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Research Institute of the McGill University Hospital, Gastroenterology, Montreal, Canada

P085

The effect of vitamin D on macrophage function and polarization in Crohn's disease

Year: 2017
Source:

Research Institute of the McGill University Hospital, Gastroenterology, Montreal, Canada

Authors:

Dionne S., Duchatellier C.-F., Seidman E.

P086

Glycosylation of T-cells as a new molecular biomarker in inflammatory bowel disease: an opportunity for new therapeutic strategies

Year: 2016
Authors:

A. M. Dias1, M. Pereira1, R. Marcos-Pinto2, A. Correia3, M. Vilanova3, C. Reis1, P. Lago2, S. S. Pinho*1

1IPATIMUP/i3S, University of Porto, Glycobiology in Cancer, Porto, Portugal, 2Porto Centre Hospital, Hospital Santo António, Gastrenterology department, Porto, Portugal, 3Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Immunology department, Porto, Portugal

Queen Mary University of London, London, United Kingdom

P086

MMP-12, a novel mediator of nociception in Crohn's disease

Year: 2017
Source:

Queen Mary University of London, London, United Kingdom

Authors:

Tranter M., Barakat F., Dogra H., Lindsay J., Croft N., Bulmer D.

P087

Contributions of monocytes to gut inflammation in acute and chronic colitis models

Year: 2016
Authors:

F. Becker*1, F. N. Gavins2, T. Vowinkel1, I. Tsunoda3, E. Rijcken1, D. V. Ostanin4, J. S. Alexander2

1University Hospital Muenster, Department of General and Visceral Surgery, Muenster, Germany, 2Louisiana State University Health Sciences Centre-Shreveport, Department of Molecular & Cellular Physiology, Shreveport, Louisiana, United States, 3Louisiana State University Health Sciences Centre-Shreveport, Department of Microbiology and Immunology, Shreveport, Louisiana, United States, 4Louisiana State University Health Sciences Centre-Shreveport, Centre of Excellence for Arthritis and Rheumatology, Shreveport, Louisiana, United States

1Universidad de Valencia-CIBERehd, Pharmacology, Valencia, Spain 2Universidad de Valencia, Medicine, Valencia, Spain 3Universidad de Valencia, Pharmacology, Valencia, Spain 4FISABIO Hospital Peset, Pharmacology, Valencia, Spain

P087

Increased wnt ligands expression in M2c macrophages is associated with fibrosis in Stat6 knockout mice

Year: 2017
Source:

1Universidad de Valencia-CIBERehd, Pharmacology, Valencia, Spain 2Universidad de Valencia, Medicine, Valencia, Spain 3Universidad de Valencia, Pharmacology, Valencia, Spain 4FISABIO Hospital Peset, Pharmacology, Valencia, Spain

Authors:

Ortiz-Masia D.*1,2, Salvador P.3, Macias-Ceja D.C.4, Gisbert-Ferrándiz L.3, Hernandez C.4, Calatayud S.3, Esplugues J.V.3,4, Barrachina D.3

1Second University of Naples, Department of Woman, Child and General and Specialistic Surgery, Naples, Italy 2University Federico II of Naples, Department of Translational Medical Science, Section of Pediatrics, Naples, Italy

P088

Evaluation of Free Vitamin D levels in IBD pediatric patients: the role of inflammation

Year: 2017
Source:

1Second University of Naples, Department of Woman, Child and General and Specialistic Surgery, Naples, Italy 2University Federico II of Naples, Department of Translational Medical Science, Section of Pediatrics, Naples, Italy

Authors:

Strisciuglio C.*1, Cenni S.2, Giugliano F.P.2, Miele E.2, Cirillo G.1, Martinelli M.2, Vitale A.1, Staiano A.2, Miraglia del Giudice E.1, Perrone L.1

P088

Loss of intestinal Desmoglein 2 promotes chemically and pathogenic induced colitis

Year: 2016
Authors:

A. Gross*1, L. Pack1, S. Kant2, C. Krusche2, G. Sellge1, C. Trautwein1, R. Leube2, P. Strnad1

1University Hospital Aachen, Medicine III, Aachen, Germany, 2University Hospital Aachen, Institute of Molecular and Cellular Anatomy, Aachen, Germany

1Nordic Bioscience A/S, Biomarkers and Research, Herlev, Denmark 2University of Southern Denmark and Odense University Hospital, Department of Medical Gastroenterology, Odense, Denmark

P089

Extracellular matrix fragments as markers of cytokine driven intestinal damage or protection; test in a novel intestinal ex vivo model

Year: 2017
Source:

1Nordic Bioscience A/S, Biomarkers and Research, Herlev, Denmark 2University of Southern Denmark and Odense University Hospital, Department of Medical Gastroenterology, Odense, Denmark

Authors:

Olesen M.L.*1,2, Krag A.2, Karsdal M.1, Kjeldsen J.2, Bay-Jensen A.-C.1, Mortensen J.H.1

P089

Stimulation of the ω-3 docosahexaenoic acid metabolism via MFSD2A as a novel therapy for inflammatory bowel disease.

Year: 2016
Authors:

F. Ungaro*1, 2, C. Correale1, P. Corsetto3, L. Massimino4, P. Fonteyne1, C. Tacconi1, K. R. Maddipati5, A. Rizzo3, S. D’Alessio1, 2, S. Danese1

1Humanitas Research Institute, Laboratory of Immunology in Gastroenterology, Milan, Italy, 2University of Milan, Department of Biotechnology and Translational Medicine, Milan, Italy, 3University of Milan, Department of Pharmacology and Biomolecular Science, Milan, Italy, 4San Raffaele Research Institute, Division of Neuroscience, Milan, Italy, 5Wayne State University, Department of Pathology, Detroit, Michigan, United States

P090

Differences in expression of G protein–coupled receptor 55 (GPR55) in patients with Crohn’s disease and ulcerative colitis

Year: 2016
Authors:

M. Wlodarczyk*1, A. Sobolewska-Włodarczyk1, A. Cygankiewicz2, D. Jacenik2, W. Krajewska3, K. Stec-Michalska1, A. Piechota-Polanczyk4, J. Fichna4, M. Wisniewska-Jarosinska1

1Medical University of Lodz, Department of Gastroenterology, Lodz, Poland, 2University of Lodz, Department of Cytobiochemistry, Lodz, Poland, 3University of Lodz, Cytobiochemistry, Lodz, Poland, 4Medical University of Lodz, Department of Biochemistry, Lodz, Poland

1Asan Medical Center, Seoul, South Korea 2Asan Institute for Life Science, Seoul, South Korea

P090

Metformin induces late Apoptosis and modulates dysbiosis in western-style diet induced colitic cancer

Year: 2017
Source:

1Asan Medical Center, Seoul, South Korea 2Asan Institute for Life Science, Seoul, South Korea

Authors:

Chung E.J.*1, Do E.J.2, Myung S.-J.1,2

P091

Sonic hedgehog inhibitor prevented colitis-associated cancer via stem inhibition

Year: 2016
Authors:

K. B. Hahm*1, Y. J. Kim2

1CHA University, Gastroenterology, Seongnam, South Korea, 2Gachon University, Gastroenterology, Incheon, South Korea

1IDIBAPS, Hospital Clínic, CIBER-EHD, Gastroenterology, Barcelona, Spain 2CIBER-EHD, Bioinformatics Platform, Barcelona, Spain 3IBD Research Laboratory, University of Campinas, Surgery, Sao Paulo, Brazil 4Hospital Universitari de Bellvitge - Institut d'Investigaciό Biomèdica de Bellvitge, Gastroenterology, Barcelona, Spain 5Boehringer-Ingelheim Pharmaceuticals Inc, Ridgefield, United States

P091

Usefulness of transcriptional whole blood biomarkers as a non-invasive surrogate marker of mucosal healing and endoscopic response in ulcerative colitis

Year: 2017
Source:

1IDIBAPS, Hospital Clínic, CIBER-EHD, Gastroenterology, Barcelona, Spain 2CIBER-EHD, Bioinformatics Platform, Barcelona, Spain 3IBD Research Laboratory, University of Campinas, Surgery, Sao Paulo, Brazil 4Hospital Universitari de Bellvitge - Institut d'Investigaciό Biomèdica de Bellvitge, Gastroenterology, Barcelona, Spain 5Boehringer-Ingelheim Pharmaceuticals Inc, Ridgefield, United States

Authors:

Planell N.*1,2, Masamunt M.C.1, Franco Leal R.3, Rodríguez L.4, Esteller M.1, Lozano J.J.2, Ramírez A.1, Setsuko Ayrizono M.d.L.3, Saddy Rodrigues Coy C.3, Alfaro I.1, Ordás I.1, Visvanathan S.5, Ricart E.1, Guardiola J.4, Panés J.1, Salas A.1

P092

Characterisation of the lymphoid stress surveillance response performed by human colon resident γδ T-cells

Year: 2016
Authors:

R. J. Dart*1, 2, 3, R. Woolf2, P. M. Irving3, A. C. Hayday1, 2

1Francis Crick Institute, Immunosurveillance Lab, London, United Kingdom, 2King’s College London, Immunobiology, DIIID, London, United Kingdom, 3Guy’s and St Thomas’ NHS Foundation Trust, IBD Centre, London, United Kingdom

