Policlinico Sant’Orsola-Malpighi, Malattie Infiammatorie Croniche Intestinali Prof. Gionchetti, Bologna, Italy

¹University Hospital Southampton NHS Foundation Trust, Department of Gastroenterology, Southampton, UK, ²Biogen International GmbH, n/a, Baar, Switzerland, ³University of Stellenbosch, Department of Statistics and Actuarial Science, Stellenbosch, South Africa, ⁴Biogen Idec, n/a, Maidenhead, UK, ⁵University of Southampton, School of Health Sciences, Southampton, UK

Department of IBD, Moscow Scientific Center named after A. S. Loginov, Moscow, Russian Federation

¹Beaumont Hospital, Department of Gastroenterology, Dublin, Ireland, ²Beaumont Hospital, Department of Colorectal Surgery, Dublin, Ireland

¹Hokkaido University Hospital, Department of Gastroenterology, Sapporo City- Hokkaido, Japan, ²Sapporo Higashi Tokushukai Hospital, Inflammatory Bowel Disease Center, Sapporo City- Hokkaido, Japan

¹AOU Careggi, IBD Referral Center- Gastroenterology Unit, Firenze, Italy, ²Università Degli Studi di Firenze, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, Firenze, Italy, ³Institute for Cancer Research- Prevention and Clinical Network ISPRO, Molecular and Nutritional Epidemiology Unit, Firenze, Italy

¹Analysis Group Inc., Health Economics and Outcomes Research, Boston, USA, ²H. E. Outcomes, Health Economics and Outcomes Research, Los Angeles, USA, ³Icahn School of Medicine at Mount Sinai, Dr Henry D. Janowitz Division of Gastroenterology, New York, USA, ⁴Shire- a Takeda company, Health Economics- Outcomes Research and Epidemiology, Lexington, USA

Rostov State Medical University, Department of Gastroenterology, Rostov-on-Don, Russian Federation

Medical University of Tunis, Gastroenterology-Military Hospital-Tunis, Tunis, Tunisia

Hospital Sant Joan de Déu, Unit for the Comprehensive Care of Pediatric Inflammatory Bowel Disease. Department of Pediatric Gastroenterology- Hepatology and Nutrition, Esplugues de Llobregat, Spain

¹CHU Estaing, Department of Digestive and Hepatobiliary Medicine- Department of Gastroenterology, Clermont-Ferrand, France, ²CHU Estaing, Radiology Department, Clermont-Ferrand, France, ³CHU, Biostatistics Unit, Clermont-Ferrand, France

¹Tel-Aviv University, Sackler Faculty of Medicine, Tel Aviv-Jaffa, Israel, ²Rabin Medical Center, IBD Center- Division of Gastroenterology, Petah-Tikva, Israel, ³Shaare Zedek Medical Center- The Hebrew University of Jerusalem, The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Jerusalem, Israel

¹University of Chicago Medicine, Gastroenterology, Chicago, USA, ²Rabin Medical Center, Gastroenterology, Petach-Tikva, Israel

¹McMaster University, Department of Gastroenterology, Hamilton, Canada, ²University of Chicago, Gastroenterology, Chicago, USA, ³The Royal Melbourne Hospital, Gastroenterology, Melbourne, Australia

