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P013: Immunophenotyping of peripheral whole blood from 743 IBD patients identifies patterns of association between immune cell populations and T-cell subsets with disease occurrence, severity and medication useECCO '18 Vienna
Year: 2018
Authors:

R. Kosoy1,2, S. Kim-Schulze3, A. Rahman1,4, L. Peters1,2, A. El-ad1, J. Perrigoue5, A. Castillo6, J. Rogers6, A. Atreja6, A. Hurley1,2, M. Merad3, J.F. Colombel6, M. Dubinsky7, J.R. Friedman5, C. Brodmerkel5, S. Plevy5, E. Schadt1, B. Sands6, A. Kasarskis1,2, C. Argmann1,2, M. Suarez-Farinas1,2,8*

1Icahn School of Medicine at Mount Sinai, Genetics and Genomics Sciences, New York, USA, 2Icahn Institute for Genomics and Multiscale Biology, New York, USA, 3Icahn School of Medicine at Mount Sinai, Hematology and Medical Oncology, New York, USA, 4Icahn School of Medicine at Mount Sinai, Human Immune Monitoring Center, New York, USA, 5Janssen R&D, Spring House, PA, USA, 6Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, USA, 7Icahn School of Medicine at Mount Sinai, Pediatric GI and Hepatology, New York, USA, 8Icahn School of Medicine at Mount Sinai, Population Health Science and Policy, New York, USA

P014: Proinflammatory cytokines and bile salts inhibit the cellular uptake of butyrate by Caco-2 cellsECCO '18 Vienna
Year: 2018
Authors:

M. Couto1,2,3*, N. Andrade1,2, A. Correia-Branco1,2, F. Magro4,5, F. Martel1,2

1Unit of Biochemistry, Faculty of Medicine, University of Porto, Department of Biomedicine, Porto, Portugal, 2I3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal, 3Centro Hospitalar Tondela-Viseu, E.P.E., Department of General Surgery, Viseu, Portugal, 4Unit of Pharmacology and Therapeutics. Faculty of Medicine, University of Porto, Department of Biomedicine, Porto, Portugal, 5Centro Hospitalar São João, E.P.E., Department of Gastroenterology, Porto, Portugal

P015: Extracellular matrix fragments of the basement membrane and the interstitial matrix are markers of disease activity and disease progressionECCO '18 Vienna
Year: 2018
Authors:

M.L. Olesen1*, T. Manon-Jensen1, A. Krag2, M. Karsdal1, J. Kjeldsen2, J.H. Mortensen1

1Nordic Bioscience A/S, Biomarkers and Research, Herlev, Denmark, 2University of Southern Denmark and Odense University Hospital, Department of Medical Gastroenterology, Odense, Denmark

P016: GI restricted ROCK inhibitors show potential to treat fibrosis and stenosis associated with inflammatory bowel diseaseECCO '18 Vienna
Year: 2018
Authors:

C. Jones1*, P. Bunyard1, K. Eckersley1, N. Hawkins1, R. Armer1, M. Bingham1, C. Phillips1, T. Holvoet2, S. Devriese2, K. Castermans3, S. Boland3, D. Leysen3, Y.-P. Vandewynckel2, L. Devisscher2, L. Van den Bossche2, S. Van Welden2, M. Dullaers4,5, R. Vandenbroucke4,5, R. De Rycke4,5, K. Geboes6, A. Bourin3, O. Defert3, P. Hindryckx2, M. De Vos2, D. Laukens2

1Redx Pharma, Alderley Park, UK, 2Ghent University, Gastroenterology, Ghent, Belgium, 3Amakem Therapeutics, Diepenbeek, Belgium, 4Inflammation Research Centre, VIB, Ghent, Belgium, 5Ghent University, Pulmonary Medicine, Ghent, Belgium, 6Ghent Q1 University, Pathology, Ghent, Belgium

P017: Human intestinal pro-inflammatory CD11chigh macrophages, but not their transient CD11cdim or tolerogenic CD11c- counterparts, are expanded in inflammatory bowel diseaseECCO '18 Vienna
Year: 2018
Authors:

