P0009: Comparative analysis of ileal mucus in healthy individuals and Crohn’s Disease patients using scanning electron microscopy suggests changes in network structureECCO'25Year: 2025
Authors: Mönch, P.W.(1)*;Kramer, C.(1);Timm, S.(2);Kerkhoff, Y.(3);Ludwig, K.(3);Ochs, M.(2);Siegmund, B.(1);
(1)Charité Universitätsmedizin Berlin, Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Charité Universitätsmedizin Berlin, Core Facility Electron Microscopy, Berlin, Germany;(3)Freie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany;
1. Johansson, M. E. V., Sjövall, H., & Hansson, G. C. (2013). The gastrointestinal mucus system in health and disease. Nature Reviews Gastroenterology & Hepatology, 10(6), 352-361. https://doi.org/10.1038/nrgastro.2013.35
2. Bansil, R., & Turner, B. S. (2018). The biology of mucus: Composition, synthesis and organization. Advanced Drug Delivery Reviews, 124, 3-15. https://doi.org/10.1016/j.addr.2017.09.019
3. Kramer, C., RulD, H., Ziegler, J. F., et al. (2024). Ileal mucus viscoelastic properties diDer in Crohn’s disease. Mucosal Immunology, 17(4), 713-722. https://doi.org/10.1038/s41385-023-00567-9
4. Atreya, R., Siegmund, B. (2021). Location is important: differentiation between ileal and colonic Crohn’s disease. Nature Reviews Gastroenterology & Hepatology, 18(8), 544-558. https://doi.org/10.1038/s41575-021-00452-3
P0010: Characterization of proliferating memory CD4⁺ T cells reveals a distinct immune signature in anti-α4β7 integrin therapy non-responders Inflammatory Bowel Disease patientsECCO'25Year: 2025
Authors: Cancino, C.(1,2)*;Horn, V.(1,2,3);Obermayer, B.(4,5);Fritz, K.(1,2);Nguyen, A.(1,6);Juhran, K.(1,2);Bösel, D.(1,2);Conrad, T.(7,8);Sonnenberg, E.(1);Weidinger, C.(1);Siegmund, B.(1);Thurley, K.(2,9);Hegazy, A.(1,2,5);
(1)Charité Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;(2)Deutsches Rheuma-Forschungszentrum, ein Institut der Leibniz-Gemeinschaft, Berlin, Germany;(3)Weill Cornell Medicine- Cornell University, Department of Medicine- Division of Gastroenterology and Hepatology, New York, United States;(4)Berlin Institute of Health at Charité Universitätsmedizin Berlin, Core Unit Bioinformatics, Berlin, Germany;(5)Berlin Institute of Health at Charité Universitätsmedizin Berlin, Berlin Institute of Health Academy- Clinician Scientist Program, Berlin, Germany;(6)Monash University and Alfred Health, Department of Gastroenterology- Central Clinical School, Melbourne, Australia;(7)Max Delbrück Center for Molecular Medicine in the Helmholtz Association MDC, Genomics Technology Platform, Berlin, Germany;(8)Berlin Institute of Health at Charité Universitätsmedizin Berlin, Core Unit Genomics, Berlin, Germany;(9)University Hospital Bonn, Institute for Experimental Oncology- Biomathematics Division, Bonn, Germany;
P0011: Differential Impact of Diet and FMT on Colonic and Ileal Inflammation in humanized IBD ModelsECCO'25Year: 2025
Authors: DeleuDVM- PhD, S.(1)*;Vidmar, K.(2);Troisi, S.(3);Wargo, H.(2);Masi, L.(4);Williams, J.(2);Artone, S.(5);De Santis, S.(2);De Salvo, C.(2);Petito, V.(4);Lopetuso, L.(6);Cominelli , F.(7);Pizarro, T.T.(2);Scaldaferri, F.(4);
