P009: Disease classifier and microbial dysbiosis index tools cross-predict various pathogenic conditions due to general microbial signalECCO'21 VirtualYear: 2021
Authors: Abbas Egbariya, H.(1);Braun, T.(2);Hadar , R.(2);Gal-Mor, O.(1);Shental, N.(3);Haberman, Y.(4);Amir, A.(2);
(1)Tel Aviv university - Faculty of Medicine, microbiology, Tel Aviv, Israel;(2)Sheba medical center, microbiome center, Ramat Gan, Israel;(3)The Open University of Israel, Department of Mathematics and Computer Science, Ra’anana, Israel;(4)Sheba medical center, pediatric gastroenterology, Ramat Gan, Israel
P010: GSDMB-mediated pyroptosis exacerbates intestinal inflammation by destroying intestinal epithelium in Crohn’s diseaseECCO'21 VirtualYear: 2021
Authors: Gong, W.(1);Liu, P.(2);Ren, J.(3);
(1)Southeast University, School of Medicine, Nanjing, China;(2)Nanjing University, School of Medicine, Nanjing, China;(3)Jinling Hospital, General Surgerry, Nanjing, China
P011: Serum adhesion G protein coupled receptor levels are associated with disease activity in pediatric patients with Crohn’s diseaseECCO'21 VirtualYear: 2021
Authors: Werner, L.(1);Weiss, B.(2);Shamir, R.(1);Shouval, D.(1);
(1)Schneider Children's Medical Center of Israel, Institute of Gastroenterology- Nutrition and Liver Diseases, Petah Tiqwa, Israel;(2)Edmond and Lily Safra Children's Hospital- Sheba Medical Center, Pediatric Gastroenterology, Ramat Gan, Israel
P012: Low frequencies of circulating inhibitory TIGIT+CD38+ effector T cells identify an immunologically distinct subgroup of pediatric patients with severe Crohn's diseaseECCO'21 VirtualYear: 2021
Authors: Heredia, M.(1);Costes, L.(1);Tindemans, I.(1);Aardoom, M.(2);Klomberg, R.(2);Kemos, P.(3);Joosse, M..(1);van Haaften, D.(1);Tuk, B.(1);Ruemmele, F.(4);Croft, N.(3);Escher, J.(2);de Ridder, L.(2);Samsom, J.(1);
(1)Erasmus University Medical Center-Sophia Children’s Hospital, Laboratory of Pediatrics- division Gastroenterology and Nutrition, Rotterdam, The Netherlands;(2)Erasmus University Medical Center-Sophia Children’s Hospital, Pediatric Gastroenterology, Rotterdam, The Netherlands;(3)Blizard Institute- Queen Mary University of London, Centre for Immunobiology, London, United Kingdom;(4)Necker-Enfants Malades University Hospital- Institut Imagine- AP-HP- Université de Paris, Pediatric Gastroenterology, Paris, France
P013: Potential Role of Epithelial Protein Disulphide Isomerases in Crohn’s Disease FibrosisECCO'21 VirtualYear: 2021
Authors: Vieujean, S.(1,2);Hu, S.(2);Bequet, E.(2,3);Salée, C.(2);Massot, C.(2);Bletard, N.(4);Pierre, N.(2);Quesada Calvo, F.(2);Baiwir, D.(5);Mazzucchelli, G.(6);De Pauw, E.(6);Coimbra Marques, C.(7);Delvenne, P.(4);Edouard, L.(1,2);Meuwis, M.A.(2);
(1)CHU Liège- Sart Tilman, Department of Gastroenterology, Liège, Belgium;(2)University of Liège, Laboratory of Translational Gastroenterology, Liège, Belgium;(3)University Hospital of Liège, Division of Hepato-Gastroenterology- Department of Paediatrics, Liège, Belgium;(4)University Hospital CHU of Liège, Pathological Anatomy and Cytology, Liège, Belgium;(5)University of Liège, GIGA Proteomics Facility, Liège, Belgium;(6)University of Liège, MolSys Research Unit- Laboratory of Mass Spectrometry, Liège, Belgium;(7)University Hospital CHU of Liège, Abdominal Surgery Department, Liège, Belgium
P014: Untargeted serum metabolome in longitudinal Crohn's Disease (CD) cohort enrolled during remission shows strong individualized signature and CD-associated signals that are maintained also in patients who normalized their fecal calprotectinECCO'21 VirtualYear: 2021
Authors: Levhar, N.(1,2);Hadar, R.(1);Braun, T.(1);Efroni, G.(1);Abramovich, I.(3);Gottlieb, E.(3);Sosnovski, K.(1,2);Abass, H.(1,2);Berger, T.(4);Granot, M.(4);Neuman, S.(5);Selinger, L.(5);Picard, O.(5);Yavzuri, M.(5);Lahat, A.(2,5);Eliakim, R.(2,5);Weiss, B.(4);Kopylov, U.(2,5);Ben-Horin, S.(2,5);Amir, A.(1);Haberman, Y.(1,2,4,6);
(1)Tel-HaShomer Sheba Medical Center, The Pediatric Gastroenterology Unit and Sheba Microbiome Center, Ramat Gan, Israel;(2)Tel-Aviv University, Sackler Faculty of Medicine, Tel-Aviv, Israel;(3)Technion Institute, The Ruth and Bruce Rappaport- Faculty of Medicine, Haifa, Israel;(4)Tel-HaShomer Sheba Medical Center, The Pediatric Gastroenterology Unit- The Edmond and Lily Safra Children’s Hospital, Ramat Gan, Israel;(5)Tel-HaShomer Sheba Medical Center, Department of Gastroenterology, Ramat Gan, Israel;(6)Cincinnati Children’s Hospital Medical Center- University of Cincinnati, Department of Pediatrics- College of Medicine, Cincinnati- Ohio, United States
P015: Differential expression in colitis-associated cancer compared to Crohn´s disease and ulcerative colitisECCO'21 VirtualYear: 2021
Authors: Manna, S.(1);Sehn, M.(2);Cardoso da Silva, D.(1);Elezkurtaj, S.(3);Cineus, R.(1);Hegazy, A.(1);Siegmund, B.(1);Weixler, B.(2);Hummel, M.(3);Gröne, J.(2);Schumann, M.(1);
(1)Charité Universitätsmedizin Berlin, Department of Gastroenterology, Berlin, Germany;(2)Charité Universitätsmedizin Berlin, Department of Visceral Surgery, Berlin, Germany;(3)Charité Universitätsmedizin Berlin, Institute of Pathology and Molecular Pathology, Berlin, Germany
P016: SZN-1326, a Wnt signal activator, is more efficacious than cyclosporine A in an acute DSS modelECCO'21 VirtualYear: 2021
Authors: Xie, L.(1);Baribault, H.(1);Lu, C.(2);Handa, P.(1);Newman, M.(3);Le, L.(3);Liu, A.(1);Mutha, D.(1);Deshmukh, S.(2);Shah, D.(2);Tun, C.(1);Le, T.(1);Fletcher, R.(2);Chen, H.(4);Ye, J.(4);Tibbitts, J.(3);Srinivasan, U.(3);Li, Y.(4);Vanhove, G.(3);Yeh, W.C.(1);
(1)Surrozen. INC, In vivo pharmacology, South San Francisco, United States;(2)Surrozen. INC, Discovery biology, South San Francisco, United States;(3)Surrozen. INC, Pre-Clinical, South San Francisco, United States;(4)Surrozen. INC, Protein Science, South San Francisco, United States
P017: Small bowel transcriptomics define similarities and divergent pathways between Crohn, environmental enteric dysfunction (EED), and celiac diseases, implicating role for the microbiome in the pathogenesisECCO'21 VirtualYear: 2021
Authors: Haberman Ziv, Y.(1);Iqbal, N.T.(2);Braun, T.(1);Dexheimer, P.J.(3);Hadar, R.(1);Rahman, N.(2);Syed, S.(4);Moskaluk, C.(4);Moore, S.R.(4);Ali, S.A.(2);Denson, L.A.(3);
(1)Tel-HaShomer Sheba Medical Center, Department of Pediatric Gastroenterology, Ramat Gan, Israel;(2)Aga Khan University, Department of Pediatrics, Karachi, Pakistan;(3)Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, Cincinnati, United States;(4)University of Virginia- Charlottesville, Department of Pediatrics, Charlottesville, United States; The Study of Environmental Enteropathy and Malnutrition (SEEM) Pakistan and CCF-supported RISK study
P018: Myeloid diversity in inflammatory bowel disease revealed by single-cell transcriptomicsECCO'21 VirtualYear: 2021
Authors: Garrido Trigo, A.(1);Corraliza, A.M.(1);Melón-Ardanaz, E.(1);Veny, M.(1);Ordás, I.(2);Ricart, E.(2);Masamunt, M.C.(2);Panès, J.(2);Hemberg, M.(3);Mereu, E.(4);Heyn, H.(5);Azucena, S.(1);
(1)IDIBAPS, Inflammatory bowel disease group, Barcelona, Spain;(2)Hospital Clinic de Barcelona, Inflammatory Bowel Disease Unit, Barcelona, Spain;(3)Harvard Medical School, The Evergrande Center for Immunologic Diseases- Brigham and Women's Hospital, Boston- MA, United States;(4)Josep Carreras Research Institute, Cellular Systems Genomics Group, Barcelona, Spain;(5)National Centre for Genomic Analysis- Centre for Genomic Regulation, Single Cell Genomics Group, Barcelona, Spain
P019: Differential effects of first-line IFX and conventional treatment on inflammatory serum proteins of paediatric moderate- to-severe Crohn’s disease patients.ECCO'21 VirtualYear: 2021
Authors: JongsmaMSc, M.(1);Costes, L.M.M.(2);Tindemans, I.(2);Cozijnsen, M.A.(1);Raatgeep, R.H.C.(2);van Pieterson, M.(1);Li, Y.(3);Escher, J.C.(1);de Ridder, L.(1);Samsom, J.N.(2);
(1)Erasmus MC - Sophia Children's hospital, Department of Pediatric Gastroenterology, Rotterdam, The Netherlands;(2)Erasmus MC - Sophia Children's hospital, Laboratory of Paediatrics- division Gastroenterology and Nutrition, Rotterdam, The Netherlands;(3)Erasmus University Medical Centre/Erasmus MC Cancer Institute, Department of Pathology & Clinical Bioinformatics, Rotterdam, The Netherlands
P020: Mapping the changing intercellular communication and its downstream effect in Ulcerative ColitisECCO'21 VirtualYear: 2021
Authors: Potari-gul, L.(1);Modos, D.(1,2);Turei, D.(3);Valdeolivas, A.(3);Madgwick, M.(1,2);Saez-Rodriguez, J.(3,4);Korcsmaros, T.(1,2);
(1)Earlham Institute- Norwich Research Park, Organisms and Ecosystems, Norwich, United Kingdom;(2)Quadram Institute Bioscience- Norwich Research Park, Gut Microbes and Health Programme, Norwich, United Kingdom;(3)Heidelberg University, Faculty of Medicine and Heidelberg University Hospital- Institute of Computational Biomedicine- Bioquant, Heidelberg, Germany;(4)RWTH Aachen University, Faculty of Medicine- Joint Research Centre for Computational Biomedicine JRC-COMBINE, Aachen, Germany
P021: Circulating inflammatory protein and cellular profiles at time of diagnosis classify inflammatory bowel disease patients according to their underlying immune response and clinical disease courseECCO'21 VirtualYear: 2021
Authors: Heredia, M.(1);Charrout, M.(2);Klomberg, R.(3);Aardoom, M.(3);Jongsma, M.(3);Kemos, P.(4);van Haaften, D.(1);Tuk, B.(1);van Berkel, L.(1);Bley Folly, B.(1);Mahfouz, A.(2);Reinders, M.(2);Ruemmele, F.(5);Croft, N.(4);Escher, J.(3);de Ridder, L.(3);Samsom, J.(1);
(1)Erasmus University Medical Center-Sophia Children’s Hospital, Laboratory of Pediatrics- division Gastroenterology and Nutrition, Rotterdam, The Netherlands;(2)Delft University of Technology, Delft Bioinformatics Lab, Delft, The Netherlands;(3)Erasmus University Medical Center-Sophia Children’s Hospital, Pediatric Gastroenterology, Rotterdam, The Netherlands;(4)Blizard Institute- Queen Mary University of London, Centre for Immunobiology, London, United Kingdom;(5)Necker-Enfants Malades University Hospital- Institut Imagine- AP-HP- Université de Paris, Pediatric Gastroenterology, Paris, France
P022: Pathologic involvement of the farnesoid X receptor/fibroblast growth factor 19 axis to the Crohn’s disease early postsurgical recurrence.ECCO'21 VirtualYear: 2021
Authors: Suau, R.(1);Garcia-Jaraquemada, A.(2);Lorén, V.(1);Torres, P.(2);Jou, E.(2);Llaves, M.(2);Aterido, A.(3);Julià, T.(3);Zabana, Y.(4);Lozano, J.J.(5);Domènech, E.(6);Mañosa, M.(6);Manyé, J.(1);
(1)CIBER-'Germans Trias i Pujol' Research Institute, IBD Research Group, Badalona, Spain;(2)'Germans Trias i Pujol' Research Institute, IBD Research Group, Badalona, Spain;(3)Vall d'Hebron Research Institute, Rheumatology Research Group, Barcelona, Spain;(4)Hospital Mutua de Terrassa, Gastroenterology Department, Terrassa, Spain;(5)CIBER in Liver and Gastroenterology, Bioinformatics Unit, Barcelona, Spain;(6)'Germans Trias i Pujol' University Hospital CIBER, Gastroenterology Department, Badalona, Spain
P023: SZN-1326, a Wnt agonist, improved epithelial healing and ameliorated colitis in a chronic DSS model, in stark contrast to anti-TNF and anti-IL-12/23p40 antibodiesECCO'21 VirtualYear: 2021
Authors: Xie, L.(1);Handa, P.(1);Tun, C.(1);Liu, A.(1);Lu, C.(2);Baribault, H.(1);Newman, M.(3);Le, L.(3);Shah, D.(2);Deshmukh, S.(2);Mutha, D.(1);Le, T.(1);Fletcher, R.(2);Chen, H.(4);Ye, J.(4);Tibbitts, J.(3);Srinivasan, U.(3);Li, Y.(4);Vanhove, G.(3);Yeh, W.C.(1);
(1)Surrozen. INC, In vivo pharmacology, South San Francisco, United States;(2)Surrozen. INC, Discovery biology, South San Francisco, United States;(3)Surrozen. INC, Pre-Clinical, South San Francisco, United States;(4)Surrozen. INC, Protein science, South San Francisco, United States
P024: Development of a treatment for short bowel syndrome using small intestinal organoidsECCO'21 VirtualYear: 2021
Authors: Sugimoto, S.(1);Kobayashi, E.(2);Fujii, M.(3);Ohta, Y.(3);Ishikawa, K.(1);Nanki, K.(1);Hakamata, Y.(4);Kanai, T.(5);Sato, T.(1);
(1)Keio University School of Medicine, Department of Organoid Medicine- Department of Gastroenterology, Tokyo, Japan;(2)Keio University School of Medicine, Department of Organ Fabrication, Tokyo, Japan;(3)Keio University School of Medicine, Department of Organoid Medicine, Tokyo, Japan;(4)Nippon Veterinary and Life Science University, School of Veterinary Nursing and Technology, Tokyo, Japan;(5)Keio University School of Medicine, Department of Gastroenterology, Tokyo, Japan
P025: Identification and validation of predictors for tofacitinib through supervised and unbiased approaches in Inflammatory Bowel DiseaseECCO'21 VirtualYear: 2021
Authors: Liu, B.(1);Spalinger, M.(2);Perez , L.G.(1);Machicote, A.(1);Gagliani, N.(1);Scharl, M.(2);Huber, S.(1);
(1)University Medical Center Hamburg-Eppendorf, I. Department of Medicine, Hamburg, Germany;(2)University Hospital Zurich, Department for Gastroenterology and Hepatology, Zurich, Switzerland
