P071: T-cell, B-cell and monocytic infiltrations of myenteric plexus in IBDECCO’23 CopenhagenYear: 2023
Authors: Wiese, J.J.(1)*;Fascì, A.(1);Kühl, A.A.(1);Atreya, R.(2);Patankar, J.(2);Siegmund, B.(1);Prüß, M.S.(1);Schumann, M.(1);
(1)Charité - Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology- Campus Benjamin Franklin, Berlin, Germany;(2)University Hospital Erlangen, Deptartment of Internal Medicine 1- Faculty of Medicine, Erlangen, Germany;
P072: : Circadian misalignment by simulated night shifts decreases colonoid barrier integrity in Ulcerative ColitisECCO’23 CopenhagenYear: 2023
Authors: Swanson, G.(1)*;Shaikh, M.(1);Keshavarzian, A.(1);Scheer, F.(2);
(1)Rush University Medical Center, Center of Integrated Microbiology and Chronobiology, Chicago, United States;(2)Harvard University, Division of Sleep Medicine, Boston, United States;
P073: Let´s talk about sex: an unicentric cross-sectional study on sexual dysfunction, sexual satisfaction and body schema disorders in Inflammatory Bowel DiseaseECCO’23 CopenhagenYear: 2023
Authors: Lindenthal, D.(1);Kranzeder, A.(2)*;Hirning, C.(2);von Wietersheim, J.(2);Klaus, J.(1);
(1)University Hospital Ulm, Department of Internal Medicine I, Ulm, Germany;(2)University Hospital Ulm, Department of Psychosomatic Medicine and Psychotherapy, Ulm, Germany;
P075: Characterisation and structural analysis of a new murine model to study postoperative fibrotic recurrence in Crohn's disease combining ileocecal resection with chronic colitisECCO’23 CopenhagenYear: 2023
Authors: Schmidt, K.(1)*;Li, C.(1);Buck, A.(1);Wilhelm, D.(1);Friess, H.(1);Weber, M.C.(1);Neumann, P.A.(1);
(1)Technical University of Munich- Klinikum rechts der Isar, Department of Surgery, Munich, Germany;
P076: Abdominal pain severity for IBD in remission correlates with genetic clustering and enzymatic activity of faeces-derived Candida albicans strainsECCO’23 CopenhagenYear: 2023
Authors: Van Thiel, I.(1,2)*;Maasland, T.(3);van Wassenaer, E.(4);Hoekman, D.(5);Spooren, C.(6,7);Hakvoort, T.(1,8);Admiraal, I.(1,8);Theelen, B.(2);Levin, E.(3);Benninga, M.(5);Jonkers, D.(6,7);D'Haens, G.(4);Rosendahl, S.(9);Boekhout, T.(2,10);Hagen, F.(10,11,12);de Jonge, W.(1,4,13);van den Wijngaard, R.(1,4);
(1)AmsterdamUMC- loc. AMC, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(2)Westerdijk Fungal Biodiversity Institute, Yeast Research, Utrecht, The Netherlands;(3)Horaizon, Horaizon, Delft, The Netherlands;(4)AmsterdamUMC- loc. AMC, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands;(5)AmsterdamUMC- loc. AMC, Department of Pediatric Gastroenterology and Nutrition, Amsterdam, The Netherlands;(6)Maastricht University Medical Centers+, Department of Internal Medicine- Division Gastroenterology-Hepatology, Maastricht, The Netherlands;(7)Maastricht University, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands;(8)AmsterdamUMC- loc. AMC, Microbiota Center Amsterdam, Amsterdam, The Netherlands;(9)University of Copenhagen, Department of Biology- Section for Ecology & Evolution, Copenhagen, Denmark;(10)University of Amsterdam, Institute of Biodiversity and Ecosystem Dynamics IBED, Amsterdam, The Netherlands;(11)Westerdijk Fungal Biodiversity Institute, Medical Mycology Group, Utrecht, The Netherlands;(12)University Medical Center Utrecht, Medical Microbiology, Utrecht, The Netherlands;(13)University Hospital Bonn, Department of General- Visceral- Thoracic and Vascular Surgery, Bonn, Germany;
P077: Group 1 innate lymphoid cells in creeping fat of Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Mori, R.(1)*;Ogino, T.(1,2);Sekido, Y.(1);Hata, T.(1);Hamabe, A.(1);Takahashi, H.(1);Miyoshi, N.(1);Uemura, M.(1);Mizushima, T.(1,2,3);Doki, Y.(1);Eguchi, H.(1);
(1)Osaka University, Department of Gastroenterological Surgery- Graduate School of Medicine, Suita- Osaka, Japan;(2)Osaka University, Department of Therapeutics for Inflammatory Bowel Diseases- Graduate School of Medicine, Suita- Osaka, Japan;(3)Osaka Police Hospital, Department of Gastroenterological Surgery, Osaka, Japan;
P078: Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids.ECCO’23 CopenhagenYear: 2023
