P077: Different granulocyte subsets are involved in the pathogenesis in Crohn’s disease fistulaECCO'22Year: 2022
Authors: Beckerdrs., M.(1);Koelink, P.(1);de Krijger, M.(1);Bemelman, W.(2);de Jonge, W.(1);Buskens, C.(2);Wildenberg, M.(1);
(1)Tytgat Institute for Liver and Intestinal Research, Gastroenterology, Amsterdam, The Netherlands;(2)Amsterdam UMC, Surgery, Amsterdam, The Netherlands;DigeST
P078: Vedolizumab Treatment of ex-vivo Human Ulcerative Colitis (UC) Explants Results in Altered Inflammatory Protein Secretion ProfilesECCO'22Year: 2022
Authors: Corcoran, R.(1);O'Connell, F.(2);O'Sullivan, J.(2);Kevans, D.(1);
(1)St James’s Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity Translational Medicine Institute- Trinity College Dublin, Department of Surgery- Trinity College Dublin- St James’s Hospital- Dublin 8- Ireland, Dublin, Ireland;
P081: Therapeutic Drug Monitoring of infliximab in Crohn’s Disease: Cut-off points during maintenance therapy.ECCO'22Year: 2022
Authors: Valdes, T.(1);Vilches Arenas, A.(2);Maldonado Perez, B.(1);Castro Laria, L.(1);Merino Bohorquez, V.(3);Argüelles Arias, F.(1);
(1)University Hospital Virgen Macarena, Gastroenterology Department, Sevilla, Spain;(2)University Hospital Virgen Macarena, Preventive Medicine, Sevilla, Spain;(3)University Hospital Virgen Macarena, Pharmacy Department, Sevilla, Spain;
P082: The profibrogenic role of neutrophil extracellular traps in stenotic Crohn's disease: a new antifibrotic target?ECCO'22Year: 2022
Authors: Dragoni, G.(1,2);Ke, B.J.(3);Verstockt, B.(3,4);Abdurahiman, S.(3);Innocenti, T.(1,2);Giudici, F.(5);De Hertogh, G.(6);Milla, M.(1);Bagnoli, S.(1);Picariello, L.(2);Galli, A.(1,2);Matteoli, G.(3);Vermeire, S.(3,4);
(1)Careggi University Hospital, Department of Gastroenterology, Firenze, Italy;(2)University of Florence, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, Firenze, Italy;(3)KU Leuven, Department of Chronic Diseases- Metabolism and Ageing CHROMETA, Leuven, Belgium;(4)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(5)University of Florence, Department of Clinical and Experimental Medicine- Surgical Unit, Firenze, Italy;(6)KU Leuven, Department of Imaging and Pathology- Translational Cell & Tissue Research, Leuven, Belgium;
P083: An integrative analysis of DNA methylation and RNA-Seq data in human adipose-stem cells of Crohn’s Disease patients with different clinical activityECCO'22Year: 2022
Authors: Serena, C.(1);Montfort-Ferré, D.(1);Caro, A.(2);Menacho, M.(3);Espina, B.(2);Boronat-Toscano, A.(1);Martí, M.(4);Espín, E.(4);Millán, M.(5);Vendrell, J.(1);Fernández-Veledo, S.(1);
(1)Health Institute Pere Virgili IISPV, Hospital Joan XXIII of Tarragona, Tarragona, Spain;(2)Hospital Universitari Joan XXIII of Tarragona, Surgery Service, Tarragona, Spain;(3)Hospital Universitari Joan XXIII of Tarragona, Gastroenterology Service, Tarragona, Spain;(4)Hospital Univeristari Vall Hebrón, Surgery Service, Barcelona, Spain;(5)Hospital La Fe, Surgery Service, Valencia, Spain;
P084: Secreted inflammatory protein profiles following treatment of ex-vivo human Ulcerative Colitis and Crohn’s Disease explants with licenced biologic therapiesECCO'22Year: 2022
Authors: Corcoran, R.(1);O'Connell, F.(2);O'Sullivan, J.(2);Kevans, D.(1);
(1)St James’s Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity Translational Medicine Institute- Trinity College Dublin- Ireland, Department of Surgery, Dublin, Ireland;
P085: Paneth cells translate dietary lipid exposure into gut inflammationECCO'22Year: 2022
Authors: Grabherr, F.(1);Meyer, M.(1);Schmitz, J.J.(1);Schwärzler, J.(1);Mayr, L.(1);Philipp, M.(1);Jukic, A.(1);Grander, C.(1);Tilg, H.(1);Adolph, T.E.(1);
(1)Medizinische Universität Innsbruck, Innere Medizin 1 - Gastroenterologie- Hepatologie und Endokrinologie, Innsbruck, Austria;
