¹Rijnstate Hospital, Department of Gastroenterology and Hepatology, Arnhem, The Netherlands, ²Rijnstate Hospital, Department of Pathology, Arnhem, The Netherlands, ³Rijnstate Hospital, Department of Microbiology and Immunology, Arnhem, The Netherlands

¹IIS Hospital la Fe, Inflammatory Bowel Disease Research Group, Valencia, Spain, ²Biomedical Research Centre- Hepatic and Digestive Diseases Network, CIBERehd, Madrid, Spain, ³Hospital la Fe, Gastroenterology, Valencia, Spain, ⁴IIS Hospital la Fe, Biostatistics Unit, Valencia, Spain, ⁵Universitat Politecnica de Valencia, IBMCP. Instituto de Biologia Molecular y Celular de Plantas, Valencia, Spain

¹Samsung Medical Center, Department of Gastroenterology, Seoul, Republic of Korea, ²Samsung Medical Center, Gastroenterology, Seoul, Republic of Korea

¹GSK, Adaptive Immunity Research Unit, Stevenage, UK, ²GSK, Innate Immunity Research Unit, Philadelphia, USA, ³GSK, In Vitro/In Vivo Translation, Ware, UK, ⁴GSK, 3In Vitro/In Vivo Translation, Ware, UK, ⁵GSK, Dmpk, Stevenage, UK

¹Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Trondheim, Norway, ²St. Olav’s University Hospital, Clinic of Medicine, Trondheim, Norway, ³Norwegian University of Science and Technology, Centre of Molecular Inflammation Research, NTNU, Trondheim, Norway, ⁴Linköping University, Department of Biomedical and Clinical Sciences BVK, Linköping, Sweden, ⁵St. Olav’s University Hospital, Department of Pathology, Clinic of Laboratory Medicine, Trondheim, Norway, ⁶St. Olav’s University Hospital, Department of Gastroenterology, Clinic of Medicine-, Trondheim, Norway, ⁷Linköping University Hospital, Department of Gastroenterology and Hepatology, Linköping, Sweden

Gastroenterology Department, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Terrassa. Centro de Investigación Biomédica en red de enfermedades hepáticas y digestivas CIBERehd, Gastroenterology Department, Terrassa, Spain

¹Nordic Bioscience A/S, Biomarkers and Research, Herlev, Denmark, ²University Hospital Centre Zagreb, Department of Gastroenterology and Hepatology, Zagreb, Croatia, ³University Hospital Centre Zagreb, Department for Clinical Nutrition, Zagreb, Croatia

¹The Second Affiliated Hospital of South China University of Technology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou First People’s Hospital, Guangdong Institute of Gastroenterology, Guangdong Province Key Laboratory of Colorectal and Pelvic Floor Diseases, Gastroenterology, Guangzhou, China, ²The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangdong Institute of Gastroenterology- Guangdong Province Key Laboratory of Colorectal and Pelvic Floor Diseases, Gastroenterology, Guangzhou, China

Department of Gastroenterology, Ewha Womans University College of Medicine, Seoul, Republic of Korea

¹School of Medicine, University College Dublin, Dublin, Ireland, ²Department of Biological Sciences, University of Limerick, Dublin, Ireland

¹Yonsei University College of Medicine, Brain Korea 21 PLUS Project for Medical Science, Seoul, Republic of Korea, ²Yonsei University College of Medicine, Department of Medicine, Seoul, Republic of Korea, ³Yonsei University College of Medicine, Department of Internal Medicine and Institute of Gastroenterology, Seoul, Republic of Korea

¹Asuits Cattinara Hospital, Gastroenterology, Trieste, Italy, ²Istituto Milanese di Psicoterapia Cognitivo Comportamentale - IMIPSI, Psychology, Milano, Italy, ³Ospedale IRCCS ‘Sacro Cuore - Don Calabria’ Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Classificato e Presidio Ospedaliero Accreditato - Regione Veneto, Gastroenterology, Verona, Italy, ⁴Azienda Ospedaliero Universitaria di Pisa – AOUP, Gastroenterology, Pisa, Italy, ⁵Ospedale San Martino, Genova, Psychology, Genova, Italy, ⁶Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, VascularSciences and Public Health, University of Padova, Biostatistics, Padova, Italy, ⁷Ospedale S. Michele Brotzu, Gastroenterology, Cagliari, Italy, ⁸Ospedali Riuniti Villa Sofia-Cervello, Internal Medicine, Palermo, Italy, ⁹Ospedale Regionale Casa Sollievo della Sofferenza IRCCS di San Giovanni Rotondo, Gastroenterology, San Giovanni Rotondo, Italy, ¹⁰IBD Unit Presidio Columbus-Fondazione Policlinico Universitario A. Gemelli IRCCS e Università Cattolica del Sacro Cuore, Gastroenterology, Roma, Italy

¹IBDome-DE Investigators, Charité – University Medicine Berlin, CBF and German Rheumatism Research Center-Berlin, Department of Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, ²Deutsches Rheuma-Forschungszentrum, ein Institut der Leibniz-Gemeinschaft, Inflammatory Mechanisms Group, Berlin, Germany, ³Charité-Universitätsmedizin Berlin, iPath.Berlin-Immunopathology for Experimental Models, Berlin, Germany

CDISC, Standards Development, Austin, USA

PMI, Systems toxicology, Neuchatel, Switzerland

¹Pharmazentrum Frankfurt, Institute of Pharmacology and Toxicology, Frankfurt am Main, Germany, ²Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany, ³Department of Gastroenterology and Clinical Nutrition, DGD Clinics Sachsenhausen, Frankfurt am Main, Germany

Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité – Universitätsmedizin Berlin, Berlin, Germany

¹University Hospital Zagreb, Unit of Clinical Nutrition, Zagreb, Croatia, ²Faculty of Food Technology and Biotechnology, Laboratory of Nutrition Science, Zagreb, Croatia, ³Department of Gastroenterology and Hepatology, University Hospital Zagreb, Zagreb, Croatia

¹Universidad Autónoma de Madrid. Hospital Universitario de La Princesa, Medicina, Madrid, Spain, ²Unidad de Análisis de Datos. Hospital Universitario de La Princesa, Análisis de Datos, Madrid, Spain, ³Universidad de Alcalá., Farmacia, Alcalá de Henares Madrid, Spain, ⁴Instituto de Medicina Molecular Aplicada IMMA. Universidad San Pablo CEU., Medicina, Madrid, Spain, ⁵Universidad Autónoma de Madrid. Hospital Universitario de La Princesa. CIBERehd., Medicina, Madrid, Spain, ⁶Hospital Universitario de La Princesa, Medicina, Madrid, Spain, ⁷Hospital Universitario de La Princesa. CIBERehd., Medicina, Madrid, Spain, ⁸Mucosal Immunolgy lab. Instituto de de Biología y Genética Molecular IBGM., Medicina, Valladolid, Spain, ⁹Both authors had equal contribution- as senior authors, Medicina, Madrid, Spain

Gastroenterology and Hepatology Section, University of Palermo, PROMISE, Palermo, Italy