(1)KU Leuven, Chronic Diseases & Metabolism, Leuven, Belgium;(2)Case Western Reserve University, Pathology, Cleveland, United States;(3)Fondazione Policlinico Universitario “A. Gemelli” IRCCS- Rome- Italy, CeMAD Translational Research Laboratories- Digestive Disease Center CeMAD- Department of Medical and Surgical Sciences, Roma, Italy;(4)Fondazione Policlinico Universitario “A. Gemelli” IRCCS, CeMAD Translational Research Laboratories- Digestive Disease Center CeMAD- Department of Medical and Surgical Sciences, Roma, Italy;(5)Case Western Reserve Univeristy, Pathology, Cleveland, United States;(6)University of Chieti-Pescara, Scienze Mediche e Chirurgiche, Chieti, Italy;(7)Case Western Reserve University, Gastroenterology and hepatology, Cleveland, United States;
P0012: The predictive value of the mesorectal macrophage profile for pouch outcomes in ulcerative colitisECCO'25Year: 2025
Authors: Haanappel, A.(1)*;van der Does de Willebois, E.(1);Becker, M.(2);Vlug, M.(1);Bemelman, W.(1);Buskens, C.(1);Wildenberg, M.(2);
(1)Amsterdam UMC, Surgery, Amsterdam, The Netherlands;(2)Amsterdam Gastroenterology & Metabolism- Tytgat Institute for Liver and Intestinal Research- Amsterdam UMC- University of Amsterdam, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands;
- de Groof EJ, van der Meer JHM, Tanis PJ, de Bruyn JR, van Ruler O, D'Haens G, et al. Persistent Mesorectal Inflammatory Activity is Associated With Complications After Proctectomy in Crohn's Disease. J Crohns Colitis. 2019;13(3):285-93.
2. Bloemendaal FM, Becker M, Koelink PJ, van der Bilt JD, Bemelman WA, D’Haens GRAM, et al. DOP82 Macrophages in Crohn’s disease mesentery are predominantly inflammatory and produce calprotectin. Journal of Crohn's and Colitis. 2020;14(Supplement_1):S121-S2.
P0013: Protein-Energy Malnutrition Induces Microbiome-Dependent Long-Lasting Changes in Intestinal Epithelial CompositionECCO'25Year: 2025
Authors: Schuran , F.A.(1)*; Mishra , N.(1); López-Agudelo , V.(1); Sommer , N.(1); P. Bernardes , J.(1); Walker , A.(2); Hinrichsen , F.(1); Gong , T.(1); Gilbert , F.(1); Schröder , L.(1); Bhardwaj , A.(1); Künzel , S.(3); Weber-Stiehl , S.(1); Ito , G.(4); Tran , F.(1); Schreiber , S.(3); Penninger , J.M.(5); Blumberg , R.(6); Schmitt-Kopplin , P.(2); Baines , J.F.(7); Sommer , F.(1); Rosenstiel , P.(1);
(1)Institute of Clinical Molecular Biology IKMB, University Hospital Schleswig-Holstein UKSH, Kiel, Germany;(2)Research Unit Analytical BioGeoChemistry, Helmholtz Munich, München, Germany;(3)Max Planck Institute for Evolutionary Biology, Department for Evolutionary Genetics, Plön, Germany;(4)Institute of Clinical Molecular Biology- Christian-Albrechts-University and University Hospital Schleswig-Holstein, Department of Gastroenterology and Hepatology- Tokyo Medical and Dental University, Tokyo, Japan;(5)Innovative Organoid Forschung, Helmholtz-Zentrum für Infektionsforschung, Braunschweig, Germany;(6)Gastroenterology Division- Department of Medicine, Brigham and Women's Hospital- Harvard Medical School, Boston, United States;(7)Institute of Experimental Medicine, University of Kiel, Kiel, Germany;
1. World Health Organization (2024). World health statistics 2024: monitoring health for the SDGs, Sustainable Development Goals.
2. UNICEF, WHO, and WORLD BANK (2023). Level and trend in child malnutrition. World Health Organization, 4.
3. Soeters, P., Bozzetti, F., Cynober, L., Forbes, A., Shenkin, A., and Sobotka, L. (2017). Defining malnutrition: A plea to rethink. Clinical Nutrition 36, 896–901. https://doi.org/10.1016/J.CLNU.2016.09.032.
