P037: MicroRNA-31 and microRNA-200 family reflect disease activity in Crohn’s disease: results from the BIOMIR studyECCO'22Year: 2022
Authors: Cristina, T.(1);Mateescu, B.(2);Mitroi, A.(3);Cozaru, G.(3);Brinzan, C.(3);State, M.(2);Dumitru, A.(1);Rafti, R.(1);Dina, E.(1);Alexandrescu, L.(1);Dumitru, E.(1);
(1)County Clinical Emergency Hospital of Constanta, Gastroenterology, Constanta, Romania;(2)Colentina Hospital Bucharest, Gastroenterology, Bucharest, Romania;(3)County Clinical Emergency Hospital of Constanta, Genetics, Constanta, Romania;
P038: Targeting the hepcidin-ferroportin axis with Nrf2 agonists to treat iron deficiency anaemia in Inflammatory Bowel DiseaseECCO'22Year: 2022
Authors: Martin, J.(1,2);Aksan, A.(1,2,3);Steinhilber, D.(2);Ulrich-Rückert, S.(1,2);Stein, J.M.(1,2,4);
(1)Interdisciplinary Crohn-Colitis Centre Rhein-Main, Clinical Research, Frankfurt am Main, Germany;(2)Goethe University Frankfurt, Institute of Pharmaceutical Chemistry, Frankfurt am Main, Germany;(3)Justus-Liebig University Giessen, Institute of Nutritional Science, Giessen, Germany;(4)DGD Clinics Sachsenhausen, Department of Gastroenterology and Clinical Nutrition, Frankfurt am Main, Germany;
P039: The role of α4β7+CLA+ ‘dual tropic’ T cells in inflammatory bowel diseaseECCO'22Year: 2022
Authors: Gordon, H.(1);Rodger, B.(2);Hornsby, E.(2);McGuire, J.(1);Kok, K.B.(1);Lindsay, J.O.(1);Stagg, A.J.(2);
(1)Royal London Hospital, Department of Gastroenterology- Barts Health NHS Trust, London, United Kingdom;(2)The Blizard Institute, Department of Immunobiology, London, United Kingdom;
P040: Reduced serological response to COVID-19 vaccines in patients with IBD is further diminished by TNF inhibitor therapy; Early results of the VARIATION study (VAriability in Response in IBD Against SARS-COV-2 ImmunisatiON)ECCO'22Year: 2022
Authors: Doherty, J.(1);Stack, R.(1);O' Morain, N.(1);Girod, P.(1);Tosetto, M.(1);Inzitari, R.(2);Sheridan, J.(1);Cullen, G.(1);Buckley, M.(3);Mulcahy, H.(1);Ryan, E.J.(4);Daghfal, D.(5);Doran, P.(2);O Morain, C.(6);Doherty, G.(1);
(1)Centre for Colorectal Disease- St Vincent's University Hospital, Gastroenterology, Dublin, Ireland;(2)School of Medicine- University College Dublin, School of Medicine- University College Dublin, Dublin, Ireland;(3)St Michaels Hospital- Dun Laoighre, Gastroenterology, Dublin, Ireland;(4)University of Limerick, Department of Biological Sciences- Health Research Institute, Limerick, Ireland;(5)Abbot Diagnostics, Lake Forest, Illinois, United States;(6)Beacon Hospital, Gastroenterology, Dublin, Ireland;INITIative IBD research network (www.initiativeibd.ie)
P041: Characterization of cytokine and drug concentrations in serum, mucosa and faeces during induction treatment of moderate-to-severe ulcerative colitis with anti-TNF monoclonal antibodiesECCO'22Year: 2022
Authors: Van Oostrom, J.(1);Hanzel, J.(1,2);Verstockt, B.(3,4);Singh, S.(5);Smith, J.(5);Stylli, J.(5);Vermeire, S.(3);D'Haens, G.(1);
(1)Amsterdam UMC- Meibergdreef 9- 1105 AZ Amsterdam- The Netherlands, Gastroenterology, Amsterdam, The Netherlands;(2)UMC Ljubljana- Japljeva ul. 2- 1000 Ljubljana- Slovenia, Gastroenterology, Lubljana, Slovenia;(3)University Hospitals Leuven- KU Leuven- Leuven- Belgium, Department of Gastroenterology and Hepatology, Leuven, Belgium;(4)KU Leuven- Leuven- Belgium, Department of Chronic Diseases and Metabolism-, Leuven, Belgium;(5)Progenity Inc, Progenity laboratories, San Diego, United States;
P042: Succinate promotes the conversion from white to beige adipose tissue in Crohn’s DiseaseECCO'22Year: 2022
Authors: Montfort-Ferré, D.(1);Menacho, M.(2);Caro, A.(3);Espina, B.(3);Boronat-Toscano, A.(1);Nuñez-Roa, C.(1);Martí, M.(4);Espin, E.(4);Vendrell, J.(1);Fernández-Veledo, S.(1);Serena, C.(1);
(1)Health Institute Pere Virgili IISPV, Hospital Joan XXIII of Tarragona, Tarragona, Spain;(2)Hospital Joan XXIII of tarragona, Gastroenterology Service, Tarragona, Spain;(3)Hospital Joan XXIII of Tarragona, Surgery Service, Tarragona, Spain;(4)Hospital Universitari Vall Hebron, Surgery Service, Barcelona, Spain;
P043: 3-oxo-C12:2, a Quorum Sensing molecule from the gut, exerts anti-inflammatory effects through a bitter taste receptorECCO'22Year: 2022
Authors: Coquant, G.(1);Aguanno, D.(2);Brot, L.(1);Belloir, C.(3);Briand, L.(3);Grill, J.P.(1);De Sordi, L.(1);Thenet, S.(4);Seksik, P.(1);
(1)Sorbonne Université, Medecine Faculty, Paris, France;(2)Technische Universität München, Lehrstuhl für Ernährung und Immunologie, Freising, Germany;(3)INRAE, Centre des Sciences du Goût et de l'Alimentation, Dijon, France;(4)PSL university, Ecole Pratique des Hautes Etudes, Paris, France;
P044: Enteric dopaminergic pathways in mouse and human intestinal inflammationECCO'22Year: 2022
Authors: Cerantola, S.(1);Faggin, S.(1);Caputi, V.(2);Cortese, V.(1);Bosi, A.(3);Banfi, D.(3);Rambaldo, A.(4);Porzionato, A.(4);Giaroni, C.(3);Savarino, E.V.(5);Giron, M.C.(1);
(1)University of Padova, Department of Pharmaceutical and Pharmacological Sciences, Padova, Italy;(2)University of Arkansas, Department of Poultry Science, Fayetteville, United States;(3)University of Insubria, Department of Clinical and Experimental Medicine, Varese, Italy;(4)University of Padova, Department of Neuroscience, Padova, Italy;(5)University of Padova, Department of Surgery- Oncology and Gastroenterology, Padova, Italy;
P045: TIGIT expression differentiates regulatory from inflammatory Th1* gut-homing effector CD4+ T cells in inflammatory bowel disease patientsECCO'22Year: 2022
Authors: Heredia, M.(1);Costes, L.M.M.(1);Tindemans, I.(1);Aardoom, M.A.(2);Klomberg, R.C.W.(2);Kemos, P.(3);Joosse, M.E.(1);van Haaften, D.H.(1);Tuk, B.(1);Ruemmele, F.(4);Croft, N.M.(3);Escher, J.C.(2);de Ridder, L.(2);Samsom, J.N.(1);
(1)Erasmus University Medical Center-Sophia Children’s Hospital, Laboratory of Pediatric Gastroenterology, Rotterdam, The Netherlands;(2)Erasmus University Medical Center-Sophia Children’s Hospital, Pediatric Gastroenterology, Rotterdam, The Netherlands;(3)Blizard Institute- Queen Mary University of London, Centre for Immunobiology, London, United Kingdom;(4)Hôpital Necker-Enfants Malades- Institut Imagine- AP-HP- Université de Paris, Pediatric Gastroenterology, Paris, France;
P046: Effects of CB2 and TRPV1 stimulation on osteoclast overactivity induced by iron in pediatric inflammatory bowel diseaseECCO'22Year: 2022
Authors: Strisciuglio, C.(1);Tortora, C.(1);Di Paola, A.(2);Creoli, M.(2);Cenni, S.(3);Argenziano, M.(1);Martinelli, M.(3);Miele, E.(3);Rossi, F.(1);
(1)Department of pediatrics- University of Campania @Vanvitelli@, Department of Woman- Child and General and Specialist Surgery, Naples, Italy;(2)University of Campania “Luigi Vanvitelli”, Department of Experimental Medicine, Naples, Italy;(3)University of Naples @Federico II@, Department of Translational Medical Science- Section of Pediatrics, Naples, Italy;
P047: Effect of infliximab and vedolizumab on M1 and M2 macrophages derived from THP-1 cells.ECCO'22Year: 2022
Authors: Notararigo, S.(1);Viñuela-Roldán, J.(1);Zurita-Gonzalez, M.J.(1);Dominguez Medina, E.(2);Dominguez-Munos, J.E.(1);Barreiro-de Acosta, M.(1);
(1)Fundacion IDIS, Digestive, Santiago de Compostela, Spain;(2)Fundacion IDIS, BioPharma, Santiago de Compostela, Spain;Fundación IDIS Complejo Hospitalario Santiago de Compostela A Coruña 15706 Spain
P048: Bridging the Gap Between Body and Soul: A Pilot Study Examining Inflammation and Depression / Anxiety in Inflammatory Bowel Disease PatientsECCO'22Year: 2022
Authors: Mekori - Domachevsky, E..(1);Avinir, A.(2);Dar, S.(3);Haj, O.(1);Ben - Horin, S.(1);Gothelf, D.(4);Kopylov, U.(1);Taler, M.(3);
(1)Sheba Medical Center, Gastroenterology Department, Ramat Gan, Israel;(2)Sheba Medical Center, Child and Adolescent Psychiatry Clinic, Ramat Gan, Israel;(3)Sheba Medical Center, Laboratory of Pediatric Molecular Psychiatry, Ramat Gan, Israel;(4)Sheba Medical Center, Child and Adolescent Psychiatry Division, Ramat Gan, Israel;
P049: The treatment effect of tonsil-derived mesenchymal stem cells (T-MSCs) via regulating programmed death-1/programmed death ligand-1 (PD-1/PD-L1) in ulcerative colitisECCO'22Year: 2022
Authors: Song, E.M.(1);Joo, Y.H.(1);Park, Y.(1);Choe, A.R.(1);Tae, C.H.(1);Moon, C.M.(1);Kim, S.E.(1);Jung, H.K.(1);Shim, K.N.(1);Jung, S.A.(1);
(1)EWHA Womans University- School of Medicine, Department of Internal Medicine- Department of Gastroenterology, Seoul, Korea- Republic Of;
P050: A comparison of the Gut Microbiota in Pregnant Women with and without Inflammatory Bowel Disease and Their Offspring in Hong Kong and United StatesECCO'22Year: 2022
Authors: Hu, J.(1);Agrawal, M.(2);Tarassishin, L.(1);Rendon, A.(1);Picker, M.(1);Kalash, O.(1);Eisele, C.(1);Ching, J.Y.(3);Wong, A.(3);Zhan, H.(3);Ng, S.C.(3);Colombel, J.F.(2);Peter, I.(1);
(1)Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York City, United States;(2)Icahn School of Medicine at Mount Sinai, The Henry D. Janowitz Division of Gastroenterology- Department of Medicine, New York City, United States;(3)The Chinese University of Hong Kong, Department of Medicine and Therapeutics- Microbiota I-Center MagIC, Hong Kong, China;
P051: IFNγ-macrophages could mediate EMT in Crohn’s disease through the WNT pathwayECCO'22Year: 2022
Authors: Edo, M.M.(1);Macias-Ceja, D.C.(2);Bauset, C.(2);Lis-Lopez, L.(2);Coll, S.(2);Seco-Cervera, M.(3);Cosin-Roger, J.(3);Calatayud, S.(2);Barrachina, M.D.(2);Ortiz-Masiá, D.(1);
(1)Universitat de Valencia, Medicine, Valencia, Spain;(2)Universitat de Valencia, Pharmacology, Valencia, Spain;(3)FISABIO, Pharmacology, Valencia, Spain;
P052: Comparing T cell responses to food antigens in Inflammatory Bowel Disease patients and healthy donorsECCO'22Year: 2022
Authors: Schiffer, A.(1);Tran, F.(4);Sievers, L.K.(2);Kümpers, J.(2);Hinrichsen, H.(3);Seegers, B.(3);Bergfeld, A.(2);Lessing, M.(2);Schreiber, S.(4);Bacher, P.(4);
(1)Christian-Albrechts-University, Institute of Immunology, Kiel, Germany;(2)UKSH Schleswig-Holstein, Department of Internal Medicine I, Kiel, Germany;(3)Gastroenterologisch-Hepatologisches Zentrum, Gastroenterology and Hepatology, Kiel, Germany;(4)Christian-Albrechts-University, Institute of Clinical Molecular Biology, Kiel, Germany;
P053: The intestinal complement system and its role in dysregulation of the intestinal B-cell compartment in Crohn’s Disease patientsECCO'22Year: 2022
Authors: Raschdorf, A.(1);Preisker, S.(1);Brethack, A.K.(1);Bokemeyer, A.(2);Bettenworth, D.(2,3);Sina, C.(1,4);Derer, S.(1);
(1)Institute of Nutritional Medicine-UKSH Lübeck, Molecular Gastroenterology, Lübeck, Germany;(2)Department of Medicine B-University Hospital Münster, Gastroenterology and Hepatology, Münster, Germany;(3)Practice of Internal Medicine Münster, IBD focus, Münster, Germany;(4)1st Department of Medicine-UKSH Lübeck, Section of Nutritional Medicine, Lübeck, Germany;
P054: LHFPL3-AS2 long non-coding (lncRNA) is reduced in mucosal biopsies of Crohn Disease, and its reduction in tissue culture disrupts epithelial polarityECCO'22Year: 2022
Authors: Sosnovski, K.(1);BenShoShan , M.(2);Braun , T.(3);Barshack , I.(4);Denson , L.(5);Haberman , Y.(6);
(1)Tel-Aviv University, Sackler, Tel-Aviv, Israel;(2)Tel-Aviv, Sackler, Tel-Aviv, Israel;(3)Sheba Medical Centre, Gastroenterology, Ramat-Gan, Israel;(4)Sheba Medical Center, Pathology, Ramat-Gan, Israel;(5)Cincinnati Children’s Hospital, Gastroenterology, Cincinnati, United States;(6)Sheba Medical Center, Gastroenterology, Ramat-Gan, Israel;
P056: Local nanocarrier delivery of JAK1 siRNA for IBD treatment: an in vivo mouse modelECCO'22Year: 2022
Authors: Garrido Trigo, A.(1);Veny, M.(1);Dotti, I.(1);Esteller, M.(1);Sulpice, E.(2);Jary, D.(3);Clément, F.(4);Gidrol, X.(2);Navarro, F.(3);Salas, A.(1);
(1)IDIBAPS, Inflammatory bowel disease group, Barcelona, Spain;(2)University of Grenoble Alpes- CEA- INSERM- IRIG-BGE, UGA/Biomics, Grenoble, France;(3)University of Grenoble Alpes- CEA- LETI, Microfluidic Systems and Bioengineering, Grenoble, France;(4)Institute for Advanced Biosciences, Inserm, La Tronche, France;
