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P415 The anti-IL-23/IL-12 agent Ustekinumab is an effective and safe induction therapy in patients with Crohn’s disease refractory or intolerant to anti-TNF: a multicentre Italian study

ECCO'20 Vienna

Year: 2020
Authors:

A. Gubbiotti1, B. Barberio1, F. Zingone1, R. D’Incà1, L. Bertani2, A. Ferronato3, M.T. Urbano4, R. Sablich4, E.V. Savarino1

1Department of Surgery- Oncology and Gastroenterology, University of Padua, Padua, Italy, 2Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy, 3ULSS7 Pedemontana- Santorso VI, Digestive Endoscopy Unit, Santorso, Italy, 4Gastroenterology Unit, Santa Maria Degli Angeli Hospital- Pordenone, Pordenone, Italy

P416 Results of the first paediatric randomised controlled trial of faecal microbiota transplant for ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

N. Pai2, J. Popov3, L. Hill4, E. Hartung1, K. Grzywacz5, D. Godin5, L. Thabane6, C. Lee7, W. Khan7, M. Surette2,8,9, P. Moayyedi2,8

1McMaster Paediatric FMT Research Program, 1Division of Gastroenterology and Nutrition- McMaster Children’s Hospital, Paediatrics, Hamilton, Canada, 2Farncombe Family Digestive Health Research Institute, Department of Medicine- McMaster University, Hamilton, Canada, 3College of Medicine and Health, University College Cork, Cork, Ireland, 4Department of Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa, 5Division de Gastroentérologie- Hépatologie et Nutrition- Université de Montréal, Département de Pédiatrie, Montreal, Canada, 6Department of Health Research Methods- Evidence- and Impact, McMaster University, Hamilton, Canada, 7Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada, 8Department of Medicine, Division of Gastroenterology and Hepatology- McMaster University, Hamilton, Canada, 9Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada

P417 Do ACE inhibitors and angiotensin II receptor blockers improve disease outcomes in inflammatory bowel disease?

ECCO'20 Vienna

Year: 2020
Authors:

K. FAIRBRASS1, D. Hoshen1, A.C. Ford1,2, D. Gracie1

1Leeds Gastroenterology Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK, 2Leeds Institute of Medical Research at St. James’s, University of Leeds, Leeds, UK

P418 Filgotinib decreases molecular markers of JAK1 signal transduction in Crohn’s disease: concordance with endoscopy and histopathology

ECCO'20 Vienna

Year: 2020
Authors:

W. Reinisch1, J. Brodbeck2, R. Galien3, E. Grant2, X. Hébuterne4, M. Kłopocka5, R. Petryka6, X. Roblin7, A. Serone2, C. Tasset8, O.K. Yoon2, S. Zaboli2, S. Vermeire9

1Division Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria, 2Gilead Sciences, Inc., Foster City, USA, 3Galapagos SASU, Parc Biocitech, Romainville, France, 4Department of Gastroenterology and Nutrition and Archet 2 Hospital, Centre Hospitalier Universitaire de Nice and University Côte d’Azur Nice, France, 5NC Department of Gastroenterology and Nutrition, University in Toruñ and Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland, 6NZOZ ViVamed, Zamiejska 17 03-580, Warsaw, Poland, 7Department of Gastroenterology, University Hospital of Saint Etienne, Saint Etienne, France, 8Galapagos NV, Generaal De Wittelaan L11A3, Mechelen, Belgium, 9Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium

P419 Clinical effectiveness and safety of first-line biologic vedolizumab as a monotherapy or combination therapy in ulcerative colitis and Crohn’s disease patients: results from the EVOLVE study

ECCO'20 Vienna

Year: 2020
Authors:

B. Bressler1, A. Yarur2, U. Kopylov3, M. Bassel4, N. Brett4, C. Colby5, C. Lopez6, S. Saha7, C. Kifnidi8, C. Agboton9, S. Adsul9, D. Demuth10, M. Luo11, S. Wang11, G.J. Mantzaris12

1Gastroenterology, St. Paul’s Hospital, Vancouver, Canada, 2Gastroenterology, Medical College of Wisconsin, Milwaukee, USA, 3Gastroenterology, Sheba Medical Center, Tel Aviv, Israel, 4Evidera, Real-World Evidence, Montreal, Canada, 5Evidera, Real-World Evidence, San Francisco, USA, 6Takeda Pharmaceuticals USA Inc., Medical Affairs, Deerfield, USA, 7Takeda Canada Inc., Medical Affairs, Oakville, Canada, 8Takeda Hellas S.A, Medical Affairs, Athens, Greece, 9Takeda Pharmaceuticals International AG, Global Medical Affairs, Zurich, Switzerland, 10Takeda Pharmaceuticals International, Evidence Generation and Publications, Singapore, Singapore, 11Takeda Pharmaceuticals International, Global Outcomes Research, Boston, USA, 12Evangelismos Hospital, Gastroenterology, Athens, Greece

P420 A randomised, observer-blinded phase Ib multiple, ascending dose study of UTTR1147A, an IL-22Fc fusion protein, in healthy volunteers and ulcerative colitis patients

ECCO'20 Vienna

Year: 2020
Authors:

F. Wagner1, J. Mansfield2, C. Geier1, A. Dash3, Y. Wang3, C. Li3, A. Lekkerkerker3, T. Lu3

1Charité Research Organisation, Charité – Universitätsmedizin Berlin, Berlin, Germany, 2Gastroenterology, Newcastle Upon Tyne Hospitals, Newcastle upon Tyne, UK, 3Genentech, Research and Early Development, South San Francisco, USA

P421 Prognostic and therapeutic long-term outcome of patients with ulcerative proctitis: analysis from a large referral centre cohort study

ECCO'20 Vienna

Year: 2020
Authors:

E. Dubois, A. Moens, J. Sabino, M. Ferrante, S. Vermeire

Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium

P422 Tofacitinib induces clinical and endoscopic remission in biologic refractory ulcerative colitis patients: a real-world Belgian cohort study

ECCO'20 Vienna

Year: 2020
Authors:

A. Cremer1, T. Lobaton2, S. Vieujan3, P. Bossuyt4, J.F. Rahier5, F. Baert6, O. Dewit7, M. Somers8, E. Macken8, A. Vijverman9, P. Van Hootegem10, F. Mana11, B. Willandt12, P. Caenepeel13, E. Humblet13, F. D’Heygere14, A. Verreth15, A. El Nawar16, J.L. Coenegrachts17, S. Dewit18, S. De Coninck19, N. Schoofs20, S. Delen21, J. Dutre22, C. Thienpont23, S. Vanden Branden24, D. Staessen25, D. Franchimont1, Belgian Inflammatory Bowel Disease Research and Development (BIRD) Group

1Department of Gastroenterology, Erasme University Hospital- ULB, Brussels, Belgium, 2Department of Gastroenterology, University Hospital Ghent, Ghent, Belgium, 3Department of Gastroenterology, CHU Sart Tilman, Liège, Belgium, 4Department of Gastroenterology, Imelda General Hospital, Bonheiden, Belgium, 5Department of Gastroenterology, CHU UCL Namur, Yvoir, Belgium, 6Department of Gastroenterology, AZ Delta, Roeselare, Belgium, 7Department of Gastroenterology, Clin Univ Saint Luc, Brussels, Belgium, 8Department of Gastroenterology, University Hospital Antwerp, Edegem, Belgium, 9Department of Gastroenterology, CHR de la Citadelle, Liège, Belgium, 10Department of Gastroenterology, AZ Sint-Lucas, Brugge, Belgium, 11Department of Gastroenterology, Clinique Saint-Jean, Brussels, Belgium, 12Department of Gastroenterology, AZ Sint-Jan, Brugge, Belgium, 13Department of Gastroenterology, Ziekenhuis Oost-Limburg Sint-Jan, Genk, Belgium, 14Department of Gastroenterology, AZ Groeninge, Kortrijk, Belgium, 15Department of Gastroenterology, AZ Sint-Jozef, Malle, Belgium, 16Department of Gastroenterology, CH Mouscron, Mouscron, Belgium, 17Department of Gastroenterology, Jessa ZH, Hasselt, Belgium, 18Department of Gastroenterology, Maria ZH Noord-Limburg, Overpelt, Belgium, 19Department of Gastroenterology, Sint-Andries ZH, Tielt, Belgium, 20Department of Gastroenterology, Sint-Trudo ZH, Sint-Truiden, Belgium, 21Department of Gastroenterology-, ZH Maas en Kempen, Maaseik, Belgium, 22Department of Gastroenterology, ZNA Jan Palfijn, Merksem, Belgium, 23Department of Gastroenterology, ZNA Antwerpen, Antwerpen, Belgium, 24Department of Gastroenterology, Onze-Lieve-Vrouwziekenhuis, Aalst, Belgium, 25Department of Gastroenterology, GZA Sint-Vincentius ZH, Antwerpen, Belgium

P423 NF-kB as a prognostic marker of response to biologic therapy in children with IBD

ECCO'20 Vienna

Year: 2020
Authors:

T. Radigina1, A. Illarionov2, D. Kuptsova1, A. Potapov3, S. Petrichuk1, A.P. Fisenko1

1National Medical Research Center for Children’s Health, Laboratory of Experimental Immunology and Virology, Moscow, Russian Federation, 2Pediatrics and Rheumatology, Sechenov First Moscow State Medical University, Moscow, Russian Federation, 3Gastroenterology and Hepatology, National Medical Research Center for Children’s Health, Moscow, Russian Federation

P424 Economic evaluation of vedolizumab SC for the treatment of moderate-to-severe ulcerative colitis in Canada

ECCO'20 Vienna

Year: 2020
Authors:

A. FISCHER1, M. Oppe2, S. Stypa1, V. Lukyanov3, I. Petrakis4

1Takeda Canada Inc., Patient Value and Access, Toronto, Canada, 2Axentiva Solutions, Pharmacoeconomic, Sta. Cruz de Tenerife, Spain, 3IQVIA, Real-World Insights, Amsterdam, The Netherlands, 4Takeda Inc., Payer Value and Patient Access, Boston, USA

P425 SPOSIB SB2: a Sicilian prospective observational study of patients with inflammatory bowel disease treated with infliximab biosimilar SB2

ECCO'20 Vienna

Year: 2020
Authors:

F.S. Macaluso1, W. Fries2, A. Viola2, A. Centritto2, M. Cappello3, E. Giuffrida3, A.C. Privitera4, G. Piccillo4, A. Magnano5, E. Vinci5, R. Vassallo6, A. Trovatello7, N. Belluardo8, E. Giangreco8, S. Camilleri9, S. Garufi9, C. Bertolami10, M. Ventimiglia1, S. Renna1, R. Orlando1, G. Rizzuto1, M. Grova1, A. Orlando1

1Sicilian Network for Inflammatory Bowel Disease (SN-IBD), 1Department of Medicine, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy, 2A.O.U. Policlinico ‘G. Martino’, Inflammatory bowel disease Unit, Messina, Italy, 3A.O.U. Policlinico ‘P. Giaccone’, Gastroenterology and Hepatology Unit, Palermo, Italy, 4A.O. ‘Cannizzaro’, Inflammatory Bowel Disease Unit, Catania, Italy, 5Gastroenterology Unit, A.O.U. Policlinico ‘Vittorio Emanuele’, Catania, Italy, 6Gastroenterology and Endoscopy Unit, A.O. ‘Buccheri La Ferla Fatebenefratelli’, Palermo, Italy, 7A.O. ‘Umberto I’, Surgery Unit, Siracusa, Italy, 8Gastroenterology Unit, A.O. ‘Guzzardi’,Vittoria, Italy, 9Gastroenterology Unit, A.O.O.R. ‘S. Elia- M. Raimondi’, Caltanissetta, Italy, 10Gastroenterology Unit, A.O.O.R. ‘Papardo Piemonte’, Messina, Italy

P426 In failure of non-optimised adalimumab (ADA) with therapeutic serum levels, a change in biotherapy class is greater than an intensification of ADA dose in IBD patients

ECCO'20 Vienna

Year: 2020
Authors:

X. Roblin1, C. genin1, N. williet1, P. veyrard1, G. boschetti2, A.E. berger3, B. flourie2, S. nancey2, S. Paul3

1Department of Gastroenterology and Hepatology- Inserm- CIC1408, CHU Saint Etienne - Hospital Nord, Saint-Priest en Jarez, France, 2Department of Gastroenterology and Hepatology, CHU Lyon sud, Lyon, France, 3CHU Saint Etienne - Hospital Nord, Immunology, Saint-Priest en Jarez, France

P427 A hybrid approach of handling missing data in inflammatory bowel disease (IBD) trials: results from VISIBLE 1 and VARSITY

ECCO'20 Vienna

Year: 2020
Authors:

J. Chen1, S. Hunter2, K. Kisfalvi3, R.A. Lirio4

1Takeda, Statistics and Quantitative Sciences, Cambridge, USA, 2Cytel, Biostatistics, Cambridge, USA, 3Takeda, Research and development- Global Clinical Sciences, Cambridge, USA, 4Takeda, Clinical Science, Cambridge, USA

P428 Oral mesalamine use in Crohn’s disease after implementation of the American College of Gastroenterology guidelines: a TARGET-IBD cohort study

ECCO'20 Vienna

Year: 2020
Authors:

N. Gupta1, B.E. Sands2, M. Regueiro3, M. Dubinsky4, D. Rubin5, J. Hanson6, F. Aberra7, M. Weiss8, S. Watkins9, D. Gazis10, M. Long11

1Atlanta Gastroenterology, Gastroenterology, Atlanta, USA, 2Icahn School of Medicine at Mount Sinai Medical Center, Dr Henry D. Janowitz Division of Gastroenterology, New York, USA, 3Cleveland Clinic, Gastroenterology- Hepatology and Nutrition, Cleveland, USA, 4Ichan School of Medicine- Mount Sinai Hospital, Pediatric GI and Nutrition, New York, USA, 5Gastroenterology, University of Chicago, Chicago, USA, 6Atrium Health, Gastroenterology and Hepatology, Charlotte, USA, 7Gastroenterology, University of Pennsylvania, Philadelphia, USA, 8Gastroenterology, Gastro Florida, Tampa, USA, 9TARGET PharmaSolutions, Scientific and Medical Affairs, Durham, USA, 10TARGET PharmaSolutions, Statistics, Durham, USA, 11Gastroenterology, University of North Carolina at Chapel Hill, Chapel Hill, USA

P429 Clinical utility of thiopurine metabolite monitoring in inflammatory bowel disease and its impact on healthcare utilisation in Singapore

ECCO'20 Vienna

Year: 2020
Authors:

J.Q. Yeo1, H.L. Wee1, H.H. Cheen2, A. WONG2, T.G. Lim2, W.F. Leong3, B. Chowbay3, E. Salazar4, H.H. Shim4, W.P.W. Chan4, S.C. Kong5, W.C. Ong2

1Department of Pharmacy- Faculty of Science, National University of Singapore, Singapore, Singapore, 2Department of Pharmacy, Singapore General Hospital, Singapore, Singapore, 3Clinical Pharmacology, Singhealth, Singapore, Singapore, 4Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore, 5Department of Gastroenterology and Hepatology, Sengkang General Hospital, Singapore, Singapore

P430 Feasibility and reliability of gastrointestinal ultrasound in pregnant inflammatory bowel disease patients

ECCO'20 Vienna

Year: 2020
Authors:

F. de Voogd1, H. Joshi2, E. Van Wassenaer1, G. D’Haens1, K. Gecse1

1Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands, 2Gastroenterology, Sir H N Reliance Hospital, Mumbai, India

P431 Vitamin D binding protein in the limelight: IBD-related inflammation and circulating levels of vitamin D binding protein, total, free and bioavailable 25-hydroxyvitamin D

ECCO'20 Vienna

Year: 2020
Authors:

A. Aksan1,2,3, K. Böttger2,4, N. Hein4, Y. Caicedo-Zea5, I. Diehl6, C. Schumann5, F.P. Armbruster7, J.M. Stein1,2,4

1J. W Goethe University, Institute of Pharmaceutical Chemistry, Frankfurt am Main, Germany, 2Interdisciplinary Crohn-Colitis Centre Rhein-Main, Clinical and Scientific Research, Frankfurt am Main, Germany, 3Justus-Liebig-Universität, Institute of Nutritional Science, Giessen, Germany, 4DGD Clinics Frankfurt-Sachsenhausen, Gastroenterology and Clinical Nutrition, Frankfurt/Main, Germany, 5Immundiagnostik AG, Vitamin D Research, Bensheim, Germany, 6Immundiagnostik AG, Immunoassays, Bensheim, Germany, 7Immundiagnostik AG, Managing Director, Bensheim, Germany

P432 Effects and safety of a colon-long absorbing budesonide product in patients with mild to moderate ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

D. Pigniczki, K. Szántó, M. Rutka, K. Farkas, A. Bálint, R. Bor, A. Fábián, Z. Szepes, T. Molnár

Department of Medicine I, University of Szeged, Szeged, Hungary

P433 A real-world observational study assessing treatment persistence in ulcerative colitis patients receiving anti-TNF treatment (golimumab or adalimumab)

ECCO'20 Vienna

Year: 2020
Authors:

S. Hoque1, S. Boccaletti2, A. Puenpatom3, C. Brown2, C. Black3, J. Roberts4, I. Rajkovic4, G. Milligan4

1Gastroenterology, Barts Health NHS Trust, London, UK, 2Merck Sharp and Dohme Ltd., Outcomes Research, Hertfordshire, UK, 3Merck and Co.- Inc., Outcomes Research, New Jersey, USA, 4Adelphi Real World, Observational Research, Manchester, UK

P434 Effectiveness and safety of ustekinumab in ulcerative colitis: real-world evidence from Eneida Registry

ECCO'20 Vienna

Year: 2020
Authors:

M. Chaparro1, A. Garre1, M. Iborra2, M. Barreiro-de Acosta3, M.J. Casanova1, L. De Castro4, A. Fernández-Clotet5, J. Hinojosa6, M. Boscá-Watts7, D. Busquets8, A. López-García9, R. Lorente10, N. Manceñido11, T. Martínez12, D. Monfort13, J.L. Pérez-Calle14, A. Villoria15, T. Angueira16, F. Bermejo17, A.Y. Carbajo18, D. Carpio19, C. González-Muñoza20, F. Gomollón21, J.M. Huguet22, M. Rivero23, E. Iglesias-Flores24, M. Sierra25, L. Hernández-Villalba26, E. Domènech27, J.P. Gisbert1

1Hospital Universitario de La Princesa- IIS-IP- Universidad Autónoma de Madrid and CIBEREHD, Servicio de Aparato Digestivo, Madrid, Spain, 2Hospital Universitario y Politécnico La Fe and CIBEREHD, Gastroenterology Unit, Valencia, Spain, 3Complejo Hospitalario Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain, 4Hospital Álvaro Cunqueiro-Complexo Hospitalario Universitario de Vigo, Gastroenterology Unit, Vigo, Spain, 5Hospital Clìnic, Gastroenterology Unit, Barcelona, Spain, 6Hospital de Manises, Gastroenterology Unit, Valencia, Spain, 7Hospital Clínico de Valencia. Universitat de València, Gastroenterology Unit, Valencia, Spain, 8Hospital Universitario de Girona Dr. Josep Trueta, Gastroenterology Unit, Gerona, Spain, 9Hospital del Mar and Institut Hospital del Mar d’Investigacions Mèdiques, Gastroenterology Unit, Barcelona, Spain, 10Hospital General Universitario de Ciudad Real, Gastroenterology Unit, Ciudad Real, Spain, 11Hospital Infanta Sofía, Gastroenterology Unit, San Sebastián de los Reyes, Spain, 12Hospital Virgen de la Luz, Gastroenterology Unit, Cuenca, Spain, 13Consorci Sanitari de Terrasa, Gastroenterology Unit, Barcelona, Spain, 14Hospital Universitario Fundación Alcorcón, Gastroenterology Unit, Madrid, Spain, 15Hospital de Sabadell. Depàrtament de Medicina. Universitat Autònoma de Barcelona y CIBEREHD, Gastroenterology Unit, Barcelona, Spain, 16Hospital General de Tomelloso and CIBEREHD, Gastroenterology Unit, Ciudad Real, Spain, 17Hospital Universitario Fuenlabrada and Instituto de Investigación Sanitaria del Hospital de La Paz IdiPAZ, Gastroenterology Unit, Madrid, Spain, 18Hospital Universitario Río Hortega, Gastroenterology Unit, Valladolid, Spain, 19Complexo Hospitalario Universitario de Pontevedra, Gastroenterology Unit, Pontevedra, Spain, 20Hospital de la Sta Creu i San Pau, Gastroenterology Unit, Barcelona, Spain, 21HCU Lozano BLesa- IIS Aragón and CIBEREHD, Gastroenterology Unit, Zaragoza, Spain, 22Hospital General Universitario de Valencia, Gastroenterology Unit, Valencia, Spain, 23Hospital Universitario Márques de Valdecilla and IDIVAL, Gastroenterology Unit, Santander, Spain, 24Hospital Universitario Reina Sofía, Gastroenterology Unit, Córdoba, Spain, 25Complejo Asistencial Universitario de León, Gastroenterology Unit, León, Spain, 26Hospital Santos Reyes, Gastroenterology Unit, Burgos, Spain, 27Hospital Universitario Germans Trials i Pujol and CIBEREHD, Gastroenterology Unit, Barcelona, Spain