¹Hospital Universitario de La Princesa, IIS-IP , Universidad Autónoma de Madrid and CIBEREHD, Gastroenterology Unit, Madrid, Spain, ²Hospital Clínico Universitario de Valencia, Gastroenterology Unit, Valencia, Spain, ³Hospital Clínic i Provincial, CIBEREHD and IDIBAPS, Gastroenterology Unit, Barcelona, Spain, ⁴Hospital Universitario Clínico San Carlos, Gastroenterology Unit, Madrid, Spain, ⁵Hospital Universitario Miguel Servet and CIBEREHD, Gastroenterology Unit, Zaragoza, Spain, ⁶Hospital Universitario de Bellvitge, Gastroenterology Unit, Barcelona, Spain, ⁷Hospital Universitario Ramón y Cajal, Gastroenterology Unit, Madrid, Spain, ⁸Hospital Universitario Reina Sofía, Gastroenterology Unit, Córdoba, Spain, ⁹Hospital Universitario y Politécnico La Fe and CIBEREHD, Gastroenterology Unit, Valencia, Spain, ¹⁰Hospital Universitario de Burgos, Gastroenterology Unit, Burgos, Spain, ¹¹Hospital Universitario Puerta de Hierro Majadahonda, Gastroenterology Unit, Madrid, Spain, ¹²Hospital de Manises, Gastroenterology Unit, Valencia, Spain, ¹³Hospital Universitario Central de Asturias, Gastroenterology Unit, Oviedo, Spain, ¹⁴Hospital Universitario Germans Trias i Pujol and CIBEREHD, Gastroenterology Unit, Badalona, Spain, ¹⁵Hospital de Sabadell. Corporació Sanitària Universitària Parc Taulí and CIBEREHD, Gastroenterology Unit, Sabadell, Spain, ¹⁶Hospital Universitario Fundación de Alcorcón, Gastroenterology Unit, Madrid, Spain, ¹⁷Hospital Universitario La Paz and Instituto de Investigación de La Paz (IdiPaz), Gastroenterology Unit, Madrid, Spain, ¹⁸Hospital Universitari de Girona Dr. Josep Trueta, Gastroenterology Unit, Gerona, Spain, ¹⁹Hospital Universitario Marqués de Valdecilla and IDIVAL, Gastroenterology, Santander, Spain, ²⁰Consorci Sanitari Terrassa, Gastroenterology, Tarrasa, Spain, ²¹Hospital Universitario Río Hortega, Gastroenterology, Valladolid, Spain, ²²Hospital Universitario Mutua Terrasa, Gastroenterology Unit, Tarrasa, Spain, ²³Hospital del Mar, Gastroenterology Unit, Barcelona, Spain, ²⁴Hospital General Universitario de Ciudad Real and CIBEREHD, Gastroenterology Unit, Ciudad Real, Spain, ²⁵Hospital de la Santa Creu i Sant Pau, Gastroenterology Unit, Barcelona, Spain, ²⁶Complejo Hospitalario Universitario de Vigo, Gastroenterology Unit, Vigo, Spain, ²⁷Hospital Universitario de Fuenlabrada and Instituto de Investigación de La Paz (IdiPaz), Gastroenterology Unit, Madrid, Spain, ²⁸Hospital Universitario Cruces, Baracaldo, Spain, ²⁹Hospital Clínico Universitario de Salamanca, Gastroenterology Unit, Salamanca, Spain, ³⁰Hospital Universitario Doce de Octubre, Gastroenterology Unit, Madrid, Spain, ³¹Hospital de Torrejón, Gastroenterology Unit, Madrid, Spain, ³²Hospital Universitario Virgen de la Victoria, Gastroenterology Unit, Málaga, Spain, ³³Hospital General San Jorge, Gastroenterology Unit, Huesca, Spain, ³⁴Hospital de Basurto, Gastroenterology Unit, Bilbao, Spain, ³⁵Hospital Clínico Universitario Lozano Blesa, Gastroenteroogy Unit, Zaragoza, Spain, ³⁶Hospital Clínico Universitario de Valladolid, Gastroenterology Unit, Valladolid, Spain, ³⁷Hospital General Universitario de Elche, Gastroenterology Unit, Elche, Spain, ³⁸Hospital de Galdakao-Usansolo, Gastroenterology Unit, Galdakao, Spain, ³⁹Hospital General Universitario de Alicante and CIBEREHD, Gastroenterology Unit, Alicante, Spain, ⁴⁰Hospital Universitario Virgen Macarena, Gastroenterology Unit, Sevilla, Spain, ⁴¹Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Gastroenterology Unit, Pamplona, Spain, ⁴²Hospital Universitario Nuestra Señora de la Candelaria, Gastroenterology Unit, Santa Cruz de Tenerife, Spain, ⁴³Hospital Universitario de Donostia, Instituto Biodonostia, Universidad del País Vasco (UPV/EHU) and CIBEREHD, Gastroenterology Unit, San Sebastián, Spain, ⁴⁴ALTHAIA Xarxa Assistencial Universitària de Manresa, Gastroenterology Unit, Manresa, Spain, ⁴⁵Hospital Universitario de Cabueñes, Gastroenterology Unit, Gijón, Spain, ⁴⁶Hospital Universitario de Canarias, Gastroenterology Unit, La Laguna, Spain, ⁴⁷Consorcio Hospital General Universitario de Valencia, Gastroenterology Unit, Valencia, Spain, ⁴⁸Hospital General Universitario de Castellón, Gastroenterology Unit, Castellón, Spain, ⁴⁹Hospital General Universitario de Santa Lucía, Gastroenterology Unit, Murcia, Spain, Hospital de Sant Joan Despí Moisès Broggi, Gastroenterology Unit, Sant Joan Despí, Spain, Hospital de Viladecans, Gastroenterology Unit, Barcelona, Spain, Hospital Universitario de Álava, Gastroenterology Unit, Vitoria, Spain, Hospital General de Tomelloso, Gastroenterology Unit, Ciudad Real, Spain, Hospital Universitario Arnau de Vilanova, Gastroenterology Unit, Lérida, Spain, Complejo Asistencial Universitario de Palencia, Gastroenterology Unit, Palencia, Spain, Hospital Royo Villanova, Gastroenterology Unit, Zaragoza, Spain, Hospital Marina Baixa, Gastroenterology Unit, Alicante, Spain, Hospital Universitario Infanta Sofía, Gastroenterology Unit, Madrid, Spain, Hospital Universitario Son Espases, Gastroenterology Unit, Palma de Mallorca, Spain

