P144: Modulation of Immunometabolism via NLRX1 or PLXDC2: Novel Bimodal Mechanisms for the Treatment of Inflammatory Bowel DiseasesECCO'24Year: 2024
Authors: Danese, S.(1)*;Colombel, J.F.(2);Rieder, F.(3);Peyrin-Biroulet, L.(4);Siegmund, B.(5);Vermeire, S.(6);Dubinsky, M.(7);Schreiber, S.(8);Yarur, A.(9);Panaccione, R.(10);Feagan, B.(11);Mosig, R.(12);Cataldi, F.(13);Verstockt, B.(14);
(1)IRCCS San Raffaele Scientific Institute- Vita-Salute San Raffaele University, Gastroenterology and Gastrointestinal Endoscopy Unit, Milan, Italy;(2)Icahn School of Medicine at Mount Sinai, The Dr. Henry D. Janowitz Division of Gastroenterology, New York, United States;(3)Cleveland Clinic, Department of Inflammation and Immunity- Lerner Research Institute- Department of Gastroenterology- Hepatology and Nutrition- Digestive Disease Institute, Cleveland, United States;(4)Nancy University Hospital- University of Lorraine- Paris IBD Center- and McGill University Health Centre, Department of Gastroenterology- INSERM- NGERE- INFINY Institute- FHU-CURE- Groupe Hospitalier privé Ambroise Paré - Hartmann- Division of Gastroenterology and Hepatology, Vandoeuvre-les-Nancy, France;(5)Charité - Universitätsmedizin Berlin- corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Division of Gastroenterology, Berlin, Germany;(6)University Hospitals Leuven- KU Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(7)Mount Sinai Kravis Children@E@s Hospital- Icahn School of Medicine Mount Sinai, Division of Pediatric Gastroenterology and Nutrition, New York, United States;(8)Christian-Albrechts-University and University Hospital Schleswig-Holstein- Campus Kiel, Institute of Clinical Molecular Biology- Department of Internal Medicine, Kiel, Germany;(9)Cedars Sinai Medical Center, Division of Gastroenterology and Hepatology- Center for Inflammatory Bowel Diseases, Los Angeles, United States;(10)Cumming School of Medicine- University of Calgary, Division of Gastroenterology & Hepatology- Department of Medicine, Calgary, Canada;(11)Western University, Department of Medicine- Division of Gastroenterology and Department of Epidemiology and Biostatistics, London, Canada;(12)Landos Biopharma- Inc, Corporate Development, Blacksburg, United States;(13)Landos Biopharma- Inc, Medicine, Boston, United States;(14)University Hospitals Leuven- KU Leuven, Department of Gastroenterology and Hepatology- Department of Chronic Diseases and Metabolism, Leuven, Belgium;
P145: Phagocyte responses to gut-derived C. albicans are modified in inflammatory bowel diseaseECCO'24Year: 2024
Authors: Mathew, L.(1)*;Carlson, S.(2);Savage, M.(1);Pardieu, C.(1);Sze, N.(3);Munro, C.(4);Naglik, J.(5);Stagg, A.(1);Kok, K.(2);O. Lindsay, J.(2);McCarthy, N.(1);
(1)Queen Mary University of London, Centre for Immunobiology, London, United Kingdom;(2)Barts and the London School of Medicine and Dentistry, Gastroenterology, London, United Kingdom;(3)Brock University, Health Sciences, Ontario, Canada;(4)University of Aberdeen, Medical Sciences, Aberden, United Kingdom;(5)Kings College London, Fungal Pathogenesis and Immunology, London, United Kingdom;
P146: Latent activation of the extrinsic coagulation pathway in patients with ulcerative colitisECCO'24Year: 2024
Authors: Drygiannakis, I.(1)*;Valatas, V.(1);Filidou, E.(2);Tzenaki, N.(1);Archontoulaki, E.(1);Dovrolis, N.(2);Kandilogiannakis, L.(2);Kefalogiannis, G.(3);Sidiropoulos, P.(1);Kolios, G.(2);Koutroubakis, I.E.(1);
(1)University of Crete, School of Medicine, Heraklion, Greece;(2)Democritus University of Thrace, Department of Medicine, Alexandroupolis, Greece;(3)Heraklion University Hospital, Laboratory of Clinical Immunology, Heraklion, Greece;
P147: IBD relevant pathways are upregulated in Paneth cells in a murine model of dietary induced intestinal inflammationECCO'24Year: 2024
Authors: Grabherr, F.(1)*;Meyer, M.(1);Christina, P.(2);Marteau, V.(2);Schwärzler, J.(1);Mayr, L.(1);Enrich, B.(1);Jukic, A.(1);Grander, C.(1);Trajanoski, Z.(2);Tilg, H.(1);Adolph, T.E.(1);
(1)Medical University Innsbruck, Internal Medicine I - Gastroenterology- Hepatology & Endocrinology, Innsbruck, Austria;(2)Medical University Innsbruck, Biocenter- Institute of Bioinformatics, Innsbruck, Austria;
P148: Longitudinal single-cell data informs deterministic modelling of inflammatory bowel disease.ECCO'24Year: 2024
Authors: Kilian, C.(1)*;Ulrich, H.(1);Zouboulis, V.(1);Sprezyna, P.(1);Büttner, M.(2);Biton, M.(3);Villablanca, E.J.(4);Huber, S.(1);Adlung, L.(1);
(1)University Medical Center Hamburg-Eppendorf, I. Department of Medicine, Hamburg, Germany;(2)LLC, Calico Life Sciences, South San Francisco, United States;(3)Weizmann Institute of Science, Department of Immunology and Regenerative Biology, Rehovot, Israel;(4)Karolinska Institutet, Division of Immunology and Allergy & Center of Molecular Medicine, Stockholm, Sweden;
P149: Bacteroides uniformis ameliorates pro-inflammatory diet-exacerbated colitis by targeting endoplasmic reticulum stress-mediated ferroptosisECCO'24Year: 2024
Authors: Liu, C.(1)*;Zhuang, X.(1);Zhan, S.(1);Tian, Z.(1);Mao, R.(1);Zhang, S.(1);Chen, M.(1);Zeng, Z.(1);
(1)The First Affiliated Hospital- Sun Yat-sen University, Department of Gastroenterology, Guangzhou, China;
P150: Ulcerative Colitis Patients’ Luminal Zinc Induces Clostridioides difficile Virulence and Exacerbates Inflammatory ResponsesECCO'24Year: 2024
Authors: Wu, T.(1)*;Zhou, H.(1);Li, X.(1);Lin, J.(1);Wang, F.(1);Da, Y.(1);Liang, J.(1);
(1)Fourth Military Medical University, Xijing Hospital of Digestive Diseases, Xi@E@an, China;
P151: Characterization of platelet activation profile in Inflammatory Bowel DiseaseECCO'24Year: 2024
Authors: Rueda Garcia, J.L.(1,2)*;Martín Arranz, E.(1,2);Ramírez García, L.(1,2);Suárez Ferrer, C.(1,2);Sánchez Azofra, M.(1,2);Poza Cordón, J.(1,2);Amiama Roig, C.(1);Noci Belda, J.(1,2);Perosanz, L.(1,2);Cubillo García, C.(1,2);García-Rojas, C.(2);Silva, K.(2);Monzón Manzano, E.(2,3);G. Arias-Salgado, E.(2,3);Acuña, P.(2,3);Butta, N.(2,3);Martín Arranz, M.D.(1,2,4);
(1)La Paz University Hospital, Gastroenterology, Madrid, Spain;(2)La Paz Institute for Health Research, IdiPAZ, Madrid, Spain;(3)La Paz University Hospital, Hematology and Hemotherapy Unit, Madrid, Spain;(4)Universidad Autónoma de Madrid, Facultad de Medicina, Madrid, Spain;Immune-mediated Gastrointestinal Diseases.
P152: Longitudinal immune profiling of peripheral blood in patients with Ulcerative Colitis.ECCO'24Year: 2024
Authors: Wider-Eberspächer, E.(1)*;Garza, A.P.(1);Albrecht, T.(1);Rosania, R.(2);Dunay, I.R.(1);
(1)Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Hospital, Magdeburg, Germany;(2)Department of Gastroenterology Hepatology and Infectious Disease, Otto-von Guericke University Hospital, Magdeburg, Germany;
P153: Artificial Intelligence to predict interleukin-23 signalling activity from H&E stained whole slide images of Inflammatory Bowel DiseaseECCO'24Year: 2024
Authors: Qaiser , T.(1)*;Hamidinekoo , A.(1);Daniel , S.(1);Zhang , I.(1);Kekic , M.(2);Lewis , A.(1);Angermann , B.(3);Bourke , L.(4);Gehrmann , U.(5);Neisen , J.(4);Tian , S.(4);Corridoni , D.(6);Marks , D.(6);Adissu , H.(7);Burlutskiy , N.(1);
(1)AstraZeneca, Imaging and Data Analytics- Clinical Pharmacology & Safety Sciences- R&D, Cambridge, United Kingdom;(2)AstraZeneca, Imaging and Data Analytics- Clinical Pharmacology & Safety Sciences- R&D, Barcelona, Spain;(3)AstraZeneca, Translational Science and Experimental Medicine, Gothenburg, Sweden;(4)AstraZeneca, Translational Science and Experimental Medicine, Cambridge, United Kingdom;(5)AstraZeneca, Translational Science and Experimental Medicin, Gothenburg, Sweden;(6)AstraZeneca, Research and Early Development- Respiratory and Immunology R&I, Cambridge, United Kingdom;(7)AstraZeneca, Respiratory and Immunology Safety Pathology, Gaithersburg, United States;
P154: Histological disease progression and ALK5i therapeutic efficacy in a chronic DSS-induced mouse model of IBD with intestinal fibrosisECCO'24Year: 2024
Authors: Nielsen, M.H.(1)*;Zachariassen, L.(1);Sárvári, A.K.(2);Madsen, M.R.(2);Hansen, H.B.(3);Fink, L.N.(4);Fuchs, B.C.(5);Papazyan, R.(5);Aymeric , R.(6);Feigh, M.(7);
(1)Gubra A/S, Pharmacology research, Hørsholm, Denmark;(2)Gubra A/S, Histology & NGS, Hørsholm, Denmark;(3)Gubra A/S, Sales & Marketing, Hørsholm, Denmark;(4)Ferring Pharmaceuticals A/S, Discovery Biotherapeutics, Copenhagen, Denmark;(5)Ferring Pharmaceuticals A/S, Ferring Research Institute, San Diego, United States;(6)Ferring Pharmaceuticals A/S, Clinical and Translational Sciences, Copenhagen, Denmark;(7)Gubra A/S, Sales and Marketing, Hørsholm, Denmark;
P156: Gut microbiota composition in Patients with Chron@E@s Disease in Saudi ArabiaECCO'24Year: 2024
Authors: Alahdal, H.(1)*;Almuneef, G.(2); Alkhulaifi, M.M.(3);Aldibasi, O.(4);Aljouie, A.(5);Alharbi, O.(6);Rejili, M.(7);
(1)Department of Biology- Collage of Science- Princes Nourah Bint Abdulrahman University, Biology, Riyadh, Saudi Arabia;(2)Princess Nourah university, Biology, Riyadh, Saudi Arabia;(3)King Saud bin Abdulaziz university, Biology, Riyadh, Saudi Arabia;(4)King Abdullah international medical research center, Biostatistics section, Riyadh, Saudi Arabia;(5)King Abdullah international medical research center, Bioinformatics, Riyadh, Saudi Arabia;(6)King Khalid university hospital- King Saud University, medicine, Riyadh, Saudi Arabia;(7)Imam Mohammad ibn Saud Islamic University, Biology, Riyadh, Saudi Arabia;
P157: Differentiation of Tonsil-derived mesenchymal stem cells to intestinal stem cells-like cells for cell therapy of inflammatory bowel diseaseECCO'24Year: 2024
Authors: Song, E.M.(1)*;Joo, Y.H.(1);Byeon, J.(1);Choe, A.R.(1);Park, Y.(1);Moon, C.M.(1);Kim, S.E.(1);Jung, S.A.(1);
(1)EWHA Womans University- School of Medicine, Department of Internal Medicine- Department of Gastroenterology, Seoul, Korea- Republic Of;
P158: Expression of IL-19 and IL-24 in intestinal mucosa of inflammatory bowel disease: An immunohistochemical study.ECCO'24Year: 2024