P026: Microbial Diversity is affected by Cognitive Behavioral and Mindfulness-Based Stress Reduction and accompanied by an Inflammatory Response in Patients with Crohn’s DiseaseECCO'21 VirtualYear: 2021
Authors: Ilan, K.(1);Motro, Y.(2);Nemirovsky, A.(2);Lerner, L.(3);Schwartz, D.(4);Goren, G.(5);Sergienko, R.(6);Greenberg, D.(7);Slonim-Nevo , V.(5);Sarid, O.(5);Friger, M.(6);Regev, S.(5);Odes, S..(8);Moran-Gilad , J.(9);Monsonego, A.(10);
(1)Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- Faculty of Health Sciences, Beer Sheva, Israel;(2)Faculty of Health Sciences- Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics, Beer Sheva, Israel;(3)Faculty of Health Sciences- Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- and The National Institute of Biotechnology in the Negev- Zlotowski Neuroscience Center- and Regenerative Medicine and Stem Cell Research Center, Beer Sheva, Israel;(4)Faculty of Health Sciences- Ben-Gurion University of the Negev- and Soroka Medical Center, Gastroenterology & Hepatology, Beer Sheva, Israel;(5)Ben-Gurion University of the Negev, Spitzer Department of Social Work, Beer Sheva, Israel;(6)Faculty of Health Sciences- Ben-Gurion University of the Negev, Department of Public Health, Beer Sheva, Israel;(7)Faculty of Health Sciences- Ben-Gurion University of the Negev, Department of Health Systems Management- School of Public Health- Guilford Glazer Faculty of Business and Management, Beer Sheva, Israel;(8)Faculty of Health Sciences- Ben-Gurion University of the Negev, Gastroenterology & Hepatology, Metar, Israel;(9)Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- Faculty of Health Sciences- and The National Institute of Biotechnology in the Negev, Beer Sheva, Israel;(10)Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- Faculty of Health Sciences- and The National Institute of Biotechnology in the Negev- Zlotowski Neuroscience Center- and Regenerative Medicine and Stem Cell Research Center, Beer Sheva, Israel
P027: Epithelial cells of patients with ulcerative colitis do not show an increased sensitivity after microbiota stimulation compared to non-IBD controlsECCO'21 VirtualYear: 2021
Authors: Arnauts, K.(1,2);Lapierre, C.(1);Verstockt, B.(1,3);Verstockt, S.(1);Sudhakar, P.(1);Vermeire, S.(1,3);Verfaillie, C.(2);Sabino, J.(1,3);Ferrante, M.(1,3);
(1)KU Leuven, TARGID- Department of Chronic Diseases- Metabolism & Ageing, Leuven, Belgium;(2)KU Leuven, Stem Cell Institute Leuven- Department of Development and Regeneration, Leuven, Belgium;(3)KU Leuven, Department of Gastroenterology and Hepatology- University Hospitals Leuven, Leuven, Belgium
P028: The Apa I polymorphism in the Vitamin D receptor gene is associated with a stricturing behaviour in Crohn´s disease patientsECCO'21 VirtualYear: 2021
Authors: Gisbert-Ferrandiz, L.(1);Llau, J.(1);Cosin-Roger, J.(2);Coll, S.(1);Bauset, C.(1);Ortiz-Masia, D.(3);Hinojosa, J.(4);Calatayud, S.(1);Barrachina, M.D.(1);
(1)Universitat de València, Pharmacology, Valencia, Spain;(2)Unidad Mixta-Facultad de Medicina - Hospital Dr Peset, FISABIO Pharmacology, Valencia, Spain;(3)CIBERehd-Universitat València, Medicina, Valencia, Spain;(4)Hospital Manises, Gastroenterology, Valencia, Spain
