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P362 Prospective study of phArmaCokinetics of InFliximab during induction in patients with Crohn’s disease and ulcerative colitis (PACIFIC)

ECCO'20 Vienna

Year: 2020
Authors:

C. Liefferinckx1, P. Bossuyt2, D. Thomas3, J.F. Rahier4, E. Louis5, F. Baert6, P. Dewint7,8, L. Pouillon2, G. Lambrecht9, S. Vermeire10, D. Franchimont1, of Belgian Inflammatory Bowel Disease Research and Development (BIRD)

1Department of Gastroenterology, Hôpital Erasme, Brussels, Belgium, 2Department of Gastroenterology, Imelda General Hospital, Bonheiden, Belgium, 3Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium, 4Department of Gastroenterology, CHU UCL Namur, Yvoir, Belgium, 5Department of Gastroenterology, Centre Hospitalier Universitaire Sart-Tilman, Liège, Belgium, 6Department of Gastroenterology, AZ Delta, Roeselare, Belgium, 7Department of Gastroenterology, AZ Maria Middelares, Gent, Belgium, 8Department of Gastroenterology, UZ Antwerp, Antwerp, Belgium, 9Department of Gastroenterology, AZ Damian, Oostende, Belgium, 10Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium

P363 Moderate endurance and muscle training are safe to perform for patients with quiescent or mild active Crohn’s disease and increases their strength

ECCO'20 Vienna

Year: 2020
Authors:

W.A. Seeger1,2, J. Thieringer1, P. Esters1, B. Allmendinger1, H. Schulze1, A. Dignass1

1Department of Medicine I, Agaplesion Markus Hospital, Goethe-University, Frankfurt, Germany, 2Department of Gastroenterology, Infectious Diseases, Rheumatology, Charité -Universitätsmedizin, Berlin, Germany

P364 New insights into the molecular mechanisms of thalidomide in paediatric inflammatory bowel disease patients

ECCO'20 Vienna

Year: 2020
Authors:

M. Lucafò1, M. Bramuzzo2, L. Pugnetti3, M. Gerdol4, S. Greco4, M. Paci5, D. Curci6, M. Nonnis4, S. Renzo5, P. Lionetti5, A. Tommasini1, G. Decorti7, G. Stocco4

1Institute for Maternal Health - IRCCS ‘Burlo Garofolo’, Advanced in Translational Diagnostics Laboratory, Trieste, Italy, 2Institute for Maternal Health - IRCCS ‘Burlo Garofolo’, Gastroenterology- Digestive Endoscopy and Clinical Nutrition Unit, Trieste, Italy, 3Department of Medical-Surgical and Health Sciences, PhD School in Science of Reproduction and Development- University of Trieste- Trieste- Italy, Trieste, Italy, 4Department of Life Sciences, University of Trieste - Trieste - Italy, Trieste, Italy, 5Gastroenterology Unit, Anna Meyer Children’s Hospital -Florence- Italy, Florence, Italy, 6Department of Medical-Surgical and Health Sciences, PhD School in Science of Reproduction and Development, University of Trieste - Trieste - Italy, Trieste, Italy, 7Department of Medical-Surgical and Health Sciences, University of Trieste - Trieste - Italy, Trieste, Italy

P365 Identification of predictive factors of AZA/6-MP treatment outcome in paediatric luminal Crohn’s disease: a multicentre study of the paediatric IBD Porto group of ESPGHAN

ECCO'20 Vienna

Year: 2020
Authors:

T. LERCHOVA1, O. Hradsky1, M. Kulich2, G. Veres3, J.A. Dias4, M. Sladek5, S. Kolacek6, S. Van Biervliet7, J. Melek8, D. Serban9, K. Winther10, T. de Meij11, J. Schwarz12, K.L. Kolho13, J.C. Escher14, J. Bronsky1

