P036: MicroRNA composition of colon crypt-top and crypt-bottom epithelial cells in Ulcerative ColitisECCO'21 VirtualYear: 2021
Authors: Inčiūraitė, R.(1);Juzėnas, S.(1,2);Ramonaitė, R.(1);Skiecevičienė, J.(1);
(1)Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania;(2)Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany
P037: Nonclinical pharmacokinetics and absorption, distribution, metabolism, and excretion properties of MORF-057 support its clinical development as an oral selective α4β7 integrin inhibitorECCO'21 VirtualYear: 2021
Authors: Jones, J.(1);Lee, D.(1);Smukste, I.(1);Cui, D.(1);Bursavich, M.G.(2);Troast, D.(2);Zhong, C.(2);Wong , J.E.(3);Mangada, M.M.(3);Bain, G.(3);Lippa, B.(2);Ray, A.S.(3);Rogers, B.N.(4);
(1)Morphic Therapeutic, Dmpk, Waltham, United States;(2)Morphic Therapeutic, Molecular Discovery, Waltham, United States;(3)Morphic Therapeutic, Biology and Translation, Waltham, United States;(4)Morphic Therapeutic, Research, Waltham, United States
P038: Microbial regulation of T-cell fate towards regulatory profiles during T-cell transfer induced colitisECCO'21 VirtualYear: 2021
Authors: Machicote, A.(1);Pelczar, P.(1);Nawrocki , M.(1);Fazio, A.(1);Liu , B.(1);Kopplin, L.(2);Wende, M.(3);Indenbirken, D.(4);Pabst, O.(2);Strowig, T.(3);Gagliani, N.(5);Huber, S.(1);
(1)Zentrum für Innere Medizin Universitätsklinikum Hamburg-Eppendorf, I. Medizinische Klinik und Poliklinik, Hamburg, Germany;(2)Institute of Molecular Medicine, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen, Germany;(3)Helmholtz Centre for Infection Research, Department of Microbial Immune Regulation, Braunschweig, Germany;(4)Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany;(5)Zentrum für Operative Medizin, Department of General- Visceral and Thoracic Surgery, Hamburg, Germany
P039: New molecular markers of the development of ulcerative colitisECCO'21 VirtualYear: 2021
Authors: Iakovlev, A.A.(1);Volkov, A.(2);Tarasova, G.(2);Zubova, A.(2);
(1)Rostov State Medical University, Department of Gastroenterology, Rostov-on-Don, Russian Federation;(2)Rostov State Medical University, Gastroenterology, Rostov-on-Don, Russian Federation
P040: USP16 regulates p65 activation in macrophages and promotes the inflammatory-carcinoma transformation process in IBD patientsECCO'21 VirtualYear: 2021
Authors: Zhang, Y.(1);Wang, C.(1);Yao, L.(1);Li, M.(1);Jin, J.(2);Cao, Q.(1);
(1)Sir Run Run Shaw Hospital，Zhejiang University School of Medicine, Department of Gastroenterology, Hangzhou, China;(2)MOE Laboratory, Biosystem Homeostasis and Protection- and Life Sciences Institute-, Hangzhou, China
P041: CDKN2B-AS1 (ANRIL) expression is decreased in Inflammatory Bowel Disease epithelia and in Celiac, and its reduction is linked with induced cells proliferationECCO'21 VirtualYear: 2021
Authors: Benshoshan, M.(1);Sosnovski, K.E.(1);Braun, T.(2);Amir, A.(2);Anikster, Y.(2);Haberman Ziv, Y.(2);
(1)Tel-Aviv University, Sackler Medical school, Tel-Aviv, Israel;(2)Sheba Medical Center, Pediatric Gastroenterology, Rama-Gan, Israel
P043: Succinate receptor (SUCNR1) mediates leukocyte-endothelial cell interactions induced by TNFaECCO'21 VirtualYear: 2021
