P057: Mucosal microbiota adapts to ATF6-induced alterations in host lipid metabolism with prognostic value in colorectal cancerECCO'22Year: 2022
Authors: Bierwirth, S.(1);Sorbie, A.(1);Coleman, O.(1);Reuß , E.(1);Weber, P.(2);Köhler, N.(3);Kacprowski, T.(3);Dunkel, A.(4);Pauling, J.(3);Ecker, J.(5);Baumbach, J.(3);Rosenstiel, P.(6);Steiger, K.(7);Wirbel, J.(8);Zeller, G.(8);Janssen, K.P.(9);Haller, D.(1,10);
(1)Technical University of Munich, Chair of Nutrition and Immunology, Freising-Weihenstephan, Germany;(2)University of Southern Denmark, Department of Mathematics and Computer Science IMADA, Odense, Denmark;(3)Technical University of Munich, Chair of Experimental Bioinformatics, Freising-Weihenstephan, Germany;(4)Technical University of Munich, Chair of Food Chemistry and Molecular Sensory Science, Freising-Weihenstephan, Germany;(5)Technical University of Munich, Research Group Lipid Metabolism ZIEL, Freising-Weihenstephan, Germany;(6)University Hospital Schleswig-Holstein and Kiel University, Institute of Clinical Molecular Biology, Kiel, Germany;(7)Technical University of Munich, Institute of Pathology, Munich, Germany;(8)European Molecular Biology Laboratory, Structural and Computational Biology, Heidelberg, Germany;(9)Technical University of Munich, Department of Surgery Klinikum rechts der Isar, Munich, Germany;(10)Technical University of Munich, ZIEL Institute for Food and Health, Freising-Weihenstephan, Germany;
P058: IL-36 signaling in Crohn’s disease – characterization of a patient with an IL36RA mutationECCO'22Year: 2022
Authors: Hecker, J.(1);Letizia, M.(1);Loescher, B.S.(2);Franke, A.(2);Weidinger, C.(1);Siegmund, B.(1);
(1)Charité- Universitätsmedizin Berlin, Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany;
P059: Diet controls segmented filamentous bacteria in driving Crohn’s disease-like inflammation in TNFdeltaARE miceECCO'22Year: 2022
Authors: Metwaly, A.(1);Calasan, J.(1);Waldschmitt, N.(1);Khaloian, S.(1);Häcker, D.(1);Ahmed, M.(1);F. Butto, L.(1); Hammoudi, N.(2); Le Bourhis, L.(2);Mayorgas, A.(3);Siebert, K.(4);Basic, M.(5);Zeissig, S.(6);Schwerd, T.(4);Allez, M.(2);Panes, J.(3);Salas, A.(3); Bleich, A.(5);Cominelli, F.(7);Haller, D.(1);
(1)Technical University Munich, Chair of Nutrition and Immunology, Freising, Germany;(2)APHP- Hôpital Saint Louis-INSERM UMRS 1160- Sorbonne Paris-Cité University, Department of Gastroenterology, Paris, France;(3)Instituto de Investigaciones Biomédicas de Barcelona CSIC- IDIBAPS- CIBERehd, Department of Experimental Pathology, Barcelona, Spain;(4)Dr. von Hauner Children's Hospital- University Hospital- LMU Munich, Department of Pediatrics, Munich, Germany;(5)Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany;(6)University Hospital Dresden- Technische Universität TU Dresden, Department of Medicine, Dresden, Germany;(7)Case Western Reserve University School of Medicine, Digestive Health Research Institute, Clevelad, United States;
P061: Circulating inflammatory protein and cellular profiles at time of diagnosis classify inflammatory bowel disease patients according to their underlying immune response and clinical disease courseECCO'22Year: 2022
