of Gastroenterology and Hepatology, Maastricht, The Netherlands, ¹²Erasmus Medical Centre, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands, ¹³Academic Medical Centre, Department of Gastroenterology, Amsterdam, The Netherlands, ¹⁴University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, ¹⁵University of Leuven, Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium

¹University Hospitals Leuven, Leuven, Belgium, ²Icahn School of Medicine at Mount Sinai, New York, USA, ³Western University, London, Canada, ⁴University of California San Diego, La Jolla, USA, ⁵Humanitas University, Milan, Italy, ⁶Academic Medical Centre, Amsterdam, The Netherlands, ⁷University of Calgary, Calgary, Canada, ⁸University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, USA, ⁹Shafran Gastroenterology Research Center, Winter Park, USA, ¹⁰Takeda Pharmaceuticals, Cambridge, USA, ¹¹Mayo Clinic College of Medicine, Rochester, USA

¹Leiden University Medical Center, Department of Immunohematology and Blood Transfusion, Leiden, The Netherlands, ²Delft University of Technology, Delft Bioinformatics Lab, Delft, The Netherlands, ³Leiden University Medical Center, Leiden Computational Biology Center, Leiden, The Netherlands, ⁴Leiden University Medical Center, Department of Gastroenterology, Leiden, The Netherlands, ⁶Delft University of Technology, Computer Graphics and Visualization, Delft, The Netherlands, ⁷Leiden University Medical Center, Department of Paediatrics, Leiden, The Netherlands, ⁸Alrijne Hospital, Department of Gastroenterology, Leiderdorp, The Netherlands, ⁹Erasmus University Medical Center, Department of Paediatric Gastroenterology, Rotterdam, The Netherlands, ¹⁰Delft University of Technology, Pattern Recognition and Bioinformatics Group, Delft, The Netherlands, ¹¹Leiden University Medical Center, Department of LKEB Radiology, Leiden, The Netherlands

¹Translational Gastroenterology Unit, University of Oxford, Oxford, UK, ²Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK