P0496: Upadacitinib for Patients with Crohn’s Disease and Previous Biologic Failure: A Systematic Review and Meta-AnalysisECCO'25Year: 2025
Authors: Campedelli, L.(1)*;Perim, V.(2);Hueb, R.(3);
(1)Boston University/Boston Medical Center, Internal Medicine, Boston- MA, United States;(2)University of Alabama at Birmingham, General Surgery, Birmingham- AL, United States;(3)Universidade Santo Amaro, Medicine, Sao Paulo- SP, Brazil;
1.Loftus EV, Panés J, Lacerda AP, et al. Upadacitinib Induction and Maintenance Therapy for Crohn’s Disease. The New England Journal of Medicine. 2023;388(21):1966-1980. doi:https://doi.org/10.1056/nejmoa2212728
2.Sandborn WJ, Feagan BG, Loftus EV, et al. Efficacy and Safety of Upadacitinib in a Randomized Trial of Patients With Crohn’s Disease. Gastroenterology. 2020;158(8):2123-2138.e8. doi:https://doi.org/10.1053/j.gastro.2020.01.047
P0497: Faecal Incontinence and Urgency in IBD Patients on Biologic Therapy in Remission: Prevalence and Risk FactorsECCO'25Year: 2025
Authors: Jelakovic, M.(1)*;Peretin, L.(2);Kodvanj, I.(1);Brinar, M.(1);Turk, N.(1);Grgic, D.(1);Kunovic, A.(1);Cukovic-Cavka, S.(1);Krznaric, Z.(1);
(1)UHC Zagreb, Department of Gastroenterology and Hepatology, Zagreb, Croatia;(2)OB Varazdin, Department of Gastroenterology and Hepatology, Varazdin, Croatia;
P0498: Relationship Of Disease Activation And Treatment With Pulmonary Function Tests And Obstructive Sleep Apnea Syndrome In Ulcerative Colitis PatientsECCO'25Year: 2025
Authors: Metin, T.(1)*;Balkan, A.(1);Emek, H.(2);Şahan, M.A.(1);
(1)Gaziantep University School of Medicine, Gastroenterology, Gaziantep, Turkey;(2)Gaziantep University School of Medicine, Internal Medicine, Gaziantep, Turkey;
1-Wangchuk P, Yeshi K, Loukas A. Ulcerative colitis: clinical biomarkers, therapeutic targets, and emerging treatments. Trends Pharmacol Sci. 2024;45(10):892-903. doi: 10.1016/j.tips.2024.08.003.
2-Kucharzik T, Koletzko S, Kannengiesser K, Dignass A. Ulcerative Colitis-Diagnostic and Therapeutic Algorithms. Dtsch Arztebl Int. 2020;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564.
3-Hao G, Zhu B, Li Y, Wang P, Li L, Hou L.Sleep quality and disease activity in patients with inflammatory bowel disease: a systematic review and meta-analysis.Sleep Med. 2020;75:301-308. doi: 10.1016/j.sleep.2020.08.032.
P0499: A multicenter study utilizes multi-scale clinical data from Crohn's disease patients to develop large-scale language-human interaction models for predicting the progression of intestinal diseasesECCO'25Year: 2025
Authors: Li, Z.(1)*;Zhang, R.(1);Wang, Y.(1);Wang, X.(1);Mao, R.(2);Feng, S.T.(1);Li, X.(1);
(1)The First Affiliated Hospital of Sun Yat-sen University, Radiology, Guangzhou, China;(2)The First Affiliated Hospital of Sun Yat-sen University, Gastroenterology, Guangzhou, China;
P0500: Multi-Module Metaformer System for Distinguishing Crohn's Disease from Intestinal TuberculosisECCO'25Year: 2025
Authors: Chen, X.(1)*;Zhu , A.(2);Zhang, Y.(3);Zhao, L.(1);Wang, X.(1);Chen, J.(1);
(1)The Third Xiangya Hospital of Central South University, Department of Gastroenterology, Changsha, China;(2)Peking University First Hospital, Department of Gastroenterology, Beijing, China;(3)Southeast University, School of Computer Science and Engineering, Nanjing, China;
[1] Vaswani A , Shazeer N , Parmar N ,et al.Attention Is All You Need[J].arXiv, 2017; DOI:10.48550/arXiv.1706.03762.
[2] Wagner, S.J., et al., Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study. Cancer Cell, 2023; 41(9): p. 1650-1661 e4.