Authors: Walaas, G.A.(1)*;Gopalakrishnan, S.(1);Bakke, I.(1,2);Skovdahl, H.K.(1,3);Flatberg, A.(1,4);Østvik, A.E.(1,5);Sandvik, A.K.(1,3,5);Bruland, T.(1,5);
(1)Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Trondheim, Norway;(2)St. Olav's University Hospital, Clinic of Laboratory Medicine, Trondheim, Norway;(3)Norwegian University of Science and Technology, Centre of Molecular Inflammation Research, Trondheim, Norway;(4)St. Olav's University Hospital, Central Administration, Trondheim, Norway;(5)St. Olav's University Hospital, Department of Gastroenterology and Hepatology, Trondheim, Norway;
P079: Attenuation of inflammation and histologic production-dependent improvement by engineered high acetate producing Saccharomyces boulardii in DSS-induced colitisECCO’23 CopenhagenYear: 2023
Authors: Deleu, S.(1)*;Trindade de Carvalho , B.(2);Jacobs, I.(3);Arnauts, K.(1);Deprez, L.(4);Vissers , E.(1);Lenfant, M.(1);De Hertogh, G.(5);Huys, G.(6);Thevelein, J.(2);Raes, J.(6);Vermeire, S.(7);
(1)KU Leuven, Department of Chronic Diseases- Metabolism & Ageing CHROMETA, Leuven, Belgium;(2)Bio-incubator, Novelyeast, Leuven, Belgium;(3)KU Leuven, Department of Microbiology- Immunology and Transplantation- Allergy and Clinical Immunology Research Group, Leuven, Belgium;(4)KULeuven, Department of Chronic Diseases- Metabolism & Ageing CHROMETA, Leuven, Belgium;(5)University hospitals Leuven, Laboratory of Morphology and Molecular Pathology, Leuven, Belgium;(6)KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium;(7)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;MIMOSA
P080: Mucosal clock and inflammation regulatory genes are disrupted in treatment naïve pediatric patients with ulcerative colitisECCO’23 CopenhagenYear: 2023
Authors: Labes, S.(1);Tabach, Y.(1);Matar, M.(2,3);Shamir, R.(2,3);Shouval, D.S.(2,3);Froy, O.(4);Weintraub, Y.(2,3)*;
(1)Hebrew University of Jerusalem, Department of Developmental Biology and Cancer Research- Institute for Medical Research Israel-Canada, Jerusalem, Israel;(2)Schneider Children's Medical Center of Israel, Institute of Gastroenterology- Nutrition and Liver Diseases, Petach Tikva, Israel;(3)Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel;(4)The Hebrew University, Institute of Biochemistry- Food Science and Nutrition- the Robert H Smith Faculty of Agriculture- Food and Environment-, Rehovot, Israel;
P081: The application of multiomics to investigate the evolution of inflammatory bowel disease in pediatric and adult patientsECCO’23 CopenhagenYear: 2023
Authors: Maccalli, C.(1)*; Gupta, I.(2);Toufiq, M.(3);Habib, T.(4); Mathew, R.(5); Shobha Manjunath, H.(5); Missous, G.N.(6); Mifsud, W.(7); Charles, A.(7); Ammar, A.A.(8);Tomei, S.(5); van Panhuys, N.(6); Al-Kaabi, S.(9);Akobeng, A.(10);Al-Mohannadi, M.J.(9); Elawad, M.(10);
(1)Sidra Medicine, Lab. Immune and Biological Therapy-Translational Medicine, Doha-Qatar, Italy;(2)Sidra Medicine, Laboratory of Immune Biological Therapy-Research Department, Doha, Qatar;(3)Sidra Medicine, Lab. System Biology, Doha, Qatar;(4)Sidra Medicine, Lab of System Biology, Doha, Qatar;(5)Sidra Medicine, Integrated Genomic laboratory-Omics Core, Doha, Qatar;(6)Sidra Medicine, Laboratory of Immunoregulation-Research Department, Doha, Qatar;(7)Sidra Medicine, Anatomical Pathology, Doha, Qatar;(8)Hamad Medical Corporation, Anatomical Pathology, Doha, Qatar;(9)Hamad Medical Corporation, Gastroenterology- Ambulatory Care Center, Doha, Qatar;(10)Sidra Medicine, Gastroenterology- Hepatology and Nutrition, Doha, Qatar;
P082: The CCR9/CCL25 axis is specific to the ileum and is correlated with stricturing diseaseECCO’23 CopenhagenYear: 2023
Authors: Gehrmann, U.(1)*;Csomor, E.(2);Monkley, S.(3);Georgi, B.(3);Tian, S.(2);Cairns, J.(3);Angermann, B.(3);Khan, E.(4);Nys, J.(5);Marks, D.(6);
(1)AstraZeneca, Translational Science & Experimental Medicine- Early Respiratory & Immunology, Mölndal, Sweden;(2)AstraZeneca, Translational Science & Experimental Medicine, Cambridge, United Kingdom;(3)AstraZeneca, Translational Science & Experimental Medicine, Mölndal, Sweden;(4)AstraZeneca, Late Clinical Development, Cambridge, United Kingdom;(5)AtraZeneca, Bioscience Asthma, Cambridge, United Kingdom;(6)AstraZeneca, Early Clinical Development, Cambridge, United Kingdom;
