P069: Artificial intelligence (AI)-filtered Videos for Accelerated Scoring of Colonoscopy Videos in Ulcerative Colitis Clinical TrialsECCO'21 VirtualYear: 2021
Authors: Gutierrez Becker, B.(1);Giuffrida, E.(2);Mangia, M.(2);Arcadu, F.(1);Whitehill, V.(3);Guaraglia, D.(4);Schwartz, M.(4);Sabouni, R.(4);Prunotto, M.(5);Oh, Y.(6);Daperno, M.(2);
(1)Roche, Informatics, Basel, Switzerland;(2)Mauriziano Hospital, Gastroenterology Unit, Turin, Italy;(3)Genentech, PD Clinical Science - I2O Immunology- Infectious Diseases- and Ophthalmology, South San Francisco, United States;(4)Virgo Surgical Video Solutions- Inc, Virgo Surgical Video Solutions- Inc, San Francisco, United States;(5)Roche, Immunology- Infectious Disease & Ophthalmology, Basel, Switzerland;(6)Genentech, Product Development, South San Francisco, United States
P070: Efficacy of a novel non-covalent oral small molecule Nrf2 activator in a rat model of Inflammatory Bowel DiseaseECCO'21 VirtualYear: 2021
Authors: Murray, C.(1);Cooper, N.(1);Lucas, C.L.(1);Manso, A.S.(1);Ray, N.C.(1);Worthington, J.(2);Fox, J.C.(1);
(1)C4X Discovery Limited, Discovery, Manchester, United Kingdom;(2)Axis Bioservices Limited, Coleraine, Northern Ireland, United Kingdom
P071: Crohn’s Disease is associated with elevated levels of the pro-inflammatory CXCR3 ligands (CXCL9, 10 and 11) with an associated reduction in Paneth cell derived antimicrobial peptides in ex-vivo ileal biopsiesECCO'21 VirtualYear: 2021
Authors: Jones, F.(1);Doherty, G.(2);McNamee, E.(3);
(1)Centre for Colorectal Disease- St. Vincent's University Hospital, Gastroenterology, Dublin 3, Ireland;(2)Centre for Colorectal Disease- St. Vincent’s University Hospital, Gastroenterology, Dublin, Ireland;(3)Institute of Immunology, Maynooth University, Maynooth, Ireland
P072: The involvement of extracellular Nicotinamide Phosphoribosyltransferase (eNAMPT) and Nicotinate Phosphoribosyltransferase (eNAPRT) in inflammatory bowel diseaseECCO'21 VirtualYear: 2021
Authors: Colombo, G.(1);Ribaldone, D.G.(2);Caviglia, G.P.(3);Genazzani, A.(1);Travelli, C.(4);
(1)Università del Piemonte Orientale, Dipartimento di Scienze del Farmaco, Novara, Italy;(2)Università degli Studi di Torino, Department of Surgical Sciences, Torino, Italy;(3)Università degli Studi di Torino, Division of Gastroenterology- Department of Medical Sciences, Torino, Italy;(4)Università degli Studi di Pavia, Department of Pharmaceutical Sciences, Pavia, Italy
P073: An increased autophagy and decreased apoptosis is detected in intestinal fibroblasts from Crohn’s Disease patientsECCO'21 VirtualYear: 2021
Authors: Gisbert-Ferrandiz, L.(1);Queralt, M.(1);Cosín-Roger, J.(2);Coll, S.(1);Bauset, C.(1);Ortiz-Masia, D.(3);Llau, J.(1);Navarro-Vicente, F.(4);Calatayud, S.(1);Barrachina, M.D.(1);
(1)Universitat de València, Pharmacology, Valencia, Spain;(2)Unidad Mixta Facultad Medicina - Hospital Dr Peset- FISABIO, Pharmacology, Valencia, Spain;(3)CIBERehd-Univ. de València, Medicine, Valencia, Spain;(4)Hospital Manises, Surgery, Valencia, Spain
P075: Multidimensional assessment of interoceptive abilities, emotion processing and the role of early life stress in Inflammatory Bowel DiseaseECCO'21 VirtualYear: 2021
Authors: Atanasova, K.(1);Lotter, T.(2);Reindl, W.(2);Lis, S.(1);
(1)Institute of Psychiatric and Psychosomatic Psychotherapy- Central Institute of Mental Health- Mannheim, Medical Faculty Mannheim- Heidelberg University- Germany, Mannheim, Germany;(2)Medical Faculty Mannheim- Heidelberg University- Germany, Department of Medicine II, Mannheim, Germany
P076: The endocannabinoid system in the intestinal biopsies of children with Inflammatory Bowel DiseaseECCO'21 VirtualYear: 2021
Authors: Creoli, M.(1);Strisciuglio, C.(2); Vitale, A.(2); Oglio, F.(3);Paino, S.(1);Luongo, L.(1);Tortora, C.(2);Argenziano, M.(2); Di Paola, A.(1);Maione, S.(1);Rossi, F.(2);
(1)Università degli Studi della Campania 'L.Vanvitelli', Department of Experimental Medicine, Naples, Italy;(2)Università degli Studi della Campania 'L.Vanvitelli', Department of Woman- Child and General and Specialized Surgery, Naples, Italy;(3)Università degli Studi di Napoli 'Federico II, Department of Translational Medical Science, Naples, Italy
P077: What matters to Ulcerative Colitis patients when they make treatment decisions? A systematic reviewECCO'21 VirtualYear: 2021
Authors: Folan, A.M.(1);Jones, G.(1);Baker, D.(2);Brown, S.(3);Lee, M.(4);Lobo, A.(5);
(1)Leeds Beckett University, Department of Psychology, Leeds, United Kingdom;(2)Sheffield Teaching Hospitals, Academic Foundation Doctor, Sheffield, United Kingdom;(3)Sheffield Teaching Hospitals, Department of General Surgery, Sheffield, United Kingdom;(4)Sheffield Teaching Hospitals, Department of Oncology and Metabolism, Sheffield, United Kingdom;(5)Royal Hallamshire Hospital, Department of Gastroenterology, Sheffield, United Kingdom
P078: Proteomics and Lipidomics Analysis Revealed Alterations of Complement Activation and Lipid Metabolism in peripheral blood mononuclear cells of Inflammatory Bowel Disease PatientsECCO'21 VirtualYear: 2021
Authors: Notararigo, S.(1);Bravo, S.(1);Martin-Pastor, M.(2);Baston-Rey, I.(3);Quiroga-Castiñeira, A.(3);Dominguez-Munoz, J.E.(3);Domínguez Medina, E.(1);Barreiro-de Acosta, M.(3);
(1)University Hospital Santiago De Compostela CHUS, Instituto de Investigación Sanitaria de Santiago IDIS, Santiago De Compostela, Spain;(2)CACTUS, Unidade de Resonancia Magnética, Santiago, Spain;(3)University Hospital Santiago De Compostela CHUS, Department of Gastroenterology- IBD Unit, Santiago De Compostela, Spain
P079: Valproic acid increases MiR449a expression in intestinal mucosa from patients with inflammatory bowel diseaseECCO'21 VirtualYear: 2021
Authors: Felice, C.(1);Lewis, A.(2);Armuzzi, A.(3);Lindsay, J.O.(4);Silver, A.(2);
(1)University of Padua, Internal Medicine DIMED- Medicine 1- Ca' Foncello Hospital, Treviso, Italy;(2)Queen Mary University of London, Centre for Genomics and Child Health- Blizard Institute- Barts and The London School of Medicine and Dentistry, London, United Kingdom;(3)Catholic University, IBD Unit- Gemelli Hospital Foundation IRCCS, Rome, Italy;(4)Queen Mary University of London, Centre for Immunobiology- Blizard Institute- Barts and The London School of Medicine and Dentistry, London, United Kingdom
P080: Burden of Disease and Cost of Illness of Inflammatory Bowel Diseases in PortugalECCO'21 VirtualYear: 2021
Authors: Magro, F.(1);Portela, F.(2);Lago, P.(3);Chagas, C.(4);Moreira, F.(5);Pereira, F.(5);Rodrigues, B.(6);Pedrosa, H.(5);Correia, L.(7);
(1)Centro Hospitalar São João, Gastroenterology, Porto, Portugal;(2)Centro Hospitalar Universitário de Coimbra, Gastroenterolgy, Coimbra, Portugal;(3)Centro Hospitalar e Universitário do Porto, Gastroenterology, Porto, Portugal;(4)Centro Hospitalar Lisboa Ocidental, Gastroenterology, Lisboa, Portugal;(5)IQVIA, Consulting, Lisboa, Portugal;(6)Janssen, Market Access, Lisboa, Portugal;(7)Centro Hospitalar Lisboa Norte, Gastroenterology, Lisboa, Portugal
P081: Resolvin D2 attenuates colonic inflammation of Crohn’s disease patientsECCO'21 VirtualYear: 2021
Authors: Pascoal, L.B.(1);Palma, B.B.(1);Chaim, F.H.(1);Nogueira, G.(2);Rodrigues, B.L.(1);Ayrizono, M.L.S.(1);Velloso, L.A.(2);Leal, R.F.(1);