Authors: Coll, S.(1);Bauset, C.(1);Cosín-Roger, J.(2);Ortiz-Masià, D.(1);Gisbert-Ferrándiz, L.(1);Barrachina, D.(1);Calatayud, S.(1);
(1)Faculty of Medicine - University of Valencia, Pharmacology, Valencia, Spain;(2)Hospital Dr. Peset, Endocrinology and Metabolism, Valencia, Spain
P044: Transcriptome analysis identifies dysregulated pathways and targets for therapy in patients undergoing surgical resection for Crohn’s diseaseECCO'21 VirtualYear: 2021
Authors: Akiror, S.(1);Acharjee, A.(2);Jeffery, L.(1);Shivaji, U.N.(1,3);Zardo, D.(4);Gkoutos, G.(2);Ghosh, S.(1,3);Iacucci, M.(1,3);
(1)Institute of Immunology and Immunotherapy- Univsersity of Birmingham, Gastroenterology, Birmingham, United Kingdom;(2)Institute of Cancer and Genomic Sciences- Centre for Computational Biology- University of Birmingham, Computational Biology, Birmingham, United Kingdom;(3)National Institute for Health Research NIHR Birmingham Biomedical Research Centre- University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Gastroenterology, Birmingham, United Kingdom;(4)University Hospitals Birmingham NHS Foundation Trust- Queen Elizabeth Hospital Birmingham UK, Pathology, Birmingham, United Kingdom
P045: Oncostatin M induces strong fibrotic and chemokine responses from primary colonic subepithelial myofibroblastsECCO'21 VirtualYear: 2021
Authors: Kokkotis, G.(1);Tarapatzi, G.(2);Drygiannakis, I.(3);Filidou, E.(2);Kandilogiannakis, L.(2);Arvanitidis, K.(2);Valatas, V.(3);Koutroubakis, I.(3);Vradelis, S.(4);Kolios, G.(2);Bamias, G.(1);
(1)National & Kapodistrian University of Athens, GI-unit- Third Department of Internal Medicine- Sotiria Hospital, Athens, Greece;(2)Democritus University of Thrace, Laboratory of Pharmacology- Faculty of Medicine, Alexandroupolis, Greece;(3)University of Crete, Gastroenterology and Hepatology Research Laboratory- Medical School, Heraklion, Greece;(4)Democritus University of Thrace, Second Department of Internal Medicine- University Hospital of Alexandroupolis, Alexandroupolis, Greece
P046: Disease modelling of Inflammatory Bowel Disease by human colon organoidsECCO'21 VirtualYear: 2021
Authors: Molnár, T.(1,2);Jójárt, B.(1,2,3);Resál, T.(1);Szántó, K.(1);Kata, D.(4);Földesi, I.(4);Molnár, T.(1);Maléth, J.(1,2,3,5);Farkas, K.(1);
(1)University of Szeged, First Department of Medicine, Szeged, Hungary;(2)Hungarian Academy of Science, University of Szeged Momentum Epithelial Cell Signaling and Secretion Research Group, Szeged, Hungary;(3)Hungarian Centre of Excellence of Molecular Medicine, University of Szeged Molecular Gastroenterology Research Group, Szeged, Hungary;(4)University of Szeged, Institute of Laboratory Medicine, Szeged, Hungary;(5)University of Szeged, Department of Public Health, Szeged, Hungary
P047: The ATG16L1 T300A polymorphism in Crohn's Disease patients leads to abnormal autophagy flux in dendritic cellsECCO'21 VirtualYear: 2021
Authors: Quiniou, G.(1);Dinet, O.(1);Cervantes, O.(1);Verdet, M.(1);Boschetti, G.(1);Viret, C.(1);Nancey, S.(1);Faure, M.(1);Rozieres, A.(1);
(1)CIRI- Centre International de Recherche en Infectiologie- Team Autophagy Infection Immunity- Université de Lyon- Inserm U1111- Université Claude Bernard Lyon 1- CNRS- UMR5308- ENS de Lyon- F-69007- Lyon- France, ciri inserm u1111, lyon, France
P048: Intestinal inflammation and microbiome diversity are conserved more in consecutive pregnancies among women with inflammatory bowel disease compared to healthy controlsECCO'21 VirtualYear: 2021
Authors: Agrawal, M.(1);Tarassishin, L.(2);Rendon, A.(2);Hillenbrand, C.(2);Debebe, A.(2);White, S.(2);Eisele, C.(2);Hawkins, K.(2);Kim, E.S.(2,3);Thjømøe, A.(4);Mørk, E.(4);Chen, C.L.(5);Kornbluth, A.(1);George, J.(1);Legnani, P.(1);Maser, E.(1);Stone , J.(6);Dubinsky, M.(7);Sabino, J.(1,8);Torres, J.(1,9);Colombel, J.F.(1);Peter, I.(2);Hu, J.(2);
(1)Icahn School of Medicine at Mount Sinai, The Henry D. Janowitz Division of Gastroenterology, New York, United States;(2)Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York, United States;(3)Kyungpook National University School of Medicine, Department of Internal Medicine, Daegu, Korea- Republic Of;(4)Calpro AS, Lysaker, Norway;(5)Icahn School of Medicine at Mount Sinai, Department of Obstetrics- Gynecology and Reproductive Science, New York, United States;(6)Icahn School of Medicine at Mount Sinai, Division of Maternal Fetal Medicine- Department of Obstetrics- Gynecology and Reproductive Science, New York, United States;(7)Icahn School of Medicine at Mount Sinai, Department of Pediatric Gastroenterology and Nutrition, New York, United States;(8)University Hospital of Leuven, Gastroenterology Division, Leuven, Belgium;(9)Hospital Beatriz Ângelo, Division of Gastroenterology- Surgical Department, Loures, Portugal
P049: Development of human embryonic stem cell-derived intestinal organoids for in vitro studies on intestinal inflammation and fibrosisECCO'21 VirtualYear: 2021
Authors: Kandilogiannakis, L.(1);Filidou, E.(1);Drygiannakis, I.(2);Tarapatzi, G.(1);Arvanitidis, K.(1);Bamias, G.(3);Valatas, V.(2);Paspaliaris, V.(4);Kolios, G.(1);
(1)Democritus University of Thrace, Laboratory of Pharmacology- Faculty of Medicine, Alexandroupolis, Greece;(2)University of Crete, Gastroenterology and Hepatology Research Laboratory- Medical School, Heraklion, Greece;(3)National & Kapodistrian University of Athens, GI-unit- Third Department of Internal Medicine- Sotiria Hospital, Athens, Greece;(4)Tithon Biotech Inc, Tithon Biotech Inc, San Diego, United States
P050: Effect of biological treatments (anti-TNFs) in the creeping fat of Crohn’s disease patientsECCO'21 VirtualYear: 2021
Authors: Montfort-Ferré, D.(1);Serena, C.(1);Millan, M.(2);Boronat-Toscano, A.(1);Maymó-Masip, E.(3);Caro, A.(4);Espina, B.(4);Vendrell, J.(1);Fernández-Veledo, S.(1);
(1)Health Institute Pere Virgili IISPV, Hospital Joan XXIII of Tarragona, Tarragona, Spain;(2)Hospital Universitari i Politècnic La Fe, Colorectal Surgery Unit- Department of Surgery-, Valencia, Spain;(3)Health Institute Pere Virgili IISPV, Hospital Universitari Joan XXIII of Tarragona, Tarragona, Spain;(4)Hospital Universitari Joan XXIII, Colorectal Surgery Unit, Tarragona, Spain
P051: Macrophages as a source of Notch Ligands in Crohn's disease: implications in fibrosisECCO'21 VirtualYear: 2021
Authors: Jorge, M.A.(1);Barrachina, M.D.(1);Bauset, C.(1);Gisbert-Ferrándiz, L.(1);Cosin-Roger, J.(2);Coll, S.(1);Calatayud, S.(1);López-Serrano, A.(3);Ortiz-Masiá, D.(4);
