P0559: Endoscopic healing at 1-year and association with long-term quality of life in ulcerative colitis: A pooled clinical trial analysis adjusting for 1-year clinical remission statusECCO'25Year: 2025
Authors: Sanon, M.(1)*;Neff-Baro, S.(2);Gauthier, A.(2);Kachroo, S.(3);Wirth, D.(4);Eisele, L.(5);Naessens, D.(6);
(1)Janssen Global Services- LLC, Global Market Access Immunology, Raritan, United States;(2)Amaris Consulting, Statistics, Paris, France;(3)Janssen Scientific Affairs, Real World Evidence, Horsham, United States;(4)Janssen Cilag GmbH, Market Access, Neuss, Germany;(5)Janssen Cilag GmbH, Market Access HTA Methods, Neuss, Germany;(6)Janssen Pharmaceutica NV, Global Market Access, Beerse, Belgium;
P0560: Levels of disease-associated anti-integrin αVβ6 are substantially reduced after proctocolectomy in ulcerative colitis but persist in primary sclerosing cholangitisECCO'25Year: 2025
Authors: Roth, D.(1);Düll, M.(1);Horst, L.(2);Lindemann, A.(1);Elsner, X.(1);Koop, K.(1);Zundler, S.(1);Vetter, M.(1);Jefremow, A.(1);Atreya, R.(1);Geppert, C.(3);Weidemann, S.(4);Waldner, M.(1);Dietrich, P.(1);Günther, C.(1);Munoz, L.(5);Herrmann, M.(5);Neurath, M.(1);Siebler, J.(1);Schramm, C.(6);Kremer, A.(7);Leppkes, M.(1)*;
(1)Universitätskliniken Erlangen, Medizin 1, Erlangen, Germany;(2)Universitätsklinik Hamburg-Eppendorf, Martin Zeitz Center for Rare Diseases, Hamburg, Germany;(3)Universitätskliniken Erlangen, Institut für Pathologie, Erlangen, Germany;(4)Universitätskliniken Hamburg-Eppendorf, Institut für Pathologie, Hamburg, Germany;(5)Universitätskliniken Erlangen, Medizin 3, Erlangen, Germany;(6)Universitätskliniken Hamburg-Eppendorf, Martin Zeitz Center for Rare Diseases, Hamburg, Germany;(7)Universitätsspital Zürich, Klinik für Gastroenterologie und Hepatologie, Zürich, Switzerland;
P0561: Sustained Corticosteroid-Sparing Effects of Upadacitinib Maintenance Therapy in Patients With Moderate-to-Severe Crohn’s Disease: 2-Year Results From the U-ENDURE Long-Term Extension StudyECCO'25Year: 2025
Authors: Jairath , V.(1);Dubinsky , M.(2);Biedermann , L.(3)*;Fujii , T.(4);Cunneen , C.(5);Dubcenco , E.(5);Ford , S.(5);Garrison , A.(5);Loftus Jr. , E.V.(6);
(1)Western University, Department of Medicine, London, Canada;(2)Icahn School of Medicine at Mount Sinai, Susan and Lenard Feinstein IBD Clinical Center, New York, United States;(3)University Hospital Zurich, Department of Gastroenterology and Hepatology, Zurich, Switzerland;(4)Institute of Science Tokyo, Department of Gastroenterology and Hepatology, Tokyo, Japan;(5)AbbVie- Inc, Gastroenterology, North Chicago, United States;(6)Mayo Clinic College of Medicine and Science, Division of Gastroenterology and Hepatology, Rochester, United States;
1. RINVOQ [package insert], extended-release tablets, FDA Prescribing Information. AbbVie Inc; 2022. Accessed 1 June 2022.2.
2. RINVOQ [package insert], prolonged-release tablets. EMA Summary of Product Characteristics. AbbVie; 2022. Accessed 1 June 2022.
3. Loftus EV and Panes J et al. N Engl J Med 2023;388:1966-1980. J
4. M C Dubinsky, et al. JCC, 17; (Supp_1); 2023: i104–i106.
P0562: Evaluation of the impact of fistulizing disease on quality of life in Crohn's diseaseECCO'25Year: 2025
Authors: Kani, H.T.(1)*;Ergenc, I.(2);Ozsarac, B.(3);Sahin, B.N.(3);Kaya, G.(3);Ozutemiz, B.(3);Demir, B.C.(3);Atug, O.(2);Ozen Alahdab, Y.(2);
(1)Marmara University- School of Medicine, Gastroenterology, Istanbul, Turkey;(2)Marmara University School of Medicine, Gastroenterology, Istanbul, Turkey;(3)Marmara University, School of Medicine, Istanbul, Turkey;
1- Spinelli A, Yanai H, Girardi P, Milicevic S, Carvello M, Maroli A, Avedano L. The Impact of Crohn's Perianal Fistula on Quality of Life: Results of an International Patient Survey. Crohns Colitis 360. 2023 Jul 25;5(3):otad036. doi: 10.1093/crocol/otad036. PMID: 37529012; PMCID: PMC10390083.
2- Kato M, Yoneyama-Hirozane M, Iwasaki K, Matsubayashi M, Igarashi A. Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn's disease: a quantitative evaluation of patients and non-patients in Japan. J Mark Access Health Policy. 2023 Jan 15;11(1):2166374. doi: 10.1080/20016689.2023.2166374. PMID: 36684854; PMCID: PMC9848226.
3- Karki C, Athavale A, Abilash V, Hantsbarger G, Geransar P, Lee K, Milicevic S, Perovic M, Raven L, Sajak-Szczerba M, Silber A, Yoon A, Tozer P. Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn's perianal fistulas. World J Gastrointest Surg. 2023 Nov 27;15(11):2537-2552. doi: 10.4240/wjgs.v15.i11.2537. PMID: 38111766; PMCID: PMC10725550.
P0563: Prevalence and clinical impact of abnormal hepatobiliary biochemistry in newly diagnosed inflammatory bowel disease – a prospective population-based inception cohort studyECCO'25Year: 2025
Authors: Attauabi, M.(1,2,3)*;Madsen, G.R.(2,4);Bendtsen, F.(2,3,5);Seidelin, J.B.(5,6);Burisch, J.(3,5,7);
(1)Copenhagen University Hospital - Herlev and Gentofte- Herlev, Department of Gastroenterology and Hepatology, Herlev, Denmark;(2)Hvidovre Hospital, Copenhagen Center for Inflammatory Bowel Disease in Children- Adolescents- and Adults-, Hvidovre, Denmark;(3)Copenhagen University Hospital - Amager and Hvidovre- Hvidovre, Gastrounit- Medical Section, Hvidovre, Denmark;(4)Copenhagen University Hospital - Amager and Hvidovre- Hvidovre-, Gastrounit- Medical Section, Hvidovre, Denmark;(5)Faculty of Health and Medical Sciences- University of Copenhagen, Department of Clinical Medicine, Copenhagen, Denmark;(6)Rigshospitalet, Dept. of Digestive Diseases- Transplantation and General Surgery- IBD Section, Copenhagen, Denmark;(7)Hvidovre Hospital, Copenhagen Center for Inflammatory Bowel Disease in Children- Adolescents- and Adults, Hvidovre, Denmark;
1. Attauabi M, Madsen GR, Bendtsen F, et al. Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study. BMJ Open. 2022;12(6):e055779. doi:10.1136/bmjopen-2021-055779
P0564: Sexually Transmitted Infections Mimicking Inflammatory Bowel Diseases: Case Series of Infectious ProctitisECCO'25Year: 2025
Authors: Mattana, M.(1)*;Sbrozzi-Vanni, A.(2);Lapenna, L.(1);Fonte, S.(1);Cusi, G.(1);Faggiani, R.(1);Merli, M.(1);
(1)Sapienza University of Rome, Department of Translational and Precision Medicine, Rome, Italy;(2)San Camillo-Forlanini Hospital, Department of Gastroenterology and Digestive Endoscopy, Rome, Italy;
-Infectious Proctitis: When to Suspect It Is Not InflammatoryBowel DiseaseFrank Hoentjen • David T. Rubin (Dig Dis Sci (2012) 57:269–273) -Proctitis: a glance beyond inflammatory bowel diseasesStefano Rizza et all Minerva Gastroenterol Dietol. 2020 Sep;66(3):252-266
-Proctitis in Men Who Have Sex with Men. Julia M. Steed et all
P0565: Spatial Metabolic Profiles in Ulcerative colitis patients determine response to therapyECCO'25Year: 2025
Authors: Hrvat, F.(1)*;Converso, G.(1);Wozny, M.(1);Martano, G.(2);Timo, S.(2);Morosi, L.(2);Pineda, S.(3);Legrottaglie, C.(1);Carriles, A.A.(1);Mori, G.(3);Rizzo, G.(3);Oldenburg, L.(4);D’Haens, G.(4);Tran, F.(5);Rosenstiel, P.(5);Schreiber, S.(5);Armuzzi, A.(6);Vetrano, S.(3);
(1)Humanitas University, Department of Biomedical Sciences, Pieve Emanuele- Milan, Italy;(2)IRCCS Humanitas Research Hospital, Metabolomic Unit, Rozzano- Milano, Italy;(3)IRCCS Humanitas Research Hospital, Laboratory of Gastrointestinal Immunopathology, Rozzano- Milan, Italy;(4)Amsterdam University Medical Centers, Department of Gastroenterology, Amsterdam, The Netherlands;(5)University Hospital Schleswig-Holstein, Department of Internal Medicine I, Kiel, Germany;(6)IRCCS Humanitas Research Hospital, IBD Unit- Department of Gastroenterology, Rozzano- Milan, Italy;
ImmUniverse project: this project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No. 853995. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA. The content provided in this abstract reflects only the author's view and neither the IMI JU nor the European Commission are responsible for any use that may be made of the information it contains.
P0566: Submucosal, but not mucosal, wall thickness and stiffness correlate with bowel urgency in Ulcerative ColitisECCO'25Year: 2025
Authors: Serizawa, K.(1,2);SagamiMD- PhD, S.(1)*;Shibui, S.(1,2);Umeda, S.(1,2);Asonuma, K.(1,2);Komatsu, M.(1,2);Maeda, M.(1,2);Nogami, A.(1,2);Karashima, R.(1,2);Nakano, M.(1,2);Maeda, I.(3);Hibi, T.(1);Kobayashi, T.(1,2);
(1)Kitasato University Kitasato Institute Hospital, Center for Advanced IBD Research and Treatment, Tokyo, Japan;(2)Kitasato University Kitasato Institute Hospital, Department of Gastroenterology, Tokyo, Japan;(3)Kitasato University Kitasato Institute Hospital, Department of Pathology, Tokyo, Japan;
P0567: Use of a convolutional neural network to quantify and predict ulcerative colitis disease endoscopic activity and histological outcomesECCO'25Year: 2025
Authors: Morrison, S.(1)*;Chiu, C.(2);Cao, R.(1);Lim, P.(1);Shin, J.S.(3);Mackenzie, C.(3);Kench, J.(3);Corte, C.(1);Tamilarasan, A.(1);
(1)Royal Prince Alfred Hospital, AW Morrow Gastroenterology and Liver Centre, Sydney, Australia;(2)University of Sydney, Medicine, Sydney, Australia;(3)Royal Prince Alfred Hospital, Pathology, Sydney, Australia;
Hashash JG, Yu Ci Ng F, Farraye FA, Wang Y, Colucci DR, Baxi S, Muneer S, Reddan M, Shingru P, Melmed GY. Inter- and Intraobserver Variability on Endoscopic Scoring Systems in Crohn's Disease and Ulcerative Colitis: A Systematic Review and Meta-Analysis. Inflamm Bowel Dis. 2024 Mar 28:izae051. doi: 10.1093/ibd/izae051
Marchal-Bressenot A, Salleron J, Boulagnon-Rombi C, et al. Development and validation of the Nancy histological index for UC. Gut 2017;66:43-49.
P0568: Mortality and comorbidities in people with Inflammatory Bowel Disease - Crohn’s Colitis Cure data insights programECCO'25Year: 2025
Authors: Alsulaibi , O.(1,2);Su , W.K.(1,3,4);Wilson , W.(5);Sin , L.(6,7);Ng , W.(4,8);Walker , G.(9,10,11);Forbes , A.(12);Lawrance , I.(13,14);Lynch , K.(15,16);Begun , J.(17,18);Connor , S.J.(1,3,4,8)*;Andrews , J.M.(1,16,19);
(1)Crohn's Colitis Cure, CCCure, Sydney, Australia;(2)Orange Health Service, General Medicine, Orange, Australia;(3)The Ingham Institute for Applied Medical Research, Gastroenterology- Hepatology and Inflammatory Bowel Disease Research Group, Liverpool, Australia;(4)Liverpool Hospital, Department of Gastroenterology and Hepatology, Sydney, Australia;(5)Lyell McEwin Hospital, Department of Anaesthetics, Adelaide, Australia;(6)St Vincent’s Public Hospital Sydney, Department of Gastroenterology and Hepatology, Sydney, Australia;(7)University of New South Wales, St Vincent’s Clinical School, Sydney, Australia;(8)University of New South Wales, South West Sydney Clinical Campuses, Sydney, Australia;(9)Royal Brisbane and Women's Hospital, Department of Gastroenterology and Hepatology, Brisbane, Australia;(10)QIMR Berghofer, Medical Research Institute, Brisbane, Australia;(11)University of Queensland, Research UQ Centre for Clinical Research, Brisbane, Australia;(12)University of Otago, Department of Medicine, Christchurch, New Zealand;(13)Saint John of God Subiaco Hospital, Centre for Inflammatory Bowel Disease, Perth, Australia;(14)University of Western Australia, School of Medicine and Pharmacology, Perth, Australia;(15)Royal Adelaide Hospital, Department of Gastroenterology and Hepatology, Adelaide, Australia;(16)University of Adelaide, Faculty of Health Sciences, Adelaide, Australia;(17)Mater Hospital, Department of Gastroenterology and Hepatology, Brisbane, Australia;(18)Mater Research, Faculty of Medicine, Brisbane, Australia;(19)Central Adelaide Local Health Network, Department of Gastroenterology and Hepatology, Adelaide, Australia;
References
1. Persson, P. et al. (1996) ‘Survival and cause-specific mortality in inflammatory bowel disease: A population-based Cohort Study’, Gastroenterology, 110(5), pp. 1339–1345.
2. Andrews, J.M. et al. (1995) ‘Inflammatory bowel disease: A retrospective review of a specialist‐based cohort’, Medical Journal of Australia, 163(3), pp. 133–136.
3. Selinger, C.P. et al. (2013) ‘Cause-specific mortality and 30-year relative survival of crohnʼs disease and ulcerative colitis’, Inflammatory Bowel Diseases, 19(9), pp. 1880-1888.
P0569: Inflammatory Bowel Disease nursing helpline trends in a large real-world Australasian cohort: Crohn's Colitis Cure (CCC) data insights programECCO'25Year: 2025
Authors: Chan, P.(1)*;Su, W.K.(2,3);Wilson, W.(4);Cabaero, A.(2);Antoniades, S.(5);Forbes, A.(6);Arnold, K.(7);Grafton, R.(8);Andrews, J.(8,9);Connor, S.(2,3,10);
(1)Fiona Stanley Hospital, Department of Gastroenterology, Murdoch, Australia;(2)Liverpool Hospital, Department of Gastroenterology and Hepatology, Liverpool, Australia;(3)The Ingham Institute for Applied Medical Research, Gastroenterology- Hepatology and Inflammatory Bowel Disease Research Group, Liverpool, Australia;(4)Lyell McEwin Hospital, Department of Anaesthesia, Adelaide, Australia;(5)St Vincent's Hospital, Department of Gastroenterology and Hepatology, Sydney, Australia;(6)University of Otago, Department of Medicine, Dunedin, New Zealand;(7)Health New Zealand Te Whatu Ora, Department of Gastroenterology, Christchurch, Australia;(8)Royal Adelaide Hospital, Department of Gastroenterology and Hepatology, Adelaide, Australia;(9)University of Adelaide, Faculty of Health Sciences, Adelaide, Australia;(10)University of New South Wales, South West Sydney School of Clinical Medicine, Sydney, Australia;
P0570: Role of dynamic contrast-enhanced ultrasound (D-CEUS) in predicting clinical remission to advanced therapy in ulcerative colitis - a monocenter prospective pilot studyECCO'25Year: 2025
Authors: Mignini, I.(1)*;Maresca, R.(1);Calvez, V.(1);Galasso, L.(1);Esposto, G.(1);Borriello, R.(1);Schiavoni, E.(1);Napolitano, D.(1);Laterza, L.(1);Ainora, M.E.(1);Gasbarrini, A.(1);Scaldaferri, F.(1);Zocco, M.A.(1);
(1)CEMAD- Digestive Disease Center, Fondazione Policlinico Universitario "A. Gemelli" IRCCS- Università Cattolica del Sacro Cuore, Rome, Italy;
1Allocca M, Fiorino G, Bonovas S, Furfaro F, Gilardi D, Argollo M, Magnoni P, Peyrin-Biroulet L, Danese S. Accuracy of Humanitas Ultrasound Criteria in Assessing Disease Activity and Severity in Ulcerative Colitis: A Prospective Study. J Crohns Colitis. 2018 Nov 28;12(12):1385-1391. doi: 10.1093/ecco-jcc/jjy107. PMID: 30085066; PMCID: PMC6260119.
2Allocca M, Filippi E, Costantino A, Bonovas S, Fiorino G, Furfaro F, Peyrin-Biroulet L, Fraquelli M, Caprioli F, Danese S. Milan ultrasound criteria are accurate in assessing disease activity in ulcerative colitis: external validation. United European Gastroenterol J. 2021 May;9(4):438-442. doi: 10.1177/2050640620980203. Epub 2021 Feb 16. PMID: 33349199; PMCID: PMC8259285.
3 Turner D, Ricciuto A, Lewis A, D'Amico F, Dhaliwal J, Griffiths AM, Bettenworth D, Sandborn WJ, Sands BE, Reinisch W, Schölmerich J, Bemelman W, Danese S, Mary JY, Rubin D, Colombel JF, Peyrin-Biroulet L, Dotan I, Abreu MT, Dignass A; International Organization for the Study of IBD. STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD. Gastroenterology. 2021 Apr;160(5):1570-1583. doi: 10.1053/j.gastro.2020.12.031. Epub 2021 Feb 19. PMID: 33359090.
P0571: Transmural healing, assessed through the combination of faecal calprotectin and intestinal ultrasound, is associated with a reduced risk of bowel damage progression in patients with Crohn's diseaseECCO'25Year: 2025
Authors: Buisson, A.(1)*;Huet, J.(1);Dodel, M.(1);Coban, D.(1);Bazoge, M.(1);Mathieu, K.(1);Pereira, B.(1);
(1)CHU Clermont-Ferrand, IBD Unit, Clermont-Ferrand, France;
P0572: Impact of objective motility MRI scoring of ileal Crohn’s disease on gastroenterologists treatment assessment: The CONTEXT TrialECCO'25Year: 2025
Authors: Moran, G.(1)*;Naim, I.(2);Barber, J.(3);Patel, K.(4);Patel, N.(3);Ocholi, A.(4);Khodabakhshi, D.(4);Baillie, S.(4);Onyeador, N.(4);Jennings, V.(5);Vuyyuru, S.(6);Clarke, C.(7);Munya, R.(7);Bhatnagar, G.(8);Shepherd, T.(9);Upponi, S.(10);De la Revilla Negro, J.(11);Sethi-Arora, K.(12);Kuzhiyanjal, A.(12);Limdi, J.(12);Win , A.(13);Ghodekar, P.(13);Siddiuqui, A.M.(13);Tolan, D.(14);Lambie , H.(14);Fitzke, H.(15);Weston, W.(15);Harrow, P.(16);Yeo, J.(16);Hameed, M.(15);Taylor, S.(15);Menys, A.(2);