Authors: Heredia, M.(1);Charrout, M.(2);Klomberg, R.C.W.(3);Aardoom, M.A.(3);Jongsma, M.M.E.(3);Kemos, P.(4);van Haaften, D.H.(1);Tuk, B.(1);van Berkel, L.A.(1);Bley Folly, B.(1);Mahfouz, A.(2,5);Reinders, M.J.T.(2);Ruemmele, F.(6);Croft, N.(4);Escher, J.C.(3);de Ridder, L.(3);Samsom, J.N.(1);
(1)Erasmus University Medical Center-Sophia Children’s Hospital, Laboratory of Pediatric Gastroenterology, Rotterdam, The Netherlands;(2)Delft University of Technology, Delft Bioinformatics Lab, Delft, The Netherlands;(3)Erasmus University Medical Center-Sophia Children’s Hospital, Pediatric Gastroenterology, Rotterdam, The Netherlands;(4)Blizard Institute- Queen Mary University of London, Centre for Immunobiology, London, United Kingdom;(5)Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands;(6)Hôpital Necker-Enfants Malades- Institut Imagine- AP-HP- Université de Paris, Pediatric Gastroenterology, Paris, France;
P062: 31P MRS and MRI phenotyping of muscle metabolic quality in IBD fatigueECCO'22Year: 2022
Authors: Mcging, J.(1,2);Nicholas, R.(2);Serres, S.(3);Greenhaff, P.(3,4,5);Francis, S.(2);Moran, G.W.(1,5);
(1)University of Nottingham, School of Medicine, Nottingham, United Kingdom;(2)University of Nottingham, Sir Peter Mansfield Imaging Centre, Nottingham, United Kingdom;(3)University of Nottingham, School of Life Sciences, Nottingham, United Kingdom;(4)University of Nottingham, MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Nottingham, United Kingdom;(5)National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, United Kingdom;
P065: Determination of the cytokine pattern of human colon organoids derived from Inflammatory Bowel Disease patientsECCO'22Year: 2022
Authors: Molnár, T.(1,2);Jójárt, B.(1,2,3);Resál , T.(1);Szántó, K.(1);Kata, D.(4);Földesi, I.(4);Molnár, T.(1);Maléth, J.(1,2,3,5);Farkas, K.(1);
(1)University of Szeged, First Department of Medicine, Szeged, Hungary;(2)Hungarian Academy of Science, University of Szeged Momentum Epithelial Cell Signaling and Secretion Research Group, Szeged, Hungary;(3)Hungarian Centre of Excellence of Molecular Medicine, University of Szeged Molecular Gastroenterology Research Group, Szeged, Hungary;(4)University of Szeged, Institute of Laboratory Medicine, Szeged, Hungary;(5)University of Szeged, Department of Public Health, Szeged, Hungary;
P066: Lower serum concentration of sulfated bile acids is associated with Primary Sclerosing Cholangitis Inflammatory Bowel Disease comorbidity and advanced liver fibrosisECCO'22Year: 2022
Authors: Leibovitzh, H.(1);Nayeri, S.(2);Borowski, K.(2);Hernandez-Rocha, C.(1);Lee, S.H.(1);Turpin, W.(1);Stempak, J.(2);Sandhu, I.(2);Milgrom, R.(2);Smith, M.I.(2);Croitoru, K.(1);Hirschfield, G.M.(3);Gulamhusein, A.(3);Silverberg, M.S.(1);
(1)Zane Cohen Centre for Digestive Diseases- Mount Sinai Hospital, Division of Gastroenterology & Hepatology- Temerty Faculty of Medicine- University of Toronto, Toronto, Canada;(2)Zane Cohen Centre for Digestive Diseases- Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute- Sinai Health System, Toronto, Canada;(3)University of Toronto, Toronto Centre for Liver Disease- Division of Gastroenterology and Hepatology, Toronto, Canada;
P067: Human intestinal CD103+SIRPα+ conventional dendritic cells from patients with Crohn´s disease prime IL-17+ T-cells.ECCO'22Year: 2022
