P051: Immune phenotypes in acute severe ulcerative colitisECCO’23 CopenhagenYear: 2023
Authors: Meringer, H.(1)*;Canales-Herrerias, P.(2);Jha, D.(2);Livanos, A.(2);Jougon, J.(2);Cossarini, F.(3);Tankelevich, M.(2);Kayal, M.(2);Colombel, J.F.(2);Mehandru, S.(2);
(1)Assuta Ashdod medical center affiliated with Ben-Gurion university- Beer Sheva, Department of Gastroenterology and liver diseases, Ashdod, Israel;(2)Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, United States;(3)Icahn School of Medicine at Mount Sinai, Department of Infectious Diseases, New York, United States;
P053: Ustekinumab decreases circulating Th1, Th17, and MAIT cells in Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Lord, J.(1)*;Konecny, A.(2);Shows, D.(1);
(1)Benaroya Research Institute, Translational Research, Seattle, United States;(2)University of Washington, Immunology, Seattle, United States;
P054: Secreted inflammatory protein profiles following treatment of ex-vivo human inflammatory bowel disease explants with licenced biologic therapiesECCO’23 CopenhagenYear: 2023
Authors: Corcoran, R.(1)*;O'Connell, F.(2);O'Sullivan, J.(2);Kevans, D.(3);
(1)St James's Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity College Dublin, Trinity Translational Medicine Institute, Dublin, Ireland;(3)St James's Hospital, Department of Gastroenterology, Dublin, Ireland;
P056: Exposures linked with urban and rural living indicate that living in rural area but spending above 50% of daily-life in urban environment is linked with reduction in alpha-diversity, reduced rural index, and reduced microbial health index mirroring CD profileECCO’23 CopenhagenYear: 2023
Authors: Haberman Ziv, Y.(1)*;Feng, R.(2);Mao, R.(2);Braun, T.(1);Zhuo, S.(2);Toren, I.(1);Efroni, G.(1);Malik, A.(3);Picard, O.(3);Yavzori, M.(3);Hadar, R.(1);Amir, A.(1);Chen, M.(2);Ben-Horin, S.(3);
(1)Sheba Medical Center, Pediatric Gastroenterology, Ramat Gan, Israel;(2)The First Affiliated Hospital- Sun Yat-Sen University, Gastroenterology, Guangzhou, China;(3)Sheba Medical Center, Gastroenterology, Ramat Gan, Israel;The Leona M. and Harry B. Helmsley Charitable Trust SOURCE consortium investigators
P057: Development and evaluation of the i-Tracker Certolizumab and i-Tracker Anti-Certolizumab kits: rapid and innovative tests intended for monitoring patients treated with Certolizumab.ECCO’23 CopenhagenYear: 2023
Authors: Khater, G.(1)*;Noguier, G.(2);Daviere, S.(1);Guilbert, V.(2);Montaillier, C.(2);
(1)Theradiag, Theranostic, Croissy Beaubourg, France;(2)Theradiag, Research & Development, Croissy Beaubourg, France;
P058: Immunological effects of hepatitis B virus vaccination in inflammatory bowel disease patientsECCO’23 CopenhagenYear: 2023
Authors: Soleto, I.(1)*;C. Marin, A.(1);Mora, I.(1);Villagrasa, J.R.(2);Baldan-Martin, M.(1);Ramírez, C.(1);Bernardo, D.(3);Chaparro, M.(1);P. Gisbert, J.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd- Madrid. Spain, gastrointestinal unit, Madrid, Spain;(2)Hospital Universitario de La Princesa, Unidad de medicina preventiva, Madrid, Spain;(3)Mucosal Immunology Lab- instituto de Biología y Genética Molecular IBGM- Universidad de Valladolid-CISC- Valladolid- Spain, Mucosal Immunology Lab, Valladolid, Spain;
P059: Klebicin as a novel therapy for Klebsiella infection managementECCO’23 CopenhagenYear: 2023