(1)Universitat de Valencia, Facultad de Medicina, Valencia, Spain;(2)Hospital Doctor Peset, Fisabio, Valencia, Spain;(3)Hospital Doctort Peset, Servicio Digestivo, Valencia, Spain;(4)Universidad de Valencia, Facultad de Medicina, Valencia, Spain
P052: Comprehensive proteomic profiling of stool from UC and CD patients reveals expected and novel mucosal pathobiology, enabling identification of candidate non-invasive biomarkers to monitor mucosal disease activityECCO'21 VirtualYear: 2021
Authors: Harder, B.(1);Casavant, E.(1);McBride, J.(1);Park, K.T.(2);Mathews, W.R.(1);Anania, V.G.(1);Lekkerkerker, A.(1);
(1)Genentech, OMNI Biomarker Development, South San Francisco, United States;(2)Genentech, PDC Gastroenterology, South San Francisco, United States
P053: Overabundance of Lactobacillus species in gut microbiota of IBD patientsECCO'21 VirtualYear: 2021
Authors: Khusnutdinova, D.(1,2);Markelova, M.(1);Siniagina, M.(1);Boulygina, E.(1);Abdulkhakov, S.(1);Grigoryeva, T.(1);
(1)Kazan Federal University, Institute of Fundamental Medicine and Biology, Kazan, Russian Federation;(2)KIBB FRC Kazan Scientific Center of RAS, Kazan Institute of Biochemistry and Biophysics, Kazan, Russian Federation
P055: Brain-Immune Axis Regulation is Responsive to Cognitive Behavioral and Mindfulness-Based Stress Reduction in Crohn’s DiseaseECCO'21 VirtualYear: 2021
Authors: Nemirovsky, A.(1);Ilan, K.(2);Lerner, L.(2);Cohen-Lavi , L.(3);Schwartz, D.(4);Goren, G.(5);Sergienko, R.(5);Greenberg, D.(6);Slonim-Nevo , V.(7);Sarid, O.(7);Friger, M.(5);Regev, S.(7);Odes, S..(8);Hertz, T.(9);Monsonego, A.(10);
(1)Faculty of Health Sciences- Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics-, Beer Sheva, Israel;(2)Faculty of Health Sciences- Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics, Beer Sheva, Israel;(3)Faculty of Health Sciences- Ben-Gurion University of the Negev- and Vaccine and Infectious Disease Division- Fred Hutch Cancer Research Center- Seattle- WA- USA, The Shraga Segal Department of Microbiology- Immunology- and Genetics, Beer Sheva, Israel;(4)Faculty of Health Sciences- Ben-Gurion University of the Negev, Gastroenterology & Hepatology, Beer Sheva, Israel;(5)Faculty of Health Sciences- Ben-Gurion University of the Negev, Department of Public Health, Beer Sheva, Israel;(6)Faculty of Health Sciences- Ben-Gurion University of the Negev, Department of Health Systems Management- School of Public Health- Guilford Glazer Faculty of Business and Management, Beer Sheva, Israel;(7)Ben-Gurion University of the Negev, Spitzer Department of Social Work, Beer Sheva, Israel;(8)Faculty of Health Sciences- Ben-Gurion University of the Negev, Gastroenterology & Hepatology, Metar, Israel;(9)Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- Faculty of Health Sciences- and Vaccine and Infectious Disease Division- Fred Hutch Cancer Research Center- Seattle- WA- USA, Beer Sheva, Israel;(10)Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology- Immunology- and Genetics- Faculty of Health Sciences- and The National Institute of Biotechnology in the Negev, Beer Sheva, Israel