[3] He, Y., et al., Development and Validation of a Novel Diagnostic Nomogram to Differentiate Between Intestinal Tuberculosis and Crohn's Disease: A 6-year Prospective Multicenter Study. Am J Gastroenterol, 2019; 114(3): p. 490-499.
P0502: Impact of Endoscopic and Histologic Activity on Disease Relapse in Ulcerative Colitis: 3-year and 5-year follow-up.ECCO'25Year: 2025
Authors: Abbas, A.(1)*;Ching Hui Yee, C.(2);Zoughlami, A.(1);Lakatos, P.(1);Bitton, A.(1);Wild, G.(1);Afif, W.(1);Bessissow, T.(3);
(1)McGill University, Gastroenterology and Hepatology, Montreal, Canada;(2)McGill University, Internal Medicine, Montreal, Canada;(3)McGill Univeristy, Gastroenterology and Hepatology, Montreal, Canada;
References
1. Bessissow T, Kron CM, Marcus V, Lemieux C, Laneuville J, Afif W, Wild G, Lakatos PL, Brassard P, Bitton A. Impact of Endoscopic and Histologic Activity on Disease Relapse in Ulcerative Colitis. Am J Gastroenterol. 2022 Oct 1;117(10):1632-1638. doi: 10.14309/ajg.0000000000001912. Epub 2022 Jul 21. PMID: 35862833.
P0503: Submucosal hyperechogenicity on intestinal ultrasound is associated with fat deposition and is a predictor of endoscopic non-response to anti-inflammatory treatment in Ulcerative ColitisECCO'25Year: 2025
Authors: Pruijt, M.(1)*;Neefjes-Borst, A.(2);Lange, M.(2);de Voogd, F.(1);Teichert, C.(1);D'Haens, G.(1);Gecse, K.(1);
(1)Amsterdam UMC, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands;(2)Amsterdam UMC, Department of Pathology, Amsterdam, The Netherlands;
1. F. de Voogd, Inflamm Bowel Dis 2023. DOI: 10.1093/ibd/izad274.
2. F. de Voogd, Journal of Crohn's and Colitis 2021. DOI: 10.1093/ecco-jcc/jjab076.535.
P0504: The Impact of Disease Activity and Medications on Pregnancy and Fetal Outcomes in Women With Inflammatory Bowel Disease: A Cohort Study From the IBD-ME Group.ECCO'25Year: 2025
Authors: AzzamKing Saud University, N.(1)*; Almadi, M.(2,3); Alfarhan, H.(4); Altuwaijiri, M.(5);Aljebreen, A.(2);Alharbi, O.(1); Abaalkhail, M.(1); Jaran, M.(1); Altamimi, A.(1); Al Theneyan, A.(1); Al Turki, N.(6); Alharbi, L.(6); AL Ghamdi, J.(7); Al Dakhil, A.(6);Mosli, M.(8,9);
(1)King Saud University, Department of Medicine- Division of Gastroenterology, Riyadh, Saudi Arabia;(2)King Saud University, Department of Internal medicine - Gastroenterology unit, Riyadh, Saudi Arabia;(3)The McGill University Health Center- Montreal General Hospital- McGill University- Montreal- Canada., Division of Gastroenterology-, Montreal, Canada;(4)Thunayan Al Ghanim Gastroenterology Center at Al Amiri Hospital- Kuwait City- Kuwait, 3. Department of Internal Medicine- Division of Gastroenterology-, Kuwait City- Kuwait, Kuwait;(5)King Saud University, Department of Internal medicine- Gastroenterology unit, Riyadh, Saudi Arabia;(6)King Abdulaziz University, Department of Internal Medicine- Faculty of Medicine, Jeddah, Saudi Arabia;(7)King Abdulaziz University, Department of Internal Medicine- Faculty of Medicine, Jeddah-, Saudi Arabia;(8)King Abdulaziz University., Department of Internal Medicine- Faculty of Medicine, Jeddah, Saudi Arabia;(9)King Abdulaziz University Hospital., Inflammatory Bowel Disease Unit, Jeddah, Saudi Arabia; IBD-ME Group
P0505: Use of intestinal ultrasound in a tight monitoring approach in Crohn’s disease patients treated with anti-TNFα therapy: a multicentre prospective studyECCO'25Year: 2025
Authors: Palmela, C.(1)*;Revés, J.(1);Frias-Gomes, C.(1,2);Morão, B.(1);Neto, C.(1);Bargas, A.(1);Glória, L.(1);Cravo, M.(3);Dias de Castro, F.(4);Cúrdia Gonçalves, T.(4);Cotter, J.(4);Coelho, R.(5);Caldeira, A.(6);Torres, J.(1,2,3);
(1)Hospital Beatriz Ângelo- Unidade Local de Saúde Loures/Odivelas, Gastroenterology, Loures, Portugal;(2)Universidade de Lisboa, Faculdade de Medicina, Lisboa, Portugal;(3)Hospital da Luz Lisboa, Gastroenterology, Lisboa, Portugal;(4)Unidade Local de Saúde do Alto Ave, Gastroenterology, Guimarães, Portugal;(5)Centro Hospitalar de São João, Gastroenterology, Porto, Portugal;(6)Hospital Amato Lusitano, Gastroenterology, Castelo Branco, Portugal;
P0506: AZD7798, a monoclonal antibody depleting CCR9+ T cells, with the potential to target hard-to-treat small bowel Crohn’s diseaseECCO'25Year: 2025
Authors: Powell, N.(1)*;Hedin, C.(2,3);Harper, A.R.(4);MacKay, J.(4);Lundin, P.(5);Bock, D.(5);Spata, E.(4);Bouma, G.(4);Tian, S.(4);Lundahl, A.(5);Lund, J.(5);Eck, S.(6);Popińska, A.(7);Strömbeck, A.(5);Fowler, A.(4);Eberhardson, M.(5);Belvisi, M.(5);Marks, D.J.B.(4);
(1)Imperial College London, Department of Metabolism- Digestion and Reproduction, London, United Kingdom;(2)Karolinska University Hospital- Centre for Digestive Health, Department of Gastroenterology- Dermatovenereology and Rheumatology, Stockholm, Sweden;(3)Karolinska Institutet, Department of Medicine Solna, Stockholm, Sweden;(4)AstraZeneca, Biopharmaceuticals R & D, Cambridge, United Kingdom;(5)AstraZeneca, Biopharmaceuticals R & D, Gothenburg, Sweden;(6)AstraZeneca, Biopharmaceuticals R & D, Gaithersburg, United States;(7)AstraZeneca, Biopharmaceuticals R & D, Warsaw, Poland;
P0507: pTRACK generated normalised average T2 signal is an accurate and sensitive measure of Perianal Crohn’s disease activityECCO'25Year: 2025
Authors: Naim, I.(1)*;Menys, A.(1);Bhatnagar, G.(2);Greer, C.(2);Lindsay, L.(1);Carter, L.(1);Moran, G.(3);
(1)Motilent, Motilent, London, United Kingdom;(2)Frimley Park Hospital, Radiology, Frimley, United Kingdom;(3)Nottingham Digestive Diseases Centre, Gastroenterology, Nottingham, United Kingdom;
P0508: Food-related quality of life is worse in Crohn’s disease, stricturing disease and those with a surgical history: development and validation of the FR-QoL-29-Dutch (Flemish) questionnaireECCO'25Year: 2025
Authors: Wellens, J.(1)*;Guadagnoli, L.(2);Vanderstappen, J.(1);Hoekx, S.(1);Vandaele, J.(3);Ferrante, M.(1);Verstockt, B.(1);Vermeire, S.(1);Whelan, K.(4);Sabino, J.(1);
(1)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(2)Northwestern University Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Chicago- IL, United States;(3)KU Leuven, Department of Chronic Diseases and Metabolism- Translational Research Center for Gastrointestinal Disorders TARGID, Leuven, Belgium;(4)King’s College London, Department of Nutritional Sciences, London, United Kingdom;
1. Whelan K, Murrells T, Morgan M, et al. Food-related quality of life is impaired in inflammatory bowel disease and associated with reduced intake of key nutrients. Am J Clin Nutr. 2021;113(4):832-844. doi:10.1093/ajcn/nqaa3952. Hughes LD, King L, Morgan M, et al. Food-related quality of life in inflammatory bowel disease: Development and validation of a questionnaire. J Crohn’s Colitis. 2016;10(2):194-201.
2. Hughes LD, King L, Morgan M, et al. Food-related quality of life in inflammatory bowel disease: Development and validation of a questionnaire. J Crohn’s Colitis. 2016;10(2):194-201.
3. Czuber-Dochan W, Morgan M, Hughes LD, Lomer MCE, Lindsay JO, Whelan K. Perceptions and psychosocial impact of food, nutrition, eating and drinking in people with inflammatory bowel disease: a qualitative investigation of food-related quality of life. J Hum Nutr Diet. 2020;33(1):115-127.
P0509: Fecal calprotectin diagnostic level gradient along the small bowel in patients with Crohn’s diseaseECCO'25Year: 2025
Authors: Ukashi, O.(1,2)*;Kopylov, U.(1,2); Ungar, B.(1,2);Talan Asher, A.(1,2);Shachar, E.(1,2);Engel, T.(1,2);Albshesh, A.(1,2);Yablecovitch, D.(1,2);Lahat, A.(1,2,3);Eliakim, R.(1,2);Ben-Horin, S.(1,2);
(1)Sheba Medical Center Tel Hashomer, Gastroenterology Institute, Ramat gan, Israel;(2)Tel-Aviv University, Faculty of Medical and Health Sciences, Tel-Aviv, Israel;(3)Assuta Ashdod Hospital, Department of Gastroenterology, Ashdod, Israel; .
P0510: Evaluation of organizational and healthcare provider level readiness in European Inflammatory Bowel Disease centres for outcome-based quality improvementECCO'25Year: 2025
Authors: Ali, M.(1)*;West, R.L.(2);Fiorino, G.(3);Duijvestein, M.(4);Woude, C.J.V.D.(5);Deen, W.K.V.(6);
(1)Erasmus School of Health Policy and Management, Health Technology and Assessment, Rotterdam, The Netherlands;(2)Franciscus Gasthuis & Vlietland, Department of Gastroenterology & Hepatology, Rotterdam, The Netherlands;(3)San Camillo-Forlanini Hospital, IBD Center- Dept. of Gastroenterology and Digestive Endoscopy, Rome, Italy;(4)Radboud university medical centre, Department of Gastroenterology, Nijmegen, The Netherlands;(5)Erasmus MC-University Medical Centre Rotterdam, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands;(6)Erasmus School of Health Policy and Management Erasmus University Rotterdam, Division of Health Services Management and Organisation, Rotterdam, The Netherlands; the Initiative on Crohn’s and Colitis (ICC) European Crohn's and Colitis Organization (ECCO)
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3. Kim AH, Roberts C, Feagan BG, Banerjee R, Bemelman W, Bodger K, et al. Developing a standard set of patient-centred outcomes for inflammatory bowel disease—an international, cross-disciplinary consensus. Journal of Crohn’s and Colitis. 2017;12(4):408–18. doi:10.1093/ecco-jcc/jjx161
4. van Linschoten RC, Visser E, Niehot CD, van Der Woude CJ, Hazelzet JA, van Noord D, West RL. Systematic review: societal cost of illness of inflammatory bowel disease is increasing due to biologics and varies between continents. Alimentary pharmacology & therapeutics. 2021 Aug;54(3):234-48.
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P0512: Predict the risk of acute severe ulcerative colitis based on machine learning algorithm: A multicenter cohort studyECCO'25Year: 2025
Authors: Qiu, Y.(1)*;Rao, M.(1);Peng, S.(2);Zhang, C.(1);Gao, X.(3);Cao, Q.(4);Ng, S.C.(5);Chen, M.(1);
(1)The First Affiliated Hospital of Sun Yat-sen University, Department of Gastroenterology, Guangzhou, China;(2)The First Affiliated Hospital of Sun Yat-sen University, Clinical Trials Unit, Guangzhou, China;(3)The Six Affiliated Hospital of Sun Yat-sen University, Department of Gastroenterology, Guangzhou, China;(4)Sir Run Run Shaw Hospital- College of Medicine- Zhejiang University, Inflammatory Bowel Disease Center, Hangzhou, China;(5)The Chinese University of Hong Kong, Institute of Digestive Disease- Department of Medicine and Therapeutics- Li Ka Shing Institute of Health Sciences, Hong Kong, China;
P0513: Comparative Evaluation of Clinical Scores for Predicting Response to Systemic Steroid Treatment in Hospitalized Adult Patients with Acute Severe Ulcerative Colitis: A Retrospective StudyECCO'25Year: 2025
Authors: Sror, N.(1)*;Tamir-Degabli, N.(2);Leibovitzh, H.(2);Hirsch, A.(2);Thurm, T.(2);Ron, Y.(2);Maharshak, N.(2);Cohen, N.A.(2);
(1)Department of Internal Medicine B- Tel Aviv Sourasky Medical Center, Faculty of Medicine- Tel Aviv University- Tel Aviv- Israel, Tel Aviv, Israel;(2)IBD Unit- Tel Aviv Sourasky Medical Center- Tel Aviv- Israel, Faculty of Medicine- Tel Aviv University- Tel Aviv- Israel, Tel Aviv, Israel;
1. Singh S, Allegretti JR, Siddique SM, Terdiman JP. American Gastroenterological Association Technical Review on the Management of Moderate to Severe Ulcerative Colitis. Gastroenterology. 2020;158(5):1465. doi:10.1053/j.gastro.2020.01.007
2. Calméjane L, Laharie D, Kirchgesner J, Uzzan M. Review article: Updated management of acute severe ulcerative colitis: From steroids to novel medical strategies. United European Gastroenterology Journal. 2023;11(8):722. doi:10.1002/ueg2.12442
3. Bernardo S, Fernandes SR, Gonçalves AR, et al. Predicting the Course of Disease in Hospitalized Patients With Acute Severe Ulcerative Colitis. Inflamm Bowel Dis. 2019;25(3):541-546. doi:10.1093/ibd/izy256
P0514: Assessing the relationship between physician perspective and subjective disabilities in IBD patients: a comparative study using IBD-Disk and IBD-QECCO'25Year: 2025
Authors: Galletti , G.(1);Pasta , A.(1);Calabrese , F.(1)*;Saturni , A.(1);Furnari , M.(1);Marabotto , E.(1);Giannini , E.G.(1);Bodini , G.(1);
(1)University of Genoa- IRCCS Ospedale Policlinico San Martino, Gastroenterology Unit- Department of Internal Medicine, Genova, Italy;
P0515: The Role of Immunohistochemistry Staining in Diagnosing Cytomegalovirus Disease in the Gastrointestinal TractECCO'25Year: 2025
Authors: Chiu, C.H.(1,2,3)*;Yeh, P.J.(2,3,4);Wu, R.C.(2,5);Le, P.H.(2,3,6,7);
(1)Chang Gung Memorial Hospital- Linkou, Division of Pediatric Infectious Diseases- Department of Pediatrics, Taoyuan, Taiwan;(2)Chang Gung Memorial Hospital- Linkou, Chang Gung Inflammatory Bowel Disease Center, Taoyuan, Taiwan;(3)Chang Gung Memorial Hospital- Linkou, Chang Gung Microbiota Therapy Center, Taoyuan, Taiwan;(4)Chang Gung Memorial Hospital- Linkou, Department of Pediatric Gastroenterology, Taoyuan, Taiwan;(5)Chang Gung Memorial Hospital- Linkou, Department of Pathology, Taoyuan, Taiwan;(6)Chang Gung Memorial Hospital- Linkou, Department of Gastroenterology and Hepatology, Taoyuan, Taiwan;(7)TASSID, Taiwan Association for the Study of Small Intestinal Diseases, Taoyuan, Taiwan;
P0516: Chronic Rhinosinusitis and Inflammatory Bowel Disease: discovering the gut-lung axis- preliminary results from a single-center pilot studyECCO'25Year: 2025
Authors: Maresca, R.(1)*;Del Gaudio, A.(1);Iaccarino, J.(1);Murgiano, M.(1);Sessa, G.(1);Frasca, P.(1);Mignini, I.(1);Baglivo, I.(1);Pugliese, D.(1);Rigante, M.(2);Zavarella, M.A.(1);Colantuono, S.(3);Laterza, L.(1);Papa, A.(1);Gasbarrini, A.(1);Caruso, C.(4);Scaldaferri, F.(1);
(1)UOS Malattie Infiammatorie Croniche Intestinali- Centro Malattie Apparato Digerente CeMAD-Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS- Università Cattolica del Sacro Cuore, Rome, Italy;(2)Unità di Otorinolaringoiatria e Chirurgia Testa-Collo, Fondazione Policlinico "A. Gemelli" IRCCS- Università Cattolica del Sacro Cuore, Rome, Italy;(3)Unità Operativa Semplice Dipartimentale Day Hospital UOSD DH Medicina Interna e Malattie dell'Apparato Digerente, Fondazione Policlinico Universitario "A. Gemelli" IRCCS- Università Cattolica del Sacro Cuore, Rome, Italy;(4)UOSD Allergy and Clinical Immunology Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy;