¹Wilhelmina Children's Hospital, Pediatric Gastro-enterology, Utrecht, The Netherlands, ²Erasmus MC-Sophia, Pediatric Gastro-enterology, Rotterdam, The Netherlands, ³Sanquin Diagnostic Services, Biologics Lab, Amsterdam, The Netherlands

¹Abpro Corp., Woburn, USA, ²Takeda Pharmaceuticals, Cambridge, USA

¹Sant'Orsola Hospital, Alma Mater Studiorum University of Bologna, Department of Medical and Surgical Sciences, Bologna, Italy

¹Hospital Sant Joan de Déu Althaia - Manresa, Gastroenterology, Manresa- Barcelona, Spain, ²Hospital Mútua de Terrassa, Gastroenterology, Terrassa- Barcelona, Spain, ³Hospital Arnau de Vilanova, Gastroenterology, Lleida, Spain, ⁴Hospital Clínic de Barcelona, Gastroenterology, Barcelona, Spain, ⁵Hospital Universitario de la Princesa, Gastroenterology, Madrid, Spain, ⁶Hospital La Paz, Gastroenterology, Madrid, Spain, ⁷HGU de Elche, Gastroenterology, Elche- Alicante, Spain, ⁸Hospital Clínico Universitario Lozano Blesa, Gastroenterology, Zaragoza, Spain, ⁹Hospital de Galdakao, Gastroenterology, Galdakao-Vizcaya, Spain, ¹⁰HU Salamanca, Gastroenterology, Salamanca, Spain, ¹¹Hospital San Jorge, Gastroenterology, Huesca, Spain, ¹²Hospital Reina Sofía, Gastroenterology, Córdoba, Spain, ¹³Hospital dr. Josep Trueta, Gastroenterology, Girona, Spain, ¹⁴HGU Alicante, Gastroenterology, Alicante, Spain, ¹⁵Hospital Germans Trias i Pujol, Gastroenterology, Barcelona, Spain, ¹⁶Hospital Ramón y Cajal, Gastroenterology, Madrid, Spain, ¹⁷Hospital Clínico San Carlos, Gastroenterology, Madrid, Spain, ¹⁸Hospital La Fe, Gastroenterology, Valencia, Spain, ¹⁹Hospital de Bellvitge, Gastroenterology, Barcelona, Spain, ²⁰Hospital Parc Taulí, Gastroenterology, Sabadell-Barcelona, Spain, ²¹Hospital Clínico, Gastroenterology, Valencia, Spain, ²²Hospital Son Llàtzer, Gastroenterology, Mallorca, Spain, ²³Hospital de Santiago, Gastroenterology, Santiago de Compostela, Spain, ²⁴Hospital de la Santa Creu i Sant Pau, Gastroenterology, Barcelona, Spain, ²⁵Complejo Hospitalario de Burgos, Gastroenterology, Burgos, Spain, ²⁶Complejo Hospitalario de Navarra, Gastroenterology, Pamplona, Spain, ²⁷Hospital Río Hortega, Gastroenterology, Valladolid, Spain, ²⁸Hospital de Torrejón, Gastroenterology, Torrrejón-Madrid, Spain, ²⁹HU Miguel Servet, Gastroenterology, Zaragoza, Spain, ³⁰Consorci Sanitari Mútua de Terrassa, Gastroenterology, Terrassa-Barcelona, Spain, ³¹Hospital de Basurto, Gastroenterology, Basurto-Bilbao, Spain, ³²Hospital