1Department of Paediatrics, 2nd Faculty of Medicine- Charles University and Motol University Hospital, Prague, Czech Republic, 2Department of Probability and Mathematical Statistics, School of Mathematics- Charles University, Prague, Czech Republic, 3Pediatric Institute-Clinic, University of Debrecen, Debrecen, Hungary, 4Department of Paediatrics, Hospital de Sao Joao, Porto, Portugal, 5Department of Pediatrics- Gastroenterology and Nutrition, Polish-American Children’s Hospital- Jagiellonian University Medical College, Cracow, Poland, 6Department of Paediatrics, Children’s Hospital Zagreb Faculty of Medicine, Zagreb, Croatia, 7Department of Pediatrics and Medical Genetics, Ghent University- Ghent University Hospital, Ghent, Belgium, 8Department of Paediatrics, Charles University Teaching Hospital, Hradec Kralove, Czech Republic, 9Department of Gastroenterology, 2nd Clinic of Pediatrics- ‘Iuliu Hatieganu’ University of Medicine and Pharmacy- Emergency Clinical Hospital for Children, Cluj-Napoca, Romania, 10Department of Paediatrics, Hvidovre Hospital, Copenhagen, Denmark, 11Department of Paediatrics, Amsterdam UMC- Location VUMC, Amsterdam, The Netherlands, 12Department of Paediatrics, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic, 13Department of Gastroenterology, Children’s Hospital and University of Helsinki, Helsinki, Finland, 14Department of Gastroenterology, Erasmus MC−Sophia Children’s Hospital, Rotterdam, The Netherlands

P366 CRP levels and PMS as early predictors of clinical and endoscopic outcomes in adult patients with moderately-to-severely active UC treated with tofacitinib: a post hoc analysis of OCTAVE Induction 1 and 2

ECCO'20 Vienna

Year: 2020
Authors:

M.C. Dubinsky1, D.P. Hudesman2, F. Steinwurz3, N. Kulisek4, L. Salese4, J. Paulissen5, C. Su4, D. Ponce de Leon6, F. Magro7

1Icahn School of Medicine at Mount Sinai, New York, New York, USA, 2New York University, New York, New York, USA, 3Unit of Inflammatory Bowel Disease, Hospital Israelita Albert Einstein, São Paulo, Brazil, 4Pfizer Inc., Collegeville, Pennsylvania, USA, 5Syneos Health, Morrisville, North Carolina, USA, 6Pfizer Inc., Lima, Peru, Peru, 7University of Porto and Centro Hospitalar São João, Porto, Portugal, Portugal

P367 Real-life long-term effectiveness and treatment persistence of vedolizumab in a single tertiary care cohort of Crohn’s disease patients

ECCO'20 Vienna

Year: 2020
Authors:

L. Calandrini, M. Salice, H. Privitera Hrustemovic, G. Peruzzi, F. Rizzello, C. Calabrese, E. Scaioli, A. Belluzzi, P. Gionchetti

Policlinico Sant’Orsola Malpighi, Malattie Infiammatorie Croniche Prof. Gionchetti, Bologna, Italy

P368 Tofacitinib induction efficiency and intracellular cytokine dynamics in ulcerative colitis: Results from clinical practice

ECCO'20 Vienna

Year: 2020
Authors:

M. Kolar1, M. Lukas1, K. Malickova1,2, L. Prochazkova1, M. Bortlik1,3,4, D. Duricova1, V. Hruba1, N. Machkova1, K. Mitrova1, M. Vasatko1, M. Lukas1,2

1ISCARE I.V.F. a.s., IBD Clinical and Research Centre, Prague, Czech Republic, 2Institute of Medical Biochemistry and Laboratory Medicine, General University Hospital and First Faculty of Medicine-Charles University, Prague, Czech Republic, 3Institute of Pharmacology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 4Department of Internal Medicine, First Faculty of Medicine, Charles University and Military University Hospital, Prague, Czech Republic

P369 Mycobacterium tuberculosis infection among patients with inflammatory bowel disease under biologics: experience of Croatian Tertiary Centre

ECCO'20 Vienna

Year: 2020
Authors:

D. Ogresta, A. Bišćanin, V. Tomašić, Z. Dorosulić, D. Kralj, J. Forgač, P. Ćaćić, I. Lerotić, D. Hrabar

Department of Gastroenterology and Hepatology, University Hospital Center Sestre milosrdnice, Zagreb, Croatia

P370 Endoscopic balloon dilatation in paediatric stricturing Crohn’s disease: A retrospective collaborative study of the paediatric IBD Porto group of ESPGHAN

ECCO'20 Vienna

Year: 2020
Authors:

O. Ledder1, J. Viala2, D. Urlep3, D. Serban4, L. De Ridder5, M. Martinelli6, C. Romano7, S. Oliva8, S. Sharma9, M. Thomson9, D. Turner1, Paediatric IBD Porto Group of ESPGHAN

1Department of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel, 2Department of paediatric gastroenterology, Hôpitaux de Paris, Paris, France, 3Department of Paediatric Gastroenterology, Ljubljana University Medical Centre, Ljubljana, Slovenia, 4Emergency Clinical Hospital for Children, 2nd Clinic of Pediatrics, Cluj-Napoca, Romania, 5Department of Paediatric Gastroenterology, Erasmus MC/Sophia Children′s Hospital, Rotterdam, The Netherlands, 6Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy, 7Department of Paediatric Gastroenterology, University of Messina, Messina, Italy, 8Department of Paediatric Gastroenterology, Sapienza University of Rome, Rome, Italy, 9Department of Paediatric Gastroenterology, Sheffield Children’s Hospital, Sheffield, UK

P371 Self-medication with analgesics in ulcerative colitis: Results of a patient survey

ECCO'20 Vienna

Year: 2020
Authors:

I. Rodríguez-Lago1, F. Mesonero Gismeno2, M. Cañas3, C. Savini4, R. Saldaña4, L. Feo-Lucas5, S. Fernandez5, L. Cea-Calvo5, B. Juliá5

1Gastroenterology Department- IBD Unit, Hospital de Galdakao, Galdakao, Spain, 2Gastroenterology Department- IBD Unit, Hospital Ramón y Cajal, Madrid, Spain, 3Gastroenterology Department, Hospital Clínico San Carlos, Madrid, Spain, 4Spanish Confederation of Associations Of Patients with Crohn’s Disease and Ulcerative Colitis ACCU, ACCU, Madrid, Spain, 5Medical Affairs Department, Merck Sharp and Dohme of Spain, Madrid, Spain

P372 Effects of filgotinib on anaemia, thrombocytopenia and leukopenia: Phase 3 study results in patients with active rheumatoid arthritis and prior inadequate response/intolerance to biological DMARDs

ECCO'20 Vienna

Year: 2020
Authors:

R. Besuyen1, M. Genovese2, K. de Vlam3, J.E. Gottenberg4, K. Kalunian5, B. Bartok6, Y. Tan7, Y. Guo8, C. Tasset1, J. Sundy9, D. Walker10, T. Takeuchi11

1Galapagos NV, Clinical Development, Mechelen, Belgium, 2Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA, USA, 3Department of Rheumatology, Universitair Ziekenhuis Leuven, Leuven, Belgium, 4Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 5Division of Rheumatology- Allergy and Immunology, University of California, San Diego, CA, USA, 6Medical Affairs, Gilead Sciences Inc., Foster City, CA, USA, 7Clinical Development, Gilead Sciences Inc., Foster City, CA, USA, 8Biostatistics, Gilead Sciences Inc., Foster City, CA, USA, 9Clinical Research, Gilead Sciences Inc., Foster City, CA, USA, 10Department of Rheumatology, Northumbria Healthcare, Northumbria, UK, 11Division of Rheumatology and Clinical Immunology, Keio University School of Medicine, Tokyo, Japan

P373 Telemedicine and inflammatory bowel disease: Results of the IBD assistant pilot project

ECCO'20 Vienna

Year: 2020
Authors:

K. Malickova1,2, V. Pesinova1, M. Bortlik1,3,4, D. Duricova1,3, N. Machkova1, V. Hruba1, M. Lukas1,5, K. Mitrova1,6, M. Vasatko1, M. Kostrejova1,7, M. Kolar1,5, M. Lukas1,2

1Clinical and Research Center for Inflammatory Bowel Disease, ISCARE a.s. and Charles University, Prague 7, Czech Republic, 2Institute of Medical Biochemistry and Lab Diagnostics, General University Hospital and 1st Faculty of Medicine, Prague, Czech Republic, 3Institute of Pharmacology, First Faculty of Medicine of Charles University, Prague, Czech Republic, 4Department of Internal Medicine, Military University Hospital and 1st Faculty of Medicine of Charles University, Prague, Czech Republic, 5Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Libechov, Czech Republic, 6Department of Pediatry, University Hospital Motol and 2nd Faculty of Medicine of Charles University, Prague, Czech Republic, 7Department of Internal Medicine, Hospital of the Sisters of Mercy of St. Borromeo, Prague, Czech Republic