(1)Nottingham, Gastroenterology, Nottingham Digestive Diseases Centre, United Kingdom;(2)Motilent, Motilent, London, United Kingdom;(3)St George's, Radiology, London, United Kingdom;(4)St George's, Gastroenterology, London, United Kingdom;(5)Nottingham University Hospitals, Nottingham Digestive Disease Centre, Nottingham, United Kingdom;(6)Nottingham University Hospitals, Nottingham Digestive Diseases Centre, Nottingham, United Kingdom;(7)Nottingham University Hospitals, Radiology, Nottingham, United Kingdom;(8)Frimley Park Hospital, Radiology, Frimley, United Kingdom;(9)Frimley Park Hospital, Gastroenterology, Frimley, United Kingdom;(10)Addenbrooke's- University of Cambridge, Radiology, Cambridge, United Kingdom;(11)Addenbrooke's- University of Cambridge, Gastroenterology, Cambridge, United Kingdom;(12)Northern Care Alliance NHS Foundation Trust, Gastroenterology, Manchester, United Kingdom;(13)Northern Care Alliance NHS Foundation Trust, Radiology, Manchester, United Kingdom;(14)Leeds Teaching Hospitals NHS Trust, Radiology, Leeds, United Kingdom;(15)UCL, Centre for Medical imaging, London, United Kingdom;(16)UCLH, Gastroenterology, London, United Kingdom;
P0573: The Burden of Urgency in Ulcerative Colitis: Impact of Disease Duration and ActivityECCO'25Year: 2025
Authors: SingeapPhD, A.M.(1)*;Muzica, C.(1);Huiban, L.(1);Girleanu, I.(1);Stafie, R.(2);Minea, H.(1);Stanciu, C.(1);Trifan, A.(1);
(1)"Grigore T. Popa" University of Medicine and Pharmacy, Gastroenterology, Iasi, Romania;(2)"Grigore T. Popa" University of Medicine and Pharmacy, Gastroenterology, Iași, Romania;
P0575: Bronchiectasis in patients with inflammatory bowel disease – prevalence, predictors, and clinical characteristicsECCO'25Year: 2025
Authors: Freund, O.(1,2);Bar-Shai, A.(1,2);Alkhazov, A.(1,2);Stav, D.(2,3);Hadad, Y.(2,3);Perluk, T.M.(1,2);Sror, N.(2,4);Hirsch, A.(2,4);Ron, Y.(2,4);Thurm, T.(2,4);Herling, A.(2,4);Leibovitzh, H.(2,4);Maharshak, N.(2,4);Cohen, N.A.(2,4)*;
(1)Tel Aviv Medical Center, Institute of Pulmonary Medicine, Tel Aviv, Israel;(2)Tel Aviv University, Faculty of Medicine, Tel Aviv, Israel;(3)Tel Aviv Medical Center, Department of Radiology, Tel Aviv, Israel;(4)Tel Aviv Medical Center, Department of Gastroenterology and Liver Diseases, Tel Aviv, Israel;
P0577: Influence of Pregnancy on Outcomes of Inflammatory Bowel Disease and Medication AdherenceECCO'25Year: 2025
Authors: Ozturk, O.(1)*;Durak, M.B.(2);Cagir, Y.(3);Ergul, M.(1);Keskin, E.T.(1);Atay, A.(1);Yuksel, I.(1,4);
(1)Ankara Bilkent City Hospital, Department of Gastroenterology, Ankara, Turkey;(2)Hacettepe University- Faculty of Medicine, Department of Gastroenterology, Ankara, Turkey;(3)Ankara Yildirim Beyazit University- Yenimahalle Training and Research Hospital, Department of Gastroenterology, Ankara, Turkey;(4)Ankara Yildirim Beyazit University- Faculty of Medicine, Department of Gastroenterology, Ankara, Turkey;
P0578: The relationship between the concentration of D-dimer and interleukin-6 in patients with ulcerative colitis.ECCO'25Year: 2025
Authors: Knyazev, O.(1);Kagramanova, A.V.(2,3)*;
(1)Moscow Clinical Scientific Center named after A.S. Loginov, Department of IBD, Moscow, Russian Federation;(2)Moscow Clinical Scientific Center named after A. S. Loginov, Department of IBD, Moscow, Russian Federation;(3)Research Institute of Health Organization and Medical Management, Department of Coloproctology, Moscow, Russian Federation;