Authors: Karaliute, I.(1)*;Tilinde, D.(1);Ramonaite, R.(1);Kupcinskas, J.(2);Misiunas, A.(3);Denkovskiene, E.(3);Gleba, Y.(4);Razanskiene, A.(3);Skieceviciene, J.(1);
(1)Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania;(2)Lithuanian University of Health Sciences, Department of Gastroenterology, Kaunas, Lithuania;(3)Nomads UAB, Nomads UAB, Vilnius, Lithuania;(4)Biozentrum Halle, Nomad Bioscience GmbH, Halle, Germany;
P060: Restoration of occludin and claudin-1 expression in patients with Crohn's disease receiving anti-TNF treatment.ECCO’23 CopenhagenYear: 2023
Authors: Tsounis, E.(1);Geramoutsou, C.(2);Aggeletopoulou, I.(1,3);Lourida, T.(1);Pastras, P.(1);Theocharis, G.(1);Diamantopoulou, G.(1);Zolota, V.(4);Assimakopoulos, S.F.(5);Bravou, V.(2);Thomopoulos, K.(1);Triantos, C.(6)*;
(1)University Hospital of Patras, Division of Gastroenterology- Department of Internal Medicine, Patras, Greece;(2)University of Patras, Department of Anatomy-Histology-Embryology- Medical School, Patras, Greece;(3)University of Patras, Division of Hematology- Department of Internal Medicine- Medical School, Patras, Greece;(4)University of Patras, Department of Pathology- Medical School, Patras, Greece;(5)University of Patras, Division of Infectious Diseases- Department of Internal Medicine- Medical School, Patras, Greece;(6)University Hospital of Rio Patras, Department of Gastroenterology, Patras, Greece;
P061: Response to anti-α4β7 therapy in Ulcerative colitis is associated with lymphoid aggregate attrition through impaired recruitment of naïve lymphocytesECCO’23 CopenhagenYear: 2023
Authors: Canales-Herrerias, P.(1)*;Uzzan*, M.(1);Seki*, A.(1);Czepielewski, R.S.(2);Verstockt, B.(3);Dunn, A.(1);Dai, D.(1);Ko, H.M.(4);Furtado, G.C.(5);Tokuyama, M.(1);Tankelevich, M.(1);Meringer, H.(1);Cossarini, F.(1);Jha, D.(1);Paulsen, J.D.(6);Nakadar, M.Z.(6);Wong, J.(6);Sharma, K.(1);Rosenstein, A.(1);Dawson, T.(7);Singh, H.(1);Lim, J.(8);Lira, S.A.(5);Yajnik, V.(9);Reboldi, A.(10);Petralia, F.(11);Vermeire, S.(3);Polydorides, A.D.(6);Randolph, G.J.(2);Colombel , J.F.(1);Mehandru, S.(1);
(1)Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, United States;(2)Washington University School of Medicine, Pathology & Immunology, St. Louis, United States;(3)University Hospitals Leuven, Gastroenterology and Hepatology, Leuven, Belgium;(4)Columbia University, Pathology, New York, United States;(5)Icahn School of Medicine at Mount Sinai, Immunology, New York, United States;(6)Icahn School of Medicine at Mount Sinai, Pathology- Molecular and Cell Based Medicine, New York, United States;(7)Icahn School of Medicine at Mount Sinai, Human Immune Monitoring Center, New York, United States;(8)Icahn School of Medicine at Mount Sinai, Microbiology, New York, United States;(9)Takeda Pharmaceuticals, Gastroenterology, Boston, United States;(10)UMass Chan Medical School, Pathology, Worcester, United States;(11)Icahn School of Medicine at Mount Sinai, Genetics and Genomic Sciences, New York, United States;
P062: Antibody responses to SARS-CoV-2 vaccination outperform responses induced by natural infection in patients with IBD receiving immunosuppressive medications: a report from the ICARUS-IBD consortium.ECCO’23 CopenhagenYear: 2023
Authors: González Cueto, E.(1)*;Matthew, E.(1);Wellens, J.(2,3);Martinez Pazos, V.(4);Thompson, C.(5);Klenerman, P.(1,3);Cadwell, K.(6);Colombel, J.F.(4);Satsangi, J.(3);Wong, S.Y.(4);
(1)Oxford University, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom;(2)University Hospitals Leuven- KU Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(3)Oxford University- Translational Gastro-Intestinal Unit, Nuffield Department of Medicine, Oxford, United Kingdom;(4)Icahn School of Medicine at Mount Sinai, The Henry D. Janowitz Division of Gastroenterology, New York, United States;(5)Warwick Medical School- University of Warwick, Division of Biomedical Sciences, Coventry, United Kingdom;(6)University of Pennsylvania-Perelman School of Medicine, Division of Gastroenterology- Department of Medicine, Philadelphia, United States;ICARUS-IBD consortium
P063: Host-mycobiome interactions during the resolution of inflammation in experimental colitisECCO’23 CopenhagenYear: 2023
Authors: De Salvo, C.(1)*;Wargo, H.(1);Vidmar, K.(1);Di Martino, L.(2);Mahabaleshwar, G.(1);Cominelli, F.(2);Ghannoum, M.(2);Pizarro, T.(1);
(1)Case Western Reserve University- School of Medicine, Pathology, Cleveland, United States;(2)Case Western Reserve University- School of Medicine, Digestive Health Research Institute, Cleveland, United States;
P064: High intestinal Secretory Leukocyte Protease Inhibitor (SLPI) expression correlates with abundant neutrophilic inflammation and identifies Inflammatory Bowel Disease patients with a strong IL-17 response.ECCO’23 CopenhagenYear: 2023
Authors: Nugteren, S.(1);Calado, B.(1)*;Simons-Oosterhuis, Y.(1);H. Hulleman-van Haaften, D.(1);Klomberg, R.(2);Tuk, B.(1);Charrout, M.(3);J. Lindenbergh-Kortleve, D.(1);K. Smits, W.(1);Doukas, M.(4);A. Sanders, M.(5);van Beek, G.(5);C. Escher, J.(2);de Ridder, L.(2);N. Samsom, J.(1);
(1)Erasmus University Medical Center, Department of Pediatrics- division Gastroenterology and Nutrition, Rotterdam, The Netherlands;(2)Sophia Children's Hospital-Erasmus University Medical Center, Department of Pediatric Gastroenterology, Rotterdam, The Netherlands;(3)Delft University of Technology, Delft Bioinformatics Lab, Delft, The Netherlands;(4)Erasmus University Medical Center, Department of Pathology, Rotterdam, The Netherlands;(5)Erasmus University Medical Center, Department of Hematology- division Bioinformatics, Rotterdam, The Netherlands;
P065: Altered B cell expansion and maturation in Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Kappel-Latif, S.(1);Kotagiri, P.(2);Schuld, G.(1);Schlager, L.(1);Walterskirchen, N.(1);Schimek, V.(1);Jobst, J.(1);Murthy, S.(3);Messner, B.(4);Lyons, P.A.(2);Oehler, R.(1);Bergmann, M.(1);Stift, A.(1);Unger, L.(5)*;
(1)Medical University of Vienna, Dept. of General Surgery, Vienna, Austria;(2)University of Cambridge, Jeffrey Cheah Biomedical Center- Department of Medicine, Cambridge, United Kingdom;(3)Medical University of Vienna, Clinical Institute of Laboratory Medicine, Vienna, Austria;(4)Medical University of Vienna, Dept. of Cardiac Surgery, Vienna, Austria;(5)Medical University of Vienna, Dept. of General Surgery- Div. of Visceral Surgery, Vienna, Austria;
P066: ON104, a novel bioengineered antibody targeting oxidized Macrophage Migration Inhibitory Factor (oxMIF) shows efficacy in two distinct models of experimental colitisECCO’23 CopenhagenYear: 2023
Authors: Ferhat, M.(1)*;Mangano, K.(2);Nicoletti, F.(2);Landlinger, C.(1);Michael, T.(1);
(1)OncoOne, Research & Development GmbH, Vienna, Austria;(2)University of Catania, Department of Biomedical and Biotechnological Sciences, Catania, Italy;
P067: Fractal analysis of extracellular matrix as a new histological method for observer-independent quantification of intestinal fibrosis in Crohn's DiseaseECCO’23 CopenhagenYear: 2023
Authors: Weber, M.C.(1)*;Schmidt, K.(1);Buck, A.(1);Kasajima, A.(2);Becker, S.(3);Wilhelm, D.(1);Friess, H.(4);Neumann, P.A.(1);
(1)Klinikum rechts der Isar- Technical University of Munich, Department of Surgery, Munich, Germany;(2)Klinikum rechts der Isar- Technical University of Munich, Insitute of Pathology, Munich, Germany;(3)ETH Zurich, Department of Mathematics, Zurich, Switzerland;(4)Klinikum rechst der Isar- Technical University of Munich, Department of Surgery, Munich, Germany;
P068: Polyunsaturated fatty acid excess fuels pro-inflammatory transcriptional networks in GPX4 deficient intestinal epithelial cellsECCO’23 CopenhagenYear: 2023
Authors: Meyer, M.(1)*;Grabherr, F.(1);Schwärzler, J.(1);Mayr, L.(1);Jukic, A.(1);Rao, Z.(2);Rieder, D.(3);Zollner, A.(1);Grander, C.(1);Trajanoski, Z.(3);Koeberle, A.(2);Tilg, H.(1);Adolph, T.E.(1);
(1)Medical University of Innsbruck, Department of Internal Medicine I- Gastroenterology- Hepatology- Endocrinology & Metabolism, Innsbruck, Austria;(2)University of Innsbruck, Michael Popp Research Institute, Innsbruck, Austria;(3)Medical University of Innsbruck, Biocenter- Institute of Bioinformatics, Innsbruck, Austria;
P069: Elevated adaptive immune responses to multiple Lachnospiraceae bacterial flagellins in therapy-naïve pediatric CD patients are associated with distinct immune pathology.ECCO’23 CopenhagenYear: 2023
Authors: Barendregt, D.(1)*;Joosse, M.E.(1);Alexander, K.L.(2);Costes, L.M.M.(1);Tindemans, I.(1);Simons-Oosterhuis, Y.(1);Aardoom, M.A.(3);Klomberg, R.C.W.(3);Heredia, M.(1);Hulleman- van Haaften, D.H.(1);Tuk, B.(1);Nugteren, S.(1);Doukas, M.(4);Escher, J.C.(3);de Ridder, L.(3);Elson, C.O.(2);Samsom, J.N.(1);
(1)Erasmus University Medical Center-Sophia Children's Hospital, Laboratory of Pediatrics division Gastroenterology and Nutrition, Rotterdam, The Netherlands;(2)University of Alabama at Birmingham, Department of Medicine division of Gastroenterology and Hepatology, Birmingham AL, United States;(3)Erasmus University Medical Center-Sophia Children's Hospital, Department of Pediatric Gastroenterology, Rotterdam, The Netherlands;(4)Erasmus University Medical Center, Department of Pathology, Rotterdam, The Netherlands;
P070: Global cytokine—cytokine interaction framework to uncover communication channels between elements of the immune systemECCO’23 CopenhagenYear: 2023
Authors: Olbei, M.(1)*;Modos, D.(2,3);Cozzetto, D.(1);Powell, N.(1);Korcsmaros, T.(1,2,3);
(1)Imperial College London, Division of Digestive Diseases- Department of Metabolism- Digestion and Reproduction, London, United Kingdom;(2)Quadram Institute Bioscience, Systems Biology of Gut-Microbe Interactions, Norwich, United Kingdom;(3)Earlham Institute, Organisms and Ecosystems, Norwich, United Kingdom;