4. Bhutta, Z., Berkley, J., Bandsma, R. et al. Severe childhood malnutrition. Nat Rev Dis Primers 3, 17067 (2017). https://doi.org/10.1038/nrdp.2017.67
5. Smith, M.I., Yatsunenko, T., Manary, M.J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A.L., Rich, S.S., Concannon, P., Mychaleckyj, J.C., et al. (2013). Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science (1979) 339, 548–554. https://doi.org/10.1126/science.1229000.
6. Gordon, J.I., Dewey, K.G., Mills, D.A., and Medzhitov, R.M. (2012). The Human Gut Microbiota and Undernutrition. Sci Transl Med 4. https://doi.org/10.1126/SCITRANSLMED.3004347.
7. Barratt, M.J., Ahmed, T., and Gordon, J.I. (2022). Gut microbiome development and childhood undernutrition. Cell Host Microbe 30, 617–626. https://doi.org/10.1016/J.CHOM.2022.04.002.
P0014: Mesenteric inflammation-associated fibroblasts are critical in the pathogenesis of Crohn’s diseaseECCO'25Year: 2025
Authors: Park, J.(1)*;Joo, Y.H.(2);Song, E.M.(2);Park, Y.(2);Noh, G.T.(3);Choi, E.(4);Byun, J.(5);Byun, J.R.(2);Kim, H.S.(3);Ahn, Y.H.(1);Jung, S.A.(2);
(1)Ewha Womans University College of Medicine, Department of Molecular Medicine, Seoul, Korea- Republic Of;(2)Ewha Womans University College of Medicine, Department of Internal Medicine, Seoul, Korea- Republic Of;(3)Ewha Womans University College of Medicine, Department of Surgery, Seoul, Korea- Republic Of;(4)Ewha Womans University College of Medicine, Department of Pathology, Seoul, Korea- Republic Of;(5)Ewha Womans University College of Medicine, Department of Radiology, Seoul, Korea- Republic Of;
P0015: The local intestinal interstitial cytokine profile provides an insight into inflamed bionaive patients with Ulcerative ColitisECCO'25Year: 2025
Authors: Rogoll, E.(1)*;Rogoll, S.(1);Zigra, G.(1);Wilhelm, A.(2);Kräker, K.(3);Müller, D.N.(3);Siegmund, B.(4);Haag, L.M.(5);
(1)Charité - Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;(2)CheckImmune GmbH, CheckImmune GmbH, Berlin, Germany;(3)Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;(4)Charité - Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology-, Berlin, Germany;(5)Charité - Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology-, Berlin, Germany;
P0016: Comprehensive Characterization of local Cytokine Signatures in Ulcerative Colitis in Deep RemissionECCO'25Year: 2025
Authors: Rogoll, E.(1)*;Amelie, S.(1);Gluschke, H.H.(1);Zigra, G.(1);Wilhelm, A.(2);Kräker, K.(3);Kühl, A.A.(4);The TRR241, I.C.(5);Müller, D.N.(3);Siegmund, B.(6);Haag, L.M.(1);
(1)Charité - Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;(2)CheckImmune GmbH, CheckImmune GmbH, Berlin, Germany;(3)Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;(4)Charité - Universitätsmedizin Berlin, iPATH.Berlin – Core Unit Immunpathologie für Experimentelle Modelle, Berlin, Germany;(5)Charité - Universitätsmedizin Berlin, Funded by the Deutsche Forschungsgemeinschaft DFG- German Research Foundation – Project-ID 375876048 – TRR 241, Berlin, Germany;(6)Charité - Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;
P0017: Single-cell transcriptomic analysis reveals insights into the mechanism of action and immune modulation by granulocyte-monocyte apheresisECCO'25Year: 2025
Authors: Kioroglou, D.(1);Cabriada, J.L.(2);Martinez Marigorta, U.(1)*;Rodríguez-Lago, I.(2);
(1)CIC bioGUNE, Integrative Genomics lab, Derio, Spain;(2)Hospital Universitario de Galdakao, Gastroenterology Department, Galdakao, Spain;
P0018: Fat rich dietary habits: Further increasing IBD risk in first degree relativesECCO'25Year: 2025
Authors: Koentgen, S.(1)*;Cosier, D.(2);Tavakoli, P.(1);Leach, S.T.(3);Dutt, S.(4);Ghaly, S.(5);Connor, S.J.(6);Lemberg, D.A.(7);Lambert, K.(8);Hold, G.L.(1);
(1)University of New South Wales, Microbiome Research Centre, Sydney, Australia;(2)University of Wollongong, School of Medical- Indigenous and Health Sciences, Wollongong, Australia;(3)University of New South Wales, School of Clinical Medicine, Sydney, Australia;(4)Children's Hospital at Westmead, Gastroenterology, Sydney, Australia;(5)St Vincent’s Private Hospital Sydney, Gastroenterology, Sydney, Australia;(6)Liverpool Hospital, Gastroenterology and Liver, Sydney, Australia;(7)Sydney Children’s Hospital, Paediatric Gastroenterology, Sydney, Australia;(8)University of Wollongong, School of Medical- Indigenous and Health Sciences, Sydney, Australia;
1. Kaplan GG, Ng SC. Understanding and Preventing the Global Increase of Inflammatory Bowel Disease. Gastroenterology. 2017;152(2):313-321. doi:10.1053/j.gastro.2016.10.020
P0019: Investigation of the serum sphingolipid and ceramide profile in patients with Crohn's disease at different stages of the diseaseECCO'25Year: 2025
Authors: Kubesch, A.(1)*;Neumann, E.(1);Mohs, K.(2);Gurke, R.(3);Zeuzem, S.(1);Blumenstein, I.(1);
(1)Goethe University- University Hospital, Department of Internal Medicine I, Frankfurt, Germany;(2)Fraunhofer-Institute for Translational Medicine and Pharmakology ITMP, Deparment of Clinical Research/Biobank, Frankfurt, Germany;(3)Goethe University, Department of Clinical Pharmacology- Fraunhofer Institute, Frankfurt, Germany;
- Cancers 2024, 16, 789. https://doi.org/10.3390/cancers16040789Biomolecules 2020, 10, 1083.
2. Espinoza KS, Snider AJ. Therapeutic Potential for Sphingolipids in Inflammatory Bowel Disease and Colorectal Cancer. Cancers (Basel). 2024 Feb 15;16(4):789. doi: 10.3390/cancers16040789. PMID: 38398179; PMCID: PMC10887199.
3. Filimoniuk, A.; Blachnio-Zabielska, A.; Imierska, M.; Lebensztejn, D.M.; Daniluk, U. Sphingolipid Analysis Indicate Lactosylceramide as a Potential Biomarker of Inflammatory Bowel Disease in Children. Biomolecules 2020, 10, 1083. https://doi.org/10.3390/biom10071083
P0020: Type 1 and CD103+ type 2 conventional dendritic cells are decreased in patients with active ulcerative colitis but not with Crohn’s disease.ECCO'25Year: 2025
Authors: Bernardo, D.(1)*;Arribas-Rodríguez, E.(2);G de Castro, C.(2);Fiz-López, A.(2);De Prado, A.(2);Martín-Muñoz, A.(3);Fernández-Salazar, L.(4);Barrio, J.(5);Izquierdo, S.(4);García-Alonso, F.J.(5);de Andrés, B.(6);García-Abril, J.M.(7);Romero, A.(6);Sánchez-González, J.(7);Arranz, E.(2);Chaparro, M.(8);Gisbert, J.P.(8);Garrote, J.A.(9);
(1)Universidad de Valladolid, Instituto de Biomedicina y Genética Molecular, Valladolid, Spain;(2)Instituto de Biomedicina y Genética Molecular de Valladolid Universidad de Valladolid-CSIC, Immunology, Valladolid, Spain;(3)Instituto de Biomedicina y Genética Molecular de Valladolid Universidad de Valladolid-CSIC, Flow Cytometry, Valladolid, Spain;(4)Hospital Clínico Universitario de Valladolid, Gastroenterology, Valladolid, Spain;(5)Hospital Universitario Río Hortega, Gastroenterology, Valladolid, Spain;(6)Hospital Clínico Universitario de Valladolid, Surgery, Valladolid, Spain;(7)Hospital Universitario Río Hortega, Surgery, Valladolid, Spain;(8)Hospital Universitario de La Princesa, Gastroenterology, Madrid, Spain;(9)Hospital Universitario Río Hortega, Clinical Analyses, Valladolid, Spain;
P0021: Long non-coding RNAs as predictors of response to anti-TNF therapy in Ulcerative Colitis patientsECCO'25Year: 2025
Authors: Heydari, R.(1);Tavassolifar, M.J.(1);Derakhshan Nazari, M.H.(2);Shahrokh, S.(3);Meyfour, A.(1)*;
(1)Research Institute for Gastroenterology and Liver Diseases- Shahid Beheshti University of Medical Sciences, Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Tehran, Iran- Islamic Republic Of;(2)Schulich School of Medicine and Dentistry- Western University, Department of Pathology and Laboratory Medicine, London, Canada;(3)Research Institute for Gastroenterology and Liver Diseases- Shahid Beheshti University of Medical Sciences, Gastroenterology and Liver Diseases Research Center, Tehran, Iran- Islamic Republic Of;
2. Heydari R, Karimi P, Meyfour A. Long non-coding RNAs as pathophysiological regulators, therapeutic targets and novel extracellular vesicle biomarkers for the diagnosis of inflammatory bowel disease. Biomed Pharmacother. Jul 2024;176:116868. doi:10.1016/j.biopha.2024.116868
P0022: Development of primary human fibroblast cell cultures for fibrosis modelling in Inflammatory Bowel DiseasesECCO'25Year: 2025
Authors: Kajári, L.(1,2,3)*;Szabó, V.(1,2,3,4);Jójárt, B.(1,2,3,4);Bacsur, P.(1,5);Molnár, T.(1);Farkas, K.(1,5);Maléth, J.(1,2,3,4);
(1)University of Szeged, Szent-Györgyi Albert Medical School- Department of Medicine, Szeged, Hungary;(2)University of Szeged, National Academy of Scientist Education, Szeged, Hungary;(3)University of Szeged, ELKH-USZ Momentum Epithelial Cell Signaling and Secretion Research Group, Szeged, Hungary;(4)University of Szeged, HCEMM-USz Molecular Gastroenterology Research Group, Szeged, Hungary;(5)University of Szeged, HCEMM-USz Translational Colorectal Research Group, Szeged, Hungary; Epithelial Cell Signaling and Secretion Research Group
P0023: Methionine Restriction Promotes Intestinal Mucosal Repair by Regulating Selenbp1 and Modulating Macrophage PolarizationECCO'25Year: 2025
Authors: Wu, L.(1);Chen , Y.(1);Chen, R.(2);Tang, W.(2);Liu, Y.(3)*;
(1)Medical College of Soochow University, Department of Pathology and Pathophysiology, Suzhou, China;(2)the Second Affiliated Hospital of Soochow University, Department of Gastroenterology, Suzhou, China;(3)Nanjing Drum Tower Hospital- the Affiliated Hospital of Nanjing University Medical School, Department of Pathology, Nanjing, China;
P0024: Circadian regulator-mediated molecular subtypes depict the features of elderly ulcerative colitisECCO'25Year: 2025
Authors: Zhang, Y.(1)*;Xu, J.(1);Cao, S.(1);Wang, J.(1);Lin, Y.(1);Liu, Y.(1);
(1)Peking University People's Hospital, Gastroenterology, Beijing, China;
P0025: The effect of very small superparamagnetic nanoparticles on human blood cells as a diagnostic tool in Inflammatory Bowel DiseaseECCO'25Year: 2025
Authors: Hussein, S.(1,2)*;Kühl, A.A.(2);Golusda, L.(1,2);Plattner, C.(3);Heinze, N.(1,2);Sturm, G.(3);Freise , C.(4);Traube, H.(5);Trajanoski, Z.(3);Taupitz, M.(5);Schnorr, J.(4);Siegmund, B.(1);Paclik, D.(1,2);
(1)Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin- Medical Department- Division of Gastroenterology- Infectious Diseases and Rheumatology- Campus Benjamin Franklin- Hindenburgdamm 30- 12200, Berlin, Germany;(2)Charité – Universitätsmedizin Berlin, Universitätsmedizin Berlin- corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin- iPATH.Berlin- Campus Benjamin Franklin- Hindenburgdamm 30- 12200, Berlin, Germany;(3)Medical University of Innsbruck, Biocenter- Institute of Bioinformatics, Innsbruck, Austria;(4)Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin- Department of Radiology-Experimental Radiology- Campus Mitte- Virchowweg 11- 10117, Berlin, Germany;(5)Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin- Department of Radiology-Radiology- Campus Benjamin Franklin- Hindenburgdamm 30- 12200, Berlin, Germany;
P0026: Multi-omics phenotyping characterizes perturbed molecular divergence underlying different clinical scenarios of under-treatment inflammatory bowel diseaseECCO'25Year: 2025
Authors: Lee, H.S.(1)*;
(1)Inje University Busan Paik Hospital- Inje University College of Medicine- Busan- Korea, Department of Internal Medicine, Busan, Korea- Republic Of;
M. Agrawal, K.H. Allin, F. Petralia, J.-F. Colombel, T. Jess, Multiomics to elucidate inflammatory bowel disease risk factors and pathways, Nature Reviews Gastroenterology & Hepatology 19(6) (2022) 399-409.
P0027: The carbon footprint of remote monitoring of IBD patients – a green opportunity for sustainable outpatient careECCO'25Year: 2025
Authors: Hendrix , E.M.B.(1,2);de Jong , D.C.(3);de Jong , M.J.(4);Becx , M.C.J.M.(5);van Bodegraven , A.A.(6);Dijkstra , G.(7);Kimman , M.(8,9);Mahmmod , N.(5);Maljaars , J.P.(10);van der Meulen-de Jong , A.E.(10);Mujagic , Z.(1,2);Romberg-Camps , M.J.(6);Pierik , M.J.(1,2)*;Duijvestein , M.(11);
(1)Maastricht University, Research Institute for Nutrition and Translational Research in Metabolism NUTRIM, Maastricht, The Netherlands;(2)Maastricht University Medical Centre+, Department of Gastroenterology and Hepatology, Maastricht, The Netherlands;(3)Amsterdam University Medical Centre, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands;(4)Horacio Oduber Hospital, Department of Gastroenterology and Hepatology, Oranjestad, Aruba;(5)St Antonius Hospital, Department of Gastroenterology and Hepatology, Nieuwegein, The Netherlands;(6)Zuyderland Medical Centre, Department of Gastroenterology-Geriatrics-Internal and Intensive Care Medicine Co-MIK, Heerlen-Sittard-Geleen, The Netherlands;(7)University Medical Centre Groningen- Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands;(8)Maastricht University Medical Centre+, Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht, The Netherlands;(9)Maastricht University Medical Centre+, Care and Public Health Research Institute CAPHRI, Maastricht, The Netherlands;(10)Leiden University Medical Centre, Department of Gastroenterology and Hepatology, Leiden, The Netherlands;(11)Radboud University Medical Centre, Department of Gastroenterology, Nijmegen, The Netherlands;
1. de Jong MJ, van der Meulen-de Jong AE, Romberg-Camps MJ, Becx MC, Maljaars JP, Cilissen M, van Bodegraven AA, Mahmmod N, Markus T, Hameeteman WM, Dijkstra G, Masclee AAM, Boonen A, Winkens B, van Tubergen A, Jonkers DMAE, Pierik MJ. Telemedicine for management of inflammatory bowel disease (myIBDcoach): a pragmatic, multicentre, randomised controlled trial. Lancet. 2017;390(10098):959-68.