P086: Mucosal microbiota modulate host intestinal immune signatures in Inflammatory Bowel DiseaseECCO'22Year: 2022
Authors: Hu, S.(1,2);Bourgonje, A.R.(1);Gacesa, R.(1,2);Jansen, B.H.(1);Bangma, A.(1);Hidding, I.(1,2);Festen, E.A.M.(1);van Dullemen, H.M.(1);Visschedijk, M.C.(1);Dijkstra, G.(1);Harmsen, H.J.M.(3);Vich Vila, A.(1,2);Spekhorst, L.M.(1,4);Weersma, R.K.(1);
(1)University of Groningen- University Medical Center Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(2)University of Groningen- University Medical Center Groningen, Genetics, Groningen, The Netherlands;(3)University of Groningen- University Medical Center Groningen, Medical Microbiology, Groningen, The Netherlands;(4)Medisch Spectrum Twente, Gastroenterology and Hepatology, Enschede, The Netherlands;
P087: Communicating Needs and Features of IBD Experiences (CONFIDE) Survey: Impact of Ulcerative Colitis Symptoms on Daily LifeECCO'22Year: 2022
Authors: Dubinsky, M.C.(1);Schreiber, S.(2);Potts Bleakman, A.(3);Kayhan, C.(3);Ellis, H.(4);Hunter Gibble, T.(3);Flynn, E.(3);Suldecki, G.(4);Travis, S.(5);
(1)Icahn School of Medicine, Mount Sinai, New York, United States;(2)University Hospital Schleswig-Holstein, Department of Internal Medicine, Kiel, Germany;(3)Eli Lilly and Company, Eli Lilly and Company, Indianapolis, United States;(4)Adelphi Real World, Bespoke, Bollington, United Kingdom;(5)University of Oxford, Gastroenterology, Oxford, United Kingdom;
P088: Metabolomic analysis reveals differences among UC and non-IBD human colonic resections: role of GPCRsECCO'22Year: 2022
Authors: Bauset, C.(1);Carda-Diéguez, M.(2);Buetas, E.(2);Coll, S.(1);Lis-López, L.(1);Seco-Cervera, M.(3);Navarro, F.(4);Mira, Á.(2);Calatayud, S.(1);Barrachina, M.D.(1);Cosín-Roger, J.(3);
(1)Universidad de Valencia, Pharmacology, Valencia, Spain;(2)FISABIO, Genomics and Health Department, Valencia, Spain;(3)FISABIO, Unidad Mixta Facultad de Medicina-Hospital Dr. Peset, Valencia, Spain;(4)Hospital de Manises, Colorectal surgery, Valencia, Spain;
P089: Long ncRNA Landscape in the Rectum of Treatment Naïve Early Onset Ulcerative Colitis Highlights Association with Severity and Early and Late Disease Outcome, with Potential Role in Epithelial Metabolic FunctionsECCO'22Year: 2022
Authors: Haberman Ziv, Y.(1);Braun, T.(1);Sosnovski , K.(1);Amir , A.(1);VanDussen , K.(2);Igor Ulitsky , I.U.(3);Griffiths , A.(4);Walters , T.(4);Mack , D.(5);Boyle, B.(6);Kugathasan, S.(7);Jegga, A.(8);Hyams , J.(9);Denson, L.(2);
(1)Tel-HaShomer Sheba Medical Center, Department of Pediatric Gastroenterology, Ramat Gan, Israel;(2)Cincinnati Children's Hospital Medical Center, Gastroenterology, Cincinnati, United States;(3)Weizmann Institute of Science, Biology, Rehovot, Israel;(4)Hospital For Sick Children, Pediatrics, Toronto, Canada;(5)Children's Hospital of East Ontario, Pediatrics, Ottawa, Canada;(6)Nationwide Children's Hospital, Pediatrics, Colombus, United States;(7)Emory University, Pediatirics, Atlanata, United States;(8)Cincinnati Children's Hospital Medical Center, Pediatirics, Cincinnati, United States;(9)Connecticut Children’s Medical Center, Pediatrics, Hartford, United States;PROTECT cohort
P090: Unraveling the rewiring of cytokine signalling in Inflammatory Bowel Disease using a novel network biology approachECCO'22Year: 2022
Authors: Olbei, M.(1,2);Thomas, J.(1,2,3);Hautefort, I.(1);Treveil, A.(1,2);Bohar, B.(1,4);Madgwick, M.(1,2);Gul, L.(1);Csabai, L.(1,4);Modos, D.(1,2);Korcsmaros, T.(1,2,5);
