¹Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ²Gastroenterology and Hepatology Unit, Monash Medical Centre, Melbourne, Australia, ³Hudson Institute for Medical Research, Melbourne, Australia

¹Academic Medical Centre, Amsterdam, The Netherlands, ²Zymo Consulting Group, Newtown Square, USA, ³Shire, Lexington, USA, ⁴University of California San Diego, La Jolla, USA

¹Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands, ²Academic Medical Center, Gastroenterology and Hepatology, Amsterdam, The Netherlands, ³University of Veterinary Medicine, Institute of Animal Breeding and Genetics, Vienna, Austria

¹St Vincent's University Hospital, Centre for Colorectal Disease, Dublin, Ireland, ²University and Medical School of Ioannina, Ioannina, Greece, ³North Zealand University Hospital, Frederikssund, Denmark, ⁴Hôpital Saint-Louis, APHP, INSERM UMRS 1160, Université Denis Diderot, Paris, France, ⁵Beth Israel Deaconess Medical Center, Department of Gastroenterology, Boston, USA, ⁶University Hospital Jena, Department of Medicine, Jena, Germany, ⁷The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁸alesund Hospital, Department of Gastroenterology, Alesund, Norway, ⁹Hospital Universitario de La Princesa, Department of Gastroenterology, Madrid, Spain, ¹⁰Hull and East Yorkshire NHS Trust, Hull and York Medical School, Hull, UK, ¹¹Children's Memorial Health Institute, Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, Warsaw, Poland, ¹²Catholic University of Rome - A. Gemelli Hospital, Department of Internal Medicine and Gastroenterology, Rome, Italy, ¹³CHU Liege, Sart Tilman, Department of Pediatric Gastroenterology, Liege, Belgium

¹University of Calgary, Calgary, Canada, ²Icahn School of Medicine at Mount Sinai, New York, USA, ³Imelda General Hospital, Bonheiden, Belgium, ⁴AZ Delta Roeselare-Menen, Roeselare-Menen, Belgium, ⁵Hepato-Gastroenterologie HK, s.r.o., Hradec Králové, Czech Republic, ⁶Bezmialem Vakif University, Istanbul, Turkey, ⁷Medical University of Vienna, Vienna, Austria, ⁸Presidio Columbus, Fondazione Policlinico Gemelli Università Cattolica, Rome, Italy, ⁹Medicus Economics LLC, Boston, USA, ¹⁰AbbVie Inc., North Chicago, USA, ¹¹IBD Unit, Academic Medical Center, Amsterdam, The Netherlands

¹St Mark's Hospital, Colorectal Surgery, London, UK, ²Sheffield Teaching Hospitals NHS Trust, Northern General Hospital, Department of Colorectal Surgery, Sheffield, UK, ³University Hospital South Manchester, Department of Colorectal Surgery, Manchester, UK, ⁴Bristol, School of Social and Community Medicine, Bristol, UK, ⁵Clinical Trials Research Unit, School of Health and Related Research, Sheffield, UK, Sheffiled, UK, ⁶Birmingham University Hospitals NHS Trust, Birmingham, UK, ⁷Sheffield Teaching Hospitals NHS Trust, Northern General Hospital, Department of Gastroenterology, Sheffield, UK, ⁸Hull Royal Infirmary, Hull and East Yorkshire Hospitals NHS Trust, Department of Gastroenterology and Hepatology, Hull, UK, ⁹St Mark's Hospital, Gastrointestinal Imaging, London, UK, ¹⁰St Mark's Hospital, Department of IBD, London, UK, ¹¹Patient representative, Liverpool, UK, ¹²Patient representative, London, UK, ¹³St Mark's Hospital, IBD/Physiology, London, UK, ¹⁴Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Department of Colorectal Surgery, Cambridge, UK

¹Evidera, Real-World Evidence, London, UK, ²Evidera, Real World Evidence, Waltham, MA, USA, ³Takeda Development Centre Europe Ltd., Evidence and Value Generation, London, UK

¹Dartmouth-Hitchcock Medical Center, Lebanon, USA, ²Climate Interactive, Hanover, USA, ³Geisel School of Medicine at Dartmouth, Hanover, USA, ⁴Icahn School of Medicine at Mount Sinai, New York, USA

¹Icahn School of Medicine at Mount Sinai, New York, USA, ²University of Pittsburgh, Pittsburgh, USA

¹Sheffield Teaching Hospitals, Department of Gastroenterology, Sheffield, UK, ²University of Sheffield, Clinical Psychology Unit, Sheffield, UK, ³Sheffield Children’s Hospital, Gastroenterology Department, Sheffield, UK, ⁴University of Sheffield, Department of Psychology, Sheffield, UK

¹University of Calgary, Calgary, Canada, ²Icahn School of Medicine at Mount Sinai, New York, USA, ³Imelda General Hospital, Bonheiden, Belgium, ⁴AZ Delta Roeselare-Menen, Roeselare-Menen, Belgium, ⁵Hepato-Gastroenterologie HK, s.r.o., Hradec Králové, Czech Republic, ⁶Bezmialem Vakif University, Istanbul, Turkey, ⁷Medical University of Vienna, Vienna, Austria, ⁸Presidio Columbus, Fondazione Policlinico Gemelli Università Cattolica, Rome, Italy, ⁹AbbVie Inc., North Chicago, USA, ¹⁰IBD Unit, Academic Medical Center, Amsterdam, The Netherlands

NHS Lothian, Gastroenterology, Edinburgh, UK

¹Karolinska University Hospital, Gastroenterology Unit, Patient Area Gastroenterology, Dermatovenereology and Rheumatology, Stockholm, Sweden, ²Centre for Gastroenterology and Hepatology, Zurich, Switzerland, ³Barts and The London, Queen Mary's School of Medicine and Dentistry, Centre for Immunobiology, London, UK, ⁴CHUV - Centre Hospitalier Universitaire Vaudois, Department of Gastroenterology, Lausanne, Switzerland, ⁵University of Cambridge, Department of Medicine, Cambridge, UK, ⁶Universitat Autònoma de Barcelona, Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ⁷Charite - University Hospital Berlin, University Eye Clinic, Uveitis Center, Berlin, Germany, ⁸University Hospital Zurich, Department of Dermatology, Zurich, Switzerland, ⁹Leiden University Medical Center (LUMC), Department of Gastroenterology and Hepatology, Leiden, The Netherlands, ¹⁰Gastroenterologie am Bayerischen Platz, Berlin, Germany, ¹¹University and Medical School of Ioannina, Department of Internal Medicine I, Division of Gastroenterology and Hepatology, Ioannina, Greece, ¹²The Loginov Moscow Clinical Scientific Centre, IBD Department, Moscow, Russian Federation, ¹³Mayo Clinic, Gastroenterology Research Unit, Rochester, MN, USA, ¹⁴University of Zurich, Department of Gastroenterology and Hepatology, USZ, Zurich, Switzerland, ¹⁵Hospital Universitario Puerta De Hierro, Intestinal Inflammatory Disease Unit / IBD Unit, Gastroenterology and Hepatology Service / Gastroenterology and Hepatology Department, Madrid, Spain, ¹⁶Leiden University Medical Center (LUMC), Department of Rheumatology, Leiden, The Netherlands, ¹⁷Mater Dei Hospital, Department of Medicine, Division of Gastroenterology, Triq Dun Karm, L-Imsida, Malta, ¹⁸North Zealand University Hospital, Department of Gastroenterology and Hepatology, Frederikssund, Denmark, ¹⁹University Hospital Münster, Department of Medicine B, Gastroenterology and Hepatology, Münster, Germany, ²⁰Triemli Hospital, Department of Ophthalmology, Zurich, Switzerland, ²¹Sotiria Hospital, National and Kapodistrian University of Athens, GI Unit, 3rd Academic Dpt. Of Internal Medicine, Athens, Greece, ²²Cleveland Clinic Foundation, Department of Gastroenterology and Hepatology, Cleveland, USA

¹Catholic University of Sacred Heart, Internal Medicine Department, Gastroenterology Division, Rome, Italy, ²Case Western Reserve University, Pathology, Cleveland, USA

¹Francis Crick Institute, Immunosurveillance Lab, London, UK, ²King's College London, DIIID, London, UK, ³Guy's and St Thomas Foundation Trust, Department of Gastroenterology, London, UK, ⁴King's College London, DTIMB, London, UK

University of Erlangen-Nuremberg, Department of Medicine I, Erlangen, Germany

Centre for Colorectal Disease, St. Vincent's University Hospital, Univsersity College Dublin, Dublin, Ireland

¹Hospital Universitari de Tarragona Joan XXIII. Institut d´Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Tarragona, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain, Tarragona, Spain, ²Servicio de Endocrinología y Nutrición, Campus Teatinos s/n, Hospital Clínico Universitario Virgen de la Victoria, 29010, Málaga, Spain, CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain, ³Hospital Joan XIII, Digestive Unit, Tarragona, Spain, ⁴Colorectal Surgery Unit, General Surgery Service, Hospital Vall d’Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain, ⁵Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. ⁶CIBER de Diabetes y Enfermedades Metabolicas Asociadas, Barcelona, Spain. Departamento de Bioquimica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain, ⁷Hospital Joan XIII, Colorectal Surgery Unit, Tarragona, Spain

¹University Hospital Zurich, Division of Gastroenterology and Hepatology, Zurich, Switzerland, ²University Hospital Zurich, Zurich, Switzerland

¹GIGA-R, Uliege, Translational Gastroenterology, Liège, Belgium, ²CHU de Liège, Pathological anatomy, Liège, Belgium, ³CHU de Liège, Hepato-gastroenterology and digestive oncology, Liège, Belgium, ⁴Uliege,Laboratory of mass spectrometry, Chemistry, Liège, Belgium, ⁵GIGA proteomic facility, Uliege, GIGA, Liège, Belgium