¹Tel Aviv medical Center, Digestive and liver Disease Research Center, Tel Aviv, Israel, ²University of North Carolina, Center for Gastrointestinal Biology and Disease, School of Medicine, Chapel Hill, USA, ³Tel Aviv Medical Center, Division of Surgery Colorectal Unit, Tel Aviv, Israel, ⁴Tel-Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel, ⁵Tel-Aviv University, Department of Molecular and Microbiology and Biotechnology, Tel Aviv, Israel, ⁶Rabin Medical Center, Division of Gastroenterology, Petah Tikva, Israel

¹Sun Yat-sen University, Guangzhou, China, ²The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

¹National Defense Medical College, Internal Medicine, Tokorozawa, Japan, ²Jikei University School of Medicine, Internal Medicine, Tokyo, Japan

¹Western University, Medicine, London, Canada, ²Western University, Physiology and Pharmacology, London, Canada, ³Western University, Epidemiology and Biostatistics, London, Canada

¹King's College London, Centre for Inflammation and Cancer Immunology (CIBCI), London, UK, ²King's College London, NIHR Biomedical Research Center, London, UK, ³King's College London, Department of Medical and Molecular Genetics, London, UK

¹Medical Center – University of Freiburg, Department of Medicine II, Freiburg, Germany, ²Faculty of Medicine, University of Freiburg, Berta-Ottenstein-Programme, Freiburg, Germany, ³Medical Faculty Mannheim, Heidelberg University, Department of Medicine II, Mannheim, Germany, ⁴Limbach Group, Heidelberg, Germany, ⁵Medical Center – University of Freiburg, Department of Dermatology, Freiburg, Germany

¹School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil, Department of Clinical Analysis, Toxicology and Food Science, Ribeirão Preto, SP, Brazil, ²Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil, Department of Immunology and Biochemistry, Ribeirão Preto, Brazil, ³Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil, Surgery and Anatomy, Ribeirão Preto, SP, Brazil

¹Rabin Medical Center, Division of Gastroenterology, Petah Tikva, Israel, ²Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel, ³Tel Aviv University, Department of Molecular Microbiology and Biotechnology, Tel Aviv, Israel

¹St Marks Hospital, Gastroenterology, Harrow, UK, ²Imperial College London, London, UK, ³Hillingdon Hospital, Gastroenterology, Hillingdon, UK

¹Type 1 Diabetes Biology, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark, ²Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark, ³Center for non-coding RNA in Technology and Health, University of Copenhagen, Copenhagen, Denmark, ⁴Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark, ⁵Department of Cancer and Inflammation Research, Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark, ⁶Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark, ⁷Copenhagen Diabetes Research Center, Department of Pediatrics, Herlev University Hospital, Herlev, Denmark, ⁸Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

¹Centre de Recherche en Transplantation et Immunologie UMR 1064, Inserm, Université de Nantes, CHU Nantes, 44000 Nantes, France, ²Laboratoire d'Immunologie, CHU Nantes, 44000 Nantes, France, ³Clinique de Chirurgie Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif (IMAD), CHU Nantes, 44000 Nantes, France, ⁴CRCINA, INSERM, Université d'Angers, Université de Nantes, 44000 Nantes, France, ⁵Institut des Maladies de l’Appareil Digestif (IMAD), CHU Nantes, 44000 Nantes, France, ⁶UMR 1235, Neuropathies entériques et pathologies digestives, Université de Nantes, 44000 Nantes, France

¹Insitut Pasteur, Immunology, Paris, France

¹Linköping University, Department of Gastroenterology, Linköping, Sweden, ²Vall d'Hebron Institut de Recerca, Digestive Diseases Research Unit, Barcelona, Spain, ³Linköping University, Department of Clinical and Experimental Medicine and Department of Surgery, Linköping, Sweden, ⁴Linköping University, Department of Clinical and Experimental Medicine, Linköping, Sweden

¹Blizard Institute, Centre of Immunobiology, London, UK

¹Royal Liverpool University Hospital, Liverpool, UK, ²University of Liverpool, Center for genomics research, Liverpool, UK, ³Institute of Translational medicine, Department of Biostatistics, Liverpool, UK

¹University of Seville, Normal and Pathological Cytology and Histology, Seville, Spain, ²University of Seville, Medicine, Seville, Spain, ³Virgen Macarena Hospital, Gastroenterology unit, Seville, Spain

¹St James's Hospital, Department of Gastroenterology, Dublin, Ireland, ²Trinity College Dublin, Dept of Surgery, Dublin, Ireland, ³INITIative, Investigator Network Inflammatory bowel disease Therapy in Ireland, Dublin, Ireland, ⁴St James Hospital, Surgery, Dublin, Ireland, ⁵St James's Hospital, Gastroenterology, Dublin, Ireland, ⁶St James Hospital, Pathology, Dublin, Ireland

¹National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Immunology and Immunotherapy, Birmingham, UK, ²Institute of Translational Medicine, Gastroenterology, Birmingham, UK, ³Institute of Cancer and Genomics Sciences, University of Birmingham, Birmingham, UK

¹University of Antwerp, Laboratory of Experimental Medicine and Pediatrics, Antwerp, Belgium

¹Marques De Valdecilla Universitary Hospital, Gastroenterology, Santander, Spain, ²Biotechnology and Biomedicine Institute of Cantabria (IBBTEC), Santander, Spain