(1)Earlham Institute, Organisms and Ecosystems, Norwich, United Kingdom;(2)Quadram Institute BioScience, Gut Microbes and Health, Norwich, United Kingdom;(3)Norfolk and Norwich University Hospital, Department of Gastroenterology, Norwich, United Kingdom;(4)Eotvos Lorand University, Department of Genetics, Budapest, Hungary;(5)Imperial College London, Faculty of Medicine- Department of Metabolism- Digestion and Reproduction, London, United Kingdom;
P091: A single-cell RNAseq approach to understand and predict the efficacy of tofacitinib in Ulcerative ColitisECCO'22Year: 2022
Authors: Melon, E.(1);Corraliza, A.M.(1);Garrido, A.(1);Veny, M.(1);Masamunt, M.C.(1);Giner, A.(1);Ordás, I.(1);Fernández, A.(1);Ricart, E.(1);Panés, J.(1);Salas, A.(1);
(1)Institut d'Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Hospital Clinic of Barcelona - Inflammatory Bowel Disease Unit, Barcelona, Spain;
P092: Humoral and T cell responses to COVID-19 vaccination in IBDECCO'22Year: 2022
Authors: Zhang, E.(1);Bond, K.(2);Nguyen, O.(3);Allen, L.(3);Kedzierski , L.(3);Kedzierka, K.(3);Christensen, B.(1);
(1)Royal Melbourne Hospital, Gastroenterology, Melbourne, Australia;(2)Royal Melbourne Hospital, Microbiology, Victoria, Australia;(3)University of Melbourne, Microbiology and Immunology, Victoria, Australia;
P093: Probiotic strains Lactobacillus plantarum and Saccharomyces boulardii influence the fibrotic responses of human intestinal subepithelial myofibroblasts.ECCO'22Year: 2022
Authors: Tarapatzi, G.(1);Filidou, E.(1);Kandilogiannakis, L.(1);Spathakis, M.(1);Arvanitidis, K.(1);Kotzampassi , K.(2);Kolios, G.(1);Vradelis, S.(3);
(1)Laboratory of Pharmacology- Faculty of Medicine, Democritus University of Thrace- Alexandroupolis, Alexandroupolis, Greece;(2)Department of Surgery, Aristotle University of Thessaloniki- AHEPA Hospital, Thessaloniki, Greece;(3)University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece;
P094: Transcriptomic and small RNA sequencing profile in ileal resections from complicated Crohn´s Disease patientsECCO'22Year: 2022
Authors: Seco-Cervera, M.(1);Bauset, C.(2);Santana-Plata, C.(2);Civera-Barrachina, M.(2);Ortiz-Masià, D.(2);Calatayud, S.(2);Barrachina, M.D.(2);
(1)Hospital Dr Peset- FISABIO, Pharmacology, Valencia, Spain;(2)Faculty of Medicine - University of Valencia, Pharmacology, Valencia, Spain;
P095: Anti-inflammatory effect of high acetate concentration on organoid-derived epithelial monolayer from patients with Ulcerative ColitisECCO'22Year: 2022
Authors: Deleu, S.(1);Arnauts, K.(1,2);Machiels, K.(1);Huys, G.R.B.(3,4);Thevelein, J.(5,6);Raes, J.(3,4);Vermeire, S.(1,7);
(1)KU Leuven, Chrometa Targid, Leuven, Belgium;(2)KU Leuven, Development and Regeneration- Stem Cell Institute Leuven, Leuven, Belgium;(3)KU Leuven, Microbiology and Immunology- Rega Institute, Leuven, Belgium;(4)VIB, Center for Microbiology, Leuven, Belgium;(5)Erasmus High School, NovelYeast bv- Open Bio-Incubator, Brussels, Belgium;(6)KU Leuven, Molecular Cell Biology- Institute of Botany and Microbiology, Leuven, Belgium;(7)University Hospitals Leuven- KU Leuven, Gastroenterology and Hepatology, Leuven, Belgium;MIMOSA
P096: Store-Operated Calcium Entry Controls Innate and Adaptive Immune Cell Function in Inflammatory Bowel DiseaseECCO'22Year: 2022
Authors: Letizia, M.(1);Kaufmann, U.(2);Wang, Y.H.(2);Gerbeth, L.(1);Sand, A.(1);Brunkhorst, M.(1);Böttcher, C.(3);Schlickeiser, S.(4);Fernández-Zapata, C.(3);Kunkel, D.(4);Siegmund, B.(1);Feske, S.(2);Weidinger, C.(1);
(1)Charité Universitätsmedizin Berlin, Medical Department- Division of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)New York University Grossman School of Medicine, Department of Pathology, New York, United States;(3)Charité and MDC, Experimental and Clinical Research Center, Berlin, Germany;(4)Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Flow & Mass Cytometry Core Facility, Berlin, Germany;IBDome researchers TRR 241 Research Initiative
