P049: Development of human embryonic stem cell-derived intestinal organoids for in vitro studies on intestinal inflammation and fibrosisECCO'21 VirtualYear: 2021
Authors: Kandilogiannakis, L.(1);Filidou, E.(1);Drygiannakis, I.(2);Tarapatzi, G.(1);Arvanitidis, K.(1);Bamias, G.(3);Valatas, V.(2);Paspaliaris, V.(4);Kolios, G.(1);
(1)Democritus University of Thrace, Laboratory of Pharmacology- Faculty of Medicine, Alexandroupolis, Greece;(2)University of Crete, Gastroenterology and Hepatology Research Laboratory- Medical School, Heraklion, Greece;(3)National & Kapodistrian University of Athens, GI-unit- Third Department of Internal Medicine- Sotiria Hospital, Athens, Greece;(4)Tithon Biotech Inc, Tithon Biotech Inc, San Diego, United States
P050: Effect of biological treatments (anti-TNFs) in the creeping fat of Crohn’s disease patientsECCO'21 VirtualYear: 2021
Authors: Montfort-Ferré, D.(1);Serena, C.(1);Millan, M.(2);Boronat-Toscano, A.(1);Maymó-Masip, E.(3);Caro, A.(4);Espina, B.(4);Vendrell, J.(1);Fernández-Veledo, S.(1);
(1)Health Institute Pere Virgili IISPV, Hospital Joan XXIII of Tarragona, Tarragona, Spain;(2)Hospital Universitari i Politècnic La Fe, Colorectal Surgery Unit- Department of Surgery-, Valencia, Spain;(3)Health Institute Pere Virgili IISPV, Hospital Universitari Joan XXIII of Tarragona, Tarragona, Spain;(4)Hospital Universitari Joan XXIII, Colorectal Surgery Unit, Tarragona, Spain
P051: Macrophages as a source of Notch Ligands in Crohn's disease: implications in fibrosisECCO'21 VirtualYear: 2021
Authors: Jorge, M.A.(1);Barrachina, M.D.(1);Bauset, C.(1);Gisbert-Ferrándiz, L.(1);Cosin-Roger, J.(2);Coll, S.(1);Calatayud, S.(1);López-Serrano, A.(3);Ortiz-Masiá, D.(4);
(1)Universitat de Valencia, Facultad de Medicina, Valencia, Spain;(2)Hospital Doctor Peset, Fisabio, Valencia, Spain;(3)Hospital Doctort Peset, Servicio Digestivo, Valencia, Spain;(4)Universidad de Valencia, Facultad de Medicina, Valencia, Spain
P052: Comprehensive proteomic profiling of stool from UC and CD patients reveals expected and novel mucosal pathobiology, enabling identification of candidate non-invasive biomarkers to monitor mucosal disease activityECCO'21 VirtualYear: 2021
Authors: Harder, B.(1);Casavant, E.(1);McBride, J.(1);Park, K.T.(2);Mathews, W.R.(1);Anania, V.G.(1);Lekkerkerker, A.(1);
(1)Genentech, OMNI Biomarker Development, South San Francisco, United States;(2)Genentech, PDC Gastroenterology, South San Francisco, United States
P053: Overabundance of Lactobacillus species in gut microbiota of IBD patientsECCO'21 VirtualYear: 2021
Authors: Khusnutdinova, D.(1,2);Markelova, M.(1);Siniagina, M.(1);Boulygina, E.(1);Abdulkhakov, S.(1);Grigoryeva, T.(1);
(1)Kazan Federal University, Institute of Fundamental Medicine and Biology, Kazan, Russian Federation;(2)KIBB FRC Kazan Scientific Center of RAS, Kazan Institute of Biochemistry and Biophysics, Kazan, Russian Federation
P055: Brain-Immune Axis Regulation is Responsive to Cognitive Behavioral and Mindfulness-Based Stress Reduction in Crohn’s DiseaseECCO'21 VirtualYear: 2021
Authors: Nemirovsky, A.(1);Ilan, K.(2);Lerner, L.(2);Cohen-Lavi , L.(3);Schwartz, D.(4);Goren, G.(5);Sergienko, R.(5);Greenberg, D.(6);Slonim-Nevo , V.(7);Sarid, O.(7);Friger, M.(5);Regev, S.(7);Odes, S..(8);Hertz, T.(9);Monsonego, A.(10);
(1)Faculty of Health Sciences- Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics-, Beer Sheva, Israel;(2)Faculty of Health Sciences- Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics, Beer Sheva, Israel;(3)Faculty of Health Sciences- Ben-Gurion University of the Negev- and Vaccine and Infectious Disease Division- Fred Hutch Cancer Research Center- Seattle- WA- USA, The Shraga Segal Department of Microbiology- Immunology- and Genetics, Beer Sheva, Israel;(4)Faculty of Health Sciences- Ben-Gurion University of the Negev, Gastroenterology & Hepatology, Beer Sheva, Israel;(5)Faculty of Health Sciences- Ben-Gurion University of the Negev, Department of Public Health, Beer Sheva, Israel;(6)Faculty of Health Sciences- Ben-Gurion University of the Negev, Department of Health Systems Management- School of Public Health- Guilford Glazer Faculty of Business and Management, Beer Sheva, Israel;(7)Ben-Gurion University of the Negev, Spitzer Department of Social Work, Beer Sheva, Israel;(8)Faculty of Health Sciences- Ben-Gurion University of the Negev, Gastroenterology & Hepatology, Metar, Israel;(9)Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- Faculty of Health Sciences- and Vaccine and Infectious Disease Division- Fred Hutch Cancer Research Center- Seattle- WA- USA, Beer Sheva, Israel;(10)Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- Faculty of Health Sciences- and The National Institute of Biotechnology in the Negev, Beer Sheva, Israel
P056: Crohn’s Disease associated fibrosis modulates the expression of collagen receptorsECCO'21 VirtualYear: 2021
Authors: Coll, S.(1);Bauset, C.(1);Cosín-Roger, J.(2);Ortiz-Masià, D.(1);Gisbert-Ferrándiz, L.(1);Navarro-Vicente, F.(3);Barrachina, D.(1);Calatayud, S.(1);
(1)Faculty of Medicine - University of Valencia, Pharmacology, Valencia, Spain;(2)Hospital Dr. Peset, Endocrinology and Metabolism, Valencia, Spain;(3)Hospital Manises, Surgery, Valencia, Spain
P058: Proteomic analysis-based discovery of a novel biomarker that differentiates intestinal Behçet’s disease from Crohn’s diseaseECCO'21 VirtualYear: 2021
Authors: Park, J.(1);Daeun , J.(2);Youn Wook , C.(2);Jae Hee , C.(1);Ji-Hwan , R.(3);
(1)Yonsei University College of Medicine- Seoul 03722- Korea, Department of Internal Medicine, Seoul, Korea- Republic Of;(2)Yonsei University College of Medicine- Seoul 03722- Korea, Severance Biomedical Science Institute, Seoul, Korea- Republic Of;(3)Severance Biomedical Science Institute, Yonsei University College of Medicine- 50-1 Yonsei-ro- Seodaemun-gu- Seoul 03722- Korea, Seoul, Korea- Republic Of
P059: GB004 drives protective effects on immune cells and epithelial cells using human ex vivo monolayer and co-culture systemsECCO'21 VirtualYear: 2021
Authors: Taylor Meadows, K.(1);Murphy, S.(1);Levesque, B.G.(2);Carter, L.L.(3);Salter-Cid, L.(4);
(1)Gossamer Bio- Inc., Biology, San Diego, United States;(2)Gossamer Bio- Inc., Clinical Development, San Diego, United States;(3)Gossamer Bio- Inc., Research & Translational Biology, San Diego, United States;(4)Gossamer Bio- Inc., Research & Development, San Diego, United States
P060: A2B adenosine receptor deficiency ameliorates chronic murine Crohn’s-like-ileitis.ECCO'21 VirtualYear: 2021
Authors: O Connell, L.(1);Olli, K.(2);Wilkinson, C.(3);Collins, C.(1);Jedlicka, P.(4);Aherne, C.(1);
(1)Conway Institute of Biomolecular and Biomedical Science- University College Dublin- Ireland, School of Medicine, Dublin, Ireland;(2)University of Colorado School of Medicine- Aurora- CO 80045- USA., Department of Anesthesiology, Aurora, United States;(3)Digestive Health Institute- Children’s Hospital Colorado- Aurora- CO 80045- USA., Section of Pediatrics- Department of Pediatrics- Division of Gastroenterology- Hepatology and Nutrition, Aurora, United States;(4)University of Colorado School of Medicine- Aurora- CO 80045- USA., Department of Pathology-, Aurora, United States
P062: Effects of exposure to steroids on the PredictSURE whole blood prognostic assay in Inflammatory Bowel DiseaseECCO'21 VirtualYear: 2021
Authors: Alsoud, D.(1);Verstockt, S.(1);Sabino, J.(1,2);Ferrante, M.(1,2);Noor, N.(3,4);Verstockt, B.(1,2);Vermeire, S.(1,2);
(1)KU Leuven, Translational Research Center for GastroIntestinal Disorders- Department of Chronic Diseases- Metabolism and Ageing, Leuven, Belgium;(2)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(3)University College London, Medical Research Council Clinical Trials Unit, London, United Kingdom;(4)Cambridge University Hosopitals NHS Trust, Department of Gastroenterology, Cambridge, United Kingdom
P063: The immunological landscape of intestinal fibrosis in Crohn’s Disease.ECCO'21 VirtualYear: 2021
Authors: Jacobs, I.(1,2);Creyns, B.(1,2);Dragoni, G.(2,3);Cremer, J.(1,2);Bislenghi, G.(4);D'Hoore, A.(4);Ke, B.J.(2);Matteoli, G.(2);De Hertogh, G.(5);Ferrante, M.(2,4);Joao, G.S.(2,4);Breynaert, C.(1,6);Vermeire, S.(2,4);Verstockt, B.(2,4);Vanuytsel, T.(2,4);
(1)KU Leuven, Microbiology- Immunology and transplantation, Leuven, Belgium;(2)KU Leuven, Chronic Diseases and Metabolism, Leuven, Belgium;(3)University of Florence, Biomedical Clinical and Experimental Sciences, Florence, Italy;(4)University Hostpitals Leuven, Gastroenterology and Hepatology, Leuven, Belgium;(5)University Hospitals Leuven, Imaging and Pathology, Leuven, Belgium;(6)University Hospitals Leuven, General Internal Medicine, Leuven, Belgium
P064: 3-oxo-C12:2, a Quorum Sensing molecule from the gut, exerts anti-inflammatory effects through a bitter taste receptorECCO'21 VirtualYear: 2021
Authors: Coquant, G.(1);Aguanno, D.(2);Peyrottes, A.(3);Brot, L.(1);Belloir, C.(4);Briand, L.(4);Grill, J.P.(1);Thenet, S.(2);De Sordi, L.(1);Seksik, P.(1);
(1)Sorbonne Université, Medecine Faculty, Paris, France;(2)PSL University, Ecole Pratique des Hautes Etudes, Paris, France;(3)Ecole Normale Supérieure, Département de Chimie, Paris, France;(4)INRAE, AgroSup Dijon, Dijon, France
P065: Conservation of breast milk cytokine profiles in consecutive pregnancies of women with inflammatory bowel diseaseECCO'21 VirtualYear: 2021
Authors: Agrawal, M.(1);Tarassishin, L.(2);Rendon, A.(2);Debebe, A.(2);Hillenbrand, C.(2);White, S.(2);Eisele, C.(2);Hawkins, K.(2);Chen, C.L.(3);Kornbluth, A.(1);George, J.(1);Legnani, P.(1);Maser, E.(1);Stone, J.(4);Dubinsky, M.(5);Sabino, J.(1,6);Torres, J.(1,7);Colombel, J.F.(1);Peter, I.(2);Hu, J.(2);
(1)Icahn School of Medicine at Mount Sinai, The Henry D. Janowitz Division of Gastroenterology, New York, United States;(2)Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York, United States;(3)Icahn School of Medicine at Mount Sinai, Department of Obstetrics- Gynecology and Reproductive Science, New York, United States;(4)Icahn School of Medicine at Mount Sinai, Division of Maternal Fetal Medicine- Department of Obstetrics- Gynecology and Reproductive Science, New York, United States;(5)Icahn School of Medicine at Mount Sinai, Department of Pediatric Gastroenterology and Nutrition, New York, United States;(6)University Hospital of Leuven, Gastroenterology Division, Leuven, Belgium;(7)Hospital Beatriz Ângelo, Division of Gastroenterology- Surgical Department, Loures, Portugal
P067: The effect of a probiotic mix on mucosal healing and fibrotic responses in healthy colonic subepithelial myofibroblasts.ECCO'21 VirtualYear: 2021
Authors: Tarapatzi, G.(1);Filidou, E.(1);Kandilogiannakis, L.(1);Arvanitidis, K.(1);Vradelis, S.(2);Kotzampassi, K.(3);Kolios, G.(1);
(1)Democritus University of Thrace, Laboratory of Pharmacology- Faculty of Medicine, Alexandroupolis, Greece;(2)Democritus University of Thrace, Second Department of Internal Medicine- University Hospital of Alexandroupolis, Alexandroupolis, Greece;(3)Aristotle University of Thessaloniki, Department of Surgery- AHEPA Hospital, Thessaloniki, Greece
P068: The combination of JAK1 and TPL2 or IRAK4 inhibitors is more effective than single agents in reducing TLR-mediated cytokine responses in human monocyte populationsECCO'21 VirtualYear: 2021
Authors: Hornsby, E.(1);Yadon, A.N.(2);Clarke, A.(2);Grant, E.(3);Lindsay, J.O.(1);Stagg, A.J.(1);
(1)Queen Mary University of London, Blizard Institute, London, United Kingdom;(2)Gilead Sciences- Inc., 199 East Blaine Street, Seattle, United States;(3)Gilead Sciences- Inc., 333 Lakeside Dr., Foster City, United States