¹Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa IIS-IP- Universidad Autónoma de Madrid, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Unit, Madrid, Spain, ²Janssen, Medical Department, Madrid, Spain, ³Complejo Hospitalario Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain, ⁴Complejo Hospitalario de Navarra, Gastroenterology Unit, Pamplona, Spain, ⁵Hospital Universitario Santa Lucía, Gastroenterology Unit, Cartagena, Spain, ⁶Hospital Universitario Áraba, Gastroenterology Unit, Vitoria, Spain, ⁷Hospital Universitario Miguel Servet, Gastroenterology Unit, Zaragoza, Spain, ⁸Hospital Universitario Nuestra Señora de Valme, Gastroenterology Unit, Sevilla, Spain, ⁹Hospital General Universitario de Alicante and CIBERehd, Gastroenterology Unit, Alicante, Spain, ¹⁰Hospital General Universitario de Valencia, Gastroenterology Unit, Valencia, Spain, ¹¹Hospital General Universitario de Elche, Gastroenterology Unit, Elche, Spain, ¹²Complejo Asistencial Universitario de Burgos, Gastroenterology Unit, Burgos, Spain, ¹³Hospital Universitario de Fuenlabrada- Instituto de Investigación de Hospital La Paz IdiPaz- Madrid, Gastroenterolgoy Unit, Madrid, Spain, ¹⁴Hospital Universitario de Bellvitge, Gastroenterology Unit, Barcelona, Spain, ¹⁵Hospital Universitario Virgen Macarena, Gastroenterology Unit, Sevilla, Spain, ¹⁶Hospital Universitario Gregorio Marañón- IiSGM and CIBERehd, Gastroenterology Unit, Madrid, Spain, ¹⁷Hospital Universitario Virgen del Rocío, Gastroenterology Unit, Sevilla, Spain, ¹⁸Hospital Clínico Universitario, Lozano Blesa and CIBERehd- IIS Aragón, Gastroenterology Unit, Zaragoza, Spain, ¹⁹Hospital Universitario Marqués de Valdecilla, Gastroenterology Unit, Santander, Spain, ²⁰Hospital Juan Ramón Jiménez, Gastroenterology Unit, Huelva, Spain, ²¹Hospital Universitario Son Espases, Gastroenterology Unit, Palma de Mallorca, Spain, ²²Hospital Alvaro Cunqueiro, Gastroenterology Unit, Vigo, Spain, ²³Hospital Marina Baixa, Gastroenterology Unit, Alicante, Spain, ²⁴Hospital Universitario Nuestra Señora de la Candelaria, Gastroenterology Unit, Santa Cruz de Tenerife, Spain, ²⁵Hospital Universitario La Paz-Innate Immunity Group- IdiPAZ Institute for Health Research, Gastroenterology Unit, Madrid, Spain, ²⁶Hospital Universitario Central de Asturias, Gastroenterology Unit, Oviedo, Spain, ²⁷Hospital Universitario de Cabueñes, Gastroenterology Unit, Gijón, Spain, ²⁸Gastroenterology Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain, ²⁹Hospital Universitari de Girona Dr. Josep Trueta, Gastroenterology Unit., Girona, Spain, ³⁰Hospital San Pedro de Alcántara, Gastroenterology Unit, Cáceres, Spain, ³¹Complexo Hospitalario Universitario de Pontevedra, Gastroenterology Unit, Pontevedra, Spain, ³²Hospital Universitario Doce de Octubre, Gastroenterology Unit, Madrid, Spain, ³³Complejo Hospitalario Universitario de A Coruña, Gastroenterology Unit, A Coruña, Spain, ³⁴Hospital Universitario Puerta de Hierro Majadahonda, Gastroenterology Unit, Madrid, Spain, ³⁵Hospital Universitario Donostia, Gastroenterology Unit, San Sebastián, Spain, ³⁶Hospital de Sant Joan Despí Moisès Broggi, Gastroenterology Unit, Barcelona, Spain

¹Keio University School of Medicine, Division of Gastroenterology and Hepatology- Department of Internal Medicine, Tokyo, Japan, ²Keio University School of Medicine, Center for Diagnostic and Therapeutic Endoscopy-, Tokyo, Japan, ³Keio University School of Medicine, Center for Preventive Medicine- Keio University School of Medicine-, Tokyo, Japan

¹GI Alliance, Clinical Research and Education, Southlake, TX, USA, ²Digestive Health Associates of Texas, DHAT Research Institute, Richardson, TX, USA, ³Healix, Pharmacy and Clinical Research, Sugar Land, TX, USA

¹Pharmerit International, Real-World Evidence and Data Analytics, Bethesda, USA, ²Pharmerit International, Strategic Market Access, Bethesda, USA, ³Takeda Pharmaceuticals International, Global Outcomes Research and Epidemiology, Cambridge, USA, ⁴Takeda Pharmaceuticals USA Inc., US Medical, Deerfield, USA, ⁵Takeda Development Center Americas, Clinical Science, Cambridge, USA

¹Amsterdam University Medical Centers, Inflammatory Bowel Disease Centre, Amsterdam, The Netherlands, ²Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York NY, USA, ³Kitasato University Kitasato Institute Hospital, Center for Advanced IBD Research and Treatment, Tokyo, Japan, ⁴Eli Lilly and Company, Lilly Biotechnology Center, San Diego CA, USA, ⁵Eli Lilly and Company, Lilly Biomedicines, Indianapolis IN, USA, ⁶University of California San Diego, Division of Gastroenterology, La Jolla CA, USA, Background

¹Hvidovre University Hospital, Gastro Unit- Medical Division, Hvidovre, Denmark, ²Hvidovre University Hospital, Dept. of Clinical Microbiology, Hvidovre, Denmark, ³Aalborg University Hospital, Department of Gastroenterology and Hepatology, Aalborg, Denmark, ⁴The State Serum Institute, Departmentof Epidemiology Research, Copenhagen, Denmark, ⁵Aarhus University Hospital, Department of Hepatology and Gastroenterology, Aarhus, Denmark, ⁶Herlev University Hospital, Gastro Unit- Medical Division, Herlev, Denmark