P374 Disease course and fate of Crohn’s perianal fistula patients following failure of initial biologic therapy: real-world lessons on the impact of refractory disease from a tertiary centre cohort

ECCO'20 Vienna

Year: 2020
Authors:

S. Adegbola, W.Y. Mak, K. Sahnan, S. Hiles, P. Bassett, P. Lung, J. Warusavitarne, O. Faiz, R. Phillips, P. Tozer, A. Hart

Department of Colorectal Surgery, St. Mark’s Hospital, Harrow, UK

P375 Feasibility of the first paediatric randomised controlled pilot trial of faecal microbiota transplant for ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

N. PAI2, J. Popov3, E. Hartung1, L. Hill4, K. Grzywacz5, D. Godin5, L. Thabane6, C. Lee7, M. Surette2,8,9, P. Moayyedi2,8

1McMaster Paediatric FMT Research Program, 1Division of Gastroenterology and Nutrition, Department of Paediatrics- McMaster University, Hamilton, Canada, 2Farncombe Family Digestive Health Research Institute, Department of Medicine- McMaster University, Hamilton, Canada, 3College of Medicine and Health, University College Cork, Cork, Ireland, 4Department of Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa, 5Division de Gastroentérologie- Hépatologie et Nutrition, Département de Pédiatrie- Université de Montréal, Montreal, Canada, 6Department of Health Research Methods- Evidence and Impact, McMaster University, Hamilton, Canada, 7Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada, 8Division of Gastroenterology and Hepatology, Department of Medicine- McMaster University, Hamilton, Canada, 9Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada

P376 Real life health care utilisation in paediatric patients with inflammatory bowel disease in the era of biologics

ECCO'20 Vienna

Year: 2020
Authors:

S.A. Tchogna, X.Y. Yang, C. Deslandres, P. Jantchou

Department of Pediatric Gastroenterology, The Sainte-Justine University Hospital Centre, Montréal, Canada

P377 Risk factors of rectal amputation for Crohn’s disease with perianal lesion

ECCO'20 Vienna

Year: 2020
Authors:

T. Yokoo, S. Yoshikawa, T. Masuda, H. Uchida, T. Nakao, H. Kashizuka, K. Yamaoka, M. Inagaki, K. Okamoto, N. Inatsugi

Kenseikai Dongo Hospital, Nara Coloproctology Center, Yamatotakada City, Japan

P378 Mucosal healing is achieved in most of the inflammatory bowel disease patients in clinical remission with vedolizumab: a real-life single-centre experience

ECCO'20 Vienna

Year: 2020
Authors:

M.I. Calvo Moya1, I. Omella Usieto1, M.I. Vera Mendoza1, V. Matallana Royo1, I. Gonzalez Partida1, M. Manso Manrique2, B. Menchén Viso2, R. De Lucas Téllez de Meneses1, M. González Rodriguez1, P. Bella del Castillo1, Y. González Lama1

1Gastroenterology and Hepatology Department, IBD Unit, Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda Madrid, Spain, 2Pharmacy Department, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain

P379 Surveillance with chromoendoscopy to detect new dysplasia in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

C. Villar Lucas, R. Quiñones Castro, L. Vaquero Ayala, P. Suárez Álvarez, M.J. Fernández Gundin, M. Sierra Ausín

Gastroenterology, Hospital de León, León, Spain

P380 What is the optimal dose of thiopurinic drugs (azatioprine) in patients with inflammatory bowel disease under treatment combined with anti-TNFα (infliximab/adalimumab)?

ECCO'20 Vienna

Year: 2020
Authors:

J. LUCAS RAMOS, C. Suarez Ferrer, M. Sanchez Azofra, J. Poza Cordón, E. Martín Arranz, M.D. Martin Arranz

Gastroenterology, Hospital Universitario La Paz, Madrid, Spain

P381 Use of ustekinumab in Crohn’s disease: Singapore largest single-centre experience

ECCO'20 Vienna

Year: 2020
Authors:

H.H. Shim1, S.C. Kong1, W.C. Ong2, T.G. Lim2, P.W. Chan1

1Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore, 2Singapore General Hospital, Pharmacy, Singapore, Singapore