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P065

Molecular landscape of early Crohn’s disease using an integrated approach of mRNA/miRNA profiling and genomics

Year: 2016
Authors:

S. Verstockt*1, J. Van der Goten2, M. Vancamelbeke2, B. Verstockt2, F. Schuit3, P. Rutgeerts2, M. Ferrante2, S. Vermeire2, I. Arijs2, I. Cleynen1

1KU Leuven, Department of Human Genetics, Leuven, Belgium, 2KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Centre for Gastrointestinal Disorders, Leuven, Belgium, 3KU Leuven, Department of Cellular and Molecular Medicine, Gene Expression Unit, Leuven, Belgium

P066

CCR2-monocytes are essential for the resolution of inflammation and tissue repair in colitis.

Year: 2016
Authors:

M. Stakenborg, G. Goverse, G. Farro, P. J. Gomez-Pinilla, 
G. E. Boeckxstaens, G. Matteoli*

KU Leuven, P.O. Box 701, Department of Clinical and Experimental Medicine, Leuven, Belgium

1Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Academic Medical Center, Surgery, Amsterdam, Netherlands 3Academic Medical Center (AMC), Tytgat Institute for Intestinal and Liver Research, Amsterdam, Netherlands 4Academic Medical Center, Gastroenterology & Hepatology, Amsterdam, Netherlands

P066

Fibrostenotic phenotype of fibroblasts in Crohn's disease is dependent on tissue stiffness and reversed by LOX inhibition

Year: 2017
Source:

1Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Academic Medical Center, Surgery, Amsterdam, Netherlands 3Academic Medical Center (AMC), Tytgat Institute for Intestinal and Liver Research, Amsterdam, Netherlands 4Academic Medical Center, Gastroenterology & Hepatology, Amsterdam, Netherlands

Authors:

de Bruyn J.*1, van den Brink G.1, Steenkamer J.1, Buskens C.2, Bemelman W.2, Meisner S.3, Muncan V.3, te Velde A.3, D'Haens G.4, Wildenberg M.1

P067

Angiogenic characterisation of Crohn’s disease mesenteric adipose tissue

Year: 2016
Authors:

M. Eddama*1, R. Cohen1, M. Rodriguez-Justo2, I. Evans3, L. Shen4, L. Clapp4, M. Loizidou5

1University College London Hospital, Colorectal Surgery, London, United Kingdom, 2University College London Hospital, Department of Pathology, London, United Kingdom, 3University College London, Centre for Cardiovascular Biology and Medicine, London, United Kingdom, 4University College London, Institute of Cardiovascular Science, London, United Kingdom, 5University College London, Academic Department of Surgery, London, United Kingdom

1KU Leuven, Department of Human Genetics, Leuven, Belgium 2KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, Leuven, Belgium 3KU Leuven, Department of Cellular and Molecular Medicine, Gene Expression Unit, Leuven, Belgium 4Hasselt University, Faculty of Medicine and Life Sciences, Hasselt, Belgium 5Jessa Hospital, Hasselt, Belgium

P067

Molecular profiling of early Crohn's disease reveals a prominent role for WNT5A

Year: 2017
Source:

1KU Leuven, Department of Human Genetics, Leuven, Belgium 2KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, Leuven, Belgium 3KU Leuven, Department of Cellular and Molecular Medicine, Gene Expression Unit, Leuven, Belgium 4Hasselt University, Faculty of Medicine and Life Sciences, Hasselt, Belgium 5Jessa Hospital, Hasselt, Belgium

Authors:

Verstockt S.*1, Van der Goten J.2, Vancamelbeke M.2, Verstockt B.2, Van Lommel L.3, Schuit F.3, Rutgeerts P.2, Ferrante M.2, Vermeire S.2, Arijs I.2,4,5, Cleynen I.1

P068

Anti-fibrotic therapy for Crohn’s disease: in-vitro proof of concept with a selective ROCK2 inhibitor, LYC-53976, in the treatment of human intestinal myofibroblasts in stiffness and transforming growth factor β models