P083: JAK/STAT pathway and IL-6 activity in moderate to severe Ulcerative ColitisECCO’23 CopenhagenYear: 2023
Authors: Calviño Suárez, C.(1)*;Martinez-Rodriguez, A.L.(2);Baston-Rey, I.(1);Moreira-Alvarez, D.(2);Ferreiro-Iglesias, R.(1);Ardao-Palacios, I.(2);de la Iglesia-Garcia, D.(1);Porto-Silva, S.(1);Nieto-Garcia, L.(1);Varela-Liste, M.J.(2);Brea-Floriani, J.M.(2);Dominguez-Munoz, J.E.(1);Loza-Garcia, M.(2);Barreiro-de Acosta, M.(1);
(1)University Hospital Santiago De Compostela CHUS, Department of Gastroenterology- IBD Unit, Santiago De Compostela, Spain;(2)BioFarma Research Group- CIMUS Research Center and IDIS Health Research Institute, Department of Pharmacology, Santiago De Compostela, Spain;
P084: Response to appendectomy in refractory Ulcerative Colitis appears based on two distinct inflammatory phenotypesECCO’23 CopenhagenYear: 2023
Authors: Beckerdrs., M.(1)*;Heuthorst, L.(2);van Roest, M.(1);van der Bilt, J.(3);Buskens, C.(2);Wildenberg, M.(1);
(1)Tytgat Institute for Liver and Intestinal Research, Gastroenterology and Hepatology, Amsterdam, The Netherlands;(2)Amsterdam UMC, Surgery, Amsterdam, The Netherlands;(3)Flevoziekenhuis, Surgery, Almere, The Netherlands;
P085: Gut microbiota profile changes in patients with Ulcerative ColitisECCO’23 CopenhagenYear: 2023
Authors: Inčiūraitė, R.(1)*;Gedgaudas, R.(1);Lukosevicius, R.(1);Plingyte, K.(1);Muskieta, T.(1);Juzenas, S.(1);Kupcinskas, J.(1);Skieceviciene, J.(1);
(1)Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania;
P087: Calcitonin gene related peptide beta (CGRPβ): a new player in inflammatory bowel disease pathophysiologyECCO’23 CopenhagenYear: 2023
Authors: Pascual, M.(1)*;Gárate, G.(2);Serrano, M.S.(3);García García, M.J.(1);Castro, B.(3);González Quintanilla, V.(2);Crespo, J.(1);Pascual, J.(2);Rivero, M.(1);
(1)Marqués de Valdecilla University Hospital- Universidad de Cantabria- Instituto de Investigación Valdecilla IDIVAL, Gastroenterology and Hepatology, Santander, Spain;(2)Marqués de Valdecilla University Hospital- Universidad de Cantabria- Instituto de Investigación Valdecilla IDIVAL, Neurology, Santander, Spain;(3)Marqués de Valdecilla University Hospital- Instituto de Investigación Valdecilla IDIVAL, Gastroenterology and Hepatology, Santander, Spain;
P088: Restoration of gut microbiota and changes in inflammatory susceptibility by dextran sulfate sodium after antibiotic treatment in miceECCO’23 CopenhagenYear: 2023
Authors: Jeong, E.S.(1)*;Bae, S.(1);Song, E.M.(2);Byeon, J.R.(2);Lee, A.(1);Choe, A.R.(2);Hong, J.T.(1);Park, Y.H.(2);Tae, C.H.(2);Moon, C.M.(1);Jung, H.K.(1);Shim, K.N.(2);Jung, S.A.(2);Kim, S.E.(1);
(1)Ewha Womans University Mokdong Hospital, Internal medicine, Seoul, Korea- Republic Of;(2)Ewha Womans University Seoul Hospital, Internal Medicine, Seoul, Korea- Republic Of;
P089: Colonic explant lactate concentration and inflammatory protein secretion in ulcerative colitisECCO’23 CopenhagenYear: 2023
Authors: McShane, C.(1,2)*;Corcoran, R.(1,3);O'Connell, F.(2);McDonagh, P.(1);O'Sullivan, J.(2);Kevans, D.(1);
(1)St. James's Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity Translational Medicine Institute, Department of Surgery, Dublin, Ireland;(3)Trinity Translational Medicine Institute, Department of Gastroenterology, Dublin, Ireland;
P090: Low-density neutrophils are higher in individuals with active ulcerative colitisECCO’23 CopenhagenYear: 2023
Authors: Mendieta Escalante, E.A.(1)*;Dijkstra, G.(1);Faber, K.N.(1);Yamamoto Furusho, J.K.(2);Barrera-Vargas, A.(3);Torres-Ruiz, J.J.(4);Merayo-Chalico, F.(3);
(1)University Medical Center of Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(2)National Institute of Medical Sciences and Nutrition Salvador Zubirán, Inflammatory Bowel Disease Clinic, Mexico City, Mexico;(3)National Institute of Medical Sciences and Nutrition Salvador Zubirán, Rheumatology, Mexico City, The Netherlands;(4)National Institute of Medical Sciences and Nutrition Salvador Zubirán, Rheumatology, Mexico City, Mexico;
