¹New York University Medical Center, Medicine, New York, USA, ²Cleveland Clinic Medical Center, Medicine, Cleveland, USA, ³Karolinska, Clinical Epidemiology, Solna, Sweden, ⁴Gastroenterology and Hepatology, New York University Medical Center, New York, USA, ⁵Gastroenterology- Hepatology- and Nutrition, Cleveland Clinic Medical Center, Cleveland, USA

Department of Gastroenterology, University Hospital Puerta De Hierro, Majadahonda, Spain

¹Clalit health care, Occupational Medicine, Haifa, Israel, ²Technion, Israel institute of technology, Haifa, Israel, ³Clalit health care, Gastroenterology, Kfar Saba, Israel

¹Department of Pharmacy, Cambridge University Hospitals, Cambridge, UK, ²Department of Rheumatology, Cambridge University Hospitals, Cambridge, UK, ³Department of Dermatology, Cambridge University Hospitals, Cambridge, UK, ⁴Department of Gastroenterology, Cambridge University Hospitals, Cambridge, UK

¹Rabin Medical Center, IBD Center- Division of Gastroenterology, Petah-Tikva, Israel, ²Tel Aviv University, Sackler Faculty of Medicine-, Tel Aviv, Israel, ³Schneider Children’s Medical Center, The Institute of Gastroenterology- Nutrition and Liver diseases, Petah Tikva, Israel

¹Gastroenterology, Royal London Hospital- Barts Health NHS Trust, London, UK, ²Gastroenterology, University College London Hospital NHS Trust, London, UK, ³Gastroenterology, Guys and St Thomas’ Hospital NHS Trust, London, UK

¹CHU UCL Namur, Gastroenterology, Yvoir, Belgium, ²Icahn School of Medicine at Mount Sinai, Gastroenterology, New-York, USA, ³University Hospitals Leuven, Gastroenterology and Hepatology, Leuven, Belgium, ⁴University Hospital Gent, Gastroenterology, Gent, Belgium, ⁵AZ Delta, Gastroenterology, Roeselare, Belgium, ⁶Imelda General Hospital, Gastroenterology, Bonheiden, Belgium, ⁷Erasme University Hospital, Gastroenterology, Bruxelles, Belgium, ⁸University Hospital Antwerp, Gastroenterology, Edegem, Belgium, ⁹AZ Sint-Lucas, Gastroenterology, Gent, Belgium

¹Takeda, Quantitative Clinical Pharmacology, Cambridge, USA, ²University of Colorado, Department of Medicine Gastroenterology, Aurora, USA, ³Vanderbilt University Medical Center, Vanderbilt Digestive Disease Center, Nashville, USA, ⁴Morristown Medical Center, AHS Hospital Corporate, Morristown, USA, ⁵Northwestern University, Division of Gastroenterology and Hepatology, Chicago, USA, ⁶Takeda, Statistics and Quantitative Sciences, Cambridge, USA, ⁷Certara, Integrated Drug Development, Princeton, USA, ⁸Takeda, Global Program Management, Cambridge, USA, ⁹Takeda, Clinical Pharmacology, Cambridge, USA, ¹⁰Takeda, Clinical Science, Cambridge, USA

¹University of California San Diego, Division of Gastroenterology, La Jolla, USA, ²Atlanta Gastroenterology Associates, Gastroenterology, Atlanta, USA, ³University of Amsterdam- Academic Medical Center, Gastroenterology, Amsterdam, The Netherlands, ⁴Takeda Development Center Americas Inc-, Gastroenterology, Cambridge, USA, ⁵Takeda Development Center Americas Inc., Gastroenterology, Cambridge, USA, ⁶US Medical Office- Takeda Pharmaceuticals USA Inc., Gastroenterology, Deerfield, USA

¹Department of Gastroenterology, University of British Columbia, Vancouver, Canada, ²Department of Medical Affairs, Janssen Canada, Toronto, Canada, ³Department of Epidemiology and Biostatistics, Western University, London, Canada, ⁴Department of Gastroenterology, University of Calgary Calgary, Canada, ⁵Research and Development- LLC, Janssen Inc., Spring House, USA, ⁶Inflammatory Bowel Disease Centre, McGill University Health Centre, Montreal, Canada

¹Division of Internal Medicine, McGill University, Montreal, Canada, ²Division of Gastroenterology, McGill University, Montreal, Canada, ³Division of Gastroenterology, Hopital Hotel-Dieu de Lévis, Quebec City, Canada

¹Department of Colorectal Surgery, Cleveland Clinic, Cleveland, USA, ²Cedars-Sinai, Colon and Rectal Surgery, Cleveland- OH, USA

¹AbbVie, Clinical Pharmacology and Pharmacometrics, Ludwigshafen, Germany, ²Immunology Development, AbbVie, North Chicago, USA, ³Clinical Pharmacology and Pharmacometrics, AbbVie, North Chicago, USA

¹Department of Medical Biosciences- Umeå University, Clinical Chemistry, Umeå, Sweden, ²Department of Research and Development- Region Kronoberg- Växjö, Clinical Chemistry, Växjö, Sweden, ³Department of Public Health and Clinical Medicine- Umeå University, Medicine, Umeå, Sweden, ⁴Department of Public Health and Clinical Medicine- Umeå University, Nutritional Research, Umeå, Sweden

¹Division of Gastroenterology and Nutrition, Department of Paediatrics- McMaster University, Hamilton, Canada, ²Department of Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa, ³College of Medicine and Health, University College Cork, Cork, Ireland, ⁴Faculty of Health Sciences, McMaster University, Hamilton, Canada, ⁵Farncombe Family Digestive Health Research Institute, Department of Medicine- McMaster University, Hamilton, Canada

¹IQVIA, Therapeutic Science and Strategy Unit, Raleigh, USA, ²IQVIA, Project Leadership, Raleigh, USA, ³Department of Gastroenterology, University of Vienna, Vienna, Austria

¹Gastroenterology, St Vincent’s Hospital, Melbourne, Australia, ²Gastroenterology, Alfred Health, Melbourne, Australia, ³Gastroenterology, Eastern Health, Melbourne, Australia, ⁴Eastern Health, Radiology, Melbourne, Australia, ⁵Monash University, Epidemiology and Public Health, Melbourne, Australia

¹Gastroenterology, Reina Sofia Hospital, Murcia, Spain, ²Pharmacology Department, Reina Sofia Hospital, Murcia, Spain

¹Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Gastroenterologia - Divisão de Coloproctologia, São Paulo, Brazil, ²Instituto de Infectologia Emílio Ribas, Departamento de Coloproctologia, São Paulo, Brazil, ³Faculdade de Medicina da Universidade de São Paulo, Laboratório de Inovação em Câncer do Centro de Investigação Translacional em Oncologia, São Paulo, Brazil