Year: 2016
Authors:

E. Rodansky1, X. Liu2, L. A. Johnson1, K. Demock2, A. J. Celeste2, L. L. Carter2, P. D. R. Higgins*1

1University of Michigan, Internal Medicine - Gastroenterology, Ann Arbor, Michigan, United States, 2Lycera, Inc., Ann Arbor, Michigan, United States

1Ewha Womans University School of Medicine, Department of Internal Medicine, Seoul, South Korea 2Ewha Womans University School of Medicine, Department of Molecular Medicine, Seoul, South Korea

P068

Evaluation of the therapeutic potential of metformin-pretreated tonsil-derived mesenchymal stem cells in a chronic colitis model

Year: 2017
Source:

1Ewha Womans University School of Medicine, Department of Internal Medicine, Seoul, South Korea 2Ewha Womans University School of Medicine, Department of Molecular Medicine, Seoul, South Korea

Authors:

Lee K.E.*1, Jung S.-A.1, Joo Y.-H.1, Tae C.H.1, Moon C.M.1, Kim S.-E.1, Jung H.-K.1, Shim K.-N.1, Yoo K.1, Yu Y.s.2, Jo I.h.2

1Academic Medical Center (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Galvani, Bioelectronics, Stevenage, United Kingdom

P069

Sympathetic but not vagal intestinal innervation regulates murine dextran sodium sulphate-induced colitis

Year: 2017
Source:

1Academic Medical Center (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 2Galvani, Bioelectronics, Stevenage, United Kingdom

Authors:

Willemze R.*1, Welting O.1, van Hamersveld P.1, Sridhar A.2, Vervoordeldonk M.2, Seppen J.1, de Jonge W.1

P069

TD-1473, a novel, potent, and orally administered, GI-targeted, pan-Janus kinase (JAK) inhibitor

Year: 2016
Authors:

D. Beattie*, P. Tsuruda, F. Shen, P. Brassil, C. Langrish, J. Janc, Z. Ren, R. Hudson, J. Smith, S. Hegde

Theravance Biopharma, South San Francisco, United States

P070

The influence of vitamin D on M1 and M2 macrophages in patients with Crohn’s disease

Year: 2016
Authors:

E. Seidman*, S. Dionne

Research Institute of the McGill University Hospital, Gastroenterology, Montreal, Canada

Blizard Institute, London, United Kingdom

P070

TNFα production by classical monocytes is poorly controlled by IL-10 in patients with IBD

Year: 2017
Source:

Blizard Institute, London, United Kingdom

Authors:

Hoti I., McCarthy N.E., Giles E.M., Ayada I., Gordon H., Stagg A.J., Lindsay J.O.

P071

Improvement of experimental mouse models in inflammatory bowel diseases using flexible video endoscopic colon evaluation

Year: 2016
Authors:

C. Gay*1, O. Martin Rodriguez2, A. Daoui2, S. Koch1, P. Saas2, S. Valmary Degano3, S. Perruche2, L. Vuitton1

1CHU Jean Minjoz, Gastro-entérologie, besançon, France, 2UMR 1098 INSERM, Besançon, France, 3CHU Jean Minjoz, Anatomopathologie, besançon, France

1University of Limerick, Department of Surgery, Limerick, Ireland 2University of Limerick, Graduate Entry Medical School, 4i Centre for Interventions in Infection, Inflammation and Immunity, Limerick, Ireland 3University Hospital Limerick, Department of Surgery, Limerick, Ireland 4University Hospital Limerick, Department of Gastroenterology, Limerick, Ireland 5University Hospital Limerick, Department of Histopathology, Limerick, Ireland

P071

The mesentery in Crohn's disease displays mesenchymal abnormalities

Year: 2017
Source:

1University of Limerick, Department of Surgery, Limerick, Ireland 2University of Limerick, Graduate Entry Medical School, 4i Centre for Interventions in Infection, Inflammation and Immunity, Limerick, Ireland 3University Hospital Limerick, Department of Surgery, Limerick, Ireland 4University Hospital Limerick, Department of Gastroenterology, Limerick, Ireland 5University Hospital Limerick, Department of Histopathology, Limerick, Ireland

Authors:

Walsh L.*1, Kiernan M.2, Sahebally S.1, Kiely P.2, Waldron D.3, Moloney M.4, Skelly M.4, Hidayat H.3, Faul P.5, O'Leary D.P.3, Lowery A.1, Dunne C.2, Coffey J.C.2

1University of Zurich, Zurich, Switzerland 2University Hospital Zürich, Department of Gastroenterology and Hepatology, Zurich, Switzerland 3Novartis Institute for Biomedical Research, Basel, Switzerland

P072

The role of the rs8005161 polymorphism on pH-sensing G protein-coupled receptor GPR65 (TDAG8) signalling in intestinal inflammation

Year: 2017
Source:

1University of Zurich, Zurich, Switzerland 2University Hospital Zürich, Department of Gastroenterology and Hepatology, Zurich, Switzerland 3Novartis Institute for Biomedical Research, Basel, Switzerland

Authors:

Tcymbarevich I.1, Obialo N.2, Cosin-Roger J.1, Seuwen K.3, Rogler G.1,2, Misselwitz B.2, de Vallière C.*1

P072

TREM-1 stimulation ameliorates colitis in mice

Year: 2016
Authors:

H. W. Ma*1, 2, X. Che1, 2, D. H. Seo1, 2, J. H. Kim1, 2, D. H. Kim1, 
T. I. Kim1, W. H. Kim1, S. W. Kim1, 2, 3, J. H. Cheon1, 2, 3

1Yonsei University College of Medicine, Department of Internal Medicine and Institute of Gastroenterology, Seoul, South Korea, 2Yonsei University College of Medicine, Brain Korea 21 PLUS Project for Medical Science, Seoul, South Korea, 3Yonsei University College of Medicine, Severance Biomedical Science Institute, Seoul, South Korea

1University of New South Wales, Kensington, Australia 2James Fairfax Institute of Paediatric Clinical Nutrition, University of Sydney, Sydney, Australia 3The Children's Hospital at Westmead, Department of Allergy and Immunology, Westmead, Australia 4University of Sydney, Nepean Clinical School, Sydney, Australia 5Concord and Bankstown Hospitals, Department of Gastroenterology, Sydney, Australia

P073

Age dependent decrease in gut-homing CD4 lymphocytes

Year: 2017
Source:

1University of New South Wales, Kensington, Australia 2James Fairfax Institute of Paediatric Clinical Nutrition, University of Sydney, Sydney, Australia 3The Children's Hospital at Westmead, Department of Allergy and Immunology, Westmead, Australia 4University of Sydney, Nepean Clinical School, Sydney, Australia 5Concord and Bankstown Hospitals, Department of Gastroenterology, Sydney, Australia

Authors:

Oh S.*1, Lee C.H.2, Hsu P.3, Hu M.4, Nanan B.4, Gaskin K.2, Leong R.5, Nanan R.4

P073

TNF-alpha activity in plasma from patients with inflammatory bowel disease under adalimumab and infliximab treatment evaluated in a cell-based assay

Year: 2016
Authors:

P. M. Linares*1, H. De la Fuente2, M. Chaparro1, I. Guerra3, P. L. Majano4, M. Iborra5, J. L. Cabriada6, L. Bujanda7, M. Barreiro-de Acosta8, V. García-Sánchez9, I. Marín-Jiménez10, D. Bernardo1, 
J. P. Gisbert1

1Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Gastroenterology Unit, Madrid, Spain, 2Hospital Universitario de La Princesa, IIS-IP, Immunology Unit, Madrid, Spain, 3Hospital Universitario de Fuenlabrada, Gastroenterology Unit, Madrid, Spain, 4Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Molecular Biology Unit, Madrid, Spain, 5Hospital Universitario La Fe and CIBERehd, Gastroenterology Unit, Valencia, Spain, 6Hospital Galdakao, Gastroenterology Unit, Vizcaya, Spain, 7Hospital de Donostia, Instituto Biodonostia, UPV/EHU and CIBEREHD, Gastroenterology Unit, Guipuzcoa, Spain, 8Hospital Clínico Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain, 9Hospital Universitario Reina Sofía, Gastroenterology Unit, Córdoba, Spain, 10Hospital Gregorio Marañón and IiSGM, Gastroenterology Unit, Madrid, Spain

P074

Association of colonic mucosal infiltration of IgG4 plasma cells with ulcerative colitis activity and presence of primary sclerosing cholangitis

Year: 2016
Authors:

F. Alborzi*1, Z. Azizi2, N. Ebrahimi Daryani3, F. Azmude Ardalan3, N. Aletaha3, R. Taslimi3, N. Roshan3

1Tehran University of Medical Science, Gastrenterology, Tehran, Iran, Islamic Republic of, 2Iran University of Medical Science, Tehran, Iran, Islamic Republic of, 3Tehran University of Medical Science, Tehran, Iran, Islamic Republic of

1Hospital Bonorino Udaondo, IBD Section - Medicine, Buenos Aires, Argentina 2IBD Section - Hospital Bonorino Udaondo, Medicine, Buenos Aires, Argentina 3Hospital of Infectious Diseases F. J. Muñiz, Hemostasis and Thrombosis Laboratory, Buenos, Argentina 4Facultad de Medicina Universidad de Buenos Aires, Instituto de Farmacología, Buenos Aires, Argentina 5Academia Nacional de Medicina, Instituto de Medicina Experimental (IMEX), Buenos Aires, Argentina 6Facultad de Medicina Universidad de Buenos Aires, Hemostasis and Thrombosis Laboratory, Buenos Aires, Argentina 7Hospital of Infectious Diseases F. J. Muñiz, Hemostasis and Thrombosis Laboratory, Buenos Aires, Argentina 8Yale University School of Medicine, Department of Immunobiology, New Haven, United States

P074

Decreased levels of circulating protein S (PROS1) in patients with active Crohn's disease

Year: 2017
Source:

1Hospital Bonorino Udaondo, IBD Section - Medicine, Buenos Aires, Argentina 2IBD Section - Hospital Bonorino Udaondo, Medicine, Buenos Aires, Argentina 3Hospital of Infectious Diseases F. J. Muñiz, Hemostasis and Thrombosis Laboratory, Buenos, Argentina 4Facultad de Medicina Universidad de Buenos Aires, Instituto de Farmacología, Buenos Aires, Argentina 5Academia Nacional de Medicina, Instituto de Medicina Experimental (IMEX), Buenos Aires, Argentina 6Facultad de Medicina Universidad de Buenos Aires, Hemostasis and Thrombosis Laboratory, Buenos Aires, Argentina 7Hospital of Infectious Diseases F. J. Muñiz, Hemostasis and Thrombosis Laboratory, Buenos Aires, Argentina 8Yale University School of Medicine, Department of Immunobiology, New Haven, United States

Authors:

Sambuelli A.*1, Chavero P.2, de Larrañaga G.3, Errasti A.4, Carrera Silva A.5, Tessone L.6, Peres S.7, Negreira S.2, Gil A.2, Bellicoso M.2, Goncalves S.2, Huernos S.2, Tirado P.2, Rothlin C.8

The Fourth Military Medical University, State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xi'an, Shaanxi, China

P075

Calponin 2 protects against colitis associated cancer in mice through mediating inflammatory responses

Year: 2017
Source:

The Fourth Military Medical University, State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xi'an, Shaanxi, China

Authors:

Xu B., Jiang M., Qiu Z., Li X., Chen D., Chu Y., Wang W., Liang J., Wu K.

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