Authors: ToskasMD, A.(1)*;Milias, S.(2);Papamitsou, T.(3);Meditskou, S.(4);Dellis, G.(5);Sioga, A.(4);
(1)1.St Mark@E@s Hospital- London- UK. 2.Aristotle University of Thessaloniki- Thessaloniki- Greece., Gastroenterology, Harrow, United Kingdom;(2)Private Histopathology Laboratory, n/a, Thessaloniki, Greece;(3)Aristotle University of Thessaloniki- Thessaloniki- Greece., Laboratory of Histology and Embryology- Medical School-, Thessaloniki, Greece;(4)Aristotle University of Thessaloniki- Thessaloniki- Greece, Laboratory of Histology and Embryology- Medical School, Thessaloniki, Greece;(5)Aristotle University of Thessaloniki, Veterinary School of Medicine, Thessaloniki, Greece;
P159: Inhibition of Caspase-1 signalling subtly affect the gut microbiota and reduces Adherent-invasive Escherichia coli (AIEC)-induced inflammasome activationECCO'24Year: 2024
Authors: Barrett, K.(1);Aguilera, M.(1);Manning, C.(1);O@E@Sullivan, O.(2);Clarke, D.(3);MelgarPhD, S.(1)*;
(1)University College Cork, APC Microbiome Ireland, Cork City, Ireland;(2)Teagasc Food Research Centre, APC Microbiome Ireland, Fermoy, Ireland;(3)University College Cork, School of Microbiology, Cork City, Ireland;
P160: Integrative transcriptional analysis to identify predictive biomarkers for IBD severity and subtypingECCO'24Year: 2024
Authors: Balasubramanian, B.(1);Patel, S.(1);Gall, L.(2);Parker, S.(1);Carpenter, A.(1);Hannan, N.(1);Pin, C.(2);Moran, G.(3);Ordóñez Morán, P.(4)*;
(1)University of Nottingham- School of Medicine, Translational Medical Sciences, Nottingham, United Kingdom;(2)AstraZeneca, Clinical Pharmacology & Quantitative Pharmacology, Cambridge, United Kingdom;(3)Nottingham Digestive Diseases Centre- University of Nottingham- School of Medicine, Biomedical Research Unit, Nottingham, United Kingdom;(4)University of Nottingham- School of Medicine, Translational Medical Sciences Unit, Nottingham, United Kingdom;Basic Science
P161: Prevalence of undernutrition in patients with inflammatory bowel disease and improvement after nutritional adviceECCO'24Year: 2024
Authors: Kutar, M.(1);Dharap, V.(2);Dhoble, P.(2)*;Trinidade, S.(3);Gupta, T.(2);Abraham, P.(2);Desai, D.(2);
(1)P. D Hinduja National Hospital and Medical Research Center, Medical Gastroenterology, Mumbai, India;(2)P. D Hinduja National Hospital & Medical Research Institute- Mumbai, Medical Gastroenterology, Mumbai, India;(3)P. D Hinduja National Hospital & Medical Research Institute- Mumbai, Dietician, Mumbai, India;
P161: The use of Novel Natural Treatments for Inflammatory Bowel DiseasesECCO'24Year: 2024
Authors: Najafzadeh, M.(1)*;
(1)University of bradford, Chemistry and BioSciences, Bradford, United Kingdom;Mojgan Najafzadeh1* Zahra Adoul1 Shohreh Jafarinejad1 Adi Baumgartner2 Domenic Reynolds3 Mohammad Isreb4 Rojan Ghaderi5 Farshid Sefat6 Saeed Heidari 7 Diana Anderson1 1 School of Life Sciences Chemistry and Biosciences Department University of Bradford Bradford BD7 1DP UK 2 School of Science Technology and Health Biosciences York St John University York YO31 7EX UK 3Bradford Teaching Hospitals NHS Foundation Trust Bradford Royal Infirmary Bradford UK 4Faculty of Life Sciences School of Pharmacy and Medical Sciences University of Bradford Bradford BD7 1DP UK 5Department of Medicine Imperial College London London SW7 2BX 6 Department of Biomedical and Electronics Engineering Faculty of Engineering and Informatics University of Bradford Bradford UK 7 Cell Therapy and Tissue Engineering Department Faculty of Medical Sciences Shahid Beheshti University Tehran Iran