Authors: Bernardo, D.(1,2);Arribas-Rodriguez, E.(1);De Castro, C.G.(1);Fiz-Lopez, A.(1);De Prado, A.(1,3);Fernandez-Salazar, L.(4);Barrio, J.(3);Izquierdo, S.(4);Garcia-Alonso, J.(3);De Andres, B.(5);Garcia-Abril, J.M.(6);Romero, A.(5);Sanchez-Gonzalez, J.(6);Garrote, J.A.(1);Arranz, E.(1);
(1)Universidad de Valladolid, Instituto de Biomedicina y Genética Molecular, Valladolid, Spain;(2)Centro de Investigaciones Biomédicas en Red, Enfermedades Hepáticas y Digestivas CIBERehd, Madrid, Spain;(3)Hospital Universitario Río Hortega. Valladolid, Servicio de Gastroenterología, Valladolid, Spain;(4)Hospital Clínico Universitario. Valladolid. Spain, Servicio de Gastroenterología, Valladolid, Spain;(5)Hospital Clinico Universitario. Valladolid, Servicio de Cirugía General y del Aparato Digestivo, Vallasolid, Spain;(6)Hospital Universitario Río Hortega. Valladolid, Servicio de Cirugía, Valladolid, Spain;
P068: Discovery of IBD3540: A Novel Gut-Restricted Glutamate Carboxypeptidase II Inhibitor with Preclinical Anti-Colitis ActivityECCO'22Year: 2022
Authors: Peters, D.(1);Norris, L.(2);Tenora, L.(3);Snajdr, I.(3);Zhu, X.(4);Sakamoto, S.(4);Veeravalli, V.(2);Thomas, A.(2);Majer, P.(3);Rais, R.(2);Slusher, B.(2);
(1)Johns Hopkins University School of Medicine, Pharmacology and Molecular Sciences, Baltimore, United States;(2)Johns Hopkins University School of Medicine, Johns Hopkins Drug Discovery, Baltimore, United States;(3)Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic;(4)Johns Hopkins University School of Medicine, Psychiatry, Baltimore, United States;
P069: Design and delivery of anti-oxidant inorganic complexes mimicking the superoxide dismutase for inflammatory bowel diseases treatment.ECCO'22Year: 2022
Authors: Schanne, G.(1);Zoumpoulaki, M.(2);Demignot, S.(3);Delsuc, N.(2);Policar, C.(2);Seksik, P.(3);
(1)Sorbonne University, Saint Antoine Research Center, Paris, France;(2)Ecole Normale Supérieure, Department of chemistry, Paris, France;(3)INSERM, Saint Antoine Research Center, Paris, France;
P070: Novel long-acting lipidated interleukin-22 normalises colonic inflammation in an acute DSS colitis modelECCO'22Year: 2022
Authors: Van De Bunt, M.(1);Norrild, J.C.(2);Sass-Ørum, K.(3);Kjølbye, A.L.(1);Jorgensen, R.(1);
(1)Cytoki Pharma, Research & Development, Copenhagen, Denmark;(2)Cytoki Pharma, CMC and Quality, Copenhagen, Denmark;(3)Novo Nordisk A/S, Global Research Technologies, Copenhagen, Denmark;
P071: Intestinal CD8+ T cell exhaustion is linked to disease activity in ulcerative colitisECCO'22Year: 2022
Authors: Grigorian, M.(1);Salié, H.(1);Mayer, L.S.(1);Globig, A.M.(1);Hockenjos, B.(1);Krimmel, L.(1);Thimme, R.(1);Bengsch, B.(1);Hasselblatt, P.(1);
(1)Freiburg University Hospital, Department of Medicine II, Freiburg, Germany;
P072: Melanocortin MC3 and MC5 receptors expression is different according to colonic disease activity in Crohn’s Disease and Ulcerative Colitis biopsies: results from an immunohistochemical observational study.ECCO'22Year: 2022
Authors: GravinaMD, A.G.(1);Panarese, I.(2);Trotta, M.C.(3);D'Amico, M.(3);Pellegrino, R.(1);Ferraraccio, F.(2);Galdiero, M.(3);Alfano, R.(4);Loguercio, C.(1);Romano, M.(1);Grieco, P.(5);Federico, A.(1);