Viladecans, Gastroenterology, Viladecans-Barcelona, Spain, ³³HU de Fuenlabrada, Gastroenterology, Fuenlabrada-Madrid, Spain, ³⁴Hospital 12 de Octubre, Gastroenterology, Madrid, Spain, ³⁵Hospital Nuestra Señora de la Candelaria, Gastroenterology, Santa Cruz de Tenerife, Spain, ³⁶Hospital Clínico, Gastroenterology, Valladolid, Spain, ³⁷Hospital General Universitario, Gastroenterology, Valencia, Spain, ³⁸Hospital de Donostia, Gastroenterology, Donostia, Spain, ³⁹Hospital General, Gastroenterology, Ciudad Real, Spain, ⁴⁰Hospital General, Gastroenterology, Castelló, Spain, ⁴¹Hospital Marqués de Valdecilla, Gastroenterology, Santander, Spain, ⁴²HU de Álava, Gastroenterology, Álava, Spain, ⁴³Hospital Infanta Sofía, Gastroenterology, Madrid, Spain, ⁴⁴HU Central de Asturias, Gastroenterology, Oviedo, Spain, ⁴⁵Hospital General de Tomelloso, Gastroenterology, Tomelloso-Ciudad Real, Spain, ⁴⁶Hospital de Cruces, Gastroenterology, Barakaldo-Bilbao, Spain, ⁴⁷Hospital de Segovia, Gastroenterology, Segovia, Spain, ⁴⁸HU Puerta de Hierro, Gastroenterology, Majadahonda-Madrid, Spain, ⁴⁹Hospital General de Granollers, Gastroenterology, Granollers-Barcelona, Spain

¹University of Naples, Translational Medical Science, Section of Pediatrics, Naples, Italy, ²Children Hospital of Philadelphia, Gastroenterology, Hepatology and Nutrition Division, Philadelphia, USA

¹University of Missouri – Kansas City School of Pharmacy, Kansas City, USA, ²AbbVie, Chicago, USA, ³Analysis Group, Boston, USA

¹Erasmus Mc-Sophia Children's Hospital, Rotterdam, The Netherlands, ²Icahn School of Medicine, Mount Sinai, New York, USA, ³Janssen Scientific Affairs, LLC, Horsham, USA, ⁴Janssen Research and Development, LLC, Spring House, USA, ⁵The Hospital for Sick Children, University of Toronto, Toronto, Canada

¹County Durham and Darlington NHS Foundation Trust, Gastroenterology, Durham, UK, ²Hull Royal Infirmary, Gastroenterology, Hull, UK

¹University Medical Center Utrecht, Utrecht, The Netherlands

¹GlaxoSmithKline, Clinical Pharmacology and Experimental Medicine, Stevenage, UK, ²PAREXEL International, Berlin, Germany, ³PAREXEL International, London, UK, ⁴Institute of Clinical Chemistry and Clinical Pharmacology, Study Center Bonn (SZB), Bonn, Germany, ⁵GlaxoSmithKline, Stevenage, UK, ⁶GlaxoSmithKline, Upper Providence, USA, ⁷TxCell S.A., Valbonne, France, ⁸IMED Biotech, AstraZeneca, Cambridge, UK

¹Hospital Santa Maria, CHLN, Gastrenterology, Lisbon, Portugal

¹Great Ormond Street Hospital, Gastroenterology, London, UK, ²University College London Hospital, Gastroenterology, London, UK

¹McGill University Health Center, Division of Gastroenterology, Montreal, Canada, ²Semmelweis University, First Department of Internal Medicine, Budapest, Hungary, ³Geneva’s University Hospitals and University of Geneva, Division of Gastroenterology and Hepatology, Geneva, Switzerland

¹Internistische Gemeinschaftspraxis für Verdauungs- und Stoffwechselkrankheiten Leipzig und Schkeuditz, Leipzig, Germany, ²Praxis Gruemmer, Potsdam, Germany, ³Magen Darm Zentrum, Remscheid, Germany, ⁴MVZ für Gastroenterologie am Bayerischen Platz, Berlin, Germany, ⁵Gastroenterologische Gemeinschaftspraxis am Germania-Campus, Muenster, Germany, ⁶MSD Merck Sharp and Dohme AG, Global Medical Affairs, Kriens, Switzerland, ⁷MSD Sharp and Dohme GmbH, Medical Affairs, Haar, Germany

¹University Medical Centre Utrecht, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands, ²University Medical Centre Utrecht, Laboratory for Translational Immunology, Utrecht, The Netherlands, ³University Medical Centre Utrecht, Julius Centre for Health Sciences and Primary Care, Utrecht, The Netherlands, ⁴Tergooi hospitals, Department of Gastroenterology and Hepatology, Blaricum/Hilversum, The Netherlands, ⁵AZ Delta, Department of Gastroenterology, Roeselare, Belgium, ⁶Hôpital Haut-Lévêque, Service d'Hépato-gastroentérologie et Oncologie Digestive, Bordeaux, France, ⁷Imelda General Hospital, IBD Clinic, Bonheiden, Belgium, ⁸Beaujon Hospital, APHP, Paris Diderot University, Department of Gastroenterology, Clichy, France, ⁹Estaing University Hospital, Department of Gastroenterology, Clermont-Ferrand, France, ¹⁰AZ Damiaan, Department of Gastroenterology, Oostende, Belgium, ¹¹Liège University Hospital CHU, Department of Gastroenterology, Liège, Belgium, ¹²Huriez Hospital, Lille 2 University, Department of Gastroenterology, Lille, France, ¹³Maastricht University Medical Centre, Department of Gastroenterology and Hepatology, Maastricht, The Netherlands, ¹⁴Erasmus Medical Centre, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands, ¹⁵Amsterdam UMC, University of Amsterdam, Department of Gastroenterology, Amsterdam, The Netherlands, ¹⁶University Hospitals Leuven, Department of Gastroenterology and Hepathology, Leuven, Belgium

¹University Hospital of Ioannina, Division of Gastroenterology, Ioannnina, Greece, ²University Hospital of Ioannina, Universital Eye Clinic, Ioannnina, Greece

¹Hannover Medical School (MHH), Gastroenterology, Hepatology and Endocrinology, Hannover, Germany, ²Hannover Medical School (MHH), Institute for Sports Medicine, Hannover, Germany

¹Hospital Universitario y Politécnico La Fe, Gastroenterology, Valencia, Spain, ²Hospital Universitario y Politécnico La Fe, Pharmacy, Valencia, Spain

¹Erasmus MC-Sophia Children’s Hospital, Paediatric Gastroenterology, Rotterdam, The Netherlands, ²Erasmus MC-Sophia Children’s Hospital, Department of Child and Adolescent Psychiatry/Psychology, Rotterdam, The Netherlands, ³Erasmus MC, Department of Biostatistics, Rotterdam, The Netherlands, ⁴Erasmus MC, Department of Gastroenterology, Rotterdam, The Netherlands, ⁵Haga Hospital, Department of Gastroenterology, The Hague, The Netherlands, ⁶Juliana Children’s Hospital, Department of Paediatrics, The Hague, The Netherlands, ⁷Albert Schweitzer Hospital, Department of Paediatrics, Dordrecht, The Netherlands, ⁸University of Amsterdam, Research Institute of Child Development and Education, Amsterdam, The Netherlands, ⁹Academic Center for Child Psychiatry the Bascule, Department of Child and Adolescent Psychiatry, Amsterdam, The Netherlands