(1)University of Campinas UNICAMP, Inflammatory Bowel Disease Research Laboratory- Gastrocenter- Colorectal Surgery Unit- School of Medical Sciences, Campinas, Brazil;(2)University of Campinas UNICAMP, Laboratory of Cell Signaling- School of Medical Sciences, Campinas, Brazil
P082: Assessment of anti-inflammatory effect of high acetate administration in UC patient-derived epithelial monolayer culturesECCO'21 VirtualYear: 2021
Authors: Deleu, S.(1);Arnauts, K.(1,2);Machiels, K.(1);Huys, G.R.B.(3,4);Thevelein, J.(4,5,6);Raes, J.(3,4);Vermeire, S.(1,7);
(1)KU Leuven, Department of Chronic Diseases- Metabolism & Ageing CHROMETA, Leuven, Belgium;(2)KU Leuven, Department of Development and Regeneration- Stem Cell Institute Leuven, Leuven, Belgium;(3)KU Leuven, Department of Microbiology and Immunology- Rega Institute, Leuven, Belgium;(4)VIB, Center for Microbiology, Leuven, Belgium;(5)Erasmus High School, NovelYeast bv- Open Bio-Incubator, Brussels, Belgium;(6)KU Leuven, Laboratory of Molecular Cell Biology- Institute of Botany and Microbiology, Leuven, Belgium;(7)University Hospitals Leuven- KU Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium
P083: High prevalence of ulcerative appendicitis in UC patients without colonic disease activityECCO'21 VirtualYear: 2021
Authors: Heuthorst, L.(1);Mookhoek, A.(2);Wildenberg, M.(3);D'Haens, G.(4);Bemelman, W.(1);Buskens, C.(1);
(1)Amsterdam UMC- location AMC, Department of Surgery, Amsterdam, The Netherlands;(2)Amsterdam UMC, Department of Pathology, Amsterdam, The Netherlands;(3)Amsterdam UMC, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(4)Amsterdam UMC, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands
P084: C-Reactive Protein Correlates with Tumor Necrosis Factor-α in Ulcerative ColitisECCO'21 VirtualYear: 2021
Authors: McDonagh, P.(1);O'Connell, F.(2);O'Connell, J.(1);Argue, R.(1);Corcoran, R.(1);Kevans, D.(1);O'Sullivan, J.(2);
(1)St James's Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity College Dublin, Trinity Translational Medicine Institute, Dublin, Ireland
P085: Expression profiling of Wnt pathway genes in colon biopsies of patients with Ulcerative ColitisECCO'21 VirtualYear: 2021
Authors: Lu, C.(1);Shah, D.(1);Wijnands, A.(2);Oldenburg, B.(2);Yeh, W.C.(3);Vanhove, G.(4);Li, Y.(1);
(1)Surrozen Inc., Discovery Biology, South San Francisco, United States;(2)University Medical Center Utrecht, Division Internal Medicine and Dermatology - Department Gastroenterology and hepatology, Utrecht, The Netherlands;(3)Surrozen Inc., In vivo pharmacology, South San Francisco, United States;(4)Surrozen Inc., Clinical Development, South San Francisco, United States
P086: Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon immune dysregulation and intestinal permeability in a stress-induced colonic inflammationECCO'21 VirtualYear: 2021
Authors: Martin-Hernández, D.(1);Robledo Montaña, J.(2);López-Gutiérrez, I.(2);González-Prieto, M.(2);González Bris, Á.(2);Ulecia-Morón, C.(2);MacDowell, K.(2);Tendilla-Beltrán, H.(2);Moreno, B.(2);Calleja-Rodríguez, N.(2);Rodríguez-Mascarenhas, S.(2);Caso, J.R.(2);García-Bueno, B.(2);Marín-Jiménez, I.(3);Leza, J.C.(2);Menchen Viso, L.A.(3);
(1)General University Hospital Gregorio Marañón, Department of Psychatry, Madrid, Spain;(2)Universidad Complutense- Madrid, Pharmacology, Madrid, Spain;(3)General University Hospital Gregorio Marañón, Department of Gastroenterology and Digestive System Medicine, Madrid, Spain
P087: The role of bile acids in mediating fibrosis in inflammatory bowel diseaseECCO'21 VirtualYear: 2021
Authors: Hazel, K.(1);McGinley, N.(1);O'Toole, A.(2);Keely, S.(1);
(1)Royal College of Surgeons in Ireland, Department of Molecular Medicine, Dublin, Ireland;(2)Beaumont Hospital, Department of Gastroenterology, Dublin, Ireland