D. Bernardo1,2,3*, A.C. Marín1,2,3, S. Fernández Tomé1,2,3, A. Montalbán-Arqués1,2,3, A. Carrasco3,4,5, E. Tristán3,4,5, I. Mora-Gutiérrez1,2,3, A. Díaz-Guerra1,2,3, R. Caminero-Fernández1,2, P. Miranda1,2, F. Casals1,2, M. Caldas1,2, M. Jiménez1,2, S. Casabona1,2, F. De la Morena1,2, M. Esteve3,4,5, C. Santander1,2,3,6, M. Chaparro1,2,3,6, J.P. Gisbert1,2,3,6

1Hospital Universitario de La Princesa, Gastroenterology Unit, Madrid, Spain, 2Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain, 3Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain, 4Hospital Universitario Mutua Terrassa, Gastroenterology Unit, Tarrasa, Spain, 5Fundació Recerca Mútua Terrassa, Tarrasa, Spain, 6Universidad Autónoma de Madrid, Madrid, Spain

P018: Should NUDT genotyping be tested routinely prior to commencement of thiopurine therapy in Asian patients?ECCO '18 Vienna
Year: 2018
Authors:

S. Shah, M. Paradkar, D. Desai*, T. Ashavaid

Hinduja Hospital, Mumbai, India

P019: Paediatric Crohn’s disease patients in remission have a reduced skeletal muscle protein balance after feedingECCO '18 Vienna
Year: 2018
Authors:

A. Walker1*, A. Nixon1, S. Cordon1, M. Marshall1, M. Yeo2, D. Devadason2, R. Muhammed3, K. Tsintzas1, S. Kirkham2, F. Stephens4, G. Moran2,5

1University of Nottingham, School of Life Sciences, Nottingham, UK, 2Nottingham University Hospitals NHS Trust, Nottingham, UK, 3Birmingham Children's Hospitals NHS Trust, Birmingham, UK, 4University of Exeter, Sports and Health Sciences, Exeter, UK, 5NIHR Nottingham Biomedical Research Centre, Nottingham, UK

P020: The effect of bone marrow-derived mesenchymal stem cells on expansion of colon organoids and organoid implantationECCO '18 Vienna
Year: 2018
Authors:

J.-H. Kwon1,2*, J. Park1,2, Y. Park1,2, S.J. Park1,2, J.H. Cheon1,2, W.H. Kim1,2, T.I. Kim1,2

1Yonsei University College of Medicine, Internal Medicine, Seoul, South Korea, 2Yonsei University College of Medicine, Institute of Gastroenterology, Seoul, South Korea

P021: Aryl hydrocarbon receptor controls ILC3/ILC1 immunity in a colitis model of 2, 4,6-trinitrobenzene sulphonic acidECCO '18 Vienna
Year: 2018
Authors:

X. Zhao*, H. Zhang

First Affiliated Hospital of Nanjing Medical University, Department of Gastroenterology, Nanjing, China

P022: Severe disease activity in UC is associated with mucosal hypoxia measured endoscopicallyECCO '18 Vienna
Year: 2018
Authors:

C.R. Rowan1*, E. Brown2, E. Ryan3, C. Taylor2, G.A. Doherty4

1St.Vincent's University Hospital, Gastroenterology, Dublin, Ireland, 2University College Dublin, Conway Institute, Dublin, Ireland, 3St.Vincent's University Hospital, Center for Colorectal Disease, Dublin, Ireland, 4St Vincent's University Hospital, Centre for Colorectal Disease, Dublin, Ireland

P023: NOD2 support crypt survival and promote intestinal epithelial regenerationECCO '18 Vienna
Year: 2018
Authors:

S.N. Hong*, C. Lee, T.J. Kim, E.R. Kim, D.K. Chang, Y.-H. Kim

Samsung Medical Center, Sungkyunkwan University School of Medicine, Medicine, Seoul, South Korea

P024: Serum IL-10 is the best inflammatory variable to explain anti-TNF trough levels in a cohort of patients with Crohn’s diseaseECCO '18 Vienna
Year: 2018
Authors:

S. Almenara, A. Gutiérrez, L. Sempere, P. Zapater, J. Cameo, J. González-Navajas, R. Francés*

Hospital General Universitario de Alicante, Alicante, Spain

P025: Protective effect and action mechanism of apocynin in IBD mouse modelECCO '18 Vienna
Year: 2018
Authors:

S.C. Park1*, S.-J. Nam1, S.J. Lee1, W. Chun2

1Kangwon National University Hospital, Chuncheon-si, South Korea, 2Kangwon National University, Department of Pharmacology, College of Medicine, Chuncheon-si, Gangwon-do, South Korea

P026: The impact of trophic effects of multi strain probiotic preparation on paracellular permeabilityECCO '18 Vienna
Year: 2018
Authors:

V. Petito1*, L. Laterza1, C. Graziani1, D. Lucchetti2, L. Lopetuso1, A. Sgambato2, F. Scaldaferri1, A. Gasbarrini1

1Fondazione Policlinico Universitario Gemelli, Catholic University of Sacred Heart, Gastroenterological Area, Gastroenterological and Endocrino-Metabolical Sciences Department, ROME, Italy, 2Catholic University of Sacred Heart, Department of Pathology, Rome, Italy

P027: Vitamin A modulates mucosal inflammation by augmenting Th1/Th17 differentiation in inflammatory bowel diseaseECCO '18 Vienna
Year: 2018
Authors:

R. Rampal1*, M.N. Wari1, A.K. Singh1, U.K. Das1, S. Bopanna1, S. Jain1, V. Gupta1, T. Velpandian2, S. Kedia3, D. Kumar4, A. Awasthi5, V. Ahuja1

1All India Institute of Medical Sciences, Department of Gastroenterology and Human Nutrition, New Delhi, India, 2All India Institute of Medical Sciences, Ophthalmology, New Delhi, India, 3All India Institute of Medical Sciences, Gastroenterology, New Delhi, India, 4International centre for Genetic Engineering and Biotechnology, New Delhi, India, 5Translational Health Sciences and Technology Institute, Immunology, Faridabad, India

P028: A distinct cellular signature of inflammatory bowel diseaseECCO '18 Vienna
Year: 2018
Authors:

E. McDonald1*, P. Wright1, T. Zangerle-Murray2, A. Bravo-Blas1, J. Jung1, E. Robertson3,4, S. Siebert1, D. McCarey4, D. Gaya4, D. Burden5, A. McEntegart4, I. McInnes1, S. Milling1

1University of Glasgow, Infection, Immunity and Inflammation, Glasgow, UK, 2University of Manchester, Manchester, UK, 3Glasgow Royal Infirmary, Gastroenterology Unit, Glasgow, UK, 4Glasgow Royal Infirmary, Glasgow, UK, 5Western Infirmary, Glasgow, UK

P029: Modulation of intestinal epithelial permeability by plasma from patients with Crohn’s disease in a 3D cell culture modelECCO '18 Vienna
Year: 2018
Authors:

P. Xu*, E. Elamin, M. Elizalde, P. Bours, M. Pierik, A. Masclee, D. Jonkers

Maastricht University Medical Center, Maastricht, The Netherlands

P030: Intravital observation system of the colon by two photon excitation microscopyECCO '18 Vienna
Year: 2018
Authors:

T. Fukuhara1,2*, Y. Ueda1, Y. Kamioka1, K. Okazaki2, T. Kinashi1

1Kansai Medical University, Department of Molecular Genetics, Institute of Biomedical Science, Hirakata, Japan, 2Kansai Medical University, Gastroenterology and hepatology, Hirakata, Japan

P031: Effects of tobacco alkaloids on DSS-induced colitis mouse modelECCO '18 Vienna
Year: 2018
Authors:

G. Lo Sasso1*, B. Phillips2, R. Gadaleta1, A. Elamin1, A. Kondylis1, N. Ivanov1, J. Hoeng1

1PMI R&D; Philip Morris Products S.A., Neuchatel, Switzerland, 2PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Singapore, Singapore

P032 has been withdrawn.: ECCO '18 Vienna
Year: 2018
Authors: