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P535 Effects of the Janus Kinase 1 (JAK1)-selective inhibitor filgotinib on circulating cytokines and whole-blood genes/pathways of patients with moderately to severely active Crohn’s disease (CD)

ECCO'20 Vienna

Year: 2020
Authors:

X. Roblin1, A. Serone2, O.K. Yoon3, L. Zhuo3, E. Grant4, J. Woo5, J. Liu3, R. Galien6, G. D’Haens7

1Department of Gastroenterology, University Hospital of Saint Etienne, Saint-Priest-en-Jarez, France, 2Clinical Research, Gilead Sciences Inc., Foster City, USA, 3Department of Bioinformatics, Gilead Sciences Inc., Foster City, USA, 4Clinical Development, Gilead Sciences Inc., Foster City, USA, 5Biomarker Sciences, Gilead Sciences Inc., Foster City, USA, 6Developmental Liaison, Galapagos SASU, Romainville, France, 7Inflammatory Bowel Disease Centre, Amsterdam University Medical Centers, Amsterdam, The Netherlands

P536 Early prediction of intravenous corticosteroid therapy failure in moderate–severe ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

A. Croft1, A. Lord2, G. Radford-Smith1

1Department of Gastroenterology and Hepatology, Royal Brisbane and Women’s Hospital, Brisbane, Australia, 2QIMR-Berghofer Medical Research Institute, Gut Health Group, Brisbane, Australia

P537 Real-world long-term effectiveness of ustekinumab in Crohn’s disease: Results from the ENEIDA registry

ECCO'20 Vienna

Year: 2020
Authors:

M.I. Iborra Colomino1, B. Beltrán1, A. Fernández-Clotet2, E. Iglesias Flores3, P. Navarro4, M. Rivero5, A. Gutiérrez6, M. Sierra-Ausin7, F. Mesonero8, R. Ferreiro-Iglesias9, J. Hinojosa10, X. Calvet11, B. Sicilia12, C. González-Muñoza13, B. Antolín14, M. González Vivo15, A.Y. Carbajo16, S. García17, A. Martín-Cardona18, G. Surís Marín19, M.D. Martín-Arranz20, R. De Francisco21, F. Cañete22, T. Carlos23, F. Gomollón24, R. Lorente25, I. Rodríguez-Lago26, A. Forés-Bosch27, E. Bernardos28, L. Ramos29, P. Delgado30, A. Hernández31, M. Van Domselaar32, D. Hervás33, E. Domènech34, P. Nos1

1Department of Gastroenterology, Hospital Universitario y Politécnico La Fe, Valencia, Spain, 2Department of Gastroenterology, Hospital Clínic Barcelona, Barcelona, Spain, 3Department of Gastroenterology, Hospital Universitario Reina Sofía de Córdoba, Córdoba, Spain, 4Department of Gastroenterology, Hospital Clínico Universitario de Valencia, Valencia, Spain, 5Department of Gastroenterology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 6Department of Gastroenterology, Hospital General de Alicante, Alicante, Spain, 7Department of Gastroenterology, Complejo Asistencial Universitario de León, León, Spain, 8Department of Gastroenterology, Hospital Ramón y Cajal Madrid, Madrid, Spain, 9Department of Gastroenterology, Hospital Universitario de Santiago, Santiago de Compostela, Spain, 10Department of Gastroenterology, Hospital de Manises, Valencia, Spain, 11Department of Gastroenterology, Corporació Sanitària Parc Taulí de Sabadell, Sabadell, Spain, 12Department of Gastroenterology, Hospital Universitario de Burgos, Burgos, Spain, 13Department of Gastroenterology, Hospital Santa Creu i Sant Pau, Barcelona, Spain, 14Department of Gastroenterology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain, 1561712@parcdesalutmar.cat, Hospital Parc de Salut Mar, Barcelona, Spain, 16Department of Gastroenterology, Hospital Universitario Río Hortega, Valladolid, Spain, 17Department of Gastroenterology, Hospital Miguel Servet, Zaragoza, Spain, 18Department of Gastroenterology, Hospital Mutua de Terrassa, Terrassa, Spain, 19Department of Gastroenterology, Hospital de Bellvitge, Barcelona, Spain, 20Department of Gastroenterology, Hospital Universitario La Paz, Madrid, Spain, 21Department of Gastroenterology, Hospital Central de Oviedo, Oviedo, Spain, 22Department of Gastroenterology, Hospital Germans Trias i Pujol, Barcelona, Spain, 23Department of Gastroenterology, Hospital Clínico San Carlos, Madrid, Spain, 24Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, 25Department of Gastroenterology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, 26Department of Gastroenterology, Hospital Universitario de Galdakao, Galdakao, Spain, 27Department of Gastroenterology, Hospital General de Castellón, Castellón, Spain, 28Department of Gastroenterology, Hospital General La Mancha Centro, Alcázar de San Juan, Spain, 29Department of Gastroenterology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 30Department of Gastroenterology, Hospital General de Granollers, Granollers, Spain, 31Department of Gastroenterology, Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain, 32Department of Gastroenterology, Hospital Universitario de Torrejón, Madrid, Spain, 33Department of Biostatistics, Hospital Universitario y Politécnico La Fe, Valencia, Spain, 34Department of Gastroenterology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain

P538 Pregnancy outcomes in women with psoriasis, psoriatic arthritis, Crohn’s disease and ulcerative colitis treated with ustekinumab

ECCO'20 Vienna

Year: 2020
Authors:

A. Geldhof1, S. Volger2, C.B. Lin2, C. O’Brien2, I. Tikhonov2

1Department of Medical Affairs, Janssen Biologics B.V., Leiden, The Netherlands, 2Department of Immunology, Janssen Research and Development, LLC, Spring House, USA

P539 Assessment of age as a risk factor for adverse events in patients from the tofacitinib ulcerative colitis clinical programme

ECCO'20 Vienna

Year: 2020
Authors:

G.R. Lichtenstein1, B. Bressler2, S. Vermeire3, C. Francisconi4, N. Lawendy5, H. Shi5, L. Salese5, D. Judd5, E.V. Loftus Jr6

1Division of Gastroenterology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA, 2Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, 3Department of Gastroenterology, University Hospitals - Leuven, Leuven, Belgium, 4Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, Brazil, 5Pfizer Inc., Collegeville, Pennsylvania, USA, 6Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA

P540 GB004, a novel prolyl hydroxylase inhibitor for inflammatory bowel disease, leads to gut-targeted HIF-1α pathway engagement in a multiple-dose study in healthy subjects

ECCO'20 Vienna

Year: 2020
Authors:

B. Levesque1, K. Taylor Meadows2, A. Buch3, M. Flynn4, K. Peters5, A. Olson1, J. Shen1, D. Slee6, C. Van Biene7, R. Aranda1, N. Vande Casteele8, G. Opiteck1

1Clinical Development, Gossamer Bio Inc., San Diego, USA, 2Department of Biology, Gossamer Bio Inc., San Diego, USA, 3Department of Clinical Pharmacology and Pharmacokinetics, Aerpio Pharmaceuticals Inc., Cinncinati, USA, 4Department of Project Management, Aerpio Pharmaceuticals Inc., Cincinnati, USA, 5Department of Research and Development, Aerpio Pharmaceuticals Inc., Cincinnati, USA, 6Department of Research and Development, Gossamer Bio Inc., San Diego, USA, 7Department of Biometrics, Gossamer Bio Inc., San Diego, USA, 8Department of Precision Medicine, Robarts Clinical Trials, San Diego, USA

P541 Are we addressing the top ten research priorities in IBD?

ECCO'20 Vienna

Year: 2020
Authors:

J. Geldof1, J.F. LeBlanc1, L. Lucaciu2, J.P. Segal1, C.W. Lees2, A. Hart1

1IBD Unit, St Mark’s Hospital Academic Institute, London, UK, 2Gastrointestinal Unit, Western General Hospital, Edinburgh, UK

P542 The effect of age on infliximab pharmacokinetics in patients with inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

W. Kantasiripitak1, B. Verstockt2,3, T. Lobatón2,3,4, D. Thomas1, A. Gils1, S. Vermeire2,3, M. Ferrante2,3, E. Dreesen1

1Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium, 2Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium, 3Department of Chronic Diseases Metabolism and Ageing, KU Leuven, Leuven, Belgium, 4Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium

P543 UC remission mucosa displays upregulated inflammatory mediators

ECCO'20 Vienna

Year: 2020
Authors:

C. Arkteg1, R. Goll2, M. Dixon Gundersen1, E. Anderssen1, C.G. Fenton1, J. Florholmen2

1Research Group Gastroenterology Nutrition, Institute of Clinical Medicine, UiT the Arctic University of Norway, Tromsø, Norway, 2Division of Internal Medicine, Department of Gastroenterology, Tromsø, Norway

P544 Comparison of the efficacy of a second intravenous or subcutaneous anti-TNF in the treatment of ulcerative colitis: Real-world data from the ENEIDA registry

ECCO'20 Vienna

Year: 2020
Authors:

P. Torres-Rodriguez1, F. Cañete1,2, M. Calafat1, R. Sánchez-Aldehuelo3, M. Rivero4,5, M. Iborra2,6, M. González-Vivo7, I. Vera8, L. de Castro9, L. Bujanda2,10,11,12, M. Barreiro-de Acosta13, X. Calvet2,14, J.M. Benítez15,16, M. Llorente17, G. Surís18, L. Arias-García19, M. David20, A. Castaño-García21, F.J. Garcia-Alonso22, L. Rufo23, J.A. Ferrer24, P. Camo25, J.P. Gisbert2,26, J.M. Huguet27, R. Pajares28, V. Morales29, J. Llaó30, A. Rodríguez31, C. Rodríguez32, M. Navarro33, F. Gomollón2,34, M. Carrillo-Palau35, E. Sesé36, P. Almela37, P. Ramírez de la Piscina38, I. Rodríguez-Lago39, M. Papo40, M. Vela41, M. Mañosa1,2, E. Domènech1,2, on behalf of the Eneida-GETECCU investigators

1Hospital Universitari Germans Trias I Pujol, Department of Gastroenterology, Badalona, Spain, 2Department of Gastroenterology and Hepatology, CIBEREHD, Madrid, Spain, 3Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Madrid, Spain, 4Department of Gastroenterology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 5Department of Gastroenterology, IDIVAL, Santander, Spain, 6Department of Gastroenterology, Hospital Universitari i Politècnic La Fe, Valencia, Spain, 7Department of Gastroenterology, Hospital del Mar, Barcelona, Spain, 8Department of Gastroenterology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain, 9Department of Gastroenterology, Complejo Hospitalario Universitario de Vigo, Vigo, Spain, 10Department of Gastroenterology, Hospital Universitario Donostia, San Sebastián, Spain, 11Department of Gastroenterology, Universidad del País Vasco UPV/EHU, San Sebastián, Spain, 12Department of Gastroenterology, Instituto Biodonostia, San Sebastián, Spain, 13Department of Gastroenterology, Complexo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain, 14Department of Gastroenterology, Corporació Sanitària Universitària Parc Taulí, Sabadell, Spain, 15Department of Gastroenterology, Hospital Universitario Reina Sofía, Córdoba, Spain, 16Department of Gastroenterology, IMIBIC, Córdova, Spain, 17Department of Gastroenterology and Hepatology, Hospital Universitario Miguel Servet, Zaragoza, Spain, 18Department of Gastroenterology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Spain, 19Department of Gastroenterology, Hospital Universitario de Burgos, Burgos, Spain, 20Department of Gastroenterology, Consorci Sanitari Terrassa, Terrassa, Spain, 21Department of Gastroenterology, Hospital Universitario Central de Asturias, Oviedo, Spain, 22Department of Gastroenterology, Hospital Universitario Río Hortega, Valladolid, Spain, 23Department of Gastroenterology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, 24Department of Gastroenterology, Hospital Universitario Fundación de Alcorcón, Madrid, Spain, 25Department of Gastroenterology, Hospital General San Jorge, Huesca, Spain, 26Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain, 27Department of Gastroenterology, Hospital General Universitario de Valencia, Valencia, Spain, 28Department of Gastroenterology, Hospital Universitario Infanta Sofía, Madrid, Spain, 29Department of Gastroenterology and Hepatology, Hospital General de Granollers, Granollers, Spain, 30Department of Gastroenterology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain, 31Department of Gastroenterology, Hospital General Universitario de Alicante, Alicante, Spain, 32Department of Gastroenterology, Complejo Hospitalario de Navarra, Navarra, Spain, 33Department of Gastroenterology, Hospital Moisès Broggi, Sant Joan Despí, Spain, 34Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, 35Department of Gastroenterology, Hospital Universitario de Canarias, La Laguna, Spain, 36Department of Gastroenterology, Hospital Universitario Arnau de Vilanova, Lleida, Spain, 37Department of Gastroenetology, Hospital General Universitario de Castellón, Castellón, Spain, 38Department of Gastroenterology, Hospital Universitario de Álava, Vitoria, Spain, 39Department of Gastroenterology, Hospital de Galdakao-Usansolo, Galdakao, Spain, 40Department of Gastroenterology, Hospital Universitario Joan XXIII, Tarragona, Spain, 41Department of Gastroenterology, Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain

P545 Deep remission assessed by endoscopy, magnetic resonance or intestinal ultrasound, in refractory Crohn’s disease patients in clinical remission with ustekinumab: a real-life single-centre experience

ECCO'20 Vienna

Year: 2020
Authors:

M.I. Calvo Moya1, I. Omella Usieto1, Y. González Lama1, V. Matallana Royo1, I. González Partida1, B. Menchen Viso2, R. De Lucas Téllez de Meneses1, M. González Rodriguez1, P. Bella del Castillo1, M.I. Vera Mendoza1

1Hospital Universitario Puerta de Hierro, Majadahonda, Gastroenterology and Hepatology Department, IBD Unit, Majadahonda, Madrid, Spain, 2Hospital Universitario Puerta de Hierro, Majadahonda, Pharmacy Department, Majadahonda Madrid, Spain

P546 Ileal ulcer size significantly impacts the ability to achieve endoscopic remission: a post-hoc analysis from the SONIC trial

ECCO'20 Vienna

Year: 2020
Authors:

N. Narula1, E. Wong1, A. Achuthan1, P. Dulai2, J.F. Colombel3, J.K. Marshall1, M. Ferrante4, W. Reinisch5

1Department of Gastroenterology, McMaster University, Hamilton, Canada, 2Department of Gastroenterology, University of California San Diego, San Diego, USA, 3Department of Gastroenterology, Mount Sinai Medical Center, New York, USA, 4Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium, 5Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

P547 Inadequate vitamin C status and association with inflammatory biomarkers in adults with active Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

C. Wall1, K. MacFarlane2, A. Carr3, A. Day4, R. Gearry1

1Department of Medicine, University of Otago, Christchurch, New Zealand, 2Gastroenterology Department, Christchurch Hospital, Christchurch, New Zealand, 3Department of Pathology and Biomedical Sciences, University of Otago, Christchurch, New Zealand, 4Department of Paediatrics, University of Otago, Christchurch, New Zealand

P548 Efficacy, safety, and pharmacokinetics after switching from infliximab originator to biosimilar SB2 in inflammatory bowel disease patients: A long-term observational, prospective cohort study

ECCO'20 Vienna

Year: 2020
Authors:

S. Fischer1, S. Mesfin1, E. Klenske1, H. Schmitt1, F. Vitali1, S. Hirschmann1, A. Ramming2, S. Zundler1, T. Rath1, S. Krebs3, F. Dörje3, W. Uter4, D. Nagore5, S. Meyer4, M.F. Neurath1, R. Atreya1

1University Hospital Erlangen- Friedrich-Alexander-University Erlangen-Nürnberg, Department of Medicine 1, Erlangen, Germany, 2University Hospital Erlangen- Friedrich-Alexander-University Erlangen-Nürnberg, Department of Medicine 3, Erlangen, Germany, 3Friedrich-Alexander-University Erlangen-Nürnberg, Pharmacy Department- University Hospital Erlangen, Erlangen, Germany, 4Friedrich-Alexander-University Erlangen-Nürnberg, Department of Medical Informatics- Biometry and Epidemiology- Erlangen, Erlangen, Germany, 5Progenika Biopharma SA, Research and Development, Derio, Spain

P549 A virtual clinic enhances the quality use of anti-TNF dose intensification and rates of treatment success using a treat-to-target approach compared with standard outpatient care in Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

A. Srinivasan1,2,3, D.R. van Langenberg1,3, R. Little4, M.P. Sparrow3,4, P. De Cruz2,5, M.G. Ward3,4

1Department of Gastroenterology, Eastern Health, Melbourne, Australia, 2Department of Gastroenterology, Austin Health, Melbourne, Australia, 3Department of Medicine, Monash University, Melbourne, Australia, 4Department of Gastroenterology, Alfred Health, Melbourne, Australia, 5Department of Medicine, University of Melbourne, Melbourne, Australia

P550 Long-term effectiveness of anti-TNF agents in symptomatic stricturing Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

I. Rodríguez-Lago1, J. Del Hoyo2, M.J. Casanova3, A. Fernández-Clotet4, M.J. García5, R. Ferreiro-Iglesias6, M. Piqueras7, C. Suárez8, A. López-García9, M. Arroyo10, M. Sierra11, P. Delgado-Guillena12, I. Guerra13, O. Merino14, L. Arranz15, J. Llaó16, R. Plaza17, G. Molina18, P. Torres19, P. Pérez-Galindo20, C. Herrera-deGuise21, E. Armesto22, F. Mesonero23, U. Aguirre24, J.P. Gisbert25, EFATECS study group from GETECCU

1IBD Unit, Hospital de Galdakao, Biocruces Bizkaia Health Research Network, Gastroenterology, Bilbao, Spain, 2Hospital Universitari i Politècnic La Fe, Gastroenterology, Valencia, Spain, 3Hospital Universitario de La Princesa, Gastroenterology, Instituto de Investigación Sanitaria Princesa IIS-IP, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology, Madrid, Spain, 4Hospital Clinic, Gastroenterology, Barcelona, Spain, 5Hospital Universitario Marqués de Valdecilla, Gastroenterology, Santander, Spain, 6Hospital Clínico Universitario de Santiago de Compostela, Gastroenterology, Santiago de Compostela, Spain, 7Consorci Sanitari de Terrassa, Gastroenterology, Terrassa, Spain, 8Hospital Universitario La Paz, Gastroenterology, Madrid, Spain, 9Hospital del Mar, Hospital del Mar Medical Research Institute IMIM, Gastroenterology, Barcelona, Spain, 10IIS Aragón, Hospital Clínico Universitario Lozano Blesa CIBERehd, Gastroenterology, Zaragoza, Spain, 11Complejo Asistencial Universitario de León, Gastroenterology, León, Spain, 12Hospital General de Granollers, Gastroenterology, Granollers, Spain, 13Hospital Universitario de Fuenlabrada, Instituto de Investigación de La Paz IdiPaz, Gastroenterology, Fuenlabrada, Spain, 14Hospital Universitario de Cruces, Hospital Universitario de Cruces, Barakaldo, Spain, 15Hospital Ntra. Sra. Candelaria, Hospital Ntra. Sra. Candelaria, Santa Cruz de Tenerife, Spain, 16Althaia- Xarxa Assistencial Universitària de Manresa, Gastroenterology, Manresa, Spain, 17Hospital Universitario Infanta Leonor, Gastroenterology, Madrid, Spain, 18Complejo Hospitalario Universitario de Ferrol, Gastroenterology, Ferrol, Spain, 19Hospital Universitario German Trias I Pujol-, Gastroenterology, Badalona, Spain, 20Hospital Montecelo, Gastroenterology, Pontevedra, Spain, 21Hospital Universitari Vall d’Hebron, Gastroenterology, Barcelona, Spain, 22Hospital San Agustín, Gastroenterology, Avilés, Spain, 23Hospital Universitario Ramón y Cajal, Gastroenterology, Madrid, Spain, 24Hospital de Galdakao, Research Unit- Red de Investigación en Servicios de Salud en Enfermedades Crónicas REDISSEC, Galdakao, Spain, 25Hospital Universitario de La Princesa Instituto de Investigación Sanitaria Princesa IIS-IP- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology, Madrid, Spain

P551 Combination therapy in IBD Patients: Do we need to maximise the dose of Azathioprine?

ECCO'20 Vienna

Year: 2020
Authors:

C. Arieira1,2,3, F. Dias de Castro1,2,3, T. Cúrdia Gonçalves1,2,3, M.J. Moreira1,2,3, J. Cotter1,2,3

1Hospital da Senhora da Oliveira, Gastroenterology, Guimarães, Portugal, 2Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga/Guimarães, Portugal, 3ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal

P552 Withdrawal of immunomodulator medications (IM) in children with inflammatory bowel disease on combination therapy of IM and biologics

ECCO'20 Vienna

Year: 2020
Authors:

A. Chandrakumar1, M. Carroll2, J. deBruyn3, K. Jacobson4, H. Huynh2, E. Wine2, S. Lawrence4, W. El-Matary5

1Department of Pediatrics, University of Manitoba, Winnipeg, Canada, 2Department of Pediatrics, University of Alberta, Edmonton, Canada, 3Department of Pediatrics, University of Calgary, Calgary, Canada, 4Department of Pediatrics, BC children’s Hospital, Vancouver, Canada, 5Department of Paediatric Gastroenterology, University of Manitoba, Winnipeg, Canada

P553 Safety of the sequential use of biological therapy in inflammatory bowel disease: Results from a tertiary referral centre

ECCO'20 Vienna

Year: 2020
Authors:

A. Moens1,2, V. Ballet1, J. Sabino1,2, S. Vermeire1,2, M. Ferrante1,2

1Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium, 2Department of Chronic Diseases, Metabolism and Ageing, Catholic University Leuven, Leuven, Belgium

P554 Dietary practices and beliefs of patients with inactive ulcerative colitis: A prospective UK study

ECCO'20 Vienna

Year: 2020
Authors:

B. Crooks1, J. McLaughlin2, J.K. Limdi1

1Department of Gastroenterology, Northern Care Alliance, Manchester, UK, 2Division of Diabetes, Endocrinology and Gastroenterology, University of Manchester, Manchester, UK