(1)University of Campania @Luigi Vanvitelli@, Precision Medicine, Naples, Italy;(2)University of Campania @Luigi Vanvitelli@, Mental and Physical Health and Preventive Medicine, Naples, Italy;(3)University of Campania @Luigi Vanvitelli@, Experimental Medicine- Division of Pharmacology, Naples, Italy;(4)University of Campania @Luigi Vanvitelli@, Advanced Medical and Surgical Sciences DAMSS, Naples, Italy;(5)University of Naples @Federico II@, Pharmacy Department, Naples, Italy;
P073: Eosinophil depletion partially protects from colonic inflammation, but increases colonic collagen deposition in a DSS colitis modelECCO'22Year: 2022
Authors: Jacobs, I.(1);Deleu, S.(2);Cremer, J.(1,2);Guedelha Sabino, J.(2,3);Ferrante, M.(2,3);Vermeire, S.(2,3);Breynaert, C.(1,4);Verstockt, B.(2,3);Vanuytsel, T.(2,3);
(1)KU Leuven, Microbiology- Immunology and transplantation, Leuven, Belgium;(2)KU Leuven, Chronic diseases and metabolism, Leuven, Belgium;(3)University Hostpitals Leuven, Gastroenterology and Hepatology, Leuven, Belgium;(4)University Hostpitals Leuven, General Internal Medicine, Leuven, Belgium;
P074: SZN-1326 promotes colonic mucosal healing in an acute injury model of IBD by first accelerating epithelial regeneration and secondarily reducing inflammationECCO'22Year: 2022
Authors: Fletcher, R.(1);Xie, L.(2);Phipps, J.(1);Sanman, L.(1);Deshmukh, S.(1);Shah, D.(1);Hill, N.(1);Liu, A.(2);Gupta, S.(3);Sura, A.(3);Chen, H.(3);Ye, J.(3);Yeh, W.C.(2);Li, Y.(1);Lu, C.(1);
(1)Surrozen- Inc., Discovery Biology, South San Francisco, United States;(2)Surrozen- Inc., In Vivo Pharmacology, South San Francisco, United States;(3)Surrozen- Inc., Protein Sciences, South San Francisco, United States;
P075: Neutrophils prevent rectal bleeding in Ulcerative Colitis by peptidyl-arginine deiminase-4-dependent immunothrombosisECCO'22Year: 2022
Authors: Leppkes, M.(1);Lindemann, A.(1);Gößwein, S.(1);Paulus, S.(1);Roth, D.(1);Hartung, A.(1);Liebing, E.(1);Zundler, S.(1);Acera, M.G.(1);Patankar, J.V.(1);Mascia, F.(1);Scheibe, K.(1);Hoffmann, M.(2);Uderhardt, S.(2);Schauer, C.(2);Foersch, S.(3);Neufert, C.(1);Vieth, M.(4);Schett, G.(2);Atreya, R.(1);Kühl, A.A.(5);Bleich, A.(6);Becker, C.(1);Herrmann, M.(2);Neurath, M.F.(1);
(1)Universitätskliniken Erlangen, Medizin 1, Erlangen, Germany;(2)Universitätskliniken Erlangen, Medizin 3, Erlangen, Germany;(3)Universitätsmedizin Mainz, Institut für Pathologie, Mainz, Germany;(4)Friedrich-Alexander University of Erlangen-Nürnberg, Institute of Pathology- Klinikum Bayreuth, Erlangen, Germany;(5)Charité, Universitätsmedizin Berlin, Berlin, Germany;(6)Medizinische Hochschule Hannover, Institut für Versuchstierkunde, Hannover, Germany;
P076: Patients with Inflammatory Bowel Disease show IgG immune responses towards disease-associated small intestinal bacteriaECCO'22Year: 2022
Authors: Bourgonje, A.R.(1);Roo-Brand, G.(2);Lisotto, P.(2);Sadaghian Sadabad, M.(2);Reitsema, R.D.(3);de Goffau, M.C.(4);Faber, K.N.(1);Dijkstra, G.(1);Harmsen, H.J.M.(2);
(1)University of Groningen- University Medical Center Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(2)University of Groningen- University Medical Center Groningen, Medical Microbiology, Groningen, The Netherlands;(3)University of Groningen- University Medical Center Groningen, Rheumatology and Clinical Immunology, Groningen, The Netherlands;(4)Amsterdam University Medical Center- University of Amsterdam, Vascular Medicine, Amsterdam, The Netherlands;