2. de Jong MJ, Boonen A, van der Meulen-de Jong AE, Romberg-Camps MJ, van Bodegraven AA, Mahmmod N, Markus T, Dijkstra G, Winkens B, van Tubergen A, Masclee AAM, Jonkers DMAE, Pierik MJ. Cost-effectiveness of Telemedicine-directed Specialized vs Standard Care for Patients With Inflammatory Bowel Diseases in a Randomized Trial. Clin Gastroenterol Hepatol. 2020;18(8):1744-52.
3. van Linschoten RCA, van Leeuwen N, van Klaveren D, Pierik MJ, Creemers R, Hendrix EMB, Hazelzet JA, van der Woude CJ, West RL, van Noord D. Prevalence, incidence and mortality of inflammatory bowel disease in the Netherlands: development and external validation of machine learning models. Submitted.
P0028: Discovery of GLP-2R agonists using computational molecular design techniquesECCO'25Year: 2025
Authors: Scagnoli, B.(1);Righino, B.(1);Pirolli, D.(1);Lopetuso, L.(2);Chieppa, M.(3);Mocci, G.(4);Petito, V.(5);Scaldaferri, F.(6,7)*;Gasbarrini, A.(7,8);Papa, A.(7,9);De Rosa, M.C.(10);
(1)Consiglio Nazionale delle Ricerche CNR, Istituto di Scienze e Tecnologie Chimiche “Giulio Natta” SCITEC, Rome, Italy;(2)Università degli Studi "G. d'Annunzio" Chieti – Pescara, Dipartimento di Medicina e Scienze dell'Invecchiamento- Center for Advanced Studies and Technology CAST, Chieti, Italy;(3)Università del Salento - Centro Ecotekne, Dipartimento di Medicina Sperimentale, Lecce, Italy;(4)ARNAS G. Brotzu, Gastroenterologia, Cagliari, Italy;(5)Fondazione Policlinico Universitario “A. Gemelli” IRCCS, CeMAD Translational Research Laboratories- Digestive Disease Center CeMAD- Department of Medical and Surgical Sciences, Rome, Italy;(6)Fondazione Policlinico Universitario “A. Gemelli” IRCCS, CeMAD Translational Research Laboratories- Digestive Disease Center CeMAD- Department of Medical and Surgical Sciences-IBD Unit- Digestive Disease Center CeMAD- Dipartimento di Scienze Mediche e Chirurgiche, Rome, Italy;(7)Università Cattolica del Sacro Cuore, Dipartimento di Medicina e Chirurgia Traslazionale, Rome, Italy;(8)Fondazione Policlinico Universitario Gemelli IRCCS, Dipartimento di Scienze Mediche e Chirurgiche- Medicina Interna e Gastroenterologia, Rome, Italy;(9)Fondazione Policlinico Universitario “A. Gemelli” IRCCS, IBD Unit- Digestive Disease Center CeMAD- Dipartimento di Scienze Mediche e Chirurgiche, Rome, Italy;(10)Consiglio Nazionale delle Ricerche CNR, Istituto di Scienze e Tecnologie Chimiche "Giulio Natta" SCITEC, Rome, Italy;
1. Johnson TO, Akinsanmi AO, Ejembi SA, et al. Modern drug discovery for inflammatory bowel disease: The role of computational methods. World J Gastroenterol. 2023;29(2):310-331. doi:10.3748/wjg.v29.i2.310
2. Tripathi NM, Bandyopadhyay A. High throughput virtual screening (HTVS) of peptide library: Technological advancement in ligand discovery. Eur J Med Chem. 2022;243:114766. doi:10.1016/j.ejmech.2022.114766
3. Pirolli D, Righino B, Camponeschi C, Ria F, Di Sante G, De Rosa MC. Virtual screening and molecular dynamics simulations provide insight into repurposing drugs against SARS-CoV-2 variants Spike protein/ACE2 interface [published correction appears in Sci Rep. 2023 Feb 15;13(1):2707. doi: 10.1038/s41598-023-29766-8]. Sci Rep. 2023;13(1):1494. Published 2023 Jan 27. doi:10.1038/s41598-023-28716-8