1University of Valencia, Valencia, Spain 2Fisabio Hospital Peset, Valencia, Spain 3CIBERehd, Valencia, Spain

P092

Exogenous administration of IL-4-treated macrophages prevents intestinal fibrosis in Stat6 knockout mice

Year: 2017
Source:

1University of Valencia, Valencia, Spain 2Fisabio Hospital Peset, Valencia, Spain 3CIBERehd, Valencia, Spain

Authors:

Salvador P.*1, Ortiz-Masià D.1, Macias-Ceja D.C.2, Gisbert-Ferrándiz L.1, Hernández C.2,3, Esplugues J.V.1,2,3, Barrachina-Sancho M.D.1,3, Calatayud S.1,3

P093

15-d-PGJ2 – a possible regulator of iron homeostasis

Year: 2016
Authors:

J. Martin*1, 2, S. Ulrich-Rueckert2, J. Stein1, 3

1Interdisciplinary Crohn Colitis Centre Rhein-Main, Frankfurt/Main, Germany, 2Goethe University Frankfurt, Insitute of Pharmaceutical Chemistry, Frankfurt/Main, Germany, 3DGD Clinics Sachsenhausen, Frankfurt/Main, Germany

1Imperial College London, Antigen Presentation Research Group, Harrow, United Kingdom 2Imperial College London, London, United Kingdom 3University of Reading, Reading, United Kingdom 4Northwick Park & St Mark's Hospital, Harrow, United Kingdom 5Queen Elizabeth Hospital, Adelaide, Australia 6Institute of Food Research, Norwich, United Kingdom

P093

Dysregulation of cellular vs humoral immunity to the intestinal microbiota in inflammatory bowel disease

Year: 2017
Source:

1Imperial College London, Antigen Presentation Research Group, Harrow, United Kingdom 2Imperial College London, London, United Kingdom 3University of Reading, Reading, United Kingdom 4Northwick Park & St Mark's Hospital, Harrow, United Kingdom 5Queen Elizabeth Hospital, Adelaide, Australia 6Institute of Food Research, Norwich, United Kingdom

Authors:

Noble A.*1, Durant L.2, Hoyles L.2, McCartney A.L.3, Man R.4, Costello S.P.5, Hendy P.4, Reddi D.2, Segal J.4, Lim D.4, Bolton M.4, Hart A.L.4, Carding S.R.6, Knight S.C.2

1Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Academic Medical Center, Department of Clinical Genetics, Genome Diagnostics Laboratory, Amsterdam, Netherlands 3GlaxoSmithKline, Epinova Discovery Performance Unit, Stevenage, United Kingdom 4Academic Medical Center, Department of Gastroenterology, Amsterdam, Netherlands

P094

DNA methylation patterns in Crohn's disease mucosal-derived fibroblasts

Year: 2017
Source:

1Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Academic Medical Center, Department of Clinical Genetics, Genome Diagnostics Laboratory, Amsterdam, Netherlands 3GlaxoSmithKline, Epinova Discovery Performance Unit, Stevenage, United Kingdom 4Academic Medical Center, Department of Gastroenterology, Amsterdam, Netherlands

Authors:

te Velde A.A.*1, Li Yim A.Y.2,3, de Bruyn J.R.1,4, Duijvis N.W.1, de Jonge W.J.1, Wildenberg M.E.1, Mannens M.M.2, D'Haens G.R.4, Henneman P.2

P094

Human neutrophil elastase shows increased elastinolytic activity in ulcerative colitis and contributes to loss of function of anti-TNF-alpha agents in ulcerative colitis

Year: 2016
Authors:

P. Giuffrida*1, K. Kok2, A. Di Sabatino1, P. Biancheri2, A. Vanoli3, G. Mazza4, R. Curciarello2, A. Pasini1, N. Aronico1, M. Pinzani4, G. R. Corazza1, T. T. MacDonald2

1Fondazione IRCCS Policlinico San Matteo, University of Pavia, First Department of Medicine, Pavia, Italy, 2Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom, 3Fondazione IRCCS Policlinico San Matteo, University of Pavia, Department of Molecular Medicine, Pavia, Italy, 4Institute for Liver and Digestive Health, University College London, London, United Kingdom

P095

Immune compromised mice develop colitis upon denervation of the superior mesenteric nerve.

Year: 2016
Authors:

R. Willemze*1, L. Nijhuis1, O. Welting1, J. Folgering2, H. Darwinkel2, D. Chew3, A. Sridhar3, J. Witherington3, J. Seppen1, S. Heinsbroek1, W. de Jonge1

1Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 2Brains On-line B.V., Groningen, Netherlands, 3Glaxo Smith Kline, Bioelectronics, Middlesex